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131.
Babu Muhamed Gasnat Shaboodien Mark E. Engel 《American journal of medical genetics. Part C, Seminars in medical genetics》2020,184(1):159-177
Genetic association studies in rheumatic heart disease (RHD) have the potential to contribute toward our understanding of the pathogenetic mechanism, and may shed light on controversies about RHD etiology. Furthermore, genetic association studies may uncover biomarkers that can be used to identify susceptible individuals, and contribute toward developing vaccine and novel therapeutic targets. Genetic predisposition to rheumatic fever and RHD has been hypothesized by findings from familial studies and observed associations between genes located in the human leukocyte antigens on chromosome 6p21.3 and elsewhere in the genome. We sought to summarize, from published Genetic association studies in RHD, evidence on genetic variants implicated in RHD susceptibility. Using HuGENet? systematic review methods, we evaluated 66 studies reporting on 42 genes. Existing meta‐analyses of candidate gene studies suggest that TGF‐β1 [rs1800469], and IL‐1β [rs2853550] single nucleotide polymorphisms (SNPs) contribute to susceptibility to RHD, whereas the TNF‐α [rs1800629 and rs361525], TGF‐β1 [rs1800470 and rs4803457], IL‐6 [rs1800795], IL‐10 [rs1800896] were not associated with RHD. However, candidate gene studies in RF/RHD are relatively small, thus lacking statistical power to identify reliable and reproducible findings, emphasizing the need for large‐scale multicenter studies with different populations. 相似文献
132.
Fatima Nida Barra Megan E. Roberts Russel Joseph Massaad Elie Hadzipasic Muhamed Shankar Ganesh M. Shin John H. 《Neurosurgical review》2021,44(1):163-175
Neurosurgical Review - Tranexamic acid (TXA) is an effective and commonly used hemostatic agent for perioperative blood loss in various surgical specialties. It is being increasingly used in spinal... 相似文献
133.
Cardiac complications of chest trauma range from arrhythmias to valvular avulsions to myocardial contusion, rupture, and rarely
myocardial infarction. We describe a case of a young patient with blunt chest trauma after a motor vehicle accident in whom
the diagnosis of myocardial infarction was established a week later because no electrocardiogram or cardiac biomarkers were
obtained on presentation. Retrospective review of contrast-enhanced computed tomography (CT) of the chest done on presentation
demonstrated a perfusion defect in the distribution of the left anterior descending artery (LAD). Subsequent coronary angiography
demonstrated dissection in the proximal LAD. Our case illustrates the importance of electrocardiography and contrast-enhanced
chest CT in initial evaluation of patients with blunt chest trauma and suspected injury to the coronary arteries. 相似文献
134.
Masri MA Haberal MA Shaheen FA Stephan A Ghods AJ Al-Rohani M Mousawi MA Mohsin N Abdallah TB Bakr A Rizvi AH 《Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation》2004,2(2):217-220
During the seventies, sporadic renal transplants were performed in few MESOT-region countries, mainly Turkey, Iran, Egypt, and Lebanon. Since the introduction of cyclosporine in the early eighties, transplantation has become the preferred therapeutic modality for end-stage renal failure. In 1986, the Islamic theologians (Al Aloma) issued what became known as the Amman declaration, in which they accepted brain death and retrieval and transplantation of organs from living and cadaveric donors. Based on this and similar declarations, all Middle Eastern countries except Egypt passed laws that allow cadaveric transplantation and regulate live donations. Iran, Turkey, Saudi Arabia, Kuwait, Tunisia, Jordan, and Lebanon all have current active cadaveric programs and perform liver, heart, pancreas, and lung transplants. More than 5088 renal transplants/year are performed in the region with Iran leading with 1600. The cumulative number of renal transplant patients is now nearly 60,000. With a 2003 population of 600,682,175, the rate/million for renal transplantation in the MESOT region is a mere 9/million. Rates of renal transplantation range from 31/million in some countries to 0 in others. The major obstacle in establishing an accurate number of transplants is "tourist transplantation," in which the same transplanted patients are registered in different countries. Although cadaveric programs have been active for more than 10 years, live-related and nonrelated transplants account for nearly 85% of the total transplants. The data presented were collected from MESOT representatives in the region and from publications. For proper compilation of the registry, a format is being proposed that will be presented at the Congress for review and adaptation. Even with the limited resources in the region, immunosuppressive drugs for induction and maintenance therapy are available and are used. Costs for transplantation and immunosuppressive therapy are either totally or heavily supported by governmental agencies. 相似文献
135.
Echocardiographic assessment of left and right heart hemodynamics in a patient with Lutembacher's syndrome 总被引:1,自引:0,他引:1
We present a case of a 53-year-old woman with intractable shortness of breath that was originally ascribed to bronchiolitis obliterans organizing pneumonia. Subsequently evaluation by echocardiography and cardiac catheterization revealed that she had Lutembacher's syndrome, an uncommon combination of congenital atrial septal defect (ASD) and acquired mitral stenosis that is difficult to diagnose clinically. Our case illustrates the pitfalls and advantages of echocardiographic assessment of the mitral valve area (MVA) and the left atrial pressure (LAP). The pressure half-time method used most commonly for estimating MVA echocardiographically is inaccurate and may lead to underestimation of the severity of mitral stenosis in patients with Lutembacher's syndrome. On the other hand, the presence of ASD provides an additional method of calculating LAP, the most important determinant of symptoms in patients with mitral stenosis. 相似文献
136.
Sarah Bauerle Bass Amy Jessop Muhamed Gashat Laurie Maurer Mohammed Alhajji Jon Forry 《Patient education and counseling》2018,101(11):1995-2004
Objective
This paper describes the development of a mobile health tool to facilitate Hepatitis C (HCV) treatment decision making in methadone patients.Methods
Using an iterative, formative evaluation framework, we used commercial marketing techniques to create 3D maps of survey data to develop culturally relevant messaging that was concept tested. The resulting tool was then user tested and results were used to modify the tool.Results
The “Take Charge, Get Cured” tool was developed with surveys (n?=?100), perceptual mapping analysis, concept testing (n?=?5), and user testing (n?=?10). “Think aloud” sessions were audio recorded and surveys given. Patients thought the goal of the tool was to encourage treatment and it was aimed to the needs of methadone patients. Means of 6.7–7 (on a 7 point scale) were observed for survey items related to ease of use, content, and satisfaction.Conclusion
The iterative development was essential to ensuring a culturally targeted tool, specific to the needs of HCV?+?methadone patients. There was a high level of acceptance for the tool.Practice Implications
Our study indicates that using a formative evaluation strategy is essential for development of highly targeted patient communication, especially in hard-to-reach populations. 相似文献137.
Muhamed Ajanovi? Alma Kamber-?esir Adis Hamzi? Selma Tosum 《Acta stomatologica Croatica》2015,49(3):228-233
Aim
The aim of this study was to evaluate the implant stability of Bredent Sky Blue implants of different diameters following one stage sinus lift procedure.Material and methods
This study included 9 male patients with an existing indication for unilateral or bilateral sinus lift procedure. As grafting materials, combination of allograft material MinerOss® cortical & cancellous and Ossceram nano were used.Results
All implants were considered successful and ISQ levels were measured by Osstell ISQ device. The ISQ values were from 68 to 84. The mean values of stability of Bredent Sky Blue implants of different diameters following one stage sinus lift procedure were 77.73 ± 2.93 (MD) and 77.98 ± 2.72 (VO).Key words: dental implants, implant stability, sinus floor augmentation 相似文献138.
Muhamed Ajanovi? Adis Hamzi? Sead Red?epagi? Alma Kamber-?esir Lejla Kazazi? Selma Tosum 《Acta stomatologica Croatica》2015,49(2):128-136
Purpose
The aim of the study was to analyze the amount of maxillary and mandibular crestal bone loss around Bredent Sky Blue type of implants of different dimensions one year after implantation.Materials and Methods
36 implants of diameter 3.5 x 10 mm were inserted in the maxilla and 12 in the mandible. 52 implants of diameter 4.0 x 8 mm were inserted in the maxilla, and 61 in the mandible (two-stage implant surgery).Results
No statistically significant differences were found between the right and left side of the maxilla and between the right and left side of the mandible at the implant sites regarding distal and mesial bone losses as shown by analysis of variance (ANOVA).Conclusion
Statistically significant differences were found between anterior maxilla, posterior maxilla and anterior mandible and posterior mandible at implant sites regarding distal and mesial bone losses as shown by analysis of variance (ANOVA).Key words: Alveolar Bone Loss, Bone Resorption, Dental Implants, Maxilla, Mandible 相似文献139.
140.
Edo Kaluski James Maher Christine Gerula Steve Tsai Preet Randhawa Muhamed Saric Gerard Oghlakian Diane Alfano Jack Palmaro Bunyad Haider Marc Klapholz 《Cardiovascular Revascularization Medicine》2010,11(2):84-90
AimTo assess the effects of shortened door-to-intervention (DTI) time on appropriate clinical decisions regarding the four most critical and costly decisions during primary percutaneous coronary intervention (PCI): cath-lab activation (CLA), use of glycoprotein IIb/IIIa inhibitors (GPI), use of PCI, and deployment of drug-eluting stent (DES).BackgroundSTEMI PCI patients are frequently subject to decision making based on abbreviated medical encounter and limited medical information.MethodsClinical data were prospectively collected in a STEMI registry over 19 months. Retrospective chart reviews were conducted to determine the level of appropriateness of the above-mentioned decisions.ResultsBetween June 2006 and December 2007, 200 EKGs with suspected STEMI were transmitted; 88 (44%) resulted in CLA. Compared to prior year, DTI times decreased from 145.7 to 69.9 min (P=.00001). DTI was longer during nights and weekends (87.5 vs. 51.8 min, P=.001) and the initial 6 months of the registry (86.8 vs. 66.8 min, P=.07). Nineteen (21.6%) of the patients undergoing angiography did not require revascularization, 56 (63.6%) received GPIs, and 65 patients (73.8%) underwent at least one vessel PCI, and at least one DES was used in 39 patients (60% of PCI cohort).When assessed for appropriateness, CLA was appropriate in 81.8% of the time and rendered borderline or inappropriate in 5.7% and 12.5%, respectively. GPI use was appropriate in 66% of the patients but seemed borderline or inappropriate in 28.5% and 5.4%, respectively. PCI was appropriate in 90% of the lesions treated, and borderline or inappropriate in 7.1% and 2.9%, respectively. DES use was viewed appropriate in 38.4%, and borderline or inappropriate in 51% and 10.2% of the DES deployments, respectively.Conclusions(1) In view of expedited care, certain information required for decision-making process is either not available or ignored during primary PCI. (2) Appropriate use of resources in primary PCI needs to be better defined. (3) Measures of extracting patients' previous medical records and imaging studies along with in-lab immediate blood work and echocardiography and establishing new “time-out” protocols for STEMI patients may improve resource utilization and patient care and outcome. 相似文献