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排序方式: 共有113条查询结果,搜索用时 15 毫秒
1.
Nadejda Lermontova Nikolai Lukoyanov Tatyana Serkova Elena Lukoyanova Sergei Bachurin 《Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid》1998,33(1):51-61
Effects of tacrine (1,2,3,4-tetrahydro-9-aminoacridine) on memory deficits in rats treated with ethylcholine aziridinium ion (AF64A) were studied using active avoidance test in the two-way shuttle box. Neurotoxin AF64A injected at a dose of 6 nmol (icv, bilaterally) causes nonspecific tissue damage in hippocampal fields CA2 and CA3. Two weeks after treatment with 6 nmol, AF64A active avoidance performance of toxin-treated rats was significantly deteriorated compared to vehicle-treated animals estimated in learning test (68±3.5 and 83±3.2% of correct responses, respectively;p<0.01) and in retention test (53±5 and 76±3.6%, respectively;p<0.01). Under these conditions, chronic treatment with tacrine at a daily dose of 1 mg/kg for 12–14 d reverses the effect of AF64A on the active avoidance performance both in learning (78±3.2%) and retention (72±4%) tests. It is supposed that behavioral effects of tacrine considerably depend on a severity of neurodegeneration in the hippocampus. 相似文献
2.
Dimebon and Tacrine Inhibit Neurotoxic Action of β-Amyloid in Culture and Block L-type Ca2+ Channels
Lermontova NN Redkozubov AE Shevtsova EF Serkova TP Kireeva EG Bachurin SO 《Bulletin of experimental biology and medicine》2001,132(5):1079-1083
Dimebon, a Russian-made drug, inhibited toxic effects of beta -amyloid on cultured neurons. Excessive accumulation of beta-amyloid in the brain is characteristic of Alzheimer dementias. Antialzheimer preparations tacrine and dimebon improve survival of cerebellar granule cells during long-term incubation with Ab25-35, the neurotoxic fragment of beta-amyloid. Both preparations can block potential-dependent Ca2+ entry into neurons by about 20%, which is explained by their selective action on L-type Ca2+ channels. It was assumed that the neuroprotective effect of dimebon and tacrine against Ab25-35 partially depends on inhibition of potential-dependent Ca2+ entry. 相似文献
3.
Lermontova NN Lukoyanov NV Serkova TP Lukoyanova EA Bachurin SO 《Bulletin of experimental biology and medicine》2000,129(6):544-546
Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial
deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon
on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 6, pp 640–642, June, 2000 相似文献
4.
Nadejda M. Tsankova Carolyn Bevan Vaidehi Jobanputra Yen Chen Kevin Ko Elizabeth W. Mayer Jay H. Lefkowitch Mahesh Mansukhani Lewis P. Rowland Govind Bhagat Kurenai Tanji 《Acta neuropathologica》2013,126(4):595-601
We report a rare case of peripheral T-cell lymphoma arising in a 52-year-old man with biopsy-proven aggressive polymyositis, who had cardiac involvement, progressive bulbar symptoms, and died 11 months post diagnosis due to multiorgan failure. Using a multimodality approach including immunohistochemistry, genome-wide single nucleotide polymorphism (SNP)-array analysis, and high-throughput sequencing of the complementary determining region 3 (CDR3) of T-cell receptor beta (TCRβ) genes, our study demonstrates a molecular link between polymyositis and T-cell lymphoma, and provides evidence of the rapid and possibly late occurrence of genomic instability during neoplastic transformation of an oligoclonal T-cell population. Immunohistochemical analysis revealed loss of CD5, CD7, and CD8 antigen expression in autopsy tissue samples, as well as the occurrence of aberrant CD56 expression, not seen in pre-mortem biopsies, supporting the emergence of a neoplastic T-cell population. Multiplex polymerase chain reaction and next-generation sequencing of the TCRβ CDR3 region displayed two unique T-cell clones in both the diagnostic biopsy confirming polymyositis and the autopsy muscle tissue exhibiting T-cell lymphoma, linking the two pathological processes. SNP-array analysis revealed complex genomic abnormalities at autopsy but not in the pre-mortem muscle biopsies displaying polymyositis, confirming malignant transformation of the oligoclonal T-cell infiltrate. Our findings raise the possibility that clinically aggressive polymyositis might represent a preneoplastic condition in some instances, similar to certain other autoimmune and inflammatory disorders. 相似文献
5.
6.
Babyshkina Nataliya Vtorushin Sergey Dronova Tatyana Patalyak Stanislav Slonimskaya Elena Kzhyshkowska Julia Cherdyntseva Nadejda Choynzonov Evgeny 《Clinical and experimental medicine》2019,19(4):547-556
Clinical and Experimental Medicine - The luminal-A-like and luminal-B-like breast cancer groups have distinct biological features that lead to differences in the treatment response and clinical... 相似文献
7.
Yakov S. Vygodskii Alexander S. Shaplov Elena I. Lozinskaya Konstantin A. Lyssenko Denis G. Golovanov Inna A. Malyshkina Nadejda D. Gavrilova Michael R. Buchmeiser 《Macromolecular chemistry and physics.》2008,209(1):40-51
Poly(norbornene)s with pendant imidazolium moieties and three different counter anions, i.e. poly[exo,endo‐5‐norbornene‐2‐yl‐carboxyethyl‐3‐ethylimidazolium bis(trifluoromethyl‐sulfonyl)imide], poly(exo,endo‐5‐norbornene‐2‐yl‐carboxyethyl‐3‐ethylimidazolium tetrafluoroborate), and poly(exo,endo‐5‐norbornene‐2‐yl‐carboxyethyl‐3‐ethylimidazolium hexafluorophosphate) were prepared via ROMP using ionic liquids as the reaction medium. The ionic polymers possessed in the range 8.1–44 × 103 and ionic conductivity up to 1.13 × 10−5 and 1.44 × 10−4 S · cm−1 at 20 and 50 °C, respectively. The solubility of the new polymeric ionic liquids, their thermal stability and their glass transition temperatures were investigated in detail. Ionic conductivities were found to depend on the nature of the counter‐anion and on the polymers' glass transition temperature rather than its molecular weight.
8.
The centromere—the primary constriction of monocentric chromosomes—is essential for correct segregation of chromosomes during mitosis and meiosis. Centromeric DNA varies between different organisms in sequence composition and extension. The main components of centromeric and pericentromeric DNA of Brassicaceae species are centromeric satellite repeats. Centromeric DNA initiates assembly of the kinetochore, the large protein complex where the spindle fibers attach during nuclear division to pull sister chromatids apart. Kinetochore assembly is initiated by incorporation of the centromeric histone H3 cenH3 into centromeric nucleosomes. The spindle assembly checkpoint acts during mitosis and meiosis at centromeres and maintains genome stability by preventing chromosome segregation before all kinetochores are correctly attached to microtubules. The function of the spindle assembly checkpoint in plants is still poorly understood. Here, we review recent advances of studies on structure and functional importance of centromeric DNA of Brassicaceae, assembly and function of cenH3 in Arabidopsis thaliana and characterization of core SAC proteins of A. thaliana in comparison with non-plant homologues. 相似文献
9.
Nataliya Babyshkina Sergey Vtorushin Marina Zavyalova Stanislav Patalyak Tatyana Dronova Nikolay Litviakov Elena Slonimskaya Julia Kzhyshkowska Nadejda Cherdyntseva Evgeny Choynzonov 《Clinical and experimental medicine》2017,17(3):383-393
Identification of additional biomarkers associated with ER genomic and nongenomic pathways could be very useful to distinguish patients who will benefit from tamoxifen treatment. The aim of this study was to analyze the prognostic significance of the distribution pattern of ERα expression, ESR1 gene single-nucleotide polymorphisms and expression levels of growth factor receptors in Russian hormone receptor-positive breast cancer patients treated with adjuvant tamoxifen. Formalin-fixed paraffin-embedded tumor tissue samples from 97 patients were examined for the distribution pattern of ERα expression, as well as for EGFR and TGF-βR1 expression by immunohistochemistry. Genotypes for ESR1 +30T>C (rs2077647) and ESR1 2014G>A (rs2228480) were analyzed using a TaqMan assay. Progression-free survival (PFS) was used as an endpoint for the survival analyses. We found that patients with the heterogeneous distribution of ERα expression had poor prognosis on tamoxifen treatment (P = 0.021). We identified a high EGFR expression in patients who developed distant metastasis or recurrence during tamoxifen treatment (a tamoxifen-resistant group—TR) in contrast to the distant metastasis-free patients (a tamoxifen-sensitive group—TS) (80.0 vs. 41.9 %, respectively, P = 0.009). Carriers of the ESR12014A mutant allele were more prevalent among the TR patients compared to the TS patients (26.3 vs. 8.0 %, respectively, P = 0.009). EGFR expression and the distribution pattern of ERα expression were associated with the response to tamoxifen by both univariate and multivariate logistic regression analyses. The presence of these markers either alone or in combination was correlated with the worse PFS for all patients. Analysis of the distribution pattern of ERα expression and the EGFR status in tumor tissue may be valuable for patient selection for tamoxifen adjuvant therapy. 相似文献
10.
Content of Autoantibodies to Bradykinin and β-Amyloid1-42 as a Criterion for Biochemical Differences between Alzheimer's Dementias 总被引:2,自引:0,他引:2
Myagkova MA Gavrilova SI Lermontova NN Kalyn YB Selezneva ND Zharikov GA Kolykhalov IV Abramenko TV Serkova TP Bachurin SO 《Bulletin of experimental biology and medicine》2003,136(1):49-52
We measured serum content of autoantibodies to -amyloid protein A1-42, its neurotoxic fragment A25-35, vasopressin, bradykinin, thrombin, antithrombin III, 2-macroglobulin, and angiotensin II in patients with various forms of Alzheimer's dementias, including presenile and senile dementias of the Alzheimer type. The ratio of antibradykinin and anti-A1-42 autoantibody contents differed by 39% in these patients. Our results can be used for the development of a new biochemical method for differential diagnostics of dementias of the Alzheimer type. 相似文献