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排序方式: 共有1045条查询结果,搜索用时 15 毫秒
31.
Bruce A. Perkins MD Nima Soleymanlou PhD Julio Rosenstock MD Jay S. Skyler MD Lori M. Laffel MD Karl-Heinz Liesenfeld Dietmar Neubacher Matthew M. Riggs PhD Curtis K. Johnston PharmD Rena J. Eudy-Byrne PhD Ahmed Elmokadem PhD Jyothis T. George MD Jan Marquard MD Valerie Nock PhD 《Diabetes, obesity & metabolism》2020,22(3):427-433
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Abdollahpour H Appaswamy G Kotlarz D Diestelhorst J Beier R Schäffer AA Gertz EM Schambach A Kreipe HH Pfeifer D Engelhardt KR Rezaei N Grimbacher B Lohrmann S Sherkat R Klein C 《Blood》2012,119(15):3450-3457
We describe a novel clinical phenotype associating T- and B-cell lymphopenia, intermittent neutropenia, and atrial septal defects in 3 members of a consanguineous kindred. Their clinical histories included recurrent bacterial infections, viral infections, mucocutaneous candidiasis, cutaneous warts, and skin abscesses. Homozygosity mapping and candidate gene sequencing revealed a homozygous premature termination mutation in the gene STK4 (serine threonine kinase 4, formerly having the symbol MST1). STK4 is the human ortholog of Drosophila Hippo, the central constituent of a highly conserved pathway controlling cell growth and apoptosis. STK4-deficient lymphocytes and neutrophils exhibit enhanced loss of mitochondrial membrane potential and increased susceptibility to apoptosis. STK4 deficiency is a novel human primary immunodeficiency syndrome. 相似文献
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Nima Sepehri Maryam Mohammadi-Khanaposhtani Nafise Asemanipoor Samanesadat Hosseini Mahmood Biglar Bagher Larijani Mohammad Mahdavi Haleh Hamedifar Parham Taslimi Nastaran Sadeghian Ilhami Gulcin 《Archiv der Pharmazie》2020,353(10):2000109
Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin–1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including α-glycosidase (α-Gly), α-amylase (α-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. The new coumarin–1,2,3-triazole-acetamide hybrids showed Ki values in the range of 483.50–1,243.04 nM against hCA I, 508.55–1,284.36 nM against hCA II, 24.85–132.85 nM against AChE, 27.17–1,104.36 nM against BChE, 590.42–1,104.36 nM against α-Gly, and 55.38–128.63 nM against α-Amy. The novel coumarin–1,2,3-triazole-acetamide hybrids had effective inhibition profiles against all tested metabolic enzymes. Also, due to the enzyme inhibitory effects of the new hybrids, they are potential drug candidates to treat diseases such as epilepsy, glaucoma, type-2 diabetes mellitus (T2DM), Alzheimer's disease (AD), and leukemia. Additionally, these inhibition effects were compared with standard enzyme inhibitors like acetazolamide (for hCA I and II), tacrine (for AChE and BChE), and acarbose (for α-Gly and α-Amy). Also, those coumarin–1,2,3-triazole-acetamide hybrids with the best inhibition score were docked into the active site of the indicated metabolic enzymes. 相似文献
36.
Non‐Newtonian Blood Flow Simulation of Diastolic Phase in Bileaflet Mechanical Heart Valve Implanted in a Realistic Aortic Root Containing Coronary Arteries 下载免费PDF全文
Pedram Hanafizadeh Nima Mirkhani Mohammad Reza Davoudi Mahtab Masouminia Keyvan Sadeghy 《Artificial organs》2016,40(10):E179-E191
Coronary arteries, which are branched from the sinuses, have tangible effects on the hemodynamic performance of the bileaflet mechanical heart valve (BMHV), especially in the diastolic phase. To better understand this issue, a computer model of ascending aorta including realistic sinus shapes and coronary arteries has been generated in this study in order to investigate the BMHV performance during diastole. Three‐dimensional transient numerical analysis is conducted to simulate the diastolic blood flow through the hinges and in coronary arteries under the assumption of non‐Newtonian behavior. Results indicate that as blood flows to the coronary arteries mainly during diastole, leakage flow from the hinge and other gaps will change considering the influence of coronary arteries. In addition, BMHV in the case of aortic replacement will increase blood flow rate into the coronary arteries about 100% as the mechanical valve resistance is higher than a native heart valve. Also, it will change the wall shear stress (WSS) distribution and increase coronary artery disease (CAD) potential. It is found out that although less leakage flow reduces the velocity magnitudes through the gaps, the shear stress acting on blood elements with non‐Newtonian assumption will be detrimental in the hinge corner at the ventricular side. High WSS of 1800 Pa is observed at beginning of diastole at this region. 相似文献
37.
Laleh Sharifi Abbas Mirshafiey Nima Rezaei Gholamreza Azizi Kabir Magaji Hamid Ali Akbar Amirzargar 《Expert Review of Clinical Immunology》2016,12(2):195-207
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immune deficiency and is characterized by hypogammaglobulinemia, defect in specific antibody response and increased susceptibility to recurrent infections, malignancy and autoimmunity. Patients with CVID often have defects in post-antigenic B-cell differentiation, with fewer memory B cells and impaired isotype switching. Toll-like receptors (TLRs) are expressed on various immune cells as key elements of innate and adaptive immunity. TLR signaling in B cells plays multiple roles in cell differentiation and activation, class-switch recombination and cytokine and antibody production. Moreover, recent studies have shown functional alteration of TLRs responses in CVID patients including poor cell proliferation, impaired upregulation of co-stimulatory molecules and failure in cytokine and immunoglobulin production. The purpose of the present review is to discuss the role of TLRs in B-cell development and function as well as their role in the immunopathogenesis of CVID. 相似文献
38.
Oral squamous cell carcinoma of the tongue: Prospective and objective speech evaluation of patients undergoing surgical therapy 下载免费PDF全文
39.
Hamid Irannejad Nima Naderi Saeed Emami Roja Qobadi Ghadikolaei Alireza Foroumadi Tina Zafari Ali Mazar-Atabaki Sakineh Dadashpour 《Medicinal chemistry research》2014,23(5):2503-2514
A series of 5,6-bisaryl-1,2,4-triazine-3-thiol derivatives were synthesized through microwave-promoted chemistry by condensation of the aromatic 1,2-diketones and thiosemicarbazide in a mixed green solvent. Subsequently, S-alkylation of 1,2,4-triazine-3-thiols afforded S-substituted derivatives. The anticonvulsant activity of the synthesized compounds was evaluated in vivo by electroshock and pentylenetetrazole (PTZ)-induced seizures tests. Among them, compound 4a bearing 4-pyridylmethylthio moiety on the triazine ring showed the highest protection in both electroshock and PTZ-induced seizures tests. Compound 4a showed no sign of neurotoxicity at the dose of 100 mg/kg in both rotarod and chimney tests. 相似文献
40.
Hasti Rouhani Nima Sepehri Hamed Montazeri Mohammad Reza Khoshayand Mohammad Hossein Ghahremani Seyed Nasser Ostad Fatemeh Atyabi Rassoul Dinarvand 《Pharmaceutical research》2014,31(8):2124-2139