全文获取类型
收费全文 | 255篇 |
免费 | 17篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 2篇 |
基础医学 | 17篇 |
临床医学 | 24篇 |
内科学 | 58篇 |
神经病学 | 95篇 |
特种医学 | 7篇 |
外科学 | 14篇 |
综合类 | 5篇 |
预防医学 | 1篇 |
药学 | 23篇 |
肿瘤学 | 10篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 6篇 |
2018年 | 3篇 |
2017年 | 2篇 |
2016年 | 6篇 |
2015年 | 4篇 |
2014年 | 7篇 |
2013年 | 6篇 |
2012年 | 20篇 |
2011年 | 18篇 |
2010年 | 8篇 |
2009年 | 5篇 |
2008年 | 17篇 |
2007年 | 15篇 |
2006年 | 10篇 |
2005年 | 10篇 |
2004年 | 13篇 |
2003年 | 18篇 |
2002年 | 15篇 |
2001年 | 14篇 |
2000年 | 13篇 |
1999年 | 10篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1966年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有272条查询结果,搜索用时 390 毫秒
11.
Anja von Au Matthaeus Vasel Sabrina Kraft Carla Sens Norman Hackl Alexander Marx Philipp Stroebel J?rg Hennenlotter Tilman Todenh?fer Arnulf Stenzl Sarah Schott Hans-Peter Sinn Antoinette Wetterwald Justo Lorenzo Bermejo Marco G Cecchini Inaam A Nakchbandi 《Neoplasia (New York, N.Y.)》2013,15(8):925-938
Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation. The relative contribution of local and circulating fibronectin to blood vessel formation in vivo remains unknown despite evidence for unexpected roles of circulating fibronectin in various diseases. Using transgenic mouse models, we established that circulating fibronectin facilitates the growth of bone metastases by enhancing blood vessel formation and maturation. This effect is more relevant than that of fibronectin produced by endothelial cells and pericytes, which only exert a small additive effect on vessel maturation. Circulating fibronectin enhances its local production in tumors through a positive feedback loop and increases the amount of vascular endothelial growth factor (VEGF) retained in the matrix. Both fibronectin and VEGF then cooperate to stimulate blood vessel formation. Fibronectin content in the tumor correlates with the number of blood vessels and tumor growth in the mouse models. Consistent with these results, examination of three separate arrays from patients with breast and prostate cancers revealed that a high staining intensity for fibronectin in tumors is associated with increased mortality. These results establish that circulating fibronectin modulates blood vessel formation and tumor growth by modifying the amount of and the response to VEGF. Furthermore, determination of the fibronectin content can serve as a prognostic biomarker for breast and prostate cancers and possibly other cancers. 相似文献
12.
13.
Schuch Felipe Barreto Bulzing Rugero A. Meyer Jacob López-Sánchez Guillermo F. Grabovac Igor Willeit Peter Vancampfort Davy Caperchione Cristina M. Sadarangani Kabir P. Werneck André O. Ward Philip B. Tully Mark Smith Lee 《Sport Sciences for Health》2022,18(1):155-163
Sport Sciences for Health - The COVID-19 pandemic imposed major changes on daily-life routine worldwide. To the best of our knowledge, no study quantified the changes on moderate to vigorous... 相似文献
14.
Sotirios Tsimikas Stefan Kiechl Johann Willeit Manuel Mayr Elizabeth R Miller Florian Kronenberg Qingbo Xu Claes Bergmark Siegfried Weger Friedrich Oberhollenzer Joseph L Witztum 《Journal of the American College of Cardiology》2006,47(11):2219-2228
OBJECTIVES: The purpose of this work was to determine the predictive value of oxidized phospholipids (OxPLs) present on apolipoprotein B-100 particles (apoB) in carotid and femoral atherosclerosis. BACKGROUND: The OxPLs are pro-inflammatory and pro-atherogenic and may be detected using the antibody E06 (OxPL/apoB). METHODS: The Bruneck study is a prospective population-based survey of 40- to 79-year-old men and women initiated in 1990. Plasma levels of OxPL/apoB and lipoprotein (a) [Lp(a)] were measured in 765 of 826 (92.6%) and 671 of 684 (98.1%) subjects alive in 1995 and 2000, respectively, and correlated with ultrasound measures of carotid and femoral atherosclerosis. RESULTS: The distribution of the OxPL/apoB levels was skewed to lower levels and nearly identical to Lp(a) levels. The OxPL/apoB and Lp(a) levels were highly correlated (r = 0.87, p < 0.001), and displayed long-term stability and lacked correlations with most cardiovascular risk factors and lifestyle variables. The number of apolipoprotein (a) kringle IV-2 repeats was inversely related to Lp(a) mass (r = -0.48, p < 0.001) and OxPL/apoB levels (r = -0.46, p < 0.001). In multivariable analysis, OxPL/apoB levels were strongly and significantly associated with the presence, extent, and development (1995 to 2000) of carotid and femoral atherosclerosis and predicted the presence of symptomatic cardiovascular disease. Both OxPL/apoB and Lp(a) levels showed similar associations with atherosclerosis severity and progression, suggesting a common biological influence on atherogenesis. CONCLUSIONS: This study suggests that pro-inflammatory oxidized phospholipids, present primarily on Lp(a), are significant predictors of the presence and extent of carotid and femoral atherosclerosis, development of new lesions, and increased risk of cardiovascular events. The OxPL biomarkers may provide valuable insights into diagnosing and monitoring cardiovascular disease. 相似文献
15.
16.
17.
ILR Genetics Consortium Emerging Risk Factors Collaboration Sarwar N Butterworth AS Freitag DF Gregson J Willeit P Gorman DN Gao P Saleheen D Rendon A Nelson CP Braund PS Hall AS Chasman DI Tybjærg-Hansen A Chambers JC Benjamin EJ Franks PW Clarke R Wilde AA Trip MD Steri M Witteman JC Qi L van der Schoot CE de Faire U Erdmann J Stringham HM Koenig W Rader DJ Melzer D Reich D Psaty BM Kleber ME Panagiotakos DB Willeit J Wennberg P Woodward M Adamovic S Rimm EB Meade TW Gillum RF Shaffer JA 《Lancet》2012,379(9822):1205-1213
18.
The recent discovery that microRNAs (miRNAs) are present in the circulation sparked interest in their use as potential biomarkers. In this review, we will summarize the latest findings on circulating miRNAs and cardiovascular disease but also discuss analytical challenges. While research on circulating miRNAs is still in its infancy, high analytical standards in statistics and study design are a prerequisite to obtain robust data and avoid repeating the mistakes of the early genetic association studies. Otherwise, studies tend to get published because of their novelty despite low numbers, poorly matched cases and controls and no multivariate adjustment for conventional risk factors. Research on circulating miRNAs can only progress by bringing more statistical rigour to bear in this field and by evaluating changes of individual miRNAs in the context of the overall miRNA network. Such miRNA signatures may have better diagnostic and prognostic value. 相似文献
19.
20.
Lucie Bartova Konstantinos Papageorgiou Ivan Milenkovic Markus Dold Ana Weidenauer Matthaeus Willeit Dietmar Winkler Siegfried Kasper 《European neuropsychopharmacology》2018,28(8):980-982
Rapid anti-suicidal and antidepressant effects of ketamine have repeatedly been confirmed in unipolar and bipolar depression. Although meaningful antidepressant efficacy of ketamine has also been shown in depressed patients with a history of psychotic symptoms, its administration in psychotic disorders has largely been neglected due to its potential to exacerbate dissociative or psychotic symptoms. Presenting a case of a young female inpatient suffering from schizophrenia with a severe post-psychotic depression, we demonstrate a robust anti-suicidal and antidepressant effect of S-ketamine infusions administered thrice weekly for 3 weeks in total. Importantly, no relevant psychotic or dissociative symptoms occurred during the whole augmentation treatment period leading to a sustained remission of depressive symptoms and suicidality. Our safe and effective experience with intravenous S-ketamine might encourage researchers and clinicians to widen its administration range beyond the diagnosis of depression to enrich the current knowledge of ketamine effects in psychotic disorders. 相似文献