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101.
Without appropriate commitment dedication from all sectors of government the significance of health objectives set forth in Healthy People will continue to be diluted more importantly the health of this nation will not improve.Ann Coulston MS RD FADA as part of ADA'S official comments to the US 《Journal of the American Dietetic Association》1999,99(4):420
102.
JEAN-XAVIER GUINARD PhD MS PAMELA J. SECHEVICH MS KATE MEAKER PhD SATYA S. JONNALAGADDA PhD PENNY KRIS-ETHERTON PhD MS RD 《Journal of the American Dietetic Association》1999,99(6):690
Objective To examine the effects of manipulating dietary fat in foods on sensitivity and hedonic response to fat in selected foods.Design Twenty subjects were randomly assigned to a sequence of three 8-week experimental diets (average American diet, step 1 diet, low-saturated-fat diet) that varied in energy from fat (37%, 30%, and 26%, respectively) and saturated fat (17%, 10%, and 6%, respectively). Subjects participated in sensory tests designed to assess their sensitivity to and liking for fat in several foods, before the study (baseline), after consumption of each diet, and after the study (washout).Subjects/setting Subjects were participants in the Dietary Effects on Lipoprotein and Thrombogenic Activity (DELTA) study.Results No significant differences were found among diets for difference thresholds (ie, just noticeable differences) for fat in milk and pudding, ad libitum mixing of low- and high-fat samples of milk and soup, and hedonic scaling of fat concentrations in milk and muffins and of cheese, mayonnaise, hot dog, and pastry samples.Applications/conclusions Within the dietary fat ranges and for the fat stimuli tested in this study, dietary fat as percentage of energy from fat and saturated fat was not a significant determinant of sensitivity to and/or liking for fat. Sensory factors should not be a barrier to the implementation of low-fat diets such as the step 1 and low-saturated-fat diets. J Am Diet Assoc. 1999;99:690–696. 相似文献
103.
Chung F Lane R Spraggs C McQuade B Jacka M Luttropp HH Alahuta S Rocherieux S Roy M Duvaldestin P Curtis P 《European journal of anaesthesiology》1999,16(10):669-677
Nausea and vomiting are common side effects of opioids administered for pain control. This double-blind, randomized, parallel-group study evaluated the anti-emetic efficacy and tolerability of single intravenous (i.v.) doses of ondansetron 8 mg, ondansetron 16 mg and metoclopramide 10 mg in the treatment of opioid-induced emesis. Adult patients undergoing low emetogenic surgical procedures, using a standardized anaesthesia regimen were assessed for 24 h following administration of study anti-emetic to treat established post-surgical opioid-induced emesis. A total of 4511 patients were enrolled of whom 1366 experienced opioid-induced emesis and received randomized study medication. Ondansetron 8 mg and 16 mg were significantly better than metoclopramide 10 mg (P < 0.05) for both complete control of emesis, complete control of nausea and other efficacy measures. There were no significant differences between the two ondansetron groups. All three treatments were well tolerated. In conclusion, this large, multicentre study demonstrates that ondansetron is more effective than metoclopramide in the treatment of opioid-induced emesis following administration of post-surgical opioids to control pain. 相似文献
104.
Rationale: Although physically aversive stimuli induce functional changes in central noradrenergic neurones, little is known about the
noradrenergic response to environmentally aversive stimuli. Objectives: The first aim was to characterise environmental features that are perceived as stressful by rats. The second was to investigate
whether changes in the concentration of extracellular noradrenaline are induced by these environmental features. Methods: A light/dark shuttle-box was used to test rats’ behavioural response to a range of stimuli (novelty, bright light, and the
presence of an unfamiliar rat), either before or after microdialysis probe implantation. Changes in the concentration of extracellular
noradrenaline in the frontal cortex and hypothalamus in vivo were then evaluated on exposure to these same test conditions. Results: Naive rats spent less time in a brightly-lit test arena than a dark one. However, the behavioural response to the light arena
was attenuated by the presence of an unfamiliar rat. Probe implantation intensified the response to the light arena but did
not affect behaviour in the dark arena. In the microdialysis studies, there was no change in the concentration of extracellular
noradrenaline on transfer of rats to the dark arena but there was an increase in both the frontal cortex (+45%) and hypothalamus
(+75%) on exposure to the light arena. A similar increase was induced in both brain regions when the light arena contained
an unfamiliar rat. Conclusions: Implantation of a microdialysis probe modifies the behavioural responses to certain environmental stimuli. Regardless of
this, the extent to which rats perceive a novel environment as aversive is not the only determinant of the noradrenergic response
to such stimuli. However, differences in stimulus controllability in the microdialysis and the behavioural experiments could
influence the apparent intensity of the stress.
Received: 29 October 1998 / Final version: 19 March 1999 相似文献
105.
Alan Balsam PhD RD Nicole Grant MS Beatrice L. Rogers PhD 《Journal of community health》1996,21(1):37-49
The nutritional status of persons with HIV and AIDS [PWAs] is constantly challenged throughout the progression of the illness. Home-delivered meals programs for PWAs are rapidly developing across the country to address this problem among the growing population of people with HIV infection and AIDS. This study examined client socio-demographic characteristics (sex, age, ethnicity), types of services offered by these programs, organizational and financial criteria, and characteristics of survey respondents.Data for this study was obtained from 15 of the 17 known home-delivered meals programs for PWAs in the United States through an original, cross-sectional survey instrument conducted by telephone interview between March 1994 and May 1994.Results from this study show an increase in the number of minority populations who participate in these programs (36% African-American and 12% Hispanic vs. 51% Caucasian), as well as women (17.2%) and children (7%). Geographic location was an important determinant for program eligibility. The number of meals served weekly varied greatly (from 510 to 12,600 per week). Other significant services included nutrition counselling, newsletters, and holiday-basket programs. Enhancing service-delivery systems was one of the more prevalent high-priority concerns cited, especially with regard to food quality and safety.These results show that these programs are catering increasingly to minority populations, women and children, and that they are expanding their services to meet the growing needs of their client populations. These findings suggest that there is a greater need for meals and other home-based services for persons living with HIV and AIDS.This research was supported by the Massachusetts Department of Public Health.He formerly was Director of Elder Health at the Massachusetts Department of Public Health, Boston, MA; he is a founder and serves on the Board of Directors of Community Servings 相似文献
106.
Smidt GL McQuade KJ Wei SH 《The Journal of orthopaedic and sports physical therapy》1992,16(4):182-188
Several factors can be involved in evaluating a motion analysis system. The purposes of this study were to evaluate: 1) the accuracy, repeatability, and linearity of the Skeletal Analysis System (Metrecom System) and 2) the reliability of bony landmark identification with a method using the Metrecom Skeletal Analysis System (Metrecom Method) to obtain coordinates for human skeletal landmarks. A calibration control object with 20 known three-dimensional coordinates in a rectangular field was used as the gold standard for evaluating the Metrecom System for measuring X, Y, and Z spatial coordinates. The Metrecom Method was then evaluated using a test-retest approach for 10 bony landmarks on each of 10 normal subjects examined by two different examiners. Relative to the Metrecom System, the results demonstrated that the hysteresis was minimal (1.8 mm), and linearity was excellent. The differences between the true and measured distances for the 20 known points were not statistically significant (p >/= .05). The variability for any point within the field of measurement was homogeneous (p = .05). The accuracy (average difference between known and measured points) of the Metrecom System was found to be 2.7 mm. Repeatability in terms of the stability of the Metrecom System as indicated by deviations along the X, Y, and Z axes was .22, .57, and .31 mm, respectively. The results involving the Metrecom Method showed that the intraexaminer and interexaminer differences were not statistically significant (p >/= .05). The mean intrarater reliability (ICC) for identification of coordinates for 10 bony landmarks was .95 for one examiner and .96 for the other examiner. The mean interrater ICC was .87, with all coefficients being above .80. In conclusion, use of the Metrecom System is affected by controllable human factors, in which case valid and reliable measurements for skeletal landmarks can be obtained. J Orthop Sports Phys Ther 1992;16(4):182-188. 相似文献
107.
FJ O'Callaghan AC Clarke H Joffe B Keeton R Martin A Salmon RD Thomas JP Osborne 《Archives of disease in childhood》1998,78(2):159-162
This report highlights the association between tuberous sclerosis and Wolff-Parkinson-White syndrome. Ten patients with concurrent diagnoses of Wolff-Parkinson-White syndrome and tuberous sclerosis were identified. Wolff-Parkinson-White syndrome presented early in life, nine cases being diagnosed in the first year. Eight of the 10 cases were male. In eight cases, the syndrome was associated with supraventricular tachycardias, and in nine with cardiac rhabdomyomata. One child died from cardiac failure secondary to obstruction of the left ventricular outflow tract by a rhabdomyoma. Five of nine survivors showed resolution of Wolff-Parkinson-White syndrome on follow up. The accessory pathway was localised in nine patients from surface electrocardiograms: six children had left sided pathways and three had right sided pathways. 相似文献
108.
Comprehensive mutational scanning of the p53 coding region by two- dimensional gene scanning 总被引:2,自引:0,他引:2
A comprehensive mutational scanning test for the p53 coding region based on
multiplex PCR and two-dimensional DNA electrophoresis was designed and
evaluated. In a 2-step multiplex PCR, the p53 coding region (exons 2-11)
was amplified as a single 8646-bp fragment by long- distance PCR in step
one. This fragment served as a template for the subsequent co-amplification
of the individual exons in two multiplex groups in step two. The multiplex
products were then separated, first on the basis of size in non-denaturant
polyacrylamide gels and then on the basis of sequence by denaturing
gradient gel electrophoresis (DGGE). Primers for optimal PCR, melting
behavior and 2-D gel distribution were designed using a recently developed
computer program. The resulting two-dimensional gene scanning (TDGS) test
was evaluated by screening, in a blinded fashion, 29 coded DNA samples from
Li- Fraumeni syndrome patients with previously identified germline
mutations. All mutations were correctly detected. This assay provides an
accurate, cost-effective and non-radioactive method for simultaneous
mutational scanning of all p53 coding exons.
相似文献
109.
110.