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Amino acid and peptide absorption in patients with coeliac disease and dermatitis herpetiformis 下载免费PDF全文
A double-lumen perfusion technique has been used to study amino acid and peptide absorption in eight normal control subjects, 13 patients with untreated adult coeliac disease, and 16 patients with dermatitis herpetiformis who had varying morphological abnormalities of the small bowel. All subjects were perfused with isotonic solutions containing 10 mM glycyl-L-alanine and 10 mM glycine + 10 mM L-alanine.Patients with adult coeliac disease had impaired absorption of glycine (p < 0.01) and L-alanine (p < 0.05) from the amino acid solution compared with the control subjects. Amino acid uptake from the dipeptide solution was not significantly impaired, although four individual patients had impaired uptake of both amino acids. In contrast to these findings, very few patients with dermatitis herpetiformis had impaired amino acid absorption from either solution.Sodium absorption was impaired from both solutions when the groups of patients with adult coeliac disease and dermatitis herpetiformis with subtotal villous atrophy and partial villous atrophy were studied, and there were patients in each group who secreted sodium and water.The results suggest that malabsorption of dietary protein is unlikely to occur in dermatitis herpetiformis but may occur and contribute to protein deficiency seen in some severe cases of adult coeliac disease. The impairment of sodium and water absorption provides evidence that there may be functional impairment of the jejunal mucosa in dermatitis herpetiformis as well as in adult coeliac disease. 相似文献
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Singh Mhaveer Kamal Y. T. Khan Mohammed A. Parveen Rabea Ansari S. H. Ahmad Sayeed 《Proceedings of the National Academy of Sciences, India. Section B.》2015,85(2):607-614
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - In vitro antioxidant potential of methanolic extract of saffron and crocetin was assessed along with... 相似文献
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Salina Parveen Syed Ahmed Morshed Keiji Arima Mikio Nishioka Albert J. Czaja Wan Cheng Chow Hans-Seong Ng 《Digestive diseases and sciences》1998,43(6):1322-1331
To assess whether demography is one of theimportant factors determining antibody response tonuclear antigens [ANA: SSA-Ro (52K and 60K), SSB-La,snRNPs (A, 70K, B/B), and Cenp-B], weinvestigated 95 and 47 sera of autoimmune hepatitis (AIH) fromNorth America and Asia, respectively, byimmunofluorescent (IF) and recombinant ELISA.Correlations among nuclear IF patterns, ELISA, anddisease indices were analyzed. The frequency and titer of individualantibodies differed significantly between the groups.Patients with speckled patterns were younger in bothregions and had higher aspartate aminotransferase levels only in North America. HLA-A1, B8, DQ2,and DR4 or DR3 or both in North America, and A2, B61,DQ7, and DR4 in Asia were predominant. In Asia, B61correlated with anti-70K, and DQ7 correlated with antibodies to 52K, Cenp-B, and B/B. InNorth America, A1, B8, DR3 haplotype, and DQ2 correlatedwith antibodies to A and 70K. Anti-B/B and DR4 inNorth America, and A2 in Asia, were associated withconcurrent immunologic disorder. Individual ANA clusterscorrelated with individual HLA in the demography, anddifferent HLA alleles might determine disease expressionas well as different ANA being produced inAIH. 相似文献
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Kayoko Hayakawa MD PhD Dror Marchaim Jason M. Pogue Kevin Ho Shakila Parveen Priyanka Nanjireddy Bharath Sunkara Manit Singla Kavyashri Kodlipet Jagadeesh Judy A. Moshos Sarah Bommarito Rida MrouePaul R. Lephart PhD Emily T. Martin Michael J. Rybak Keith S. Kaye 《American journal of infection control》2012
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Muhammad Akram Muhammad Riaz Naveed Munir Akhtar Rasul Muhammad Daniyal Syed Muhammad Ali Shah Mohammad Ali Shariati Ghazala Shaheen Naheed Akhtar Farzana Parveen Naheed Akhter Aymen Owais Ghauri Abdul Wadood Chishti Muhammad Usman Sarwar Fahad Said Khan 《Clinical and experimental pharmacology & physiology》2020,47(7):1107-1119
The advent of antibiotics revolutionized medical care resulting in significantly reduced mortality and morbidity caused by infectious diseases. However, excessive use of antibiotics has led to the development of antibiotic resistance and indeed, the incidence of multidrug-resistant pathogens is considered as a major disadvantage in medication strategy, which has led the scholar's attention towards innovative antibiotic sources in recent years. Medicinal plants contain a variety of secondary metabolites with a wide range of therapeutic potential against the resistant microbes. Therefore, the aim of this review is to explore the antibacterial potential of traditional herbal medicine against bacterial infections. More than 200 published research articles reporting the therapeutic potential of medicinal plants against drug-resistant microbial infections were searched using different databases such as Google Scholar, Science Direct, PubMed and the Directory of Open Access Journals (DOAJ), etc., with various keywords like medicinal plants having antibacterial activities, antimicrobial potentials, phytotherapy of bacterial infection, etc. Articles were selected related to the efficacious herbs easily available to local populations addressing common pathogens. Various plants such as Artocarpus communis, Rheum emodi, Gentiana lutea L., Cassia fistula L., Rosemarinus officinalis, Argemone maxicana L, Hydrastis canadensis, Citrus aurantifolia, Cymbopogon citrates, Carica papaya, Euphorbia hirta, etc, were found to have significant antibacterial activities. Although herbal preparations have promising potential in the treatment of multidrug-resistant bacterial infection, still more research is required to isolate phytoconstituents, their mechanism of action as well as to find their impacts on the human body. 相似文献
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Although X-linked retinoschisis is a common retinal degeneration condition, the presence of a large retinal cyst obscuring the visual axis in an infant is a rare presentation. Herein, we describe such a case of a child who presented to us with the diagnosis of retinal detachment in both the eyes. However, following multimodal imaging and electrophysiology, the child was found to have bilateral juvenile retinoschisis with a large retinoschisis cyst involving the visual axis seen intraoperatively in the left eye. A limbal approach followed by lensectomy was used to excise the inner retinal layer of the cyst. The intracystic fluid was then drained and the stretched retinal vessels were endocauterized and severed without causing any iatrogenic outer retinal breaks and retinal detachment. The correct diagnosis and meticulous preoperative planning of the surgical procedure helped us manage this challenging case with a favorable anatomical and functional outcome. 相似文献
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Naveed A. Khawaja Hesham Khalil Kauser Parveen Ahmad M. Alghamdi Ra’ed A. Alzahrani Sa’ad M. Alherbi 《Saudi Pharmaceutical Journal》2014,22(6):545-549