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101.
Kinugasa Eriko Igawa Ken Shimada Hisaki Kondo Morihiro Funakoshi Satoshi Imada Naoki Itami Noritomo Fukazawa Naoki Takubo Ryoko Kawata Yuichi Murota Hiroyuki 《Clinical and experimental nephrology》2021,25(8):875-884
Clinical and Experimental Nephrology - The pathophysiology of uremic pruritus (UP), which is characterized by systemic and intractable itching, remains unclear. As interleukin (IL)-31 may be... 相似文献
102.
Kobayashi Mana Kageyama Yutaro Ando Takashi Sakamoto Junko Kimura Shohji 《Clinical and experimental nephrology》2021,25(8):854-864
Clinical and Experimental Nephrology - Rituximab is conditionally approved in Japan for use in patients with refractory nephrotic syndrome. To meet the conditions of approval, an all-case... 相似文献
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106.
Shunsuke Kageyama Hiroshi Yamamoto Mitsuyo Nagano Harumi Arisaka Takashi Kayahara Ryota Yoshimoto 《British journal of pharmacology》1997,122(1):165-171
- A murine anti-human vWF monoclonal antibody, AJvW-2, was developed that inhibited the interaction between platelet glycoprotein Ib (GPIb) and von Willebrand factor (vWF) during the ristocetin- (IC50=0.7±0.1 μg ml−1) and botrocetin- (IC50=1.8±0.3 μg ml−1) induced aggregation of human platelets.
- AJvW-2 inhibited the high shear stress (10.8 N m−2) induced aggregation of human platelets dose-dependently with an IC50=2.4±0.3 μg ml−1, but had no effect on low shear stress induced platelet aggregation (1.2 N m−2) up to 100 μg ml−1.
- AJvW-2 also inhibited the high shear stress (5.0 N m−2) induced adhesion of human platelets to collagen I with the same efficacy (IC50=2.4±0.3 μg ml−1), but had no effect at low shear conditions (1.5 N m−2).
- AJvW-2 inhibited the botrocetin-induced aggregation of platelets from guinea-pig, rat, rabbit, dog and pig at the same concentration range as human platelets; it likewise also inhibited the high shear stress induced aggregation and adhesion to collagen I of guinea-pig platelets.
- AJvW-2 prevented arterial thrombus formation in guinea-pigs at a dose of 100 μg kg−1 without prolonging the template bleeding time, whereas the GPIIb/IIIa antagonist lamifiban mediated inhibition of thrombosis at 1000 μg kg−1 was accompanied by a significant prolongation of the bleeding time.
- These results suggest that AJvW-2 is a potent inhibitor of the GPIb-vWF interaction and a potential novel antithrombotic agent with lower bleeding risk than GPIIb/IIIa antagonists.
107.
Inoue Y Katayama N Yoshioka N Yoshikawa K Kashima M Shimizu T Tsukune Y Ohtomo K 《Annals of nuclear medicine》1999,13(6):453-456
The aim of this study was to evaluate breast parenchymal activity on scintimammography with bone-seeking agents and 99mTc-MIBI. Scintimammography was performed with bone-seeking agents in 61 patients and with 99mTc-MIBI in 33 patients. Activity in the breast parenchyma contralateral to the suspected lesion was visually assessed by two independent observers. Increased breast parenchymal activity was shown in 19 of 61 patients examined with bone-seeking agents, while it was demonstrated in only two of 33 patients examined with 99mTc-MIBI. Breast parenchymal activity of bone-seeking agents was higher in patients aged 50 years or younger than in those older than 50. Increased parenchymal activity of bone-seeking agents may disturb visualization of primary breast cancer especially in relatively young patients. Low parenchymal activity is suggested to be a favorable characteristic of 99mTc-MIBI as a scintimammographic agent. 相似文献
108.
Nine clinical benign prostatic hyperplasia (BPH) patients were treated with oral terazoin monotherapy (2 mg daily) for 12 weeks. Serum lipid levels (total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, apoproteins) were estimated prior to and every 4 weeks during treatment in 5 patients. International Prostate Symptom Score (IPSS) and pressure-flow study were evaluated before and 12 weeks after treatment in 4 patients. The total cholesterol level decreased from a baseline of 210 +/- 36.6 mg/dl by 6.6% at the 12th week. This result was not significant but suggested a favorable effect of terazosin on diminishing the risk of coronary heart disease. This effect was marked especially in patients with a total cholesterol level over 200 mg/dl. On the other hand, IPSS improved in all cases. The mean change ranged from 19.5 to 10.0 and the mean peak flow rate from 9.0 to 15.7 ml/s. On Sh?ffer's nomogram, 1 patient showed improvement of obstruction and the other 3 patients were diagnosed as having week detrusor without obstruction. Clinical BPH patients with hyperlipidemia may markedly benefit from terazosin, which is a safe and useful initial treatment for BPH. 相似文献
109.
When the diaphragm is excised so wiely that the defect cannot be closed directly during an operation on either thoracic or
epigastric tumors, a reconstruction of the defect is necessary. We used harvested autologous fascia lata to reconstruct the
diaphragm in a patient undergoing a pleuropneumonectomy with a partial diaphragmatic resection for malignant mesothelioma. 相似文献
110.
Shibun Ra Hikaru Aoki Tomoaki Fujioka Fumio Sato Takashi Kubo Naoki Yasuda 《The Journal of urology》1996,156(2):522-525