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Lengacher CA Reich RR Post-White J Moscoso M Shelton MM Barta M Le N Budhrani P 《Journal of behavioral medicine》2012,35(1):86-94
To investigate prevalence and severity of symptoms and symptom clustering in breast cancer survivors who attended MBSR(BC).
Women were randomly assigned into MBSR(BC) or Usual Care (UC). Eligible women were ≥ 21 years, had been diagnosed with breast
cancer and completed treatment within 18 months of enrollment. Symptoms and interference with daily living were measured pre-
and post-MBSR(BC) using the M.D. Anderson Symptom Inventory. Symptoms were reported as highly prevalent but severity was low.
Fatigue was the most frequently reported and severe symptom among groups. Symptoms clustered into 3 groups and improved in
both groups. At baseline, both MBSR(BC) and the control groups showed similar mean symptom severity and interference; however,
after the 6-week post-intervention, the MBSR(BC) group showed statistically-significant reduction for fatigue and disturbed
sleep (P < 0.01) and improved symptom interference items, compared to the control group. For the between-group comparisons, 11 of
13 symptoms and 5 of 6 interference items had lower means in the MBSR(BC) condition than the control condition. These results
suggest that MBSR(BC) modestly decreases fatigue and sleep disturbances, but has a greater effect on the degree to which symptoms
interfere with many facets of life. Although these results are preliminary, MBSR intervention post-treatment may effectively
reduce fatigue and related interference in QOL of breast cancer survivors. 相似文献
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Stéphanie Castagnet Hélène Blasco Patrick Vourc'h Isabelle Benz‐De‐Bretagne Charlotte Veyrat‐Durebex Christelle Barbet Azmi Alnajjar Bénédicte Ribourtout Matthias Buchler Jean‐Michel Halimi Christian R. Andres 《Journal of clinical laboratory analysis》2012,26(5):376-383
Estimated glomerular filtration rate (eGFR) methods are not sufficiently reliable in renal transplant recipients (RTR) and should be replaced by iohexol plasma clearance measurement. However, this method has poor availability in health centers. The aim of our study was to develop a high‐performance liquid chromatography (HPLC) method for plasma iohexol measurement in routine practice and to evaluate its plasma clearance as a reference of GFR. We developed an HPLC method using UV detection. We evaluated sample storage conditions to provide recommendations for routine practice. Then, we compared GFRbased on plasma iohexol clearance (GFR‐iohexol) to eGFR using modification of diet in renal disease, Cockcroft and Gault, and CDK‐EPIequations in 40 RTR. The method was validated over a concentration range of 15–300 μg/l. Excellent linearity (r > 0.998), inter‐ and intraday precision (CV < 3.3%), and accuracy (>96.8%) were complied with ICH guidelines. We also demonstrated excellent samples stability (9 days). Although eGFR methods are not references in RTR, we found a correct concordance between eGFR and GFR‐iohexol in our population. To conclude, our method is simple, rapid, accurate, and reliable for routine clinical and research use especially in RTR. J. Clin. Lab. Anal. 26:376‐383, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
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