全文获取类型
收费全文 | 1720篇 |
免费 | 166篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 102篇 |
妇产科学 | 24篇 |
基础医学 | 124篇 |
口腔科学 | 39篇 |
临床医学 | 214篇 |
内科学 | 410篇 |
皮肤病学 | 9篇 |
神经病学 | 215篇 |
特种医学 | 163篇 |
外科学 | 249篇 |
综合类 | 39篇 |
预防医学 | 77篇 |
眼科学 | 6篇 |
药学 | 132篇 |
中国医学 | 5篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 5篇 |
2022年 | 5篇 |
2021年 | 22篇 |
2020年 | 9篇 |
2019年 | 14篇 |
2018年 | 47篇 |
2017年 | 48篇 |
2016年 | 45篇 |
2015年 | 40篇 |
2014年 | 57篇 |
2013年 | 73篇 |
2012年 | 65篇 |
2011年 | 65篇 |
2010年 | 80篇 |
2009年 | 73篇 |
2008年 | 77篇 |
2007年 | 61篇 |
2006年 | 65篇 |
2005年 | 69篇 |
2004年 | 55篇 |
2003年 | 51篇 |
2002年 | 40篇 |
2001年 | 63篇 |
2000年 | 44篇 |
1999年 | 26篇 |
1998年 | 62篇 |
1997年 | 56篇 |
1996年 | 58篇 |
1995年 | 55篇 |
1994年 | 38篇 |
1993年 | 43篇 |
1992年 | 30篇 |
1991年 | 33篇 |
1990年 | 34篇 |
1989年 | 28篇 |
1988年 | 28篇 |
1987年 | 26篇 |
1986年 | 27篇 |
1985年 | 16篇 |
1984年 | 16篇 |
1983年 | 24篇 |
1982年 | 7篇 |
1981年 | 33篇 |
1980年 | 15篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 11篇 |
1976年 | 15篇 |
1975年 | 9篇 |
1973年 | 10篇 |
排序方式: 共有1897条查询结果,搜索用时 31 毫秒
51.
A sensitive and precise radioreceptor assay for determining plasma levels of human factor VIII/von Willebrand's factor (FVIII/vWF) has been developed by taking advantage of the FVIII/vWF receptor sites on human platelets. Paraformaldehyde-fixed platelets, which were processed and then stored, retained FVIII/vWF binding activity and therefore could be used as a convenient source of receptors. The human plasma samples to be tested were initially filtered on 4% agarose columns to concentrate the FVIII/vWF protein in the void volume and to remove the factor(s) that interferes with the assay. The percent recovery of FVIII/vWF in the pooled eluent was measured by the recovery of added trace 125I-FVIII/vWF. The coefficients of intra- and interassay variation were 6% and 10%, respectively. The plasma FVIII/vWF concentrations determined by the assay for pooled normal plasma, hemophilia A plasma, and plasmas from two patients with von Willebrand's disease were 16.3 +/- 0.5, 52.6 +/- 1.5, 6.8 +/- 0.8, and 3.2 +/- 0.2 microgram/ml, respectively. The range of plasma FVIII/vWF concentrations varied between 8.3 microgram/ml and 24.9 microgram/ml for 10 normal adults. The plasma FVIII/vWF concentrations determined by the radioreceptor assay correlated well with levels measured by the ristocetin-induced platelet aggregation method, thus demonstrating the functional relevancy of the radioreceptor assay for plasma FVIII/vWF. 相似文献
52.
53.
Christoph J. Jensen Sarah Lusebrink Alexander Wolf Thomas Schlosser Kai Nassenstein Christoph K. Naber Georg V. Sabin Oliver Bruder 《International journal of medical sciences》2015,12(5):378-386
Background/Objectives: Non-ST segment elevation myocardial infarction (MI) poses similar detrimental long-term prognosis as ST-segment elevation MI. No marker on ECG is established to predict successful reperfusion in NSTEMI. QT dispersion is increased by myocardial ischemia and reduced by successful restoration of epicardial blood flow by PCI. Whether QT dispersion reduction translates to smaller infarcts and thus indicates successful reperfusion is unknown.We hypothesized that the relative reduction of QT dispersion (QTD-Rrel ) on a standard ECG in acutely reperfused NSTEMI is related to infarct size and infarct transmurality as assessed by delayed enhancement CMR (DE-CMR).Methods and Results: 69 patients with a first acute NSTEMI were included. QTD-Rrel was stratified according to LV function and volumes, infarct transmurality and size as assessed by DE-CMR. Extensive myocardial infarction was defined as above median infarct size.LV function and end-systolic volume were only mildly related to QTD-Rrel . QTD-Rrel was inversely related to infarct size (r=-0.506,p=0.001) and infarct transmurality (r=-0.415, p=0.001). QTD-Rrel was associated with extensive myocardial infarction in univariate analysis (odds ratio (OR) 0.958, CI 0.935-0.982; p=0.001). Compared to clinical and angiographic data QTD-Rrel remained the only independent predictor of non-transmural infarcts (OR 1.110, CI 1.055-1.167; p=0.049).Conclusion: In patients with acute Non-ST-Segment Myocardial infarction QTd-Rrel calculated on a surface ECG prior and post PCI for restoration of epicardial blood flow detects small, non-transmural infarcts as assessed by delayed enhancement CMR. Thus, QTd-Rrel can indicate successful reperfusion therapy. 相似文献
54.
Long‐term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6‐month randomized,vehicle‐controlled clinical trial 下载免费PDF全文
55.
56.
BO Motayo PA Akinduti FA Adeyakinu PO Okerentugba JC Nwanze CC Onoh HC Innocent-Adiele IO Okonko 《African health sciences》2013,13(4):1091-1097
Background
The increased reports of ESBL dissemination from various centres in south western, Nigeria and the recent emergence of carbapenem resistant bacteria prompted the conception of this study.Objectives
To demonstrate the relationship between high molecular weight plasmids and the expression of antibiotic multi-resistance including ESBL and carbapenemase.Methods
We investigated 97 isolates of selected organisms consisting of 67 E. coli and 30 Klebseilla spp for the presence of plasmids expressing ESBL including carbapenem-hydrolysing enzymes. Beta-lactamase was determined using acidometric method, while ESBL and carbapenemase activity was determined using the double-disk diffusion test as well as the Modified Hodge test (MHT). Plasmid profiles of ESBL and carbapenemase positive isolates were determined according to standard protocols.Results
An ESBL prevalence rate of 21.6% and carbapenem- resistance rate of 9.3% was recorded. Antibiotic susceptibility profile of ESBL isolates showed 100.0% resistance against Amoxicillin, Cotrimoxazole and Erythromycin. Moderate susceptibility was recorded against the Quinolone class of antibiotics; Meropenem remained the most active antibiotic against ESBL isolates with 62.5% against E. coli and 60% against K. pneumoniae. The plasmid profiles of our study isolates ranged from 11.8kbp to 35.5kbp.Conclusion
Due to the relationship between high molecular weight plasmids and multi-drug resistance, we hereby recommend regular molecular surveillance of this form in our study setting. 相似文献57.
58.
59.
非酒精性脂肪性肝炎(non—alcoholicsteatohepatitis,NASH)现已成为肝移植愈来愈重要的基础肝病。鉴于晚期NASH患者常并存多种影响肝移植转归的临床问题,而至今尚无针对NASH患者进行肝移植的评估和治疗指南,为此英国移植学会(British Transplant Society,BTS)邀请相关专家制定了指南,以指导肝移植前后NASH患者的处理。 相似文献