全文获取类型
收费全文 | 3379篇 |
免费 | 267篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 85篇 |
妇产科学 | 89篇 |
基础医学 | 324篇 |
口腔科学 | 53篇 |
临床医学 | 280篇 |
内科学 | 1045篇 |
皮肤病学 | 94篇 |
神经病学 | 230篇 |
特种医学 | 95篇 |
外科学 | 587篇 |
综合类 | 83篇 |
一般理论 | 1篇 |
预防医学 | 177篇 |
眼科学 | 62篇 |
药学 | 153篇 |
中国医学 | 20篇 |
肿瘤学 | 247篇 |
出版年
2024年 | 3篇 |
2023年 | 54篇 |
2022年 | 112篇 |
2021年 | 250篇 |
2020年 | 154篇 |
2019年 | 181篇 |
2018年 | 229篇 |
2017年 | 136篇 |
2016年 | 127篇 |
2015年 | 117篇 |
2014年 | 170篇 |
2013年 | 206篇 |
2012年 | 286篇 |
2011年 | 259篇 |
2010年 | 158篇 |
2009年 | 101篇 |
2008年 | 160篇 |
2007年 | 188篇 |
2006年 | 169篇 |
2005年 | 140篇 |
2004年 | 131篇 |
2003年 | 98篇 |
2002年 | 95篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 10篇 |
1998年 | 8篇 |
1997年 | 7篇 |
1996年 | 8篇 |
1995年 | 11篇 |
1994年 | 8篇 |
1993年 | 13篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 2篇 |
1970年 | 1篇 |
1961年 | 1篇 |
1943年 | 1篇 |
1923年 | 2篇 |
排序方式: 共有3662条查询结果,搜索用时 31 毫秒
91.
92.
Thye Foo Choo Mohamad Amran Mohd Salleh Kuan Ying Kok Khamirul Amin Matori Suraya Abdul Rashid 《Materials》2020,13(22)
Grog is an additive material that plays important roles in ceramic making. It improves the fabrication process of green bodies as well as the physical properties of fired bodies. Few low-cost materials and wastes have found their application as grog in recent years, thus encouraging the replacement of commercial grogs with cost-saving materials. Coal fly ash, a combustion waste produced by coal-fired power plant, has the potential to be converted into grog owing to its small particle sizes and high content of silica and alumina. In this study, grog was derived from coal fly ash and mixed with kaolin clay to produce ceramics. Effects of the grog addition on the resultant ceramics were investigated. It was found that, to a certain extent, the grog addition reduced the firing shrinkage and increased the total porosity of the ceramics. The dimensional stability of the ceramics at a firing temperature of 1200 °C was also not noticeably affected by the grog. However, the grog addition in general had negative effects on the biaxial flexural strength and refractoriness of the ceramics. 相似文献
93.
94.
95.
Mohamad S. Hakim Michelle Spaan Harry L. A. Janssen Andre Boonstra 《Reviews in medical virology》2014,24(2):125-138
Chronic HBV and HCV infections are the leading cause of liver‐related morbidity and mortality. For effective antiviral immunity, virus‐specific T cells are required, but these cells have been shown to be weak or absent in chronic HBV and HCV patients. One of the mechanisms that underlies the impaired T‐cell response is the result of the continuously high viral load that causes HBV‐specific and HCV‐specific T cells to become exhausted, which is characterized by impaired proliferation, cytokine production and cytotoxic activity of T cells as well as high susceptibility to apoptosis. In vitro studies from chronic HBV and HCV patients as well as in vivo studies in animal models demonstrated a reversible state of T‐cell exhaustion, which can be manipulated to reinvigorate the specific antiviral immune responses. In chronic HCV infection, this concept has been explored in clinical trials by administration of specific antibody to block the inhibitory pathways. The manipulation of inhibitory receptors is a promising and potential strategy for immunotherapeutic interventions in chronic HBV and HCV patients to facilitate complete elimination of the viruses or sustained viral control. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
96.
Mastura Shafinaz Zainal Abidin Tahsin Morshed Hironori Chikita Yuki Kinoshita Shunpei Muta Mohammad Anisuzzaman Jong-Hyeok Park Ryo Matsumura Mohamad Rusop Mahmood Taizoh Sadoh Abdul Manaf Hashim 《Materials》2014,7(2):1409-1421
The effects of annealing temperatures on composition and strain in SixGe1−x, obtained by rapid melting growth of electrodeposited Ge on Si (100) substrate were investigated. Here, a rapid melting process was performed at temperatures of 1000, 1050 and 1100°C for 1 s. All annealed samples show single crystalline structure in (100) orientation. A significant appearance of Si-Ge vibration mode peak at ~00 cm−1 confirms the existence of Si-Ge intermixing due to out-diffusion of Si into Ge region. On a rapid melting process, Ge melts and reaches the thermal equilibrium in short time. Si at Ge/Si interface begins to dissolve once in contact with the molten Ge to produce Si-Ge intermixing. The Si fraction in Si-Ge intermixing was calculated by taking into account the intensity ratio of Ge-Ge and Si-Ge vibration mode peaks and was found to increase with the annealing temperatures. It is found that the strain turns from tensile to compressive as the annealing temperature increases. The Si fraction dependent thermal expansion coefficient of SixGe1−x is a possible cause to generate such strain behavior. The understanding of compositional and strain characteristics is important in Ge/Si heterostructure as these properties seem to give significant effects in device performance. 相似文献
97.
Abdul Amir H. Kadhum Abu Bakar Mohamad Leiqaa A. Hammed Ahmed A. Al-Amiery Ng Hooi San Ahmed Y. Musa 《Materials》2014,7(6):4335-4348
A new coumarin derivative, N,N′-((2E,2′E)-2,2′-(1,4-phenylenebis(methanylylidene))bis(hydrazinecarbonothioyl))bis(2-oxo-2H-chromene-3-carboxamide) PMBH, was synthesized and its chemical structure was elucidated and confirmed using spectroscopic techniques (Infrared spectroscopy IR, Proton nuclear magnetic resonance, 1H-NMR and carbon-13 nuclear magnetic resonance 13C-NMR). The corrosion inhibition effect of PMBH on mild steel in 1.0 M HCl was investigated using corrosion potential (ECORR), potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and electrochemical frequency modulation (EFM) measurements. The obtained results indicated that PMBH has promising inhibitive effects on the corrosion of mild steel in 1.0 M HCl across all of the conditions examined. Scanning electron microscopy (SEM) was used to investigate the morphology of the mild steel before and after immersion in 1.0 M HCl solution containing 0.5 mM of PMBH. Surface analysis revealed improvement of corrosion resistance in presence of PMBH. 相似文献
98.
Usefulness of 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study
下载免费PDF全文
![点击此处可从《Arthritis care & research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mikael Ebbo Aurélie Grados Eric Guedj Delphine Gobert Cécile Colavolpe Mohamad Zaidan Agathe Masseau Fanny Bernard Jean‐Marie Berthelot Nathalie Morel François Lifermann Sylvain Palat Julien Haroche Xavier Mariette Bertrand Godeau Emmanuelle Bernit Nathalie Costedoat‐Chalumeau Thomas Papo Mohamed Hamidou Jean‐Robert Harlé Nicolas Schleinitz 《Arthritis care & research》2014,66(1):86-96
99.
Ibrahim H. Eissa Ahmed M. Metwaly Amany Belal Ahmed B.M. Mehany Rezk R. Ayyad Khaled El‐Adl Hazem A. Mahdy Mohammed S. Taghour Kamal M.A. El‐Gamal Mohamad E. El‐Sawah Souad A. Elmetwally Mostafa. A. Elhendawy Mohamed M. Radwan Mahmoud A. ElSohly 《Archiv der Pharmazie》2019,352(11)
In continuation of our previous work on the design and synthesis of topoisomerase II (Topo II) inhibitors and DNA intercalators, a new series of quinoxaline derivatives were designed and synthesized. The synthesized compounds were evaluated for their cytotoxic activities against a panel of three cancer cell lines (Hep G‐2, Hep‐2, and Caco‐2). Compounds 18b, 19b, 23, 25b , and 26 showed strong potencies against all tested cell lines with IC50 values ranging from 0.26 ± 0.1 to 2.91 ± 0.1 µM, comparable with those of doxorubicin (IC50 values ranging from 0.65 ± 0.1 to 0.81 ± 0.1 µM). The most active compounds were further evaluated for their Topo II inhibitory activities and DNA intercalating affinities. Compounds 19b and 19c exhibited high activities against Topo II (IC50 = 0.97 ± 0.1 and 1.10 ± 0.1 µM, respectively) and bound the DNA at concentrations of 43.51 ± 2.0 and 49.11 ± 1.8 µM, respectively, whereas compound 28b exhibited a significant affinity to bind the DNA with an IC50 value of 37.06 ± 1.8 µM. Moreover, apoptosis and cell‐cycle tests of the most promising compound 19b were carried out. It was found that 19b can significantly induce apoptosis in Hep G‐2 cells. It has revealed cell‐cycle arrest at the G2/M phase. Moreover, compound 19b downregulated the Bcl‐2 levels, indicating its potential to enhance apoptosis. Furthermore, molecular docking studies were carried out against the DNA–Topo II complex to examine the binding patterns of the synthesized compounds. 相似文献
100.
Landy M. Wu Adel Ekladious Luke Wheeler Abdulrazak A. Mohamad 《Internal medicine journal》2020,50(1):121-123
A 17‐year‐old female was diagnosed with Wilson disease and commenced on oral zinc therapy. She re‐presented 6 months later with a fall and had classical signs of subacute combined degeneration of the spinal cord confirmed on nerve conduction studies, as a result of zinc‐induced copper deficiency. After 6 months of copper therapy, she made a complete recovery with no residual neurological deficits. Early detection of zinc‐induced copper deficiency and stringent follow‐up mechanisms are crucial. Early initiation of copper replacement may both limit and completely reverse neurological deficits. 相似文献