全文获取类型
收费全文 | 7322篇 |
免费 | 458篇 |
国内免费 | 64篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 161篇 |
妇产科学 | 184篇 |
基础医学 | 1150篇 |
口腔科学 | 63篇 |
临床医学 | 590篇 |
内科学 | 1853篇 |
皮肤病学 | 294篇 |
神经病学 | 743篇 |
特种医学 | 237篇 |
外科学 | 576篇 |
综合类 | 15篇 |
预防医学 | 444篇 |
眼科学 | 76篇 |
药学 | 624篇 |
中国医学 | 14篇 |
肿瘤学 | 775篇 |
出版年
2024年 | 5篇 |
2023年 | 54篇 |
2022年 | 101篇 |
2021年 | 253篇 |
2020年 | 144篇 |
2019年 | 195篇 |
2018年 | 184篇 |
2017年 | 164篇 |
2016年 | 214篇 |
2015年 | 266篇 |
2014年 | 289篇 |
2013年 | 367篇 |
2012年 | 603篇 |
2011年 | 612篇 |
2010年 | 310篇 |
2009年 | 292篇 |
2008年 | 491篇 |
2007年 | 472篇 |
2006年 | 482篇 |
2005年 | 496篇 |
2004年 | 437篇 |
2003年 | 393篇 |
2002年 | 322篇 |
2001年 | 55篇 |
2000年 | 46篇 |
1999年 | 63篇 |
1998年 | 72篇 |
1997年 | 54篇 |
1996年 | 51篇 |
1995年 | 35篇 |
1994年 | 28篇 |
1993年 | 30篇 |
1992年 | 27篇 |
1991年 | 27篇 |
1990年 | 28篇 |
1989年 | 20篇 |
1988年 | 27篇 |
1987年 | 12篇 |
1986年 | 12篇 |
1985年 | 24篇 |
1984年 | 13篇 |
1983年 | 7篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 14篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1975年 | 8篇 |
1966年 | 4篇 |
排序方式: 共有7844条查询结果,搜索用时 15 毫秒
101.
102.
Giuseppe Fanetti Giulia Marvaso Delia Ciardo Annaisabel Rese Rosalinda Ricotti Elena Rondi Stefania Comi Federica Cattani Dario Zerini Cristiana Fodor Ottavio de Cobelli Roberto Orecchia Barbara A. Jereczek-Fossa 《Medical oncology (Northwood, London, England)》2018,35(5):75
To evaluate outcome in patients treated with stereotactic body radiotherapy (SBRT) on bone oligometastases from castration-sensitive prostate cancer after primary treatment. We retrospectively collected data of patients with less than five lesions at time of SBRT and hormone-naïve disease at the first extra-regional localization, treated between 03/2012 and 11/2016. Prostate-specific antigen (PSA) was measured every 3 months after SBRT. Imaging was performed in case of progression. Survival analysis was performed with Kaplan–Meier (log-rank test) approach. Fifty-five patients were treated on 77 bone oligometastases. Median age, initial PSA and pre-SBRT PSA were 72 years, 9.12 and 3.5 ng/mL, respectively. Twenty-five patients (45%) received SBRT alone while the remaining 30 patients (55%) received concomitant ADT. Median follow-up was 24.6 months (range 3.0–67.2 months). No acute or late toxicity of grade?>?1 was reported. Clinical progression was observed in 38 (69%) patients. 1-year biochemical progression-free survival (b-PFS), clinical progression-free survival (c-PFS), prostate-specific survival (PCSS) and local control (LC) rates were 51, 56, 100 and 83%, respectively. Comparing patients treated with SBRT alone and with concomitant ADT, no significant differences were found for those outcomes. SBRT is safe and allows high 1-year LC rate (83%) with low toxicity profile. No significant improvement in outcomes was registered with the addition of ADT to SBRT. 相似文献
103.
Mauro Giammarino Piero Quatto Stefania Squadrone Maria Cesarina Abete 《Bulletin of environmental contamination and toxicology》2014,93(4):410-416
This study aims to examine the possible presence of lead and cadmium in the liver and kidneys of hooded crows (Corvus cornix). Liver and kidneys of hooded crow carcasses were collected in Province of Cuneo (Piedmont, Italy) in order to detect lead and cadmium content. Significant differences were found in lead and cadmium levels between areas of intensive cultivation versus areas where meadows are prevalent. Moreover, age greatly influenced the burden of heavy metals, while sex did not seem to affect the level of contamination. The source of contamination may be phosphate fertilizers used for intensive cultivation in the study area. 相似文献
104.
105.
106.
E. Laurent A. Lemaignen G. Gras J. Druon K. Fèvre P. Abgueguen G. Le Moal E. Stindel A.-S. Domelier S. Touchais C. Arvieux L. Bernard P. Rosset L. Grammatico-Guillon 《Revue d'épidémiologie et de santé publique》2019,67(3):149-154
Background
In France, the most severe bone and joint infections (BJI), called “complex” (CBJI), are assessed in a multidisciplinary team meeting (MTM) in a reference center. However, the definition of CBJI, drawn up by the Health Ministry, is not consensual between physicians. The objective was to estimate the agreement for CBJI classification.Methods
Initially, five experts from one MTM classified twice, one-month apart, 24 cases as non-BJI, simple BJI or CBJI, using the complete medical record. Secondly, six MTMs classified the same cases using standardized information. Agreements were estimated using Fleiss and Cohen kappa (κ) coefficients.Results
Inter-expert agreement during one MTM was moderate (κ = 0.49), and fair (κ = 0.23) when the four non-BJIs were excluded. Intra-expert agreement was moderate (κ = 0.50, range 0.27–0.90), not improved with experience. The overall inter-MTM agreement was moderate (κ = 0.58), it was better between MTMs with professor (κ = 0.65) than without (κ = 0.51) and with longer median time per case (κ = 0.60) than shorter (κ = 0.47). When the four non-BJIs were excluded, the overall agreement decreased (κ = 0.40).Conclusion
The first step confirmed the heterogeneity of CBJI classification between experts. The seemingly better inter-MTM than inter-expert agreement could be an argument in favour of MTMs, which are moreover a privileged place to enhance expertise. Further studies are needed to assess these results as well as the quality of care and medico-economic outcomes after a MTM. 相似文献107.
108.
Francesco Venturelli Giuliano Carrozzi Letizia Sampaolo Lara Bolognesi Sandro Baldissera Nicoletta Bertozzi Stefano Campostrini Benedetta Contoli Gianluigi Ferrante Maria Masocco Valentina Minardi Angelo D'Argenzio Pirous F Moghadam Luana Penna Alberto Perra Elisa Quarchioni Mauro Ramigni Massimo O Trinito Stefania Salmaso 《Lancet》2014
BackgroundInfluenza is an important public health problem, with potential severe consequences among people with chronic diseases. The aim of this study was to obtain reliable measures of seasonal influenza vaccine uptake in this population, otherwise not available in Italy.MethodsProgressi delle Aziende Sanitarie per la Salute in Italia (PASSI) is a nationwide surveillance system of health-related behaviours and acceptance of preventive interventions (including influenza immunisation) offered by the Italian National Health Service. Data are collected with telephone interviews at local health unit level for supporting local activities. The survey sample is randomly selected from local health unit lists of adult residents. The trend of annual vaccine coverage since 2008 was estimated for people aged 18–64 years who reported having at least one chronic disease. To obtain a sufficient sample size in subgroups, we analysed the characteristics of vaccinated people in the 2010–13 cumulative dataset. Univariate, multivariate, and logistic regression analyses were undertaken.FindingsIn 2008–13, 13 659 individuals with at least one chronic disease were interviewed. Vaccination coverage fell significantly from 29·7% (95% CI 27·2–32·4) in 2007–08 to 19·9% (18·0–22·1) in 2012–13. During 2010–13, the overall proportion of vaccinated people with a chronic disease was 25·6% (24·5–26·7). Vaccine coverage of people with diabetes (34·3%, 31·7–36·9) or cardiovascular diseases (31·8%, 29·6–34·2) was greater than that of people affected by renal failure, respiratory diseases, tumours, or chronic liver diseases (26·5% [22·5–30·7], 24·9% [23·2–26·7], 22·2% [20·0–24·6], and 20·6% [17·5–24·6], respectively). Vaccination coverage increased with age (from 13·1% [11·0–15·5] in the 18–34 year age group to 33·4% [31·9–35·1] in people aged 50–64 years); it was higher among people with a low educational level than among those with a high educational level, higher in those having economic difficulties than in those with no economic difficulties, and higher among Italian citizens than among non-citizens.InterpretationIn the past few years, prevalence of influenza vaccination in Italian adults with at least one chronic disease was well below the Ministry of Health's goal (75% minimum) and showed a downward trend. A major reason of this evolution is probably the changing public perception of the benefits and risks of vaccines. PASSI is a source of useful data not otherwise available for public health intervention.FundingItalian Ministry of Health. 相似文献
109.
Enrica Calce Elena Petricci Michele Saviano Stefania De Luca 《Sustainable Chemistry and Pharmacy》2017
New eco-friendly materials have been developed via esterification of several natural fatty acids by pectin alcoholic functions. The quaternization of the obtained pectin-fatty acid conjugates was performed as subsequent synthetic step. By using microwave heating and solvent-free conditions, the conjugation procedure of fatty acid chains and quaternary ammonium groups to the natural polysaccharide was clean, fast and efficient. In other words, it can be considered a low environmental impact process. 相似文献
110.
Julie Page Kim Roos Andreas Bänziger Isabel Margot-Cattin Stefania Agustoni Emmanuelle Rossini 《Scandinavian journal of occupational therapy》2015,22(6):403-415
Background: The contemporary occupational therapy literature suggests that different quality criteria exist for setting goals in occupational therapy: a focus on occupation; a link to the International Classification of Functioning, Disability, and Health (ICF); and adherence to the SMART recommendations, which advises goals to be specific, measurable, agreed, realistic, and timed. Aim: To identify the extent to which Swiss occupational therapists (OTs) adhere to the criteria cited above. Material: A total of 1 129 goals formulated with the Goal Attainment Scale (GAS) collected in 2008. Results: In slightly more than half the investigated cases at least one goal addressed an aspect of occupation. Nearly two-thirds of the goals related to the ICF component “activity and participation”. Nearly 90% of the goals were specific, measurable, and/or realistic. Conclusions: Goals mirror, to some extent, what is done in everyday practice. Several influences on goal formulations of OTs were identified, including the practice models traditionally used in different specialist fields; the cultural contexts in which OTs were trained; and the legal framework that obliges OTs to formulate their goals in a certain way in order to obtain funding for their services. Significance: Based on these results evidence-based products have been developed (a further education course; written recommendations for practice). 相似文献