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排序方式: 共有714条查询结果,搜索用时 15 毫秒
91.
Sibel Caglar Okur Yasemin Pekin Dogan Murat Mert Ozge Aksu Ozer Burnaz Nil Sayiner Caglar 《中华民国医用超音波学会杂志》2017,25(3):150-156
Objective
The prevalence of musculoskeletal complications in diabetes mellitus (DM) increases with the duration of disease and with poor glycemic control. Our aim was to evaluate lower extremity musculoskeletal complications in patients with DM using the Glasgow Ultrasound Enthesitis Scoring System, and to reveal the relationship between clinical and sonographic findings.Materials and methods
A total of 67 patients (25 men, 42 women) with DM were included in the study. All the diabetic patients were selected if they did not have any symptom of musculoskeletal system in the lower extremities. They were divided into four groups. Ultrasonographic assessment was performed according to the Glasgow Ultrasound Enthesitis Scoring System with an Esaote MyLab 5 device equipped with a 5–13 MHz linear transducer. Correlation between diabetes duration and lower extremity enthesopathy scores were evaluated.Results
There was a significant correlation between duration of DM and total Glasgow Ultrasound Enthesitis Scoring System scores (p < 0.001). In addition, duration of DM was significantly correlated with enthesophyte scores and erosion scores (both p < 0.001). There was a significant difference among Groups 1–4 for the mean enthesophyte score and mean erosion score (both, p < 0.001).Conclusion
Musculoskeletal ultrasonography is an effective, inexpensive, and useful tool without radiation for evaluating diabetic patients for the early diagnosis of musculoskeletal complications. 相似文献92.
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95.
Chronic nonspherocytic hemolytic anemia has been observed in a recently described glucose-6-phosphate dehydrogenase (G6PD) variant, G6PDWayne. The mechanical properties of these erythrocytes and other G6PD variants were examined. The deformability of G6PD-deficient erythrocytes was normal, as determined by osmotic scan ektacytometry, and was not significantly affected by hemolytic crisis. In the common varieties of G6PD deficiency, the mechanical stability of the red blood cell (RBC) membrane was greater than normal, but G6PDWayne membranes were abnormally susceptible to shear-induced fragmentation. There was no evidence for a concurrent genetic defect in spectrin, because self- association constants and tryptic digests were normal. The fragility of G6PDWayne membranes appeared to be a consequence of oxidative damage to membrane thiol groups associated with a low glutathione (GSH) level in these RBCs. Associations among GSH level, thiol oxidation, and membrane instability were also found when a larger group of G6PD-deficient RBCs were examined. In normal erythrocytes, 1-chloro-2,4-dinitrobenzene was used to reduce GSH levels by 50%. Membrane thiol oxidation and membrane fragility both increased when these cells were kept at 4 degrees C for 3 to 5 days. Our findings suggest that chronic depletion of GSH leads to the destabilization of membrane skeleton through oxidation of membrane protein thiols. 相似文献
96.
Molecular pathogenesis of inflammatory bowel disease: Genotypes,phenotypes and personalized medicine
Philippe Goyette Catherine Labbé Truc T. Trinh Ramnik J. Xavier John D. Rioux 《Annals of medicine》2013,45(3):177-199
Crohn's disease (CD) and ulcerative colitis (UC), also known as inflammatory bowel diseases (IBD), are characterized by chronic inflammation of the gastrointestinal tract. IBD is among the few complex diseases for which several genomic regions and specific genes have been identified and confirmed in multiple replication studies. We will review the different loci implicated in disease risk in the context of three proposed mechanisms leading to chronic inflammation of the gut mucosa: 1) deregulation of the innate immune response to enteric microflora or pathogens; 2) increased permeability across the epithelial barrier; and 3) defective regulation of the adaptive immune system. As our knowledge of genetic variation, analytical approaches and technology improves, additional genetic risk factors are expected to be identified. With the identification of novel risk variants, additional pathophysiological mechanisms are likely to emerge. The resulting discoveries will further our molecular understanding of IBD, potentially leading to improved disease classification and rational drug design. Moreover, these approaches and tools can be applied in the context of variable drug response with the goal of providing more personalized clinical management of patients with IBD. 相似文献
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98.
Unal M Eskandari HG Erçetin N Doğruer ZN Pata YS 《ORL; journal for oto-rhino-laryngology and its related specialties》2007,69(2):113-115
Nitric oxide (NO) plays an important role in the regulation of upper respiratory function. Patients with untreated allergic rhinitis (AR) have an increased level of NO in the nasal cavity compared to normal individuals. We aimed to investigate serum levels of arginase and NO metabolites nitrite/nitrate in patients with AR during the symptomatic period. The patient and control groups consisted of 14 males and 12 females (mean age: 29, range: 20-40 years), and 10 males and 10 females (mean age: 27, range: 22-38 years), respectively. Nitrite/nitrate levels were 0.98 +/- 0.33 ng/ml in the patients with AR, and 0.78 +/- 0.26 ng/ml in the control group (p = 0.03). Arginase levels were 28.8 +/- 14.1 ng/ml in the patients with AR, and 20.8 +/- 13.5 ng/ml in the control group. The difference between the groups was statistically insignificant (p = 0.24). Our results support the view that NO plays an important role in the pathogenesis of AR, and NO metabolites may be used as a marker for monitoring the disease activity and therapy. 相似文献
99.
Stutterers demonstrate unique functional neural activation patterns during speech production, including reduced auditory activation, relative to nonstutterers. The extent to which these functional differences are accompanied by abnormal morphology of the brain in stutterers is unclear. This study examined the neuroanatomical differences in speech-related cortex between stutterers and nonstutterers using voxel-based morphometry. Results revealed significant differences in localized grey matter and white matter densities of left and right hemisphere regions involved in auditory processing and speech production. 相似文献
100.
Dorothy Pfiffner Bruno Lanfranconi Rico Nil Roberto Buzzi und Karl Bättig 《Sozial- und Pr?ventivmedizin》1986,31(4-5):223-225
Zusammenfassung Die Beziehung zwischen Typ-A-Verhalten und psychophysiologischer Reaktivität wurde bei 77 gesunden Männern untersucht. Die Typ A's unterschieden sich von den Typ B's nicht wie erwartet in erhöhter kardiovaskulärer Reaktivität, sondern in erhöhter Körpermotorik, Atmungsfrequenz und erhöhtem EMG. Körpermotorik und EMG konnten das Typ-A-Verhalten am besten während den beiden Sprechtests voraussagen.
Psychophysiological reactivity and its relationship to the Type A behavior pattern
Summary This relationship was examined in 77 healthy men. Stress reactivity in the 26 Type A was not more increased than in the 12 Type B men for the cardiovascular variables (heart rate, pulse transit time, finger vasoconstriction and blood pressure), but for body movement, EMG, respiration frequency. Body movement and EMG were the best predictable physiological variables for the Type A behavior Pattern, and this mainly in the two speech tests.
Réactivité psychophysiologique et sa relation avec le style de comportement Type A
Résumé Cette relation était examiné pour 77 hommes sains. La comparaison entre 26 hommes de Type A et 12 hommes de Type B n'a pas montré de réactivité élevée pour les Type A envers le stress en ce qui concerne les variables cardiovasculaires (fréquence cardiaque, le temps de transmission du pouls, vasoconstriction du doigt et pression sanguine) mais elle en a montré pour la motorique corporelle, l'EMG et la respiration. La motorique corporelle et l'EMG prédisaient mieux le style de comportement Typ A, particulièrement dans les deux tests de conversation.相似文献