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121.
AG Sutcliffe SW D'Souza J Cadman B Richards IA McKinlay B Lieberman 《Archives of disease in childhood》1995,72(4):290-293
A cohort of 91 children from cryopreserved embryos and 83 control children who were conceived normally had their development assessed using the Griffiths's scales of mental development. The controls (81 singletons and two twins) of a similar age, sex, and social class were selected from siblings, cousins, and peers of the cryopreserved embryo group (68 singleton, 20 twins, and three triplets). Children from cryopreserved embryos had a lower mean birth weight and mean gestational age and a higher proportion were born by caesarean section. One child from the cryopreserved embryo group had Down's syndrome, three had squints, and four had conductive hearing loss while in the control children, six had squints, and nine had conductive hearing loss. In both groups, including the child with Down's syndrome, the mean Griffiths's quotient was greater than the standard 100. In the children from cryopreserved embryos, the singleton and multiple birth subgroups had statistically similar assessment results. The mean (SD) Griffiths's quotient was 105.69 (13.55) in children from cryopreserved embryos and 108.18 (9.80) in controls at a chronological age of 25.08 (12.86) and 29.19 (14.65) months respectively. Overall, the development in children from cryopreserved embryos did not cause concern though formal testing had highlighted small differences compared with other children conceived normally and of a similar social class. 相似文献
122.
123.
非手术与桡骨短缩术治疗Kiebock氏病的疗效比较@J Salm on
@JK Stam ley
@IA T rail
@范少勇$江西中医学院!南昌330006 相似文献
124.
The practice of general paediatricians in the initial evaluation of congenital hypothyroidism (CHT) was assessed. This was performed by a questionnaire survey of paediatricians in East Anglia of whom 84% responded. Nineteen of 25 clinicians based in seven district hospitals managed children with CHT. The median number of children in the care of each clinician was 4 (range 1-17) and the median number of children attending each hospital was 12 (range 5-23). All except one clinician arranged to confirm the diagnosis with a serum thyroid stimulating hormone concentration and free or total thyroxine. There was variation of opinion on the value of serum triiodothyronine and free triiodothyronine measurements, antibody screening, knee radiographs, and thyroid isotope scans. One clinician sought advice when notified of new children and two expressed the need for an investigation protocol. These findings indicate that most general paediatricians in East Anglia manage only a few children with CHT; the initial diagnosis is appropriately confirmed but they are uncertain about the value of other investigations. 相似文献
125.
126.
Jeppe Schultz Christensen Ole Raaschou-Nielsen Anne Tj?nneland Kim Overvad Rikke B. Nordsborg Matthias Ketzel Thorkild IA S?rensen Mette S?rensen 《Environmental health perspectives》2016,124(3):329-335
Background
Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight.Objectives
We aimed to investigate the relationship between residential traffic and railway noise and adiposity.Methods
In this cross-sectional study of 57,053 middle-aged people, height, weight, waist circumference, and bioelectrical impedance were measured at enrollment (1993–1997). Body mass index (BMI), body fat mass index (BFMI), and lean body mass index (LBMI) were calculated. Residential exposure to road and railway traffic noise exposure was calculated using the Nordic prediction method. Associations between traffic noise and anthropometric measures at enrollment were analyzed using general linear models and logistic regression adjusted for demographic and lifestyle factors.Results
Linear regression models adjusted for age, sex, and socioeconomic factors showed that 5-year mean road traffic noise exposure preceding enrollment was associated with a 0.35-cm wider waist circumference (95% CI: 0.21, 0.50) and a 0.18-point higher BMI (95% CI: 0.12, 0.23) per 10 dB. Small, significant increases were also found for BFMI and LBMI. All associations followed linear exposure–response relationships. Exposure to railway noise was not linearly associated with adiposity measures. However, exposure > 60 dB was associated with a 0.71-cm wider waist circumference (95% CI: 0.23, 1.19) and a 0.19-point higher BMI (95% CI: 0.0072, 0.37) compared with unexposed participants (0–20 dB).Conclusions
The present study finds positive associations between residential exposure to road traffic and railway noise and adiposity.Citation
Christensen JS, Raaschou-Nielsen O, Tjønneland A, Overvad K, Nordsborg RB, Ketzel M, Sørensen TI, Sørensen M. 2016. Road traffic and railway noise exposures and adiposity in adults: a cross-sectional analysis of the Danish Diet, Cancer, and Health cohort. Environ Health Perspect 124:329–335; http://dx.doi.org/10.1289/ehp.1409052 相似文献127.
We have developed a self-regulating thermoseed for interstitial hyperthermia treatment of tumors. The seeds are made of a 70.4% nickel-29.6% copper alloy, and they have a Curie point at 50 degrees C. When exposed to an oscillating magnetic field (90 kHz, 50 Oersted amplitude), these seeds show a sharp drop in the rate of heat production at temperatures above the Curie point. In a simulated treatment of a small visceral mass that had negligible blood flow, the tissue temperature stabilized at the Curie point of the alloy with good temperature homogeneity throughout the volume heated by an array of thermoseeds. 相似文献
128.
Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states 总被引:9,自引:0,他引:9
Agarwal SK; Kester MB; Debelenko LV; Heppner C; Emmert-Buck MR; Skarulis MC; Doppman JL; Kim YS; Lubensky IA; Zhuang Z; Green JS; Guru SC; Manickam P; Olufemi SE; Liotta LA; Chandrasekharappa SC; Collins FS; Spiegel AM; Burns AL; Marx SJ 《Human molecular genetics》1997,6(7):1169-1175
Familial multiple endocrine neoplasia type 1 (FMEN1) is an autosomal
dominant trait characterized by tumors of the parathyroids, gastro-
intestinal endocrine tissue, anterior pituitary and other tissues. We
recently cloned the MEN1 gene and confirmed its identity by finding
mutations in FMEN1. We have now extended our mutation analysis to 34 more
unrelated FMEN1 probands and to two related states, sporadic MEN1 and
familial hyperparathyroidism. There was a high prevalence of heterozygous
germline MEN1 mutations in sporadic MEN1 (8/11 cases) and in FMEN1 (47/50
probands). One case of sporadic MEN1 was proven to be a new MEN1 mutation.
Eight different mutations were observed more than once in FMEN1. Forty
different mutations (32 FMEN1 and eight sporadic MEN1) were distributed
across the MEN1 gene. Most predicted loss of function of the encoded menin
protein, supporting the prediction that MEN1 is a tumor suppressor gene. No
MEN1 germline mutation was found in five probands with familial
hyperparathyroidism, suggesting that familial hyperparathyroidism often is
caused by mutation in another gene or gene(s).
相似文献
129.
Temperatureisanimportantfactorinfluencingthenervoussystem Forinstance ,coolingtherapyhasprotectiveeffectsonacutecerebralvasculardisease However,ifthetemperatureistooloworfluctuating ,itcanexacerbatenervepathology Thiswasconfirmedinmilitaryaccountsduringt… 相似文献
130.