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31.
Norimasa Nomi Naoyuki Morishige Naoyuki Yamada Tai-ichiro Chikama Teruo Nishida 《Japanese journal of ophthalmology》2008,52(6):440-443
Background We describe two severe cases of methicillin-resistant Staphylococcus aureus (MRSA) keratitis following Epi-LASIK surgery.
Cases One patient was a 23-year-old man who underwent Epi-LASIK surgery in both eyes. He developed an infectious corneal ulcer in
one eye 2 days after surgery and was referred to us 7 days post-surgery with corneal perforation, for which we performed therapeutic
penetrating keratoplasty. The other patient was a 32-year-old man who developed infectious keratitis in one eye 4 days after
bilateral Epi-LASIK and was referred to us 2 days later.
Observations Microbial testing revealed MRSA infection as the cause of the keratitis in both patients which was successfully treated with
vancomycin eyedrops.
Conclusion Infectious keratitis after refractive surgery is uncommon; it is important to diagnose this condition, identify the causative
agent, and initiate treatment with appropriate antibiotics as soon as possible. 相似文献
32.
The EEC syndrome 总被引:1,自引:0,他引:1
33.
M J O'Connell Z J Chen H Yang M Yamada M Massaro A Mittelman S Ferrone 《Seminars in surgical oncology》1989,5(6):441-447
Tumor-associated antigens (TAA) provide appropriate targets for selective manipulation of the patient's immune response in the immunotherapy of cancer. Active specific immunotherapy utilizing antiidiotypic antibodies to anti-TAA antibodies has been implemented in phase I clinical trials both in patients with colorectal carcinoma and in those with melanoma. The theoretical basis for immunotherapy with antiidiotypic antibodies, the results of these clinical trials, and an evaluation of appropriate parameters for future clinical trials of active specific immunotherapy with antiidiotypic antibodies in patients with solid tumors are reviewed. 相似文献
34.
E G Elias A Mittelman W Wieckowska S Shapiro R Jones 《Journal of surgical oncology》1969,1(3):261-271
The syndrome of rheumatoid arthritis, splenomegaly, leukopenia, and neutropenia is rare. When it occurs, it could become complicated by infection that does not respond to antibiotics and steroid therapy. We feel that splenectomy should be carried out once the diagnosis of Felty's syndrome is made. In the presence of infection, prompt splenectomy should be done, even if the patient shows signs of systemic toxicity. Splenectomy is the most beneficial treatment and may prevent a fatal outcome in these cases. Splenectomy is usually followed by immediate hematologic response. Steroid therapy may alter the arthritic symptoms but has no effect in altering or controlling the infection in these cases, even if accompanied by antibiotic therapy. Radiation of the spleen may reduce its size, but does not prevent or control the infections in patients with Felty's syndrome. 相似文献
35.
Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection 总被引:6,自引:0,他引:6
Kashizuka H Sho M Nomi T Ikeda N Kuzumoto Y Akashi S Tsurui Y Mizuno T Kanehiro H Yagita H Nakajima Y Sayegh MH 《Transplantation》2005,79(9):1045-1050
BACKGROUND: Inducible costimulator (ICOS) is the third member of the CD28 superfamily and has a unique role in T cell activation and function. Recent studies indicated that the ICOS-B7h pathway plays an important role in alloimmune responses. We further investigated the role of the ICOS pathway in the pathologic process of chronic rejection in vivo. METHODS: An established major histocompatibility complex class II disparate cardiac transplantation model was used. We treated mice with a blocking anti-B7h monoclonal antibody (mAb) either in the initiation phase (early blockade) or in the progression phase (delayed blockade) of disease. In addition, some mice received mAb in the entire period (whole blockade). At 6 weeks after transplantation, cardiac grafts were evaluated by histopathologic analysis in terms of vasculopathy, fibrosis, and cellular infiltration. The intragraft expressions of cytokines and chemokines were also examined by quantitative real-time polymerase chain reaction analysis. RESULTS: Early blockade of the ICOS-B7h pathway did not show any protective effect on chronic allograft rejection compared with untreated controls. In contrast, delayed blockade significantly inhibited the development of vasculopathy, fibrosis, and cellular infiltration (P=0.043, P=0.004, and P=0.03 vs. untreated control, respectively). Interestingly, whole blockade did not prevent the chronic rejection process. Furthermore, the inhibitory effect of delayed ICOS blockade on chronic rejection was associated with down-regulation of local intragraft expression of several cytokines and chemokines. CONCLUSIONS: These data suggest that the ICOS-B7h pathway is critical in the activation of effector/memory T cells that are necessary for the progression of chronic rejection and provide the rationale to develop novel and specific therapies to prevent this process. 相似文献
36.
Sho M Akashi S Kanehiro H Hamada K Kashizuka H Ikeda N Nomi T Kuzumoto Y Tsurui Y Yoshiji H Wu Y Hicklin DJ Briscoe DM Nakajima Y 《Transplantation》2005,80(6):717-722
BACKGROUND: We have recently reported that vascular endothelial growth factor (VEGF) functions as a proinflammatory cytokine to regulate the trafficking of leukocytes into allografts in the early posttransplant period. VEGF binds two major VEGF receptors: VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR). Here, we wished to investigate the expression and function of VEGF receptors in the process of acute allograft rejection in vivo. METHODS: We performed fully MHC-mismatched C57BL/6 (H-2b) into BALB/c (H-2d) vascularized heterotopic murine cardiac transplants and we examined the expression of VEGF and VEGF receptors by immunohistochemistry during acute allograft rejection. Next, we treated mice with specific neutralizing monoclonal antibodies against murine VEGFR-1 and VEGFR-2 and examined their effect on the development of acute allograft rejection by histology and by analysis of graft survival. The intragraft expression of cytokines and chemokines were also evaluated by quantitative real-time PCR analysis. RESULTS: The expression of VEGF, VEGFR-1 and VEGFR-2 were significantly up-regulated during allograft rejection as compared to isografts. Administration of either anti-VEGFR-1 or anti-VEGFR-2 alone failed to inhibit allograft rejection. However, coadministration of both antibodies together inhibited leukocyte infiltration of allografts and prolonged allograft survival. Furthermore, the effect of VEGFR blockade was associated with the downregulation of intragraft cytokine and chemokine expression. CONCLUSIONS: Our data suggest that VEGF-VEGFR interactions function in the alloimmune response in vivo. Targeting VEGFRs may represent a novel therapy to protect allografts following clinical transplantation. 相似文献
37.
P F Engstrom J M MacIntyre H O Douglass F Muggia A Mittelman 《American journal of clinical oncology》1983,6(2):175-180
Two hundred thirty-two patients with advanced measurable colorectal cancer previously treated with 5-fluorouracil (5-Fu) were randomized to one of the following treatments: A) semustine (MeCCNU) plus vincristine (VCR); B) MeCCNU plus dacarbazine (DTIC); C) MeCCNU plus DTIC plus VCR; D) MeCCNU plus beta-2'-deoxythioguanosine (beta-TGdR). Platelet nadirs less than 50,000/mm3 were noted in 9% (Treatment A) to 19% (D) of the patients while WBC nadirs less than 2,000/mm3 were noted in 7% (B) to 12% (C,D) of the patients. Severe vomiting was noted in 2% (D) to 14% (B) of the patients. The partial response rates and median survival times from date of randomization were as follows: Treatment A: 3/54 (6%), 19 weeks; B: 9/59 (16%), 28 weeks; C: 3/60 (5%), 25 weeks; D: 2/59 (4%), 19 weeks. Differences in response rate and median survival are not statistically significant. 相似文献
38.
Nils Wilking Nicholas Petrelli Lemuel Herrera Arnold Mittelman 《Cancer chemotherapy and pharmacology》1985,15(3):300-302
Summary Fifteen patients with advanced squamous cell carcinoma of the anal canal were treated with a combination of bleomycin, vincristine, and high-dose methotrexate (BOM) with leucovorin rescue. Three out of twelve patients with measurable disease had objective responses of 1, 2, and 5 months. Five of the fifteen patients had severe or life-threatening complications as a result of this treatment regimen. The narrow therapeutic index of the BOM therapy makes it a less than ideal drug combination for the treatment of advanced squamous cell carcinoma of the anal canal.Aided by Grant JFCF 793, American Cancer Society, New York, New York 相似文献
39.
CONCLUSIONS: These results indicate that extensive, multiple cervical micrometastases occurred from an early stage in patients with T2N0 tongue cancer. The presence of micrometastases suggests the necessity of preventive neck dissection for Level I-IV nodes as a radical treatment. OBJECTIVE: Cervical lymph node metastases occur with a relatively high frequency in patients with T2N0 squamous cell carcinoma of the tongue, and control of the metastases greatly influences the prognosis of patients. In this study, micrometastases in the cervical lymph nodes were investigated to clarify the necessity and required extent of preventive neck dissection. MATERIAL AND METHODS: We investigated micrometastases in 24 subjects who had previously been diagnosed with T2N0 tongue cancer. We performed immunostaining with anti-cytokeratin antibody cocktail AE1/AE3 of sections of 401 paraffin-embedded lymph nodes obtained from these patients. RESULTS: Micrometastases were observed in 14 patients (58%) and were most abundant in Level II nodes (n=11; 46%). Micrometastases were observed in the Level IV nodes of 3 patients (13%), and upstaging to pN2b occurred in 7 patients (29%). 相似文献
40.