全文获取类型
收费全文 | 3379篇 |
免费 | 267篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 85篇 |
妇产科学 | 89篇 |
基础医学 | 324篇 |
口腔科学 | 53篇 |
临床医学 | 280篇 |
内科学 | 1045篇 |
皮肤病学 | 94篇 |
神经病学 | 230篇 |
特种医学 | 95篇 |
外科学 | 587篇 |
综合类 | 83篇 |
一般理论 | 1篇 |
预防医学 | 177篇 |
眼科学 | 62篇 |
药学 | 153篇 |
中国医学 | 20篇 |
肿瘤学 | 247篇 |
出版年
2024年 | 3篇 |
2023年 | 54篇 |
2022年 | 112篇 |
2021年 | 250篇 |
2020年 | 154篇 |
2019年 | 181篇 |
2018年 | 229篇 |
2017年 | 136篇 |
2016年 | 127篇 |
2015年 | 117篇 |
2014年 | 170篇 |
2013年 | 206篇 |
2012年 | 286篇 |
2011年 | 259篇 |
2010年 | 158篇 |
2009年 | 101篇 |
2008年 | 160篇 |
2007年 | 188篇 |
2006年 | 169篇 |
2005年 | 140篇 |
2004年 | 131篇 |
2003年 | 98篇 |
2002年 | 95篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 10篇 |
1998年 | 8篇 |
1997年 | 7篇 |
1996年 | 8篇 |
1995年 | 11篇 |
1994年 | 8篇 |
1993年 | 13篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 2篇 |
1970年 | 1篇 |
1961年 | 1篇 |
1943年 | 1篇 |
1923年 | 2篇 |
排序方式: 共有3662条查询结果,搜索用时 640 毫秒
41.
Marina Díaz-Beyá Myriam Labopin Johan Maertens Mahmoud Alijurf Jakob Passweg Beelen Dietrich Harry Schouten Gerard Socié Nicolaas Schaap Rainer Schwerdtfeger Liisa Volin Mauricette Michallet Emmanuelle Polge Jorge Sierra Mohamad Mohty Jordi Esteve Arnon Nagler the Acute Leukaemia Working Party of the European Society for Blood Marrow Transplantation 《British journal of haematology》2020,189(5):920-925
Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a poor-risk entity, commonly associated with FLT3-ITD (internal tandem duplication). Allogeneic stem-cell tranplantation (allo-SCT) is recommended, although studies analysing the outcome of allo-SCT in this setting are lacking. We selected 195 patients with t(6;9) AML, who received a first allo-SCT between 2000 and 2016 from the EBMT (European Society for Blood and Marrow Transplantation) registry. Disease status at time of allo-SCT was the strongest independent prognostic factor, with a two-year leukaemia-free survival and relapse incidence of 57% and 19% in patients in CR1 (first complete remission), 34% and 33% in CR2 (second complete remission), and 24% and 49% in patients not in remission, respectively (P < 0·001). This study, which represents the largest one available in t(6;9) AML, supports the recommendation to submit these patients to allo-SCT in CR1. 相似文献
42.
43.
Embryonic stem cell gene expression signatures in the canine mammary tumor: a bioinformatics approach
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mohamad Zamani‐Ahmadmahmudi 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2016,124(8):659-668
Canine breast cancer was considered as an ideal model of comparative oncology for the human breast cancer, as there is significant overlap between biological and clinical characteristics of the human and canine breast cancer. We attempt to clarify expression profile of the embryonic stem cell (ES) gene signatures in canine breast cancer. Using microarray datasets (GSE22516 and GSE20718), expression of the three major ES gene signatures (modules or gene‐sets), including Myc, ESC‐like, and PRC modules, was primarily analyzed through Gene‐Set Enrichment Analysis (GSEA) method in tumor and healthy datasets. For confirmation of the primary results, an additional 13 ES gene‐sets which were categorized into four groups including ES expressed (ES exp1 and ES exp2), NOS targets (Nanog targets, Oct4 targets, Sox2 targets, NOS targets, and NOS TFs), Polycomb targets (Suz12 targets, Eed targets, H3K27 bound, and PRC2 targets), and Myc targets (Myc targets1, and Myc targets2) were tested in the tumor and healthy datasets. Our results revealed that there is a valuable overlap between canine and human breast cancer ES gene‐sets expression profile, where Myc and ESC‐like modules were up‐regulated and PRC module was down‐regulated in metastatic canine mammary gland tumors. Further analysis of the secondary gene‐sets indicated overexpression of the ES expressed, NOS targets (Nanog targets, Oct4 targets, Sox2 targets, and NOS targets), and Myc targets and underexpression of the Polycomb targets in metastatic canine breast cancer. 相似文献
44.
Jacques Lalevée Guillaume Povie Mohamad Ali Tehfe Sofia Telitel Fabrice Morlet‐Savary Bernadette Graff Jean Pierre Fouassier 《Macromolecular chemistry and physics.》2012,213(15):1618-1622
Upon demand, 1,3‐diamino‐propane‐triethylborane (DAPTB) is photolyzed in the presence of an acid generator such as a diphenyliodonium salt. Interestingly, triethylborane is released. In the presence of oxygen, ethyl radicals are generated and initiate an acrylate polymerization. This is the first example of a phototriggered production of a triethylborane usable in the photoinitiation of acrylate polymerizations. This approach is also worthwhile to overcome the oxygen inhibition for free‐radical polymerization processes. 相似文献
45.
Vogl Brennan J. Darestani Yousef M. Crestanello Juan A. Lindman Brian R. Alkhouli Mohamad A. Hatoum Hoda 《Annals of biomedical engineering》2022,50(8):941-950
Annals of Biomedical Engineering - Predicting potential complications after aortic valve replacement (AVR) is a crucial task that would help pre-planning procedures. The goal of this work is to... 相似文献
46.
Paul L. Aronson M.D. Samir S. Shah M.D. M.S.C.E. Zeinab Mohamad M.S. Albert C. Yan M.D. 《Pediatric dermatology》2013,30(2):215-221
Abstract: There is concern that the use of topical corticosteroids in patients with eczema herpeticum may facilitate dissemination of herpes simplex virus and worsen disease. Our primary aim therefore was to determine whether topical corticosteroid use in children hospitalized with eczema herpeticum is associated with longer hospital length of stay (LOS). We performed a multicenter retrospective cohort study of 1,331 children ages 2 months to 17 years admitted with a diagnosis of eczema herpeticum between January 1, 2001, and March 31, 2010, to 42 tertiary care children’s hospitals in the Pediatric Health Information System database. Multivariable linear regression models determined the association between receipt of topical corticosteroid therapy on the first day of hospitalization and the main outcome measure: LOS. Receipt of topical corticosteroid therapy on day 1 of hospitalization was not associated with a longer LOS on unadjusted or multivariable analysis (p = 0.75). Receipt of topical calcineurin inhibitors during the hospitalization was also not associated with a longer LOS (p = 0.12). Receipt of systemic corticosteroids was associated with an 18% adjusted longer LOS (95% confidence interval 2%–36%; p = 0.03). Further study is needed to identify which children with eczema herpeticum may benefit from topical corticosteroids, but their use during active infection is not associated with poorer outcomes, although the use of systemic corticosteroids was associated with a longer LOS and should be avoided in patients with eczema herpeticum pending future prospective study. 相似文献
47.
48.
Noorlidah Abdullah Rosnina Abdulghani Siti Marjiana Ismail Mohamad Hamdi Zainal Abidin 《Food and Agricultural Immunology》2017,28(3):374-387
Polysaccharides isolated from mushrooms have recently attracted attention due to its potential immune-stimulatory activity. The aim of this study was to validate the in vitro immune-stimulatory activities of various mushroom extracts. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that Pleurotus eryngii, with the highest β-glucan (18.94%) content, displayed highest viability on macrophage cells of 62.59% at 200?μg/ml concentration. Pleurotus cystidiosus, with 18.16% β-glucan, content showed highest activation of NF-kB (0.7?µg/ml) at a concentration of 100?µg/ml. Termitomyces heimii, with the lowest percentage of β-glucan (0.51%), exhibited highest phagocytosis index of 9.38 at 12.5?µg/ml. The brown strain of Agaricus bisporus with 1.54% of β-glucan stimulates the highest nitric oxide (NO) production of 12.39?µM nitrite oxide at 100?µg/ml. This study revealed that hot water extracts of mushrooms have different β-glucan contents and produced varying immune-stimulatory activities. Among these, Pleurotus spp. demonstrated the highest percentage of β-glucan content and viability of macrophage cells. Pleurotus spp. are deemed immune-stimulatory by increasing phagocytic activity, NO production, and triggered the activation of NF-kB. 相似文献
49.
50.
Hsi ED Kopecky KJ Appelbaum FR Boldt D Frey T Loftus M Hussein MA 《British journal of haematology》2003,120(6):1017-1025
CD38 expression on chronic lymphocytic leukaemia (CLL) cells is a poor prognostic factor, however, methods for measuring this vary. The QuantiBRITETM flow cytometry (FC) system yields an absolute antigen expression value (antibodies bound/cell, ABC) and may be useful in standardizing CD38 expression analysis. We evaluated cryopreserved pretreatment CLL cells for CD20 ABC, CD38 ABC, and percentage of CD38+ B cells from 131 patients requiring therapy. The 92 patients (70%) with >/= 100 CD38 ABC had worse overall survival (OS; 34% at 5 years) compared with those with < 100 CD38 ABC (70% at 5 years, mortality hazard ratio 2.30, 95% confidence interval 1.28-4.12; two-tailed P = 0.003). Among the 64 patients with < 30% CD38+ cells, OS of the 25 with >/= 100 ABC was worse than that of the 39 with < 100 ABC (P = 0.018). OS of patients with < 30% CD38+ cells and >/= 100 ABC was actually similar to that of patients with >/= 30% CD38+ cells. BrightCD20 expression (>/= 20 000 ABC) was not associated with a worse OS (P = 0.10). The presence of >/= 100 CD38 ABC in CLL patients requiring therapy is an unfavourable prognostic factor for OS and quantitative FC may be superior to percentage CD38+ cell assessment. Prospective trials are required to determine more precisely the prognostic significance of absolute expression levels in fresh CLL cells. 相似文献