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101.
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Fraile M Gubern JM Rull M Julián FJ Serra C Llatjós M Culell P Puig P Solà M Vallejos V Mariscal A Janer J Deulofeu P Fusté F 《Nuclear medicine communications》2006,27(10):785-789
BACKGROUND: The indication for sentinel node biopsy (SNB) has not been fully established yet for patients with ductal carcinoma in situ (DCIS). AIM: To relate the conversion rate to invasive carcinoma with sentinel node positivity in high risk DCIS, and to refine the clinical presentation analysis in order to better select patients for SNB. For this purpose, a risk score was devised. METHODS: From 1998 to 2005, 151 high-risk DCIS patients from six clinical centres were included in a prospective sentinel node database. The conversion rate to invasive carcinoma was 39%. Ten of 142 (7%) successful SNBs showed a positive sentinel node (eight micrometastatic). The sentinel node was positive in 1% of pure DCIS, in 5.5% of DCIS with micro-invasion, and in 19.5% of invasive carcinoma. RESULTS: Both clinical presentation and corresponding risk score were closely related to conversion to invasive carcinoma. The association of risk score and sentinel node positivity approached but did not reach statistical significance (P=0.06); therefore a subset of further selected higher risk patients could not be defined. CONCLUSION: The relevance of SNB positivity cannot be overlooked in high-risk DCIS patients, however, because SNB is not free from morbidity and cost, more studies are needed to refine its final indication. 相似文献
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María Andrée López Andrea Gabilondo Miquel Codony Carlos García-Forero Gemma Vilagut Pere Castellví Montse Ferrer Jordi Alonso 《Quality of life research》2013,22(5):1099-1104
Purpose
There is growing interest in the assessment of positive mental health as a global indicator of societal wealth. We aimed to adapt the Warwick–Edinburgh Mental Well-being scale (WEMWBS) into Spanish and to perform a preliminary evaluation of its metric properties.Methods
Forward and back-translations and cognitive debriefing were carried out. University students (n = 148) were recruited to evaluate the final Spanish version, following the UK original study. Distribution of WEMWBS responses, internal consistency, test–retest reliability, construct validity, and factor structure were assessed.Results
Only 4 (out of 14) items of the initial Spanish version were not rated as conceptually and linguistically equivalent to the original and were modified. The final version was clear and comprehensible. Global score’s Cronbach’s alpha (0.90), item-total score correlations (0.44–0.76), and test–retest ICC (0.84) were all satisfactory. Moderate to high correlations (r = 0.45–0.70) were observed between the WEMWBS and validity scales. Preliminary confirmatory factor analyses did not support the hypothesis of a single factor.Conclusions
A conceptually equivalent Spanish version of the WEMWBS was obtained with high internal consistency, good test–retest reliability, and similar construct validity as the original instrument. Further validity and factorial studies are necessary in larger and more heterogeneous samples. 相似文献104.
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Moore LE Hung R Karami S Boffetta P Berndt S Hsu CC Zaridze D Janout V Kollarova H Bencko V Navratilova M Szeszenia-Dabrowska N Mates D Mukeria A Holcatova I Yeager M Chanock S Garcia-Closas M Rothman N Chow WH Brennan P 《International journal of cancer. Journal international du cancer》2008,122(8):1710-1715
In a multicenter case-control study of renal cell carcinoma (RCC) conducted in central and eastern Europe, we reported a strong inverse association with high vegetable intake and RCC risk. The odds ratio (OR) for high compared to the lowest tertile of vegetable intake was OR = 0.67; (95% confidence interval (CI): 0.53-0.83; p-trend < 0.001). We hypothesized that variation in key folate metabolism genes may modify this association. Common variation in 5 folate metabolism genes (CBS: Ex9+33C > T (rs234706), Ex13 +41C > T (rs1801181), Ex18 -391 G > A (rs12613); MTHFR: A222V Ex5+79C > T (rs1801133), Ex8-62A > C (rs1801131); MTR: Ex26 20A > G (rs1805087), MTRR: Ex5+136 T > C (rs161870), and TYMS:IVS2-405 C > T (rs502396), Ex8+157 C > T (rs699517), Ex8+227 A > G (rs2790)) were analyzed among 1,097 RCC cases and 1,555 controls genotyped in this study. Having at least 1 variant T allele of MTHFR A222V was associated with higher RCC risk compared to those with 2 common (CC) alleles (OR = 1.44; 95% CI: 1.17-1.77; p = 0.001). After stratification by tertile of vegetable intake, the higher risk associated with the variant genotype was only observed in the low and medium tertiles (p-trend = 0.001), but not among those in the highest tertile (p-interaction = 0.22). The association remained robust after calculation of the false discovery rate (FDR = 0.05). Of the 3 TYMS SNPs examined, only the TYMS IVS2 -405 C (rs502396) variant was associated with a significantly lower risk compared to the common genotype (OR = 0.73; 95% CI: 0.57-0.93). Vegetable intake modified the association between all 3 TYMS SNPs and RCC risk (p-interaction < 0.04 for all). In summary, these findings suggest that common variation in MTHFR and TYMS genes may be associated with RCC risk, particularly when vegetable intake is low. 相似文献
110.
Sandra?Martín-Peláez Olga?Casta?er Valentini?Konstantinidou Isaac?Subirana Daniel?Mu?oz-Aguayo Gemma?Blanchart Sonia?Gaixas Rafael?de la Torre Magí?Farré Guillermo T?Sáez Kristina?Nyyss?nen Hans Joachim?Zunft Maria?Isabel?Covas Montse?FitóEmail author 《European journal of nutrition》2017,56(2):663-670