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41.
Acute myocardial infarction is a rare event in pregnant patients. Mechanical valves are naturally thrombogenic and require
careful anticoagulation. Pregnancy produces a hypercoagulable situation and necessitates close follow-up in pregnant patients
with mechanical heart valves. We present a 34-year-old pregnant woman who had mitral and aortic valve prosthesis. She developed
resistant pulmonary oedema in the post-partum period after myocardial infarction. Oxytocin was used in this patient to induce
midterm labour and prevent post-partum bleeding. Issues surrounding management of pulmonary oedema and use of oxytocin therapy
during pregnancy are discussed. We emphasize the need for awareness of this condition and call attention to the risk of pulmonary
oedema during labour. 相似文献
42.
Cikrikcioglu MA Halac G Hursitoglu M Erkal H Cakirca M Kinas BE Erek A Yetmis M Gundogan E Tukek T 《Acta neurologica Belgica》2011,111(4):282-286
The prevalence of restless legs syndrome (RLS) is increased in gluten sensitive enteropathy (GSE); but prevalence of GSE is not known in RLS. 96 RLS patients and 97 healthy controls, both with or without iron deficiency were enrolled. All secondary RLS patients except iron deficiency were excluded. Subjects underwent a thorough biochemistry and routine blood analyses, and tissue transglutaminase antibodies (TTGA), endomysium antibodies (EMA) and gliadin antibodies (AGA) were also tested. In RLS patients positivity rates of all GSE antibodies were similar to those in controls. The rate of iron deficiency anaemia in RLS patients with at least one positive GSE antibody was significantly higher than that of RLS patients whose GSE antibodies were all negative. The prevalence of GSE antibodies in RLS patients is not increased. GSE might have a role in the aetiology of RLS in association with iron deficiency anaemia. Since the prevalence of GSE antibodies is not increased in RLS, it seems unlikely that GSE is involved in the aetiology of RLS through different mechanisms (e.g. immunological mechanisms) other than iron deficiency as proposed in some published papers. 相似文献
43.
Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity
Kokras N Dalla C Sideris AC Dendi A Mikail HG Antoniou K Papadopoulou-Daifoti Z 《Neuropharmacology》2012,62(1):436-445
Anxiety and depression are considered as stress-related disorders, which present considerable sex differentiation. In animal models of anxiety and depression sex differences have been described and linked to the sexually dimorphic hypothalamus-pituitary-adrenals (HPA) axis. The present study aimed to adjust corticosterone, the main HPA axis stress hormone, in male and female adrenalectomized rats with oral (25 μg/ml) corticosterone replacement (ADXR). Subsequently we investigated the behavioral performance of ADXR rats in the open field, light/dark and forced swim test (FST). Male ADXR rats showed less anxiety-like behavior when compared to sham-operated controls, despite adequate corticosterone replacement. They further showed increased swimming and reduced climbing behavior in the FST, while immobility duration did not differ from sham-operated males. On the contrary, adrenalectomy and corticosterone replacement did not have significant effects on the female behavioral response. Females were generally more active and presented less anxiety-like behavior than males, while they exhibited higher depressive-like symptomatology in the FST. ADXR affected behavioral responses predominantly in males, which in turn modified sex differences in the behavioral profile. Females in proestrous and estrous did not differ from females in diestrous and methestrous in any measured behavioral response. Present results suggest that the male and not the female behavioral responses in models of anxiety and depression were mainly affected by ADXR. These findings may play a significant role in explaining the differential coping strategy of the two sexes in response to stressful experiences. This article is part of a Special Issue entitled 'Anxiety and Depression'. 相似文献
44.
45.
Gez E Mekori T Struminger L Rubinov R Nativ O Stein A Haim N Kuten A 《Cancer investigation》1999,17(4):259-263
T-cell subpopulations were evaluated in 10 patients with metastatic renal cell carcinoma treated with recombinant interleukin-2, recombinant interferon-alpha, 5-fluorouracil, and vinblastine. T-cell subpopulation was tested by flow cytometry, and the results were compared with healthy control subjects. Mean T-cell values before treatment as compared with control were as follows: CD3, 68 vs. 73%; CD4, 34 vs. 53%; CD8, 38 vs. 31%; CD4/CD8, 1.1 vs. 1.8; CD4CD69, 20 vs. 47%, and CD8CD69, 24 vs. 19%. The difference in CD4, CD4/CD8, and CD4CD69 was statistically significant. After treatment (8 weeks), the values of CD4/CD8 ratio and CD4CD69 increased. Three patients achieved complete response, two partial response, and two had stabilization of the disease. After treatment, the CD4/CD8 ratio increased in complete responders, from 1.1 to 2.0, and CD4CD69 increased in complete and partial responders, from 11 to 37% and 23 to 31%, respectively. In nonresponders, no similar change was observed. In conclusion, increases in CD4/CD8 ratio and CD4CD69 levels in metastatic renal cell carcinoma patients may be associated with response to immunochemotherapy. 相似文献
46.
Mikail Inal Sinan Tan Serkan Demirkan Veysel Burulday Özgür Gündüz Kemal Örnek 《Ultrasound in medicine & biology》2017,43(7):1348-1354
The objective of this study was to investigate the elasticity characteristics of the optic nerve using strain and shear wave elastography in patients with Behçet's disease and to compare the results with those of healthy volunteers. Forty-six optic nerves from patients with Behçet's disease and 54 optic nerves from healthy volunteers were investigated prospectively in this study using strain and shear wave elastography. There was a statistically significant difference in terms of elasticity patterns between patients and healthy volunteers (p < 0.001). Elastographic images of healthy volunteers revealed most optic nerves to be type 3 (51.8%); however, type 2 (40.7%) and type 1 (7.5%) were also observed. Elastographic examination of Behçet's disease patients revealed type 2 in 52.2%, type 1 in 43.5% and type 3 in 4.3% of patients. Statistically significant differences were observed between patients and healthy volunteers in the analysis of shear wave elastography values (p < 0.001). Receiver operating characteristic curve analysis was perfect (0.933) (95% CI = 0.885–0.980), and a cutoff value of 16.5 kPa shear had very high sensitivity and specificity for the patient group. Strain and shear wave elastography findings for the optic nerves of patients with Behçet's disease were significantly different from those for healthy volunteers. 相似文献
47.
K. Fattarsi C. Mikail L. Abou Y. Hadef A. Nicolay H. Portugal J. Kaloustian 《Phytothérapie》2011,9(2):126-135
Cutaneous allergy occurs mainly as a result of the use of domestic products and cosmetics. Some fragrances present in these products may contain compounds that are responsible for allergy (allergens). The European Council has issued a directive limiting the level of 26 allergens found in cosmetics. The GC-MS technique was used to identify 24 volatile allergens, determine detection and quantification limits and make calibration with the standard solutions of each allergen. An experimental design (Nemrod-W) was used to determine the optimal parameters of GC technique (DB5-MS column, 30 m, 0.25 mm i.d., 0.25 ??m film; 50 °C (1 min), rate 1 at 3 °C/min until 150 °C, then rate 2 at 6 °C/min until 235 °C, helium 1.70 ml/min). A run of less than 50 min could be used with good resolution between allergens and their isomers. The interest of this method is that even if many various terpeno?ds are present with allergens in fragrances and ingredients meant for cosmetics, the identification will be done easily with the use of retention times and mass spectra. The quantitation will be done in SCAN or SIM mode. 相似文献
48.
Ozlem Kar Kurt Sibel Alpar Tugrul Sipit Selma Firat Guven Hakan Erturk Mikail Koray Demirel Meliha Korkmaz Mutlu Hayran Bahar Kurt 《The American journal of emergency medicine》2010
The aim of this study was to evaluate the diagnostic contribution of alveolar dead space fraction (AVDSf) measured using capnography in patients admitted with suspected pulmonary embolism (PE). A total of 58 patients who were admitted to our hospital with suspected PE between October 2006 and January 2008 were included in this study. All patients were assessed using the Wells clinical score, capnography, computed tomographic pulmonary angiography, D-dimer measurement, lower-extremity venous Doppler ultrasonography, and V/Q scintigraphy. Forty patients (69%) had PE based on computed tomographic pulmonary angiography findings. The AVDSf value with the highest sensitivity and specificity, which was at the same time statistically significant, was 0.09. This value was consistent with the AVDSf value obtained using receiver operating characteristic analysis. In our study, the sensitivity of capnography was 70%, with a specificity of 61.1%, positive predictive value of 80%, and negative predictive value of 47.8%. The use of AVDSf in combination with any of the several scoring systems that evaluate clinical likelihood of PE and D-dimer levels resulted in higher sensitivity and specificity rates for the diagnosis of PE. 相似文献
49.
50.
Idris Ardic Mehmet Gungor Kaya Mikail Yarlioglues Orhan Dogdu Mehmet Celikbilek Mahmut Akpek Lutfi Akyol Edip Torun 《Rheumatology international》2011,31(1):121-125
Heart rate recovery after exercise is a function of vagal reactivation, and its impairment is an independent prognostic indicator
for cardiovascular and all-cause mortality. The aim of our study was to evaluate heart rate recovery in patients with familial
Mediterranean fever (FMF). The study population included 38 patients with FMF (14 men; mean age, 36.2 ± 12.1 years, and mean
disease duration = 11.3 ± 6.5 years) and 35 healthy control subjects (12 men; mean age = 34.1 ± 9.9 years). Basal electrocardiography,
echocardiography, and treadmill exercise testing were performed in all patients and control participants. The heart rate recovery
index was defined as the reduction in the heart rate from the rate at peak exercise to the rate 1st-minute (HRR1), 2nd-minute (HRR2), 3rd-minute (HRR3), and 5th-minute (HRR5) after the cessation of exercise stress testing. There are significant differences in HRR1 and HRR2 indices between patients with FMF and control group (26.4 ± 7.4 vs. 35.0 ± 8.0; P = 0.001 and 47.3 ± 11.8 vs. 54.8 ± 10.3; P = 0.002, respectively). Similarly, HRR3 and HRR5 indices of the recovery period were lower in patients with FMF, when compared with indices in the control group (56.0 ± 14.0
vs. 63.7 ± 11.2; P = 0.01 and 64.1 ± 14.7 vs. 71.5 ± 12.7; P = 0.02, respectively). There were also remarkably positive correlations between the disease duration and HRR1 (r = 0.31, P = 0.02), and HRR2 (r = 0.26, P = 0.04). The heart rate recovery index impaired in patients with FMF compared to control subjects. When the prognostic significance
of the heart rate recovery index is considered, a useful, simple, and noninvasive test may be clinically helpful in the recognition
of high-risk patients with FMF. 相似文献