全文获取类型
收费全文 | 6352篇 |
免费 | 443篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 247篇 |
妇产科学 | 137篇 |
基础医学 | 997篇 |
口腔科学 | 64篇 |
临床医学 | 718篇 |
内科学 | 1245篇 |
皮肤病学 | 64篇 |
神经病学 | 854篇 |
特种医学 | 153篇 |
外科学 | 607篇 |
综合类 | 39篇 |
预防医学 | 650篇 |
眼科学 | 56篇 |
药学 | 495篇 |
中国医学 | 26篇 |
肿瘤学 | 421篇 |
出版年
2024年 | 9篇 |
2023年 | 45篇 |
2022年 | 73篇 |
2021年 | 177篇 |
2020年 | 107篇 |
2019年 | 161篇 |
2018年 | 184篇 |
2017年 | 139篇 |
2016年 | 154篇 |
2015年 | 194篇 |
2014年 | 218篇 |
2013年 | 316篇 |
2012年 | 442篇 |
2011年 | 516篇 |
2010年 | 273篇 |
2009年 | 248篇 |
2008年 | 416篇 |
2007年 | 434篇 |
2006年 | 415篇 |
2005年 | 408篇 |
2004年 | 401篇 |
2003年 | 362篇 |
2002年 | 341篇 |
2001年 | 54篇 |
2000年 | 52篇 |
1999年 | 60篇 |
1998年 | 67篇 |
1997年 | 63篇 |
1996年 | 65篇 |
1995年 | 44篇 |
1994年 | 38篇 |
1993年 | 35篇 |
1992年 | 26篇 |
1991年 | 22篇 |
1990年 | 26篇 |
1989年 | 19篇 |
1988年 | 18篇 |
1987年 | 22篇 |
1986年 | 12篇 |
1985年 | 13篇 |
1984年 | 23篇 |
1983年 | 13篇 |
1982年 | 17篇 |
1981年 | 14篇 |
1980年 | 21篇 |
1979年 | 12篇 |
1978年 | 12篇 |
1977年 | 5篇 |
1973年 | 5篇 |
1969年 | 7篇 |
排序方式: 共有6821条查询结果,搜索用时 15 毫秒
111.
112.
Merel?de?JongEmail author Angela?G.?E.?M.?de?Boer Sietske?J.?Tamminga Monique?H.?W.?Frings-Dresen 《Journal of occupational rehabilitation》2015,25(1):182-196
Purpose To assess issues that contribute to the Quality of Working Life (QWL) of employees with a chronic physical disease. Methods A systematic literature search was conducted using the databases PubMed, PsycINFO and EMBASE. Experiences and perceptions during the working life of employees with a chronic physical disease were extracted and synthesized into issues that contributed to their QWL. We organized these synthesized QWL issues into higher order themes and categories with qualitative data analysis software. Results From a total of 4,044 articles identified by the search, 61 articles were included. Data extraction and data synthesis resulted in an overview of 73 QWL issues that were classified into 30 themes. The following five categories of themes were identified: (1) job characteristics with issues such as job flexibility and work-site access; (2) the social structure and environment containing issues about disclosure, discrimination, misunderstanding, and awareness by employers or colleagues; (3) organizational characteristics with issues such as requesting work accommodations; (4) individual work perceptions including issues about enjoyment and evaluating work or life priorities; and (5) effect of the disease and treatment including issues about cognitive and physical health and work ability. Conclusion This systematic review offers an extensive overview of issues that might contribute to the QWL of employees with a chronic physical disease. This overview may function as a starting point for occupational support, such as monitoring and evaluating the QWL of employees with a chronic physical disease during return-to-work and work continuation processes. 相似文献
113.
114.
115.
Monique Lhussier HND MSc PhD Simon Eaton BMedSci BMBS FRCP DM CertMEd Natalie Forster BA PGCert Mathew Thomas BA Sue Roberts MBBS MSc FRCP Susan M Carr BA MSc PhD 《Health expectations》2015,18(5):605-624
Objective
This article focuses on approaches within clinical practice that seek to actively involve patients with long‐term conditions (LTCs) and how professionals may understand and implement them. Personalized care planning is one such approach, but its current lack of conceptual clarity might have impeded its widespread implementation to date. A variety of overlapping concepts coexist in the literature, which have the potential to impair both clinical and research agendas. The aim of this article is therefore to explore the meaning of the concept of care planning in relation to other overlapping concepts and how this translates into clinical practice implementation.Methods
Searches were conducted in the Cochrane database for systematic reviews, CINHAL and MEDLINE. A staged approach to conducting the concept mapping was undertaken, by (i) an examination of the literature on care planning in LTCs; (ii) identification of related terms; (iii) locating reviews of those terms. Retrieved articles were subjected to a content analysis, which formed the basis of our concept maps. (iv) We then appraised these against knowledge and experience of the implementation of care planning in clinical practice.Results and Conclusions
Thirteen articles were retrieved, in which the core importance of patient‐centredness, shared decision making and self‐management was highlighted. Literature searches on these terms retrieved a further 24 articles. Our concept mapping exercise shows that whilst there are common themes across the concepts, the differences between them reflect the context and intended outcomes within clinical practice. We argue that this clarification exercise will allow for further development of both research and clinical implementation agendas. 相似文献116.
Chipanta David Pettifor Audrey Edwards Jessie Giovenco Danielle Topazian Hillary Mariko Bray Rachel M. Millington Monique C. Estill Janne Keiser Olivia Justman Jessica E. 《AIDS and behavior》2022,26(9):3068-3078
AIDS and Behavior - We aimed to measure social protection coverage among the general population, women and men living with HIV (WLHIV, MLHV), female and male sex workers (FSW, MSW), men who have... 相似文献
117.
Virginie Bernier Monique Lagacé Daniel G Bichet Michel Bouvier 《Trends in Endocrinology and Metabolism》2004,15(5):222-228
Increasing numbers of inherited diseases are found to result from mutations that lead to misfolded proteins. In many cases, the changes in conformation are relatively modest and the function of the protein would not be predicted to be affected. Yet, these proteins are recognized as "misfolded" and degraded prematurely. Recently, small molecules known as chemical and pharmacological chaperones were found to stabilize such mutant proteins and facilitate their trafficking to their site of action. Here, we review the recent published evidence suggesting that pharmacological chaperones represent promising avenues for the treatment of endocrine and metabolic diseases such as hyperinsulinemic hypoglycemia, hypogonadotropic hypogonadism and nephrogenic diabetes insipidus, and might become a general therapeutic strategy for the treatment of conformational diseases. 相似文献
118.
Visceral leishmaniasis: current status of control,diagnosis, and treatment,and a proposed research and development agenda 总被引:13,自引:0,他引:13
Guerin PJ Olliaro P Sundar S Boelaert M Croft SL Desjeux P Wasunna MK Bryceson AD 《The Lancet infectious diseases》2002,2(8):494-501
Visceral leishmaniasis is common in less developed countries, with an estimated 500000 new cases each year. Because of the diversity of epidemiological situations, no single diagnosis, treatment, or control will be suitable for all. Control measures through case finding, treatment, and vector control are seldom used, even where they could be useful. There is a place for a vaccine, and new imaginative approaches are needed. HIV co-infection is changing the epidemiology and presents problems for diagnosis and case management. Field diagnosis is difficult; simpler, less invasive tests are needed. Current treatments require long courses and parenteral administration, and most are expensive. Resistance is making the mainstay of treatment, agents based on pentavalent antimony, useless in northeastern India, where disease incidence is highest. Second-line drugs (pentamidine and amphotericin B) are limited by toxicity and availability, and newer formulations of amphotericin B are not affordable. The first effective oral drug, miltefosine, has been licensed in India, but the development of other drugs in clinical phases (paromomycin and sitamaquine) is slow. No novel compound is in the pipeline. Drug combinations must be developed to prevent drug resistance. Despite these urgent needs, research and development has been neglected, because a disease that mainly affects the poor ranks as a low priority in the private sector, and the public sector currently struggles to undertake the development of drugs and diagnostics in the absence of adequate funds and infrastructure. This article reviews the current situation and perspectives for diagnosis, treatment, and control of visceral leishmaniasis, and lists some priorities for research and development. 相似文献
119.
M Cruciani A Navarra G Di Perri M Andreoni M C Danzi E Concia D Bassetti 《Clinical infectious diseases》1992,15(2):285-289
Seven patients with staphylococcal neurosurgical shunt infections were treated with intraventricular teicoplanin. Two infants received 5 mg/d, three patients received 20 mg/d, and two patients received 20 mg every other day. Six of these patients also received intravenous antibiotics. Three patients had infections caused by methicillin-susceptible Staphylococcus epidermidis, and one patient had an infection caused by methicillin-resistant S. epidermidis. Three patients were infected with Staphylococcus aureus (one with a methicillin-resistant strain and two with methicillin-susceptible strains). The mean duration of intraventricular therapy was 16 days. Sterilization of cerebrospinal fluid (CSF) was obtained after an average of 4.4 days. All patients were cured both clinically and microbiologically. No significant adverse effects were observed in any patients. Penetration of teicoplanin into the CSF after intravenous administration was poor. However, after intraventricular administration, high and prolonged peak and trough levels of teicoplanin were detected in the CSF. Bactericidal activity of the CSF was remarkable, exceeding the 1:8 dilution in the majority of the cases. The alternate-day schedule of intraventricular administration of teicoplanin was as effective as the once-daily regimen. 相似文献
120.
High-altitude pulmonary edema at moderate altitude (< 2,400 m; 7,870 feet): a series of 52 patients 总被引:7,自引:0,他引:7
STUDY OBJECTIVES: To describe a group of patients who acquired pulmonary edema at a moderate altitude of 1,400 to 2,400 m. DESIGN: Observational, retrospective chart review (1992-2000) of a series of 52 consecutive patients admitted for high-altitude pulmonary edema (HAPE) that occurred at 1,400 to 2,400 m. SETTING: Emergency department of a community hospital in the French Alps (altitude, 500 m). PATIENTS: Vacationing skiers who met criteria for altitude-related pulmonary edema, and in whom other causes (infectious, cardiogenic, neurogenic, and toxic) were excluded. Measurements and results: All patients presented with signs of pulmonary edema. Diagnoses of infectious, cardiogenic, neurogenic, or toxic edema were ruled out in each patient. All patients were hypoxemic and had radiographic signs of pulmonary edema. Virtually all patients (96%) had dyspnea, and most (77%) had moist rales. All patients were treated with supplemental oxygen (3 to 12 L/min), bed rest, moderate fluid restriction, and continuous positive airway pressure. All recovered fully and were discharged after 4 +/- 2 days (mean +/- SD). CONCLUSION: This study suggests that HAPE at moderate altitudes is more frequent than usually reported. Patients are likely to be young, vacationing men, with no history of prior disease. The disease has a favorable prognosis, and requires simple treatment and a short hospital stay. 相似文献