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991.
Tsutomu Nakamura Toshiyuki Sakaeda Nobuko Ohmoto Takao Tamura Nobuo Aoyama Toshiro Shirakawa Takashi Kamigaki Takeshi Nakamura Ke Ih Kim Soo Ryang Kim Yoshikazu Kuroda Masafumi Matsuo Masato Kasuga Katsuhiko Okumura 《Drug metabolism and disposition》2002,30(1):4-6
The expression levels of mRNAs for MDR1 (P-glycoprotein), multidrug resistance-associated proteins (MRP1, MRP2), and cytochrome P450 3A (CYP3A) in Caco-2 cells were quantitatively compared with those in human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas. Caco-2 cells (passages 36-88) were kindly supplied by several laboratories in Japan. Human duodenal enterocytes were obtained from five healthy male volunteers. Normal colorectal tissues and colorectal adenocarcinomas were simultaneously obtained from seven patients with primary colorectal adenocarcinoma. MDR1, MRP1, MRP2, and CYP3A mRNA levels were determined by real-time quantitative polymerase chain reactions (PCR). Relative concentrations of mRNAs for target proteins (MDR1, MRP1, MRP2, and CYP3A) and glyceraldehyde-3-phosphate dehydrogenase in Caco-2 cells were 1.00 +/- 0.15, 1.02 +/- 0.06, 0.94 +/- 0.10, and 0.68 +/-0.60, respectively, and those in human enterocytes were about 12-, 3-, 7-, and 8000-fold higher than in the Caco-2 cells, respectively. In contrast, MDR1, MRP1, and CYP3A mRNA levels in Caco-2 cells were comparable to those in normal colorectal tissue and colorectal adenocarcinoma. 相似文献
992.
H Furue I Urushizaki A Wakui M Nagai S Toriyama H Niitani S Osamura K Ishihara H Sato T Taguchi 《Gan to kagaku ryoho. Cancer & chemotherapy》1987,14(8):2537-2541
We report a clinical study of toxicity and pharmacokinetics of intravenously administered natural interferon-gamma. Twenty three cases with metastatic cancer were given interferon-gamma at doses of 10 X 10(4)-400 X 10(4) IU in single injection. Another twenty three cases were administered at doses of 5 X 10(4)-50 X 10(4) IU/day every day for thirty days. Side effects associated with natural interferon-gamma administration were qualitatively similar to those previously reported for alpha, and beta interferon treatment. After intravenous injection, interferon-gamma was cleared monoexponentially with a short half-life of 120 minutes from the circulation. One case with disseminated thyroid cancer showed minor response. 相似文献
993.
R Ohno S Yokomaku M Okumura T Nagai K Kitaori T Ito T Takeo I Sugiura K Yano Y Ito 《International journal of hematology》1991,54(6):487-493
Forty-one consecutive adult patients with acute myeloid leukemia (AML) were treated with an intensive individualized induction therapy of behenoyl cytarabine, daunorubicin, and 6-mercaptopurine, 29 patients (71%) achieved complete remission (CR). Patients then received three courses of intensive consolidation therapy, including intermediate-dose continuous cytarabine (400 mg/m2, for 5 days) and non-cross resistant drugs such as mitoxantron, etoposide and vincristine. During the course of the consolidation therapy, three patients died of infections and one died of myocardial infarction. Four patients underwent allogeneic bone marrow transplantation. The patients then received six courses of moderately intensive maintenance therapy for 1 year. The predicted 5-year continuing CR and disease-free survival rates of the CR patients were 62% (95% confidence limit, 41% to 83%) and 53% (33% to 73%), respectively. Although the number of patients in this study is small, the present study indicated that it may be possible to cure a fairly large proportion of AML patients by chemotherapy alone, if intensive induction therapy is followed by intensive consolidation therapy. 相似文献
994.
Kanae Muraiso Makoto Hijikata Nobuyuki Kato Kunitada Shimotohno Nobuo Okazaki Showgo Ohkoshi Masashi Uura Shuichi Kaneko Kenichi Kobayashi Masao Omata Hiroo Ohnishi Yasutoshi Mutou Nobu Hattori 《Cancer science》1991,82(8):879-882
Enzyme-linked immunosorbent assay of the core protein of hepatitis C virus (HCV) expressed in E. coli led to detection of the antibody against this virus in patients with chronic hepatitis. Some of the negative results obtained using a different viral protein became positive with this E. coli -expressed viral protein, and were also positive for the viral RNA. Thus, use of the core protein of HCV facilitates accurate detection of HCV infection. 相似文献
995.
Nobuo Takeichi MD Hisao Ito Hideki Okamoto Toshiya Matsuyama Eiichi Tahara Kiyohiko Dohi 《Surgery today》1989,19(6):674-678
A review of ten surgical cases of medullary carcinoma of the thyroid (MCT) demonstrates the usefulness of establishing a preoperative
cytological diagnosis through the immunochemical staining of calcitonin (CT) and CEA in fine-needle aspiration (FNA) biopsy
smears. If MCT is suspected after routinely performing May-Grünwald-Giemsa stained cytology of an FNA biopsy in the outpatient
clinic, then CT and CEA staining is recommended for confirmation of MCT. The advantages of this immunochemical staining include
that it can be carried out in the outpatient clinic within one day and also that it is much less costly than measuring serum
CT and CEA. 相似文献
996.
997.
998.
Kazuto Tsuboi Nobuo Omura Fumiaki Yano Hideyuki Kashiwagi Naruo Kawasaki Yutaka Suzuki Katsuhiko Yanaga 《Esophagus》2009,6(4):237-241
Background
The influence of obesity on the outcome of laparoscopic fundoplication is yet to be determined. Furthermore, results of fundoplication in Japanese patients have not been reported. Accordingly, we examined whether obesity affects the outcome of laparoscopic fundoplication in Japanese patients. 相似文献999.
Dr. Nobuo Inouye 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1912,81(1):118-154
Ohne ZusammenfassungDer Ausdruck Cyste ist hier der Einfachheit halber gebraucht, obwohl er dem richtigen pathologischen Begriffe nicht entspricht. 相似文献
1000.
Effect of three novel K+ channel openers, cromakalim, pinacidil and nicorandil on allergic reaction and experimental asthma. 总被引:1,自引:0,他引:1
The anti-allergic and anti-asthmatic activities of three potassium (K+) channel openers, cromakalim, pinacidil, and nicorandil, were investigated. 1) Forty-eight-hour homologous passive cutaneous anaphylaxis (PCA) in mice was not affected by cromakalim, pinacidil, or nicorandil. Ketotifen significantly inhibited the reaction. 2) Antigen-induced histamine release from sensitized guinea pig lung tissue was not affected by cromakalim, pinacidil or nicorandil (except for 10(-4) M nicorandil). Salbutamol inhibited the release of histamine. 3) Histamine, serotonin and LTC4-induced vasculitis in rat back skin was not affected by any of these three K+ channel openers. 4) Antigen-induced constriction of isolated sensitized guinea pig tracheal muscle was relaxed by each of the K+ channel openers. 5) Constrictions of isolated guinea pig tracheal muscle caused by high potassium, histamine, LTC4, or U-46619 were clearly relaxed by each of the three K+ channel openers. 6) Increases of airway resistance caused by histamine, LTD4, or U-46619 in guinea pigs in vivo were inhibited by administration of each of the three K+ channel openers. 7) Experimental asthma caused by the IgE antibody and antigen system in guinea pigs was inhibited by each of the three K+ channel openers. 相似文献