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排序方式: 共有991条查询结果,搜索用时 171 毫秒
51.
Hakan Akinci Aysegul Kapucu Kadriye Akgun Dar Ozlem Celik Banu Tutunculer Gozde Sirin Buge Oz Nurperi Gazioglu Haluk Ince Süheyla Aliustaoglu Pinar Kadioglu 《Pituitary》2013,16(3):386-392
The aim of the study was to evaluate the presence of aromatase cytochrome P450 enzyme (P450AROM) expression in normal pituitary tissues and tumor tissues of patients with prolactinoma and to examine the impact of the P450AROM expression on clinical outcome. Twenty-six consecutive human pituitary tissue samples were obtained from autopsies performed at the Institute of Forensic Medicine. Sixty-four patients who had an adenomectomy between 2000 and 2009 after prolactinoma diagnosis with histologically confirmed pituitary tumor tissues were retrospectively included in this study. The slices from the pituitary tissues were subjected to immunohistochemical staining for evaluation of P450AROM and estrogen receptor beta (ER beta) subunit. Immunohistochemistry results were compared according to age, gender, remission rate, resistance and invasion status of the patients. Higher than normal P450AROM expression was found in the pituitary tissues of the patients with prolactinoma (p < 0.001). P450AROM intensity had no relation to resistance or remission in patients with prolactinoma (p = 0.44, p = 0.45, respectively). The subgroup analysis showed that compared to males without invasive adenoma, males with invasive adenoma had higher P450AROM expression (p = 0.048). ER beta was found to have an impact on resistance (p = 0.049). This study shows that P450AROM expression is present in the pituitary tissues of patients with prolactinoma and that this presence could be important in development and tumor behavior of prolactinomas. 相似文献
52.
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54.
Various techniques and different types of incisions have been used for breast augmentation, the choice of which depends on
regional and physical characteristics of the patient, an indication for the operation, and the decision of the patient and
the operator. The periareolar approach is ideal for cases of developmental hypomastia that have adequate skin and glandular
tonus and with minimum ptosis. The disadvantages of this method are a hypopigmented scar on the pigmented areola and a decrease
in sensitivity of the nipple-areola. This article presents the experiences of the Department of Plastic and Reconstructive
Surgery of the University of Istanbul, Faculty of Medicine between 1995 and 1998, on medial periareolar submuscular augmentation
approaches to five cases. During this follow-up period we had no major complications. 相似文献
55.
Management of carotid artery invasion in advanced malignancies of head and neck comparison of techniques 总被引:3,自引:0,他引:3
Aslan I Hafiz G Baserer N Yazicioglu E Kiyak E Tinaz M Biliciler N 《The Annals of otology, rhinology, and laryngology》2002,111(9):772-777
The objective of this study was to retrospectively investigate a single institution's experience with carotid artery resection performed as part of an oncological procedure and to determine acute and convalescent complication and survival rates. We performed a record review of 28 patients with head and neck malignancy invading the carotid artery. Immediate carotid artery resection and ligation on an emergent basis was performed on 12 patients (group 1), elective resection and ligation was performed on 8 patients (group 2), and elective resection and revascularization was performed on 8 patients (group 3). In group 1, although 1 patient survived for 1 year and 1 patient survived for 2 years, 1 patient died of severe neurologic deficit, 2 patients experienced neurologic deficit with good recovery, and 1 patient was moderately disabled. In group 2, 2 patients survived without disease for 5 years, and 2 patients experienced neurologic deficit, 1 with good recovery and the other with complete recovery. In group 3, only 1 patient survived for 5 years, and within this group, 1 patient died of severe neurologic deficit, 1 patient had neurologic deficit with moderate recovery, and 1 patient had neurologic deficit with complete recovery. No significant difference in mortality and morbidity rate was observed between the "resection and ligation" group and the "resection and revascularization" group (p = .52, chi(2) = 0.79). We conclude that the surgical treatment of patients with an invaded carotid artery, including carotid resection, provides a small but real chance of 5-year survival. The methods of carotid resection and repair should be guided by clinical presentation and by preoperative and intraoperative investigations. 相似文献
56.
Incidence of cochlear involvement in hyperbilirubinemic deafness 总被引:6,自引:0,他引:6
Oysu C Aslan I Ulubil A Baserer N 《The Annals of otology, rhinology, and laryngology》2002,111(11):1021-1025
Neonatal hyperbilirubinemia remains an important cause of childhood deafness, especially in developing countries. After neonatal hyperbilirubinemia, the auditory neural pathways, cochlea, or both may be affected. In this study, we aimed to determine the incidence of cochlear impairment and the appropriate means of hearing screening in hyperbilirubinemic neonates. A retrospective review of 1,032 pediatric patients with hearing loss revealed 67 cases (6.5%) of severe hyperbilirubinemia in the neonatal period. Thirty of these patients had neonatal hyperbilirubinemia as the single identifiable risk factor for hearing loss. In 26 of 30 cases (87%), otoacoustic emissions (OAEs) were absent, whereas in the remaining 4 cases (13%), robust emissions were detected despite an absent auditory brain stem response (ABR). Auditory screening of newborns with jaundice by OAEs possesses a significant risk of undiagnosed deafness. On the other hand, if the ABR is used as the single means of screening, auditory neuropathic conditions will probably be underlooked. Therefore, we recommend dual screening of hearing by ABR and OAEs in hyperbilirubinemic newborns. 相似文献
57.
Bilge I Kayserili H Emre S Nayir A Sirin A Tukel T Bas F Kilic G Basaran S Gunoz H Apak M 《Pediatric nephrology (Berlin, Germany)》2000,14(12):1111-1114
We evaluated the frequency of renal malformations in relation to nonmosaic 45,X (group A, 45 patients, 54.9%) and mosaic/structural
abnormalities of X (group B, 37 patients, 45.1%) in 82 Turkish patients with Turner syndrome (TS). Ultrasonography of the
kidneys and collecting system was performed in all patients. Of the 82 patients, 31 had different renal malformations (37.8%).
Horse-shoe kidney was observed in 9 (29.0%) of the 31 patients, and 17 patients (54.8%) had various collecting system malformations,
while 5 (16.2%) had malrotation and other positional abnormalities. The prevalence of renal malformations was significantly
higher in group A (51.1%) than group B (21.6%) (2:7.94, P<0.05). Although 8 of the 9 patients with horse-shoe kidney had the 45,X karyotype, collecting system malformations were observed
more frequently in group B. Recurrent urinary tract infections (UTIs) were detected during follow-up in 7 patients, and hypertension
developed in 3 patients. In patients who had a normal baseline nephrological evaluation, no problem suggesting renal disease
developed during follow-up. We conclude that all forms of TS should have routine nephrological screening on diagnosis, since
structural malformations of the kidney occur more frequently in nonmosaic 45,X TS, while collecting system malformations are
mostly seen in mosaic/structural X forms. Those included in the group for nephrological follow-up had an increased risk for
hypertension and/or UTI.
Received: 15 February 1999 / Revised: 20 January 2000 / Accepted: 25 January 2000 相似文献
58.
Multiple myeloma, solitary plasmacytoma, and extramedullary plasmacytoma constitute a continuum of a disease spectrum, which
is called plasma cell neoplasms. These three entities can not be differentiated from each other on a histological basis and,
for this reason, clinical evaluation is important in their differential diagnoses. Differential diagnosis guides the proper
planning of treatment and helps in estimation of survival. Multiple myeloma located within the larynx is very rare. Because
of its rarity, any established diagnostic and treatment criteria do not exist. In this report, a case of laryngeal multiple
myeloma is presented for its extraordinary presentation and also for educational purposes.
Received: 25 April 2001 / Accepted: 5 July 2001 相似文献
59.
Karaşen RM Varoğlu E Yildirim M Eryilmaz K Sütbeyaz Y Sirin S 《The Journal of laryngology and otology》1999,113(6):509-511
The aim of this study was to evaluate Eustachian tube function by ventilation scintigraphy. In 13 patients with normal tube function and 16 with one-sided tube dysfunction, 50 MBq 133Xe was applied into the nasopharyngeal space through a tube inserted into the nasal cavity. Immediately after the insufflation, the patients were asked to perform three Valsalva manoeuvres. The visualization of the middle ear was possible in 10 of the 13 patients (77 per cent) with normal tube function. Decreased uptake of the middle-ear region in the side of dysfunction was demonstrated in 11 of the 16 patients (68.7 per cent) with one-sided tube dysfunction. Quantitative evaluation by region of interest technique revealed that by using percentage retention of activity and uptake rates, there were significant differences between the sides of dysfunction and sides of normal tube function (p < 0.05) and also between sides of dysfunction and both sides of controls (p < 0.05). There was no significant differences between normal sides of patients and both sides of controls (p > 0.05). As a conclusion, this method is non-invasive, easy- to perform and has a low radiation burden in the evaluation of Eustachian tube function. Although the number of patients is limited, the test seems to be applicable with a success rate of about 74 per cent. 相似文献
60.
Generalized tonic-clonic status epilepticus: causes, treatment, complications and predictors of case fatality 总被引:3,自引:0,他引:3
We retrospectively reviewed the clinical course of 66 patients treated for generalized tonic-clonic status epilepticus at
the Ege University neurological intensive care unit from 1988 to 1997. Seventy-two per cent of the study group had a pre-existing
seizure disorder, and antiepileptic drug withdrawal was the most prominent cause of status epilepticus. The other causes included
drug toxicity, central nervous system infection, cerebrovascular disease, tumour and trauma. Seventy-three per cent of all
patients responded to the first-line therapy (diazepam and/or phenytoin), and the remainder were considered to have refractory
status epilepticus and required pentobarbital anaesthesia. Overall case fatality was 21%, but death could be attributed directly
to status epilepticus and/or treatment complication in 10% of the study group. Major determinants of fatal outcomes were:
increasing age, longer duration of status epilepticus before initiation of therapy and central nervous system infection as
a causal factor.
Received: 9 December 1997 Received in revised form: 23 February 1998 Accepted: 30 March 1998 相似文献