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141.
Akiyama N Ohwada A Kajiwara K Ohtake H Hayama M Kohri M Taira M Niitsu N Horie R Higashihara M 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2002,43(10):937-942
A 59-year-old man with a six-month history of chronic myelomonocytic leukemia (CMML) was admitted to the Kitasato University Hospital because of melena in September 2000. Colonofiberscopy and barium enema demonstrated an ulcerated tumorous lesion in the transverse colon. The histopathologic findings of the ulcer bed revealed diffuse infiltration of granulocytes at each stage of differentiation. The diagnosis of granulocytic sarcoma (GS) was made. Surgical resection was not indicated, because thrombocytopenia was hardly improved enough to allow surgery despite repetitive transfusion of platelet concentrates. CMML developed to refractory anemia with excess of blast in transformation in February 2001. Two courses of low dose cytarabine plus aclarubicin were ineffective on the GS in spite of a decrease in the peripheral blood blasts. Progression to acute myeloid leukemia eventually broke out, in July 2001. The patient died of leukemia complicated with pneumonia and intestinal obstruction. At present, nine cases of GS in the colon have been reported. However, these cases did not include CMML. This is the first report describing GS in the colon associated with CMML. 相似文献
142.
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves 总被引:1,自引:1,他引:1
Helske Satu; Syvaranta Suvi; Kupari Markku; Lappalainen Jani; Laine Mika; Lommi Jyri; Turto Heikki; Mayranpaa Mikko; Werkkala Kalervo; Kovanen Petri T.; Lindstedt Ken A. 《European heart journal》2006,27(12):1495-1504
Aims Aortic stenosis (AS) is characterized by extensive remodellingof the valves, including infiltration of inflammatory cells,extracellular matrix degradation, and fibrosis. The molecularmechanisms behind this adverse remodelling have remained obscure.In this article, we study whether cathepsin G, an angiotensinII (Ang II)-forming elastolytic enzyme, contributes to progressionof AS. Methods and results Stenotic aortic valves (n=86) and controlvalves (n=17) were analysed for cathepsin G, transforming growthfactor-ß1 (TGF-ß1), and collagens I andIII with RTPCR and immunohistochemistry. Valvular collagen/elastinratio was quantified by histochemistry. In stenotic valves,cathepsin G was present in mast cells and showed increased expression(P<0.001), which correlated positively (P<0.001) withthe expression levels of TGF-ß1 and collagens I andIII. TGF-ß1 was also present in mast cell-rich areasand cathepsin G induced losartan-sensitive TGF-ß1expression in cultured fibroblasts. Collagen/elastin ratio wasincreased in stenotic valves (P<0.001) and correlated positivelywith smoking (P=0.02). Nicotine in cigarette smoke activatedmast cells and induced TGF-ß1 expression in culturedfibroblasts. Fragmented elastin was observed in stenotic valvescontaining activated cathepsin G-secreting mast cells and innormal valves treated with cathepsin G. Conclusion In stenotic aortic valves, mast cell-derived cathepsinG may cause adverse valve remodelling and AS progression. 相似文献
143.
Nobutoshi Komatsu Utaroh Motosugi Shinya Maekawa Kuniaki Shindo Minoru Sakamoto Mitsuaki Sato Akihisa Tatsumi Mika Miura Fumitake Amemiya Yasuhiro Nakayama Taisuke Inoue Mitsuharu Fukasawa Tomoyoshi Uetake Masahiko Ohtaka Tadashi Sato Yasuhiro Asahina Masayuki Kurosaki Namiki Izumi Tomoaki Ichikawa Tsutomu Araki Nobuyuki Enomoto 《Hepatology research》2014,44(13):1339-1346
144.
Seishi Aihara Shunsuke Yamada Satoru Shichijo Kento Fukumitsu Mika Kondo Yutaro Hirashima Hideaki Oka Taro Kamimura Atsumi Harada Toshiaki Nakano Kazuhiko Tsuruya Takanari Kitazono 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2020,24(1):34-41
Vascular access intervention therapy (VAIVT) is necessary to maintain vascular access in patients undergoing hemodialysis. VAIVT‐associated vasodilatation is painful. However, few reports have focused on effective pain relief at the time of VAIVT. The present study was performed to determine whether lidocaine‐propitocain cream, a eutectic mixture of local anesthetics (EMLA), effectively reduces VAIVT‐associated pain in patients undergoing hemodialysis. This placebo‐controlled, double‐blind, crossover study was conducted in a single center. Among 210 patients who underwent a total of 437 VAIVT procedures from August 2017 to June 2018, 30 patients were randomly allocated to either the EMLA–placebo arm or placebo–EMLA arm at the time of VAIVT. EMLA application significantly reduced the visual analog scale score compared with placebo (47.0 ± 21.1 vs. 68.6 ± 20.7 mm, respectively; P < 0.05). EMLA is a safe and effective treatment for relief of VAIVT‐associated pain in patients undergoing hemodialysis. 相似文献
145.
146.
Luiz Schweitzer Alexandre Cunha Thiago Pereira Kerstin Mika Ana Maria Botelho do Rego Ana Maria Ferraria Heinz Kieburg Sven Geissler Eckart Uhlmann Janosch Schoon 《Materials》2020,13(23)
Loosening of orthodontic and orthopedic implants is a critical and common clinical problem. To minimize the numbers of revision surgeries due to peri-implant inflammation or insufficient osseointegration, developments of new implant manufacturing strategies are indicated. Ultrafast laser surface texturing is a promising contact-free technology to modify the physicochemical properties of surfaces toward an anti-infectious functionalization. This work aims to texture Ti6Al4V surfaces with ultraviolet (UV) and green (GR) radiation for the manufacturing of laser-induced periodic surface structures (LIPSS). The assessment of these surface modifications addresses key aspects of topography, morphology and chemical composition. Human primary mesenchymal stromal cells (hMSCs) were cultured on laser-textured and polished Ti6Al4V to characterize the surfaces in terms of their in vitro biocompatibility, cytotoxicity, and metal release. The outcomes of the in vitro experiment show the successful culture of hMSCs on textured Ti6Al4V surfaces developed within this work. Cells cultured on LIPSS surfaces were not compromised in terms of their viability if compared to polished surfaces. Yet, the hMSC culture on UV-LIPSS show significantly lower lactate dehydrogenase and titanium release into the supernatant compared to polished. Thus, the presented surface modification can be a promising approach for future applications in orthodontics and orthopedics. 相似文献
147.
Marine Azevedo Da Silva Archana Singh‐Manoux Martin J. Shipley Jussi Vahtera Eric J. Brunner Jane E. Ferrie Mika Kivimäki Hermann Nabi 《Journal of sleep research》2014,23(1):94-97
Depressive symptoms are associated with an increased risk of death, but most of this association remains unexplained. Our aim was to explore the contribution of sleep duration and disturbances to the association between depressive symptoms, all‐cause and cardiovascular disease mortality. A total of 5813 (4220 men and 1593 women) aged 50–74 years at baseline, participants of the British Whitehall II prospective cohort study, were included. Depressive symptoms, sleep duration and disturbances were assessed in 2003–04. Mortality was ascertained through linkage to the national mortality register until August 2012, with a mean follow‐up of 8.8 years. Depressive symptoms were associated with an increased risk of mortality from all causes [hazard ratio (HR) = 1.51; 95% confidence interval (CI): 1.16–1.97)] and cardiovascular diseases (HR = 1.63; 95% CI: 1.01–2.64) after adjustment for sociodemographic characteristics. Further adjustment for sleep duration and disturbances reduced the association between depressive symptoms and cardiovascular mortality by 21% (HR = 1.53; 95% CI: 0.91–2.57). Sleep seems to have a role, as a mediator or confounder, in explaining the association between depressive symptoms and cardiovascular mortality. These findings need replication in larger studies with longer follow‐up. 相似文献
148.
MHC class I (MHC I) antigen presentation is a ubiquitous process by which cells present endogenous proteins to CD8+ T lymphocytes during immune surveillance and response. Hereditary hemochromatosis protein, HFE, is involved in cellular iron uptake but, while structurally homologous to MHC I, is unable to bind peptides. However, increasing evidence suggests a role for HFE in the immune system. Here, we investigated the impact of HFE on CD8+ T‐lymphocyte activation. Using transient HFE transfection assays in a model of APCs, we show that WT HFE (HFEWT), but not C282Y‐mutated HFE, inhibits secretion of MIP‐1β from antigen‐specific CD8+ T lymphocytes. HFEWT expression also resulted in major decreases in CD8+ T‐lymphocyte activation as measured by 4–1BB expression. We further demonstrate that inhibition of CD8+ T‐lymphocyte activation was independent of MHC I surface levels, β2‐m competition, HFE interaction with transferrin receptor, antigen origin, or epitope affinity. Finally, we identified the α1–2 domains of HFEWT as being responsible for inhibiting CD8+ T‐lymphocyte activation. Our data imply a new role for HFEWT in altering CD8+ T‐lymphocyte reactivity, which could modulate antigen immunogenicity. 相似文献
149.
150.
Naomi Sato Yasuhiro Nakamura Kentaro Takanami Yoshikiyo Ono Kei Omata Ryo Morimoto Fumitoshi Satoh Kazue Ise Shigeyuki Yamada Atsuko Kasajima Fumiyoshi Fujishima Mika Watanabe Yoichi Arai Hironobu Sasano 《Endocrine pathology》2014,25(4):410-415
Usually, benign tumors are not associated with an increased F-18 fluorodeoxyglucose (F-18 FDG) uptake on positron emission tomography (PET), although some exceptions have been reported in adrenal neoplasms. We present a rare case of adrenocortical oncocytoma associated with markedly increased FDG uptake, demonstrating a maximum standardized uptake value of 46.8. Histological examination demonstrated diffuse proliferation of tumor cells with eosinophilic and granular cytoplasm that were diffusely immunopositive for mitochondria and glucose transport protein 1, with focal and weak immunopositivity for 3β-hydroxysteroid dehydrogenase. Ultrastructural examination also revealed abundant mitochondria in the tumor cells. The tumor was diagnosed as adrenocortical oncocytoma and was considered benign according to Lin-Weiss-Bisceglia criteria. Diagnosis of adrenocortical oncocytoma can pose difficulties during both preoperative radiological and postoperative histopathological investigations. 相似文献