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排序方式: 共有4356条查询结果,搜索用时 15 毫秒
991.
992.
T Matsuyama K Urano M Ohkido H Ozawa A Ohta S Kaneko T Yahata C Takita T Nishimura 《Clinical and experimental allergy》1999,29(5):687-694
Peripheral blood mononuclear cells (PBMCs) obtained from atopic dermatitis (AD) patients produced low levels of IFN-gamma in response to Dermatophagoides farinae antigen (Der f Ag) plus IL-2 or OKT3 MoAb in contrast with PBMCs obtained from healthy donors. The reduced IFN-gamma production in AD patients' T cells appeared to be derived from the defect of CD4+ T cells but not CD8+ T cells. Indeed, from the cytoplasmic staining analysis of cytokines, it was demonstrated that the frequency of IFN-gamma producing CD4+ T cells (TH1 cells) in AD patients was markedly lower than that of healthy donors. From the phenotypic analysis using flow cytometry, it was also found that the number of CD4+ CD45RO+ memory type T cells was significantly reduced in AD patients compared with that of healthy donors. In addition to quantitative defect of memory type CD4+ T cells, functional defect of CD4+ CD45RO+ memory type T cells was also demonstrated in AD patients. Enriched CD4+ CD45RO+ T cells obtained from AD patients, who exhibited greatly reduced delayed-type hypersensitivity (DTH) response in tuberculin test, showed no significant TH1 immunity in terms of IFN-gamma production by stimulation with OKT3 MoAb or purified protein derivative (PPD). Thus, the immunological abnormality of TH1 immunity in AD patients appeared to be induced in concomitant with both the quantitative and qualitative defect of memory type CD4+ T cells. 相似文献
993.
994.
Soji Ozawa Koichiro Kumai Kazuhide Higuchi Tetsuo Arakawa Mototsugu Kato Masahiro Asaka Natsuya Katada Hiroyuki Kuwano Masaki Kitajima 《Journal of gastroenterology》2009,44(7):675-684
Purpose Endoluminal gastroplication (ELGP) was the first endoscopic therapy for gastroesophageal reflux disease (GERD). Data on the
long-term outcomes, including the plication status and data from Asian populations, are limited. The aim of this study was
to evaluate the short-term and long-term effectiveness and safety of ELGP for GERD in the Japanese population.
Methods This was an open-label, prospective, multicenter trial of ELGP. Forty-eight patients with GERD were enrolled. The procedure
involved placing circumferential plications 1–2 cm below the GE junction using the EndoCinch system. Outcome measurements
were improvement of heartburn, medication use, endoscopic Los Angeles grade, durability of plications, 24-h esophageal acid
exposure, esophageal manometry, and frequency of adverse events.
Results During the 24-month follow-up, the rate of complete resolution of heartburn ranged from 54 to 66%, the rate of discontinuation
or reduction of PPI/H2RA use ranged from 65 to 76%, and the rate of endoscopic classification to grade O ranged from 66 to 81%. The status with
more than one plication remaining was associated with higher rates of improvement of heartburn, PPI/H2RA use, and endoscopic findings as compared with those associated with the loss of all plications. A modest decrease of the
esophageal acid exposure level, but no change of the manometric parameters, was observed after ELGP. No serious adverse events
were observed.
Conclusions In this 24-month follow-up study conducted in Japanese subjects, ELGP was found to be effective in about 60% of patients with
GERD, and the procedure was safe. 相似文献
995.
Matsuzono Kosuke Suzuki Masayuki Miura Kumiko Ozawa Tadashi Mashiko Takafumi Koide Reiji Tanaka Ryota Fujimoto Shigeru 《Neurological sciences》2022,43(2):1079-1086
Neurological Sciences - Although the relationship between amyotrophic lateral sclerosis (ALS) and cervical spondylotic myelopathy (CSM) is important, data relating to CSM complications in ALS... 相似文献
996.
997.
H Aoyama Y Kamiyama M Ukikusa K Ozawa 《The Journal of laboratory and clinical medicine》1986,108(5):456-460
Changes in the amount of hippurate synthesized and excreted in the urine after 1.5 gm benzoate loading (intravenous hippuric acid test [HAT]) in patients with liver disease before surgery were studied in relation to arterial blood ketone body ratio (acetoacetate/beta-hydroxybutyrate) (BKBR), reflecting energy status of the liver. In these patients, the HAT values for 120 minutes were decreased significantly (1.088 +/- 0.129 gm, n = 9; 1.071 +/- 0.258 gm, n = 7; 1.258 +/- 0.126 gm, n = 10; in cirrhosis with liver tumor, cirrhosis with esophageal varix, and obstructive jaundice, respectively) as compared with the value in patients without liver disease (1.829 +/- 0.093 gm, n = 16, P less than 0.01). The correlation coefficient of the BKBR and the HAT value was 0.766, which was higher than that of the BKBR and albumin or the BKBR and choline esterase (r = 0.532 and r = 0.646, respectively). Serum levels of glutamic-oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase, leucine aminopeptidase, total and direct bilirubin, creatinine, and blood urea nitrogen were not correlated with the HAT values. Because hippurate is synthesized in liver mitochondria by the continuous supply of adenosine triphosphate through mitochondrial oxidative phosphorylation, HAT is considered to be a test that evaluates the energetic capacity of the liver to manage a metabolic load imposed on it. 相似文献
998.
Sato K Izumi T Toshima M Nagai T Muroi K Komatsu N Ozawa K 《Internal medicine (Tokyo, Japan)》2005,44(4):346-349
We describe a case of acute myeloid leukemia (AML) complicated with retropharyngeal abscess (RPA) due to methicillin-resistant Staphylococcus aureus (MRSA) in a 56-year-old man. After administration of vancomycin and lavage of the retropharyngeal space with gentamicin, complete resolution of the RPA was observed. Despite their lower frequency, deep neck infections are associated with high mortality rates. The possibility of RPA should be considered in patients who present with fever, dysphagia and limitation of neck extension. Lavage of the retropharyngeal abscess with gentamicin may be optimal in cases of large RPA. 相似文献
999.
1000.
Alteration of Glutamyltranspeptidase Binding Proteins in Postmortem Brains of Heroin Addicts 总被引:1,自引:0,他引:1
Eri Hashimoto Lutz Frölich Hiroki Ozawa Toshikazu Saito Shin Shichinohe Naohiko Takahata Peter Riederer 《Alcoholism, clinical and experimental research》1996,20(S9):301A-304A
Glutamyltranspeptidase binding (G) proteins play an important role in intracellular signal transduction downstream from many receptors, including opioid receptors. Moreover, it was recently reported that the β-subunits of G proteins, in addition to the α-subunits, regulate effector pathways. In this study, membrane G protein immunoreactivity was estimated by Western blotting with polyclonal antibodies (RM/1, AS/7, GC/2, QL, and SW/1) against specific G proteins (Gαs, Gαi-1,2, Gαo, Gαq, and Gβ, respectively) in postmortem temporal cortex obtained from 6 heroin addicts and 6 control subjects without a history of drug abuse. Immunoreactivities of the Gβ-subunit increased significantly ( p < 0.05) in heroin addicts, compared with controls, and that of Gαi-1,2 tended to increase in heroin addicts. Present findings suggest that the alterations in G protein-mediated signal transduction may be involved in the mechanism of opiate addiction. 相似文献