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991.
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Crovetto F Ossola MW Spadaccini G Duiella SF Somigliana E Fedele L 《Archives of gynecology and obstetrics》2012,285(3):599-604
Background
Intrapartum colonization with Streptococcus pneumoniae (S. pneumoniae) is a rare but important risk factor for severe courses of early-onset sepsis (EOS) in the newborn, as underlined in the case of a preterm infant born after 32 weeks of gestation described here. One potential explanation could be an immature immune response of the neonate to S. pneumoniae, however, immunological data in term and preterm infants are scarce. 相似文献993.
Britta Heimes Albrecht Lommatzsch Meike Zeimer Matthias Gutfleisch Georg Spital Martha Dietzel Daniel Pauleikhoff 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2011,249(5):639-644
Background
In phase III trials, the therapeutic efficacy of anti-VEGF therapy with ranibizumab (Lucentis) in patients with choroidal neovascularization due to AMD was demonstrated in a 24-month period with monthly injections. Other studies and models suggested that flexible reinjection regimens can provide similar visual results. The aim of the present study was to evaluate the flexible, predominantly visual acuity-driven ranibizumab retreatment regimen in clinical practice in Germany. 相似文献994.
995.
Julie Catusse Marion Leick Mareike Groch David J Clark Maike V Buchner Katja Zirlik Meike Burger 《Molecular cancer》2010,9(1):297
Background
The non-signalling chemokine receptors, including receptors DARC, D6 and CCX-CKR, have recently been shown to be involved in chemokine clearance and activity regulation. The human chemokine receptor CRAM (also known as HCR or CCRL2) is the most recently identified member of this atypical group. CRAM is expressed on B cells in a maturation-stage dependent manner and absent on T cells. We have recently shown that it competitively binds CCL19. CCL19 and its signalling receptor CCR7 are critical components involved in cell recruitment to secondary lymphoid organs and in maturation. B cell Chronic Lymphocytic Leukemia (B-CLL) is a low-grade lymphoma characterized by proliferative centres (or pseudofollicles). Proliferative centres develop due to abnormal cellular localisation and they are involved in the development of malignant cells. CCR7 is highly expressed on B cells from CLL patients and mediates migration towards its ligands CCL19 and CCL21, while CRAM expression and potential interferences with CCR7 are yet to be characterized. 相似文献996.
The acid skin surface pH has antimicrobial activities. Increased growth of Propionibacterium acnes contributes to the pathogenesis of acne. Therefore, the pH of inflammatory acne lesions was determined prior to and after lesional acidification employing Herpifix (Courage + Khazaka, Cologne, Germany), a microphoretic system. The pH was correlated with the number of acne lesions. A total of 30 volunteers with acne vulgaris participated in this crossover study applying either Herpifix or a dummy to inflammatory lesions. Prior to treatment, the pH of acne lesions was 5.7 +/- 0.2 (mean +/- SD) and 22 lesions (mean +/- 10) were counted in an 8 x 8 cm(2) facial surface area. Fifteen volunteers (group A) used Herpifix first for 3 weeks and then the dummy, while the other group of 15 volunteers (group B) used the dummy first and then Herpifix. In group A, the lesional surface pH and number of lesions decreased (p < 0.01) initially. When the dummy was used over a second 3-week treatment period, the skin surface pH and number of acne lesions increased. Findings for group B were vice versa. When both groups were compared at the end of the study, a significant difference in pH values (p < 0.001) and the number of acne lesions (p < 0.05) was obtained. Herpifix may be considered as a new therapeutic option for inflammatory acne. 相似文献
997.
TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies
Stefanie J Klug Meike Ressing Jochem Koenig Martin C Abba Theodoros Agorastos Sylvia MF Brenna Marco Ciotti BR Das Annarosa Del Mistro Aleksandra Dybikowska Anna R Giuliano Zivile Gudleviciene Ulf Gyllensten Andrea LF Haws Aslaug Helland C Simon Herrington Alan Hildesheim Olivier Humbey Sun H Jee Jae Weon Kim Maria Blettner 《The lancet oncology》2009,10(8):772-784
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Shahzad Ahmad Christian Bannister Sven J. van der Lee Dina Vojinovic Hieab H.H. Adams Alfredo Ramirez Valentina Escott-Price Rebecca Sims Emily Baker Julie Williams Peter Holmans Meike W. Vernooij M. Arfan Ikram Najaf Amin Cornelia M. van Duijn 《Alzheimer's & dementia》2018,14(7):848-857