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Association between estrogen receptor‐α gene polymorphisms and dermatomyositis in Bulgarian patients
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S. Belousov M. Mitev K. Ilieva K. Riley O. Harling 《Applied radiation and isotopes》2011,69(12):1936-1939
An optimization study of IRT-Sofia BNCT beam tube is presented. In the study we used the MIT/FCB experience. The enlarging of filter/moderator cross section dimensions and the decreasing of collimator length within the limits of the IRT-Sofia reactor design were analyzed. The influence of beam and reactor core axes non-coincidence on the beam properties was also evaluated. The irradiation resistance of polytetrafluoroethylene (Teflon®) was also evaluated. The results provide information for making decisions on the IRT-Sofia BNCT beam construction. 相似文献
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In internal gas proportional counting, the evaluation of counting losses is important in order to obtain high accuracy measurement results. In this paper, counting losses due to the wall effect and not counted beta particles with very low energy are evaluated by analytical calculations. The calculated and experimental results are compared and a very good agreement is found. 相似文献
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Kadiyska T Yakulov T Kaneva R Nedin D Alexandrova A Gegova A Savov A Mitev V Kremensky I 《International journal of colorectal disease》2007,22(4):395-400
Background and aims Different epidemiological studies report the protective effect on colorectal cancer (CRC) exerted by vitamin D3 intake, estrogen replacement therapy, and increase of the risk of microsatellite instability (MSI) in CRC by withdrawal of
estrogens. The aim of our study was to search for association between CRC and polymorphisms in estrogen receptor-α (ER-α) and Vitamin D receptor (VDR) genes.
Materials and methods We analyzed the PvuII and XbaI polymorphisms from the ER-α gene and the BsmI polymorphism of the VDR gene in 140 patients with CRC (subsequently divided according to their MSI status) and 94 controls.
Results We have demonstrated that the presence of the PvuII pp genotype increased the risk of developing MSI(+) tumors about three times compared to MSI(−) tumors [odds ratio (OR)=3.09,
95% confidence interval (CI) 0.88–10.91]. The effect of the XbaI xx genotype was similar (OR=2.08, 95% CI 0.49–8.81). Our results for the VDR
BsmI polymorphism showed an increased risk for CRC in bb carriers (OR=1.8, 95% CI 0.81–4.05).
Conclusion We conclude that PvuII and XbaI polymorphisms in the ER-α gene were associated with the risk of developing MSI in CRC patients. The BsmI polymorphism in the VDR gene was linked to the risk of developing CRC. 相似文献
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