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101.
Masaham Kinoshita Yasuhiro Nakamura Ryuji Nakano Minoru Morimatsu Seiichi Fukuda Yasuhiro Nishimi Takeo Hashimoto 《Fetal and pediatric pathology》1989,9(4):445-457
The clinical features and morphological findings in 31 Japanese infants with trisomy 18 are presented. The majority were small-for-date infants. There was no sex predominance in our series, as opposed to male female ratios of 1:3 reported in the literature. The average age at death was greater in females than in males. Cardiovascular anomalies were consistently present; ventricular septar defect and patent ductus arteriosus being the most common malformations. Various other internal malformations including the Arnold-Chiari malformation were observed. 相似文献
102.
103.
104.
Sasaki M Nakamura H Tsuchiya S Horie S Kashiwayanagi M Saito T Murayama T 《Biological & pharmaceutical bulletin》2007,30(4):682-686
Flavonoids have been reported to be potent antioxidants and beneficial in oxidative stress related diseases. Quercetin, a major flavonoid in food, deserves much attention because of its antioxidative activity. However, the actions of flavonoids including quercetin are complex and paradoxical. Quercetin caused apoptosis and/or cell death in various cells including cancer cells and normal cells. In this study, we investigated the effects of quercetin with or without hydrogen peroxide (H2O2) on cell death of PC12 cells, a neuronal cell line. We showed that quercetin at 10-30 microM alone caused cell death accompanied by caspase-mediated DNA fragmentation in undifferentiated PC12 cells. Quercetin did not inhibit and rather enhanced 0.1 mM H2O2-induced cell death. The toxic effect of quercetin was not inhibited by antioxidants such as N-acetylcysteine and GSH, although H2O2-induced cell death was inhibited by the antioxidants. Quercetin-induced cell death was reduced by 2 h treatment with nerve growth factor and serum. In addition, quercetin caused cell death in differentiated PC12 cells that were cultured with nerve growth factor for 6 d. Genistein, a soy isoflavone that has the pro-apoptotic activity, also caused cell death with DNA fragmentation. Further evaluation of the potential of dietary flavonoids as neuroprotective reagents is needed. 相似文献
105.
Atsushi Sato Ken Shimada Masatoshi Nakamachi Jun Ushio Wataru Yamamoto Minoru Kurihara Masaaki Matsukawa 《Gastric cancer》2002,5(4):0233-0236
A 58-year-old man was diagnosed as having type 3 gastric cancer (poorly differentiated adenocarcinoma). He underwent total
gastrectomy with splenectomy, as well as D3 dissection, and received postoperative chemotherapy combining oral uracil and
futrafur (UFT) with cisplatin (CDDP), but results showed recurrence of multiple abdominal lymph node metastases around the
aorta. He therefore received various anticancer drug regimens (irinotecan [CPT-11]/CDDP; 1 M tegafur-0.4 M gimeracil-1 M oteracil
potassium [TS-1], methotrexate (MTX)/5-fluorouracil); however, final results showed growth of lymph node metastasis and simultaneous
worsening of his general condition. The patient then received combined administration of doxifluridine (5′-DFUR)/docetaxel
(5′-DFUR, 1000 mg/body [666.7 mg/m
2
], given by consecutive daily administration, orally, for days 1–14; and docetaxel, 80 mg/body [60 mg/m
2
], on day 8, by venous drip, every 3 weeks). Three courses of this regimen resulted in approximately 90% reduction of the
abdominal lymph node size, disappearance of the right cervical lymph node metastasis, reductions of the levels of two tumor
markers (carcinoembryonic antigen [CEA] and carbohydrate antigen [CA]19-9), and improvement of his general condition. In total,
seven courses of the regimen were carried out. The patient died on day 298 after starting this combined regimen and showed
a response period of 126 days. The primary toxicity identified was neutropenia (grade 4), as well as other low-grade (grade
1, 2) hematological and nonhematological toxicities. In the field of gastric cancer treatment, especially for patients showing
multiple resistance to anticancer drugs, an effective therapy is critically needed.
Received: January 15, 2002 / Accepted: July 8, 2002
Offprint requests to: A. Sato 相似文献
106.
Shibuya H Hamamura K Hotta H Matsumoto Y Nishida Y Hattori H Furukawa K Ueda M Furukawa K 《Cancer science》2012,103(9):1656-1664
The expression and implications of gangliosides in human osteosarcomas have not been systematically analyzed. In this study, we showed that gangliosides GD3 and GD2 are highly expressed in the majority of human osteosarcoma cell lines derived from oral cavity regions. Introduction of GD3 synthase cDNA into a GD3/GD2-negative (GD3/GD2-) human osteosarcoma subline resulted in the establishment of GD3/GD2+ transfectant cells. They showed increased cell migration and invasion activities in wound healing and Boyden chamber invasion assays, respectively, compared to the control cells. When treated with serum, GD3/GD2+ cells showed stronger tyrosine phosphorylation of p130Cas, focal adhesion kinase, and paxillin than GD3/GD2- cells. In particular, paxillin underwent much stronger phosphorylation, suggesting its role in cell motility. Furthermore, we tried to dissect the roles of GD3 and GD2 in the malignant properties of the transfectant cells by establishing single ganglioside-expressing cells, that is, either GD3 or GD2. Although GD3/GD2+ cells showed the most malignant properties, GD2+ cells showed almost equivalent levels to GD3/GD2+ cells in invasion and migration activities, and in the intensities of tyrosine phosphorylation of paxillin. Among Src family kinases, Lyn was expressed predominantly, and was involved in the invasion and motility of GD3- and/or GD2-expressing transfectants. Furthermore, it was elucidated by gene silencing that Lyn was located in a different pathway from that of FAK to eventually lead paxillin activation. These results suggested that GD2/GD3 are responsible for the enhancement of the malignant features of osteosarcomas, and might be candidate targets in molecular-targeted therapy. 相似文献
107.
Nakadate S Nozawa K Sato H Horie H Fujii Y Nagai M Hosoe T Kawai K Yaguchi T 《Journal of natural products》2008,71(9):1640-1642
In the course of searching for new antifungal agents, a new cyclic depsipeptide, eujavanicin A (1), was isolated from Eupenicillium javanicum as an antifungal agent against the human pathogenic filamentous fungus Aspergillus fumigatus. The structure of 1 was established by spectroscopic and chemical investigations. The absolute stereochemistry was elucidated by Marfey's method and by chiral HPLC analysis. 相似文献
108.
Prof. Dr. Michio Kasahara Yoshito Nishizawa Hitoshi Horie Shigeo Hirao 《Journal of molecular medicine (Berlin, Germany)》1938,17(36):1260-1263
Ohne Zusammenfassung 相似文献
109.
110.
Hidenori Kanazawa Kenichi Utano Shigeyoshi Kijima Takahiro Sasaki Yasuyuki Miyakura Hisanaga Horie Yoshikazu Nakamura Hideharu Sugimoto 《Japanese journal of radiology》2014,32(5):274-281