全文获取类型
收费全文 | 2234篇 |
免费 | 154篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 183篇 |
妇产科学 | 53篇 |
基础医学 | 246篇 |
口腔科学 | 21篇 |
临床医学 | 168篇 |
内科学 | 428篇 |
皮肤病学 | 82篇 |
神经病学 | 164篇 |
特种医学 | 94篇 |
外科学 | 382篇 |
综合类 | 31篇 |
预防医学 | 120篇 |
眼科学 | 51篇 |
药学 | 152篇 |
中国医学 | 3篇 |
肿瘤学 | 190篇 |
出版年
2024年 | 6篇 |
2023年 | 17篇 |
2022年 | 34篇 |
2021年 | 80篇 |
2020年 | 50篇 |
2019年 | 71篇 |
2018年 | 77篇 |
2017年 | 65篇 |
2016年 | 62篇 |
2015年 | 58篇 |
2014年 | 95篇 |
2013年 | 128篇 |
2012年 | 189篇 |
2011年 | 179篇 |
2010年 | 115篇 |
2009年 | 94篇 |
2008年 | 147篇 |
2007年 | 137篇 |
2006年 | 121篇 |
2005年 | 105篇 |
2004年 | 90篇 |
2003年 | 70篇 |
2002年 | 72篇 |
2001年 | 29篇 |
2000年 | 50篇 |
1999年 | 26篇 |
1998年 | 12篇 |
1997年 | 16篇 |
1996年 | 9篇 |
1995年 | 8篇 |
1994年 | 10篇 |
1993年 | 15篇 |
1992年 | 21篇 |
1991年 | 12篇 |
1990年 | 11篇 |
1989年 | 13篇 |
1988年 | 10篇 |
1987年 | 9篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1979年 | 4篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1971年 | 3篇 |
1967年 | 3篇 |
排序方式: 共有2390条查询结果,搜索用时 23 毫秒
121.
Lalee Varghese Sramana Mukhopadhyay Raghav Mehan Regi Kurien Meera Thomas V. Rupa 《Revista brasileira de otorrinolaringologia (English ed.)》2019,85(6):698-704
IntroductionSinonasal organising haematoma is a recently described, rare, benign inflammatory condition, which closely resembles malignancy in its clinical presentation.ObjectiveTo describe the clinical features of organising haematoma and to review the evolution of surgical options successfully used.MethodsA retrospective review of charts of all patients with a histopathological diagnosis of sinonasal organising haematoma was performed.ResultsSix (60%) of the 10 patients were male with a mean age of 47.4 years. All patients had unilateral disease with recurrent epistaxis as the presenting symptom. Maxillary sinus was the most commonly involved sinus. There was no history of trauma in any of the patients. Hypertension (80%) was the most commonly associated comorbidity. Contrast-enhanced CT scan of the paranasal sinuses showed heterogeneous sinus opacification with/without bone erosion. Histopathological examination was diagnostic. Complete endoscopic excision was done in all patients resulting in resolution of the disease.ConclusionAwareness of this relatively new clinical entity and its evaluation and treatment is important for otolaryngologists, maxillofacial surgeons and pathologists alike. Despite the clinical picture of malignancy, histopathological features of benign disease can safely dispel such a diagnosis. 相似文献
122.
Summary: Systemic lupus erythematosus (SLE) is a complex immune disorder in which loss of tolerance to nucleic acid antigens and other cross-reactive antigens is associated with the development of pathogenic autoantibodies that damage target organs including the skin, joints, brain, and kidney. B cells are essential to lupus pathogenesis, not only because they produce pathogenic autoantibodies but also because they have multiple effector functions in the immune system. There has been much recent interest therefore in targeting of B cells for the treatment of SLE and other autoimmune diseases. BAFF (B-cell activation factor belonging to the tumor necrosis factor family) is a crucial homeostatic cytokine for B cells that is upregulated during inflammation and links adaptive with innate immunity. Excessive levels of BAFF may alter selection of autoreactive B cells and contribute to perpetuation of SLE by a variety of mechanisms. BAFF antagonists have been effective in the prevention and treatment of SLE in several different murine models. Three classes of BAFF antagonists have been developed for clinical use, and initial clinical trials have begun. However, immune modulation in SLE is complicated by differences in the immune defects between patients and at different disease stages. Further work will be needed both in animal models and humans to determine the most appropriate clinical applications for BAFF blockade. 相似文献
123.
The issues that come into play when young women and girls with mental handicaps are referred for sterilisation are discussed in the light of ethical arguments. The story of sterilisation is traced over the century. An attempt is made to understand the evolution of the legal aspects of sterilisation, from a rather paternalistic/eugenic standpoint in the early 1900's to a more humanistic one in the present day, as evidenced in contemporary court decisions. A comprehensive system of analysing the various components of sterilisation referral is suggested. 相似文献
124.
125.
Cristine S. Velazco Brenna S. Fullerton Charles R. Hong Kate A. Morrow Erika M. Edwards Roger F. Soll Tom Jaksic Jeffrey D. Horbar Biren P. Modi 《Journal of pediatric surgery》2018,53(1):108-112
Background
Necrotizing enterocolitis (NEC) is classically a disease of prematurity, with less reported regarding morbidity and mortality of this disease among other infants.Methods
Data were prospectively collected from 2009 to 2015 at 252 Vermont Oxford Network member centers on neonates with birth weight > 2500 g admitted to a participating NICU within 28 days of birth.Results
Of 1629 neonates with NEC, gestational age was 37 (36, 39) weeks, and 45% had major congenital anomalies, most commonly gastrointestinal defects (20%), congenital heart defects (18%), and chromosomal anomalies (7%). For the 23% of infants who had surgery for NEC, mortality and length of stay were 23% and 63 (36, 94) days versus 8% and 34 (22, 61) days in medical NEC. Independent predictors of mortality were congenital heart defects (p < 0.0001), chromosomal abnormalities (p < 0.05), other congenital malformations (p < 0.001), surgical NEC (p < 0.0001), and sepsis (p < 0.05). All of these in addition to gastrointestinal defects were independent predictors of increased length of stay. Nutritional morbidity at discharge included 6% receiving no enteral feeds and 27% who were < 10th percentile weight-for-age.Conclusions
Major congenital anomalies are present in nearly half of > 2500 g birth weight infants diagnosed with necrotizing enterocolitis. Morbidity and mortality increase with sepsis, surgical disease, and congenital anomalies.Type of study
Prognosis Study.Level of evidence
Level II. 相似文献126.
Meera R. Chappidi Heather J. Chalfin Daniel J. Johnson Max Kates Nikolai A. Sopko Michael H. Johnson Jen-Jane Liu Steven M. Frank Trinity J. Bivalacqua 《Urologic oncology》2017,35(2):38.e17-38.e24
Background
Patients with bladder cancer undergoing radical cystectomy (RC) experience high rates of perioperative blood transfusions (PBTs) and morbidity. The aim of this study was to evaluate the effect of blood storage duration on the risk of adverse perioperative outcomes in this high-risk patient population.Materials and methods
In a retrospective review of RC patients from 2010 to 2014 who received PBTs, the average storage duration for all units transfused was used to classify patients as receiving older blood using 3 different definitions (≥21 days,≥28 days, and≥35 days). Multivariable Poisson regression models were used to determine the adjusted relative risk of perioperative infections and overall morbidity in those given older blood compared to fresher blood.Results
Of the 451 patients undergoing RC, 205 (45%) received nonirradiated PBTs. In multivariable modeling, increasing average blood storage duration, as a continuous variable, was associated with an increased risk of infections (risk ratio [RR] = 1.08 per day, 95% CI: 1.01–1.17) and overall morbidity (RR = 1.08 per day, 95% CI: 1.01–1.15). Furthermore, ≥28-day blood storage (vs.<28) was associated with increased infections (RR = 2.69, 95% CI: 1.18–6.14) and morbidity (RR = 2.54, 95% CI: 1.31–4.95), and ≥35-day blood storage (vs.<35) was also associated with increased infections (RR = 2.83, 95% CI: 1.42–5.66) and morbidity (RR = 3.35, 95% CI: 1.95–5.77).Conclusions
Although blood is stored up to 42 days, storage≥28 days may expose RC patients to increased perioperative infections and overall morbidity compared with storage<28 days. Prospective cohort studies are warranted in cystectomy and other high-risk surgical oncology patients to better determine the effect of blood storage duration. 相似文献127.
Delaney Hines Neena Modi Shoo K. Lee Tetsuya Isayama Gunnar Sj?rs Luigi Gagliardi Liisa Lehtonen Maximo Vento Satoshi Kusuda Dirk Bassler Rintaro Mori Brian Reichman Stellan H?kansson Brian A. Darlow Mark Adams Franca Rusconi Laura San Feliciano Kei Lui Naho Morisaki Natasha Musrap Prakesh S. Shah the International Network for Evaluating Outcomes of Neonates 《Acta paediatrica (Oslo, Norway : 1992)》2017,106(3):366-374
128.
129.
Sangeetha Jayaraman S. Devaji Rao Meera Govindarajan 《The Indian journal of surgery》2010,72(1):293-295
Sarcomas are connective tissue tumours, and can arise in any part of the body, more commonly in the extremities. Histological types and clinical presentation of truncal sarcomas are similar to those seen in any other anatomic locations. Radiological investigations may be contributory, but biopsy is conclusive. Surgical resection with wide margins is the initial standard treatment, however a multimodal approach including radiotherapy and chemotherapy is often favoured. Because of the high recurrence rate regardless of therapy, close follow-up is imperative. We present a case of synovial sarcoma of the anterior abdominal wall. 相似文献
130.
Sumanth Meera Nandeep Ramaiah Narasimharaju Kalidindi 《Saudi Pharmaceutical Journal》2011,19(4):279-284
The present study was taken up to illustrate the mechanism of anti-rheumatic activity of ‘Rheumavedic capsule’, a polyherbal formulation of Vedic-bio Labs, Bangalore, in adjuvant induced arthritic rats. Anti-inflammatory mechanism is illustrated using phlogistic agents induced paw edema in rats. Analgesic mechanism is illustrated using Eddy’s hot plate and acetic acid (0.6%v/v) induced writhing in mice. Histopathology of knee joint was studied.Rheumavedic showed inhibition of inflammation mediated through Histamine, 5-Hydroxy tryptamine, and Bradykinin. Rheumavedic showed protection in both acetic acid and Eddy’s hot plate induced pain. Histopathology of knee joint of rat pre-treated with rheumavedic showed significant reduction in the mononuclear infiltration, pannus formation and adhesion molecules.The anti-rheumatic mechanism of rheumavedic is due to; inhibition of inflammatory mediators i.e., Histamine, 5-Hydroxy tryptamine and Bradykinin., protection against prostaglandins mediated pain, by inhibiting cyclo-oxygenase synthesis and reduction in pannus formation, by inhibiting mononuclear infiltration. 相似文献