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41.
42.
Yogesh Patidar Meena Gupta Geeta A Khwaja Debashish Chowdhury Amit Batra Abhijit Dasgupta 《Annals of Indian Academy of Neurology》2013,16(3):428-431
Apraxia of speech (AOS) is a rare, but well-defined motor speech disorder. It is characterized by irregular articulatory errors, attempts of self-correction and persistent prosodic abnormalities. Similar to aphasia, AOS is also localized to the dominant cerebral hemisphere. We report a case of Crossed Aphasia with AOS in a 48-year-old right-handed man due to an ischemic infarct in right cerebral hemisphere. 相似文献
43.
Rajesh Krovvidi Rukmini K. Mridula S. A. Jabeen A. K. Meena 《Annals of Indian Academy of Neurology》2013,16(4):681-683
Neurological melioidosis is a very rare and very few cases have been reported from India. Presentation is an extremely varied and as this disease is associated with high mortality, high index of suspicion is needed to diagnose and treat. In this context, we report a patient presenting as Guillain Barre syndrome evaluated as melioidosis.Key Words: Guillain Barre’ syndrome, infection, melioidosis 相似文献
44.
Yogesh Patidar Meena Gupta Geeta A. Khwaja Debashish Chowdhury Amit Batra Abhijit Dasgupta 《Annals of Indian Academy of Neurology》2013,16(2):157-162
Aims:
To evaluate clinical profile and short-term outcome of psychogenic non-epileptic seizures (PNES) in Indian adult population.Setting and Design:
A prospective observational study, conducted at tertiary teaching institute at New Delhi.Materials and Methods:
Sixty-three patients with confirmed PNES were enrolled. The diagnosis was based on witnessing the event during video-electroencephalography (Video-EEG) monitoring. A detailed clinical evaluation was done including evaluation for coexistent anxiety or depressive disorders. Patients were divided into two groups on the basis of excessive or paucity of movements during PNES attacks. Patients were followed-up to 12 months for their PNES frequency.Statistical Analysis:
Means and standard deviations were calculated for continuous variables. Chi-square and Students t-test were used to compare categorical and continuous variables respectively.Results:
The mean age at onset of PNES was 25.44 years; with F:M ratio of 9.5:1. Coexistent epilepsy was present in 13 (20.63%) cases. Twenty-two patients (44%) with only PNES (n = 50) had received antiepileptic drugs. Out of 63 patients of PNES 24 (38.1%) had predominant motor phenomenon, whereas 39 (61.9%) had limp attacks. The common features observed were pre-ictal headache, ictal eye closure, jaw clenching, resistant behavior, ictal weeping, ictal vocalization, and unresponsiveness during episodes. Comorbid anxiety and depressive disorders was seen in 62.3% and 90.16% patients, respectively. Short-term (6-12 months) outcome of 45 patients was good (seizure freedom in 46.66% and >50% improvement in 24.44% cases).Conclusion:
PNES is common, but frequently misdiagnosed and treated as epileptic seizures. A high index of suspicion is required for an early diagnosis. Proper disclosure of diagnosis and management of the psychiatric comorbidities can improve their outcome.Limitation:
Limited sample size and change in seizures frequency as the only parameter for the assessment of the outcome are the two major limitations of our study. 相似文献45.
Mukesh Choudhary Mahesh Kumar Meena Narendra Chhangani Deepak Sharma Jagveer Singh Choudhary Sushil Kumar Choudhary 《The journal of maternal-fetal & neonatal medicine》2016,29(2):324-327
Aim: To study the prevalence of persistent pulmonary hypertension (PPHN) in newborn with meconium aspiration syndrome (MAS) in western Rajasthan, India.Material and methods: Hundred full-term newborns who had features of MAS at birth were included in this survey and were evaluated for PPHN using laboratory investigations, including pulse oximetry, ABG, chest X-ray, ECG and 2D color echocardiography.Results: Nineteen neonates showed PPHN, of them 16 had a shunt reversal at PFO level and the rest at PDA level. Most of these newborns were delivered by emergency cesarean section and were unplanned. A majority of neonates of PPHN (84.21%) were diagnosed within 48?h of life and 73.69% had Downey’s score more than 6. Neonates of PPHN had mean PH 7.21?±?0.07, mean PCO2 53.73?±?6.8, mean PaO2 61.10?±?10.61 and mean PaO2/FiO2 144.03?±?46.31.Conclusions: PPHN is a genuine problem in MAS-born neonates and is commonly seen in neonates born by unplanned and unmonitored delivery, and the prevalence of PPHN can be reduced by providing good antenatal care, regular follow up of high-risk pregnancy. 2D echocardiography is an important point of care in the diagnosis of PPHN in nursery and should be promoted in nurseries of developing countries as being engaged in developed countries for more reliable treatment. 相似文献
46.
This paper reports a case of a 50-year-old male with systemic sarcoidosis presenting initially with a dry mouth and bilateral swelling of the parotid salivary glands. Sarcoidosis is a multisystem granulomatous disease in which there may be multiple exocrine involvement, including the salivary and lachrymal glands. CLINICAL RELEVANCE: The diagnosis and management of this case highlights important clinical issues for dental practitioners. 相似文献
47.
Plaque bacteria are the primary initiators of periodontal disease in susceptible persons and therapy is largely based on mechanical bacterial biofilm disruption. Patients' response to periodontal treatment is unpredictable and periodontal stability is not always achieved. Locally delivered antimicrobials (LDAs) may be used as adjuncts to mechanical therapy in treatment of recalcitrant deep (> or = 5mm), active, non-responding sites, providing the patient's oral hygiene is adequate. Their use as a monotherapy cannot be justified. The literature reveals that LDAs are safe and that they achieve statistically significant, yet clinically modest, gains in clinical attachment and reductions in pocket depths. Clinical Relevance: It has been suggested that LDAs may improve the clinical outcome in the treatment of recurrent and refractory cases of periodontitis when used as an adjunct to scaling and root surface instrumentation. This paper examines and discusses the evidence. 相似文献
48.
49.
Mishra Sumit Ranjan Yadav Pavan Kumar Nandhakumar Perumal Saini Mohini Kumar Ajay Kataria Meena 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(2):511-515
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - The anti-metastatic activity of bacosine (Bacopa monnieri plant) was studied using 4T1 murine breast cancer... 相似文献
50.
Opinion statement Anemia is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) that is commonly overlooked, despite
its significant impact on quality of life. Characteristic symptoms include chronic fatigue, headache, and subtle impairment
of cognitive function, although some less common symptoms include dyspnea, dizziness, pica, angular stomatitis, shortened
attention span, and esophageal webs. Several types of anemia are associated with IBD, but iron deficiency anemia (IDA) accounts
for the majority of cases and others include anemia of chronic disease, anemia associated with vitamin deficiency (vitamin
B12 and folate), autoimmune anemia, and anemia caused by medication used to treat IBD. The diagnosis of IDA relies on laboratory
blood tests. Therefore, these tests should be obtained on a regular basis because characteristic symptoms may be absent or
not readily recognized by patients and their clinicians. Complete blood count may suffice; however, iron studies and serum
vitamin levels may be necessary to differentiate between specific types of anemia. During the diagnostic process, it is important
to consider coexistence of different types of anemia, especially if no response to therapy is noted. The therapy for anemia
is directed towards treatment of the underlying inflammatory process and supplemental therapy, depending on the type of deficiency.
Iron deficiency anemia is treated with iron preparations, first orally, and if unresponsive or if associated with untoward
adverse events leading to decrease in adherence with the therapeutic regimen, with intravenous preparations. Intramuscular
therapy has been abandoned due to high rate of complications. Intravenous therapy may be administered as a multiple-dose regimen
(intravenous iron sucrose and gluconate) or as a single intravenous dose (iron dextran), which is associated with a higher
risk of allergic infusion reactions and requires obligatory test dose administration. Treatment with erythropoietin is reserved
for a select subgroup of patients with anemia of chronic disease. With appropriate treatment, the majority of patients with
IBD will have significant improvement or resolution of anemia, which can lead to a better quality of life. However, a high
index of suspicion should be maintained in order to identify the precise cause of anemia and to prescribe the appropriate
therapy. 相似文献