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71.
Mangano C Mangano FG Shibli JA Ricci M Perrotti V d'Avila S Piattelli A 《Journal of periodontology》2012,83(1):70-78
Background: At present, only some studies have dealt with immediate loading of unsplinted implants supporting mandibular overdentures. The aim of this prospective study is to evaluate treatment outcomes of mandibular overdentures supported by four one‐piece, unsplinted, immediately loaded, direct laser metal‐forming (DLMF) implants by assessing implant survival rate, implant success, marginal bone loss, and prosthetic complications. Methods: A total of 96 one‐piece DLMF implants were inserted in the edentulous mandible of 24 patients. Four implants were placed in each edentulous mandible. Immediately after implant placement, a mandibular overdenture was connected to the implants. At 1‐year follow‐up, clinical, radiographic, and prosthetic parameters were assessed. Success criteria included absence of pain, suppuration, and implant mobility; absence of continuous peri‐implant radiolucency; and distance between the implant shoulder and the first visible bone contact <1.5 mm. Results: After a 1‐year loading time, the overall implant survival rate was 98.9%, with only one implant lost. Among the surviving 95 implants, two did not fulfill the success criteria; therefore, the implant success rate was 97.8%. The mean distance between the implant shoulder and the first visible bone contact was 0.28 ± 0.30 mm (95% confidence interval, 0.24 to 0.32). Some prosthetic complications were reported. Conclusion: Based on the present results and within the limits of this study, the immediate loading of four unsplinted DLMF implants by means of ball attachment–supported mandibular overdentures seems to represent a safe and successful procedure. 相似文献
72.
Raffaele Iorio Valentina Damato Massimiliano Mirabella Amelia Evoli Alessandro Marti Domenico Plantone Giovanni Frisullo Anna Paola Batocchi 《Journal of neurology》2013,260(9):2396-2402
Longitudinally extensive transverse myelitis (LETM) is a characteristic feature of Neuromyelitis Optica (NMO), but it can also occur in several other inflammatory diseases of the central nervous system (CNS). An IgG autoantibody that binds to aquaporin-4 (AQP4), the predominant water channel of the CNS, is a reliable biomarker of the NMO spectrum disorders, and if detected predicts the recurrence of the myelitis. In this study, we compared the clinical and neuroimaging characteristics of AQP4-IgG+ and AQP4-IgG? LETM patients. Thirty-seven first-ever LETM patients were retrospectively evaluated and divided into two groups according to the presence of AQP4 autoantibodies. AQP4-IgG was detected in the serum and in the cerebrospinal fluid of sixteen patients. The female to male ratio was higher in AQP4-IgG+ patients. Intractable nausea and vomiting and paroxysmal tonic spasms often accompanied the LETM in AQP4-IgG+ patients. T2-weighted spinal cord MRI revealed that inflammatory lesions extending into the brainstem and involving the central grey matter occurred more frequently in AQP4-IgG+ LETM patients. Hypointense lesions on T1-weighted spinal cord MRI were detected more frequently in the seropositive group, and their presence correlated with attack severity. In conclusion, this study provides clinical and spinal cord neuroimaging clues that can help distinguishing AQP4-IgG+ LETM patients. 相似文献
73.
Barbara Penolazzi Susanna Bergamaschi Massimiliano Pastore Daniele Villani Giuseppe Sartori Sara Mondini 《Neuropsychological rehabilitation》2013,23(6):799-817
In the present study we tested the cognitive effects of transcranial direct current stimulation (tDCS) in a case of probable Alzheimer disease (AD). The patient (male, 60?years, mild AD) underwent two cycles of treatments, separated by 2?months. In the first cycle, active stimulation (10 sessions, 2?mA for 20?min; anode over the left dorsolateral prefrontal cortex) was followed by computerised tasks (CTs) specifically chosen to engage the most impaired cognitive processes in the patient (tDCS+CT condition). In the second cycle, which was structured as the first, CTs were administered after placebo stimulation (sham+CT condition). Effects on cognitive performance were evaluated not only by the CTs, but also by neuropsychological tests assessing global cognitive functioning. Statistical analyses revealed that whereas the tDCS+CT condition had few effects on the CTs, it induced a stability of the patient's global cognitive functioning lasting approximately 3?months, which was not achieved when the patient underwent sham+CT condition. Therefore, the synergetic use of tDCS and CTs appeared to slow down the cognitive decline of our patient. This preliminary result, although in need of further confirmation, suggests the potentiality of tDCS as an adjuvant tool for cognitive rehabilitation in AD. 相似文献
74.
75.
Miryam Carecchio MD Monia Magliozzi BSc Massimiliano Copetti PhD Alessandro Ferraris MD PhD Laura Bernardini PhD Monica Bonetti BSc Giovanni Defazio MD Mark J. Edwards PhD Isabella Torrente BSc Fabio Pellegrini MSc Cristoforo Comi MD PhD Kailash P. Bhatia MD FRCP Enza Maria Valente MD PhD 《Movement disorders》2013,28(6):787-794
Mutations or exon deletions of the epsilon‐sarcoglycan (SGCE) gene cause myoclonus‐dystonia (M‐D), but a subset of M‐D patients are mutation‐negative and the sensitivity and specificity of current genetic testing criteria are unknown. We screened 46 newly enrolled M‐D patients for SGCE mutations and deletions; moreover, 24 subjects previously testing negative for SGCE mutations underwent gene dosage analysis. In our combined cohorts, we calculated sensitivity, specificity, positive and negative predictive values, and area under the curve of 2 published sets of M‐D diagnostic criteria. A stepwise logistic regression was used to assess which patients' characteristics best discriminated mutation carriers and to calculate a new mutation predictive score (“new score”), which we validated in previously published cohorts. Nine of 46 (19.5%) patients of the new cohort carried SCGE mutations, including 5 novel point mutations and 1 whole‐gene deletion; in the old cohort, 1 patient with a complex phenotype carried a 5.9‐Mb deletion encompassing SGCE. Current diagnostic criteria had a poor ability to discriminate SGCE‐positive from SGCE‐negative patients in our cohort; conversely, age of onset, especially if associated with psychiatric features (as included in the new score), showed the best discriminatory power to individuate SGCE mutation carriers, both in our cohort and in the validation cohort. Our results suggest that young age at onset of motor symptoms, especially in association with psychiatric disturbance, are strongly predictive for SGCE positivity. We suggest performing gene dosage analysis by multiple ligation‐dependent probe amplification (MLPA) to individuate large SGCE deletions that can be responsible for complex phenotypes. © 2013 Movement Disorder Society 相似文献
76.
Spina Emanuele Doneddu Pietro Emiliano Liberatore Giuseppe Cocito Dario Fazio Raffaella Briani Chiara Filosto Massimiliano Benedetti Luana Antonini Giovanni Cosentino Giuseppe Jann Stefano Mazzeo Anna Cortese Andrea Marfia Girolama Alessandra Clerici Angelo Maurizio Siciliano Gabriele Carpo Marinella Luigetti Marco Lauria Giuseppe Rosso Tiziana Cavaletti Guido Peci Erdita Tronci Stefano Ruiz Marta Piccinelli Stefano Cotti Schenone Angelo Leonardi Luca Gentile Luca Piccolo Laura Mataluni Giorgia Santoro Lucio Nobile-Orazio Eduardo Manganelli Fiore 《Journal of neurology》2022,269(2):907-912
Journal of Neurology - Compression of the median nerve at the carpal tunnel can give demyelinating features and result in distal motor latency (DML) prolongation fulfilling the EFNS/PNS... 相似文献
77.
Vergunst Francis Chadi Nicholas Orri Massimiliano Brousseau-Paradis Camille Castellanos-Ryan Natalie Séguin Jean R. Vitaro Frank Nagin Daniel Tremblay Richard E. Côté Sylvana M. 《European child & adolescent psychiatry》2022,31(11):1729-1738
European Child & Adolescent Psychiatry - Substance abuse is a significant public health concern that disproportionately burdens males and low-income communities. This study examined (1)... 相似文献
78.
Altieri Manuela Capuano Rocco Conte Miriana Donnarumma Giovanna Grimaldi Elena Coppola Nicola Galdiero Massimiliano dAmbrosio Alessandro Tedeschi Gioacchino Gallo Antonio 《Neurological sciences》2022,43(5):2947-2949
Neurological Sciences - Few studies investigated the immune response to SARS-CoV-2 vaccine in patients with multiple sclerosis (pwMS) treated with natalizumab (NTZ) and found a short-term efficient... 相似文献
79.
Diamanti Luca Borrelli Paola Dubbioso Raffaele Capasso Margherita Morelli Claudia Lunetta Christian Petrucci Antonio Mora Gabriele Volanti Paolo Inghilleri Maurizio Tremolizzo Lucio Mandrioli Jessica Mazzini Letizia Vedovello Marcella Siciliano Gabriele Filosto Massimiliano Mat Sabrina Montomoli Cristina 《Neurological sciences》2022,43(5):3195-3200
Neurological Sciences - Dysphagia is a common symptom during the trajectory of ALS, and it can significantly impact on the quality of life and prognosis of patients. Nowadays, no specific tool for... 相似文献
80.
Katie S. Murray Emily C. Zabor Massimiliano Spaliviero Paul Russo Wassim M. Bazzi John E. Musser A. Ari Hakimi Melanie L. Bernstein Guido Dalbagni Jonathan A. Coleman Helena Furberg 《World journal of urology》2016,34(12):1667-1672