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排序方式: 共有474条查询结果,搜索用时 15 毫秒
71.
72.
Zhongwei Jia PhD Yurong Mao Fujie Zhang Prof Yuhua Ruan Ye Ma Jian Li Wei Guo Enwu Liu Zhihui Dou Yan Zhao Lu Wang Qianqian Li Houlin Tang Jing Han Xia Jin Juan Xu Ran Xiong Decai Zhao Ping LiXia Wang MPH Liyan Wang Qianqian Qing Zhengwei Ding Ray Y Chen Prof Zhongfu Liu Prof Yiming Shao 《Lancet》2013
73.
Therapeutic efficacy of an antibiotic-loaded nanosheet in a murine burn-wound infection model 总被引:1,自引:0,他引:1
Saito A Miyazaki H Fujie T Ohtsubo S Kinoshita M Saitoh D Takeoka S 《Acta biomaterialia》2012,8(8):2932-2940
Polymeric ultra-thin films (nanosheets) possess unique properties that make them suitable materials for various biomedical applications. In our previous study, we assessed the use of an antibiotic (tetracycline, TC)-loaded nanosheet (or "TC-nanosheet") for the treatment of gastrointestinal tissue defects. The nanosheet consisted of three functional layers: layer-by-layer nanosheet as a stable platform, TC as an antimicrobial agent with autofluorescence for tracing, and a poly(vinyl acetate) nanosheet to act as a protecting layer. The TC-nanosheet has high flexibility, adhesive strength and transparency. Here, we evaluated the effectiveness of the TC-nanosheet in preventing full thickness burn-wound infections. In an in vivo study, murine dorsal skin was injured by full-thickness burns and then infected with Pseudomonas aeruginosa (P. aeruginosa), a common bacterium causing burn-associated infections. The wound site was treated either with a TC-nanosheet, TC-unloaded nanosheet or left untreated. Wound management was facilitated by the high transparency of the TC-nanosheet. The TC-nanosheet significantly improved burn-wound infection by P. aeruginosa in mice. Indeed, all mice treated with the TC-nanosheet survived, whereas the other treatment groups displayed increased rates of mortality due to bacterial infection. According to histological analyses and viable bacterial counting in the liver (bacterial translocation), the TC-nanosheets were able to prevent not only the local inflammation but also systemic inflammation. We conclude that the TC-nanosheet can act as an effective treatment for full-thickness burn-wound infection. Hence, the TC-nanosheet is a promising therapeutic tool for burn-wound management in severely burn-injured patients. 相似文献
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75.
Nakayama T Nabatame S Saito Y Nakagawa E Shimojima K Yamamoto T Kaneko Y Okumura K Fujie H Uematsu M Komaki H Sugai K Sasaki M 《Seizure》2012,21(4):295-299
We describe two individuals with the same chromosomal aberrations derived from an unbalanced translocation between chromosomes 8p and 9p, who presented with intellectual disabilities, dysmorphic features, and localization-related epilepsy. Several years after the onset of epilepsy, aggravation of widespread epileptic discharges during sleep resulted in the emergence of absence and/or atonic seizures in both patients; one patient additionally presented with psychomotor deterioration. These symptoms completely disappeared after treatment with ethosuximide and benzodiazepines, and marked improvement was observed in electroencephalographic findings. We review the clinical features of der(8)t(8;9) with particular focus on epileptic complications. We conclude that particular types of chromosomal aberrations may have a propensity to develop the condition categorized as electrical status epilepticus in sleep. 相似文献
76.
77.
Maruta T Tateishi M Fujie Y Maruta N Yamauchi K Yano T Kawano T Tsuneyoshi I 《Masui. The Japanese journal of anesthesiology》2011,60(7):862-865
We experienced anesthesia and perioperative management for hysterectomy in a patient with acquired angioedema. Angioedema due to C1 esterase inhibitor (C1-INH) deficiency (loss or dysfunction of C1-INH) is one of the rarest diseases, and is characterized by recurrent episodes of regional hard edema and ascites induced by mechanical stimuli or mental stress. Edema spreads to the subcutaneous and submucosal layer, and laryngeal edema may cause the upper airway obstruction. Tranexamic acid and C1-INH concentrates were administered perioperatively for prophylaxis of attacks, and combined spinal and epidural anesthesia was performed for hysterectomy. We could manage perioperative care without causing edema. 相似文献
78.
Taichi Kanetaka Ken-ichi Nishimura Tomo Nozawa Masako Kikuchi Nodoka Sakurai 《Modern rheumatology / the Japan Rheumatism Association》2016,26(3):362-367
Objective: To examine and delineate inflammatory focus in patients with juvenile idiopathic arthritis (JIA), 18F-Fluoro-deoxy-glucose (FDG)-positron emission tomography (PET) (18F-FDG-PET) was applied to patients with JIA, and the images of these patients were compared.Methods: Sixty-eight children (59 with systemic JIA (s-JIA) and 9 with polyarticular JIA) were included. The diagnosis of JIA was done to meet the International League of Associations for Rheumatology (ILAR) criteria. After 6-h fasting, whole-body positron emission tomography (PET) scans were acquired 60 min after intravenous injection of 3–5 MBq/kg 18F-FDG. The interpretation of 18F-FDG uptake was based on visual characteristics.Results: Two types of PET images were outstanding in s-JIA; one was 18F-FDG uptake in red bone marrow, such as the spine, pelvis, and long bones as well as spleen (12 cases), and other type was the uptake in the major joints, such as hips, elbows, wrists, knees, and ankles (8 cases). The former findings were correlated with elevated levels of inflammatory markers, while the latter were with significantly increased levels of MMP-3 (p?<?0.05).Conclusion: There was a noticeable accumulation of 18F-FDG uptake in bone marrow of s-JIA patients which may indicate the inflammatory focus of this disease and play an important role in the pathogenic basis of arthritis and systemic inflammation of s-JIA. 相似文献
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Eifuku R Yoshino I Imahayashi S Fujie H Takenoyama M Yoshimatsu T Hanagiri T So T Ichiyoshi Y Nomoto K Yasumoto K 《Breast cancer (Tokyo, Japan)》1998,5(4):367-373
Background In this study we activated breast cancer-specific cytotoxic T lymphocytes (CTL) from regional lymph node lymphocytes (RLNL)
of HLA-A2-positive patients with breast cancer.
Melthods Freshly isolated RLNL were stimulated with solid phase anti-CD3 monoclonal antibody followed by expansion with recombinant
interleukin-2. Subsequently, the RLNL were stimulated with an irradiated HLA 0201 breast cancer cell line, MCF-7, at a responder/stimulator
ratio of 10/1 once a week for 2 weeks.
Results The cultured RLNL exhibited specific lysis against MCF-7 in all 5 HLA-A2-positive patients tested, but not in 2 HLA-A2-negative
patients. Cytotoxicity against MCF-7 was substantially inhibited by addition of anti-HLA-A2 mAb. In 3 of 5 HLA-A2-positive
patients, anti-MCF-7 CTL also exhibited a substantial level of reactivity against PC-9, an HLA-A0206-positive lung adenocarcinoma
cell line. Conversely, anti-PC-9-specific CTL were inducible by multiple stimulations of RLNL with PC-9 cells in 2 of 3 patients.
Conclusions These results suggest that several common tumor antigens might exist among HLA-A2-positive breast cancers, some of which may
be shared with lung adenocarcinomas. 相似文献