全文获取类型
收费全文 | 832篇 |
免费 | 22篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 27篇 |
妇产科学 | 13篇 |
基础医学 | 120篇 |
口腔科学 | 21篇 |
临床医学 | 56篇 |
内科学 | 203篇 |
皮肤病学 | 4篇 |
神经病学 | 64篇 |
特种医学 | 11篇 |
外科学 | 117篇 |
预防医学 | 25篇 |
眼科学 | 2篇 |
药学 | 61篇 |
中国医学 | 2篇 |
肿瘤学 | 134篇 |
出版年
2023年 | 10篇 |
2022年 | 19篇 |
2021年 | 30篇 |
2020年 | 12篇 |
2019年 | 13篇 |
2018年 | 15篇 |
2017年 | 4篇 |
2016年 | 13篇 |
2015年 | 6篇 |
2014年 | 12篇 |
2013年 | 25篇 |
2012年 | 36篇 |
2011年 | 41篇 |
2010年 | 21篇 |
2009年 | 25篇 |
2008年 | 33篇 |
2007年 | 28篇 |
2006年 | 32篇 |
2005年 | 20篇 |
2004年 | 30篇 |
2003年 | 22篇 |
2002年 | 29篇 |
2001年 | 50篇 |
2000年 | 41篇 |
1999年 | 19篇 |
1998年 | 14篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1993年 | 8篇 |
1992年 | 17篇 |
1991年 | 21篇 |
1990年 | 8篇 |
1989年 | 18篇 |
1988年 | 16篇 |
1987年 | 11篇 |
1986年 | 14篇 |
1985年 | 14篇 |
1984年 | 8篇 |
1983年 | 12篇 |
1982年 | 6篇 |
1981年 | 8篇 |
1980年 | 10篇 |
1979年 | 12篇 |
1977年 | 8篇 |
1976年 | 8篇 |
1975年 | 7篇 |
1971年 | 5篇 |
1970年 | 7篇 |
1969年 | 6篇 |
排序方式: 共有861条查询结果,搜索用时 15 毫秒
61.
Onami H Kunikata H Hojo M Nakagawa Y Tamai M 《The Tohoku journal of experimental medicine》2005,206(4):361-364
We report a patient with a spontaneous intramuscular hematoma in the lateral rectus muscle of the eye that resolved without medication with maintenance of good vision. A 40-year-old woman presented with ocular pain and exophthalmos in her right eye. She had no history of trauma or surgery. Exophthalmos and limitation of abduction and supraduction of her right eye were present at the initial examination. Magnetic resonance (MR) images showed an intramuscular hematoma in the right lateral rectus muscle. Her other ocular findings were within normal limits. Five months later without any treatments, the MR images were within normal limits, and her ocular signs and symptoms were completely resolved. Careful observations including MR imaging is sufficient for patients with a spontaneous intramuscular hemorrhage in the extraocular muscle, and the visual prognosis is good. 相似文献
62.
63.
Inoue M Hojo T Yano T Katsumi Y 《Acupuncture in medicine : journal of the British Medical Acupuncture Society》2003,21(1-2):9-17
This study was designed to examine the effects of electroacupuncture with direct current (DC) on peripheral nerve regeneration. The left sciatic nerve of 55 7-month-old rats was crushed at the thigh. They were ramdomly allocated to four groups: distal cathode DC group (n = 15), distal anode DC group (n = 14), sham operated group (n = 13), and control group (n = 13). In the distal cathode DC group, a cathode electrode was connected to an insulated acupuncture needle inserted at 1 cm distal to the injured site, while an anode electrode was connected to a needle inserted at 1 cm proximal to the lesion. In the distal anode DC group, the anode and the cathode electrode were connected to the needle at 1 cm distal and proximal to the lesion respectively. In the sham operated group, no electrical stimulation was given to the insulated needle inserted at the same site, and in the control group, no treatment was given. Regeneration of the sciatic nerve was evaluated by the number of evoked EMGs recorded at 12 sites in the plantar region, by their latency, and by the weight ratio of the tibialis anterior at four weeks after the crush injury. Regeneration of the peripheral nerve was faster and more accelerated in the distal cathode DC group than in the other groups, while in the distal anode DC group the regeneration was delayed. This result suggested electroacupuncture with cathode distal orientation might be a useful treatment having the advantage of enabling deeper insertion with minimal tissue damage. 相似文献
64.
Hironori Hojo Fumiko Yano Shinsuke Ohba Kazuyo Igawa Keiji Nakajima Yuske Komiyama Akinori Kan Toshiyuki Ikeda Takayuki Yonezawa Je-Tae Woo Tsuyoshi Takato Kozo Nakamura Hiroshi Kawaguchi Ung-il Chung 《Journal of bone and mineral metabolism》2010,28(6):627-633
To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal differentiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 system and identified oxytetracycline (Oxy) as a chondrogenic compound. Oxy induced cartilaginous matrix synthesis and mRNA expressions of chondrocyte markers in ATDC5 cells. In addition, Oxy suppressed mineralization and mRNA expressions of terminal chondrocyte differentiation markers in ATDC5 cells, primary chondrocytes, and cultured metatarsal bones. Oxy’s induction of Col2 mRNA expression was decreased by the addition of Noggin and was increased by the addition of BMP2. Furthermore, Oxy increased mRNA expression of Id1, Bmp2, Bmp4, and Bmp6. These data suggest that Oxy induces chondrogenic differentiation in a BMP-dependent manner and suppresses terminal differentiation. Oxy may be useful for treatment of OA and also for regeneration of cartilage tissue. 相似文献
65.
Hideki Sudo Manabu Ito Kuniyoshi Abumi Yoshihisa Kotani Masahiko Takahata Yoshihiro Hojo Akio Minami 《European spine journal》2010,19(6):907-915
The number of reports describing osteoporotic vertebral fracture has increased as the number of elderly people has grown.
Anterior decompression and fusion alone for the treatment of vertebral collapse is not easy for patients with comorbid medical
problems and severe bone fragility. The purpose of the present study was to evaluate the efficacy of one-stage posterior instrumentation
surgery for the treatment of osteoporotic vertebral collapse with neurological deficits. A consecutive series of 21 patients
who sustained osteoporotic vertebral collapse with neurological deficits were managed with posterior decompression and short-segmental
pedicle screw instrumentation augmented with ultra-high molecular weight polyethylene (UHMWP) cables with or without vertebroplasty
using calcium phosphate cement. The mean follow-up was 42 months. All patients showed neurologic recovery. Segmental kyphotic
angle at the instrumented level was significantly improved from an average preoperative kyphosis of 22.8–14.7 at a final follow-up.
Spinal canal occupation was significantly reduced from an average before surgery of 40.4–19.1% at the final follow-up. Two
patients experienced loosening of pedicle screws and three patients developed subsequent vertebral compression fractures within
adjacent segments. However, these patients were effectively treated in a conservative fashion without any additional surgery.
Our results indicated that one-stage posterior instrumentation surgery augmented with UHMWP cables could provide significant
neurological improvement in the treatment of osteoporotic vertebral collapse. 相似文献
66.
Prognostic significance of mitotic figures in metastatic mammary ductal carcinoma to the lymph nodes
Hasebe T Iwasaki M Akashi-Tanaka S Hojo T Shibata T Sasajima Y Kinoshita T Tsuda H 《Human pathology》2011,42(12):1823-1832
We previously reported that the number of mitotic figures in metastatic mammary carcinoma to the lymph nodes accurately predicted the outcome of patients with invasive ductal carcinoma with nodal metastasis. To confirm these previous findings, the present study investigated the number of mitotic figures and other histologic characteristics in metastatic mammary carcinoma to the lymph nodes and their associations with patient outcome according to nodal status and the histologic grade of primary invasive ductal carcinomas in a different series of 1039 patients with invasive ductal carcinoma. Multivariate analyses examining well-known clinicopathologic factors, the number of mitotic figures in the primary invasive ductal carcinomas, the grading system for lymph vessel tumor emboli, the p53 Allred score risk classes of tumor-stromal fibroblasts forming and not forming a fibrotic focus, and 9 histologic features of metastatic mammary carcinoma to the lymph nodes were performed. The presence of 6 or more mitotic figures in metastatic mammary carcinoma to the lymph nodes significantly increased the hazard ratios for tumor recurrence and tumor-related death among patients with invasive ductal carcinoma as a whole, those with nodal metastasis, and those with a histologic grade of 2 or 3. The presence of 6 or more mitotic figures in metastatic mammary carcinoma to the lymph nodes also significantly increased the hazard ratio for tumor recurrence among patients with histologic grade 1 invasive ductal carcinoma. In conclusion, this study clearly confirmed the excellent outcome predictive power of the number of mitotic figures in metastatic mammary carcinoma to the lymph nodes. 相似文献
67.
Hasebe T Iwasaki M Akashi-Tanaka S Hojo T Shimizu C Andoh M Fujiwara Y Shibata T Sasajima Y Kinoshita T Tsuda H 《Human pathology》2011,42(7):998-1006
Tumor-stromal fibroblasts have recently been reported to play important roles in the tumor progression of cancer in various organs. The purpose of the present study was to investigate whether any characteristic histologic features of tumor-stromal fibroblasts could accurately predict the outcome of 318 patients with invasive ductal carcinoma of the breast who had received neoadjuvant therapy. We observed a small number of tumor-stromal fibroblasts with characteristic nuclear features existing in the tumor stroma and named these cells "atypical tumor-stromal fibroblasts." We then assessed the absence or presence of atypical tumor-stromal fibroblasts in biopsy (taken before neoadjuvant therapy) and surgical (taken after neoadjuvant therapy) materials and analyzed the outcome predictive powers of the presence of atypical tumor-stromal fibroblasts in biopsy and surgical materials using multivariate analyses that included well-known clinicopathological factors. The multivariate analyses demonstrated that the presence of atypical tumor-stromal fibroblasts assessed using biopsy materials had significantly higher hazard ratios for tumor recurrence and tumor-related death in patients with nodal metastasis and also significantly higher hazard ratios for tumor recurrence and tumor-related death independent of the hormone receptor status of the tumors. The results of this study clearly indicated that the presence of atypical tumor-stromal fibroblasts, especially in biopsy materials, is significantly associated with tumor recurrence and the tumor-related death of patients with invasive ductal carcinoma of the breast who have received neoadjuvant therapy. 相似文献
68.
69.
Tomonori Akagi Takayuki Kinoshita Tadahiko Shien Takashi Hojo Sadako Akashi-Tanaka Yusuke Murata 《Surgery today》2009,39(1):5-8
Purpose To evaluate the clinicopathological features of intracystic papillary carcinoma (ICPC), which have not been established given
its rarity and lack of standard diagnostic criteria.
Methods We reviewed the clinicopathological findings and treatment outcomes of 14 patients with ICPC diagnosed between 2002 and 2006.
Results Intracystic papillary carcinoma was diagnosed by fine-needle aspiration biopsy in three patients and by core-needle biopsy
in six patients. A preoperative diagnosis was not made in five patients. Three patients underwent magnetic resonance imaging
preoperatively, which helped to differentiate benign tumors and maintain free surgical margins. The final pathological diagnosis
was invasive carcinoma in 2 (14.2%) of the 14 patients. The patients were followed up for 1–72 months, during which time only
one died, of a cancer-unrelated cause.
Conclusion Our results show that ICPC is more difficult to diagnose than common breast cancer preoperatively. Excisional biopsy was necessary
when fine-needle aspiration and core-needle biopsy could not provide a diagnosis. Magnetic resonance imaging is helpful to
differentiate a benign tumor from invasive disease. 相似文献
70.
Sadako Akashi-Tanaka Chikako Shimizu Masashi Ando Tatsuhiro Shibata Noriyuki Katsumata Tsutomu Kouno Kotoe Terada Tadahiko Shien Miwa Yoshida Takashi Hojo Takayuki Kinoshita Yasuhiro Fujiwara Kenichi Yoshimura 《Breast (Edinburgh, Scotland)》2009,18(3):171-174
This study examined postmenopausal estrogen receptor-positive breast cancer patients who received prospective neoadjuvant endocrine therapy (NAET) with tamoxifen or anastrozole to determine if the 21-gene recurrence score (RS) predicts NAET responses. RS scores were determined from pretreatment core biopsy specimens. Although half of the specimens yielded insufficient RNA, the remaining samples were highly representative. Patients with a low RS tended to respond better than those with an intermediate or high RS (n = 43). Response rates by RS were similar between the tamoxifen and anastrozole groups. Patients with a low RS tended to have better relapse-free survival (RFS) than those with an intermediate or high RS (5y-RFS; 100% vs. 84% and 73%, respectively). These results suggest that RS predicts responses to NAET with tamoxifen or anastrozole. Because this pilot study examined a small sample size, these results should be validated in larger studies. 相似文献