全文获取类型
收费全文 | 5065篇 |
免费 | 309篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 231篇 |
妇产科学 | 183篇 |
基础医学 | 614篇 |
口腔科学 | 99篇 |
临床医学 | 604篇 |
内科学 | 1017篇 |
皮肤病学 | 166篇 |
神经病学 | 348篇 |
特种医学 | 135篇 |
外国民族医学 | 2篇 |
外科学 | 499篇 |
综合类 | 66篇 |
一般理论 | 4篇 |
预防医学 | 550篇 |
眼科学 | 150篇 |
药学 | 370篇 |
中国医学 | 7篇 |
肿瘤学 | 316篇 |
出版年
2024年 | 7篇 |
2023年 | 73篇 |
2022年 | 123篇 |
2021年 | 232篇 |
2020年 | 151篇 |
2019年 | 171篇 |
2018年 | 230篇 |
2017年 | 175篇 |
2016年 | 170篇 |
2015年 | 152篇 |
2014年 | 239篇 |
2013年 | 330篇 |
2012年 | 438篇 |
2011年 | 439篇 |
2010年 | 213篇 |
2009年 | 146篇 |
2008年 | 298篇 |
2007年 | 352篇 |
2006年 | 278篇 |
2005年 | 305篇 |
2004年 | 224篇 |
2003年 | 201篇 |
2002年 | 160篇 |
2001年 | 28篇 |
2000年 | 17篇 |
1999年 | 22篇 |
1998年 | 20篇 |
1997年 | 25篇 |
1996年 | 17篇 |
1995年 | 13篇 |
1994年 | 11篇 |
1993年 | 15篇 |
1992年 | 6篇 |
1991年 | 7篇 |
1990年 | 7篇 |
1989年 | 12篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 10篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 7篇 |
1978年 | 3篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1971年 | 3篇 |
排序方式: 共有5400条查询结果,搜索用时 15 毫秒
101.
Mona Soliman 《中华医学杂志(英文版)》2015,128(17):2360-2364
Background:
Hemorrhagic shock (HS) results in myocardial contractile dysfunction. Studies showed that 17β-estradiol protects the myocardium against contractile dysfunction. The study investigated the cardioprotective effects of treatment with 17β-estradiol before resuscitation following 1 h of HS and resuscitation.Methods:
Male Sprague-Dawley rats were assigned to 2 sets of experimental protocols: Ex vivo and in vivo treatment and resuscitation. Each set had three experimental groups (n = 6 per group): Normotensive (N), HS and resuscitation (HS-R) and HS rats treated with 17β-estradiol (E) and resuscitated (HS-E-R). Rats were hemorrhaged over 60-min to reach a mean arterial blood pressure of 40 mmHg. In the ex vivo group, hearts were resuscitated by perfusion in the Langendorff system. In the 17β-estradiol treated group, 17β-estradiol 280 µg/kg was added for the first 5 min. Cardiac function was measured. Left ventricular generated pressure (LVGP) and +dP/dt were calculated. In the in vivo group, rats were treated with 17β-estradiol 280 µg/kg s.c. after 60-min HS. Resuscitation was performed in vivo by the reinfusion of the shed blood for 30-min to restore normotension.Results:
Treatment with 17β-estradiol before resuscitation in ex vivo treated and resuscitated isolated hearts and in the in vivo treated and resuscitated rats following HS improved myocardial contractile function. In the in vivo treated group, LVGP and +dP/dt max were significantly higher in 17β-estradiol treated rats compared to the untreated group (LVGP 136.40 ± 6.61 compared to 47.58 ± 17.55, and +dP/dt 661.85 ± 49.88 compared to 88.18 ± 0.85). Treatment with 17β-estradiol improved LVGP following HS.Conclusions:
The results indicate that treatment with 17β-estradiol before resuscitation following HS protects the myocardium against dysfunction. 相似文献102.
Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma 总被引:12,自引:0,他引:12
O'Byrne PM Bisgaard H Godard PP Pistolesi M Palmqvist M Zhu Y Ekström T Bateman ED 《American journal of respiratory and critical care medicine》2005,171(2):129-136
Asthma control is improved by combining inhaled corticosteroids with long-acting beta2-agonists. However, fluctuating asthma control still occurs. We hypothesized that in patients receiving low maintenance dose budesonide/formoterol (bud/form), replacing short-acting beta2-agonist (SABA) reliever with as-needed bud/form would provide rapid symptom relief and simultaneous adjustment in antiinflammatory therapy, thereby reducing exacerbations. In this double-blind, randomized, parallel-group study, 2,760 patients with asthma aged 4-80 years (FEV1 60-100% predicted) received either terbutaline 0.4 mg as SABA with bud/form 80/4.5 microg twice a day (bud/form + SABA) or bud 320 microg twice a day (bud + SABA) or bud/form 80/4.5 microg twice a day with 80/4.5 microg as-needed (bud/form maintenance + relief). Children used a once-nocte maintenance dose. Bud/form maintenance + relief prolonged time to first severe exacerbation (p < 0.001; primary endpoint), resulting in a 45-47% lower exacerbation risk versus bud/form + SABA (hazard ratio, 0.55; 95% confidence interval, 0.44, 0.67) or bud + SABA (hazard ratio, 0.53; 95% confidence interval 0.43, 0.65). Bud/form maintenance + relief also prolonged the time to the first, second, and third exacerbation requiring medical intervention (p < 0.001), reduced severe exacerbation rate, and improved symptoms, awakenings, and lung function compared with both fixed dosing regimens. 相似文献
103.
Marwa Fathy Ebraheem Rehab Abd-El Raouf Sallam Mona A. Mohsen Basma Ahmed El-Kady Galal E. El-Hawary Azza A Baiomy 《The Egyptian Rheumatologist》2019,41(2)
Background
There is risk of premature atherosclerosis in juvenile idiopathic arthritis (JIA) patients which predisposes to cardiovascular disease (CVD) in adulthood. This can be assessed by flow mediated dilatation (FMD) and carotid intima media thickness (IMT) of the arterial wall and by soluble vascular cell adhesion molecule (sVCAM-1).Aim of the work
To assess endothelial dysfunction in JIA children and to correlate sVCAM with FMD of brachial artery and carotid IMT.Patients and methods
The study was conducted on 55 JIA patients. The following was assessed: body mass index (BMI), blood pressure, juvenile arthritis disease activity score (JADAS27). Childhood Health Assessment Questionnaire (C-HAQ), physical activity questionnaire (PAQ), fatigue assessment using The Pediatric Quality of Life (PedsQL) inventory, full blood count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), serum creatinine and lipid profile, sVCAM-1, FMD and IMT.Results
The patients’ age was 10.9?±?3.9?years and were 28 (50.9%) females. JADAS-27 and CRP was higher in systemic JIA, but fatigue scores were significantly lower. CHAQ was significantly lower in patients with polyarticular disease. Patients with high disease activity had significantly younger age of onset, lower BMI, shorter disease duration, lower fatigue scale and physical activity scores and higher CHAQ. sVCAM-1 significantly correlated with CHAQ, low-density lipoprotein, CRP and ESR while FMD significantly correlated with PedsQL and PAQ.Conclusion
JIA patients had impaired endothelial function and increased cIMT with increased sVCAM-1, impaired lipid profile, decreased physical activity and increased fatigue with a potentially higher cardiovascular risk in this pediatric population. 相似文献104.
Clinical and molecular characterization of seven Egyptian families with autosomal recessive robinow syndrome: Identification of four novel ROR2 gene mutations 下载免费PDF全文
105.
106.
107.
108.
109.
Isaac E. Hall Peter P. Reese Francis L. Weng Bernd Schr?ppel Mona D. Doshi Rick D. Hasz William Reitsma Michael J. Goldstein Kwangik Hong Chirag R. Parikh 《Clinical journal of the American Society of Nephrology》2014,9(3):573-582
Background and objectives
The influence of deceased-donor AKI on post-transplant outcomes is poorly understood. The few published studies about deceased-donor preimplant biopsy have reported conflicting results regarding associations between AKI and recipient outcomes.Design, setting, participants, & measurements
This multicenter study aimed to evaluate associations between deceased-donor biopsy reports of acute tubular necrosis (ATN) and delayed graft function (DGF), and secondarily for death-censored graft failure, first adjusting for the kidney donor risk index and then stratifying by donation after cardiac death (DCD) status.Results
Between March 2010 and April 2012, 651 kidneys (369 donors, 4 organ procurement organizations) were biopsied and subsequently transplanted, with ATN reported in 110 (17%). There were 262 recipients (40%) who experienced DGF and 38 (6%) who experienced graft failure. DGF occurred in 45% of kidneys with reported ATN compared with 39% without ATN (P=0.31) resulting in a relative risk (RR) of 1.13 (95% confidence interval [95% CI], 0.9 to 1.43) and a kidney donor risk index–adjusted RR of 1.11 (95% CI, 0.88 to 1.41). There was no significant difference in graft failure for kidneys with versus without ATN (8% versus 5%). In stratified analyses, the adjusted RR for DGF with ATN was 0.97 (95% CI, 0.7 to 1.34) for non-DCD kidneys and 1.59 (95% CI, 1.23 to 2.06) for DCD kidneys (P=0.02 for the interaction between ATN and DCD on the development of DGF).Conclusions
Despite a modest association with DGF for DCD kidneys, this study reveals no significant associations overall between preimplant biopsy-reported ATN and the outcomes of DGF or graft failure. The potential benefit of more rigorous ATN reporting is unclear, but these findings provide little evidence to suggest that current ATN reports are useful for predicting graft outcomes or deciding to accept or reject allograft offers. 相似文献110.