全文获取类型
收费全文 | 446篇 |
免费 | 17篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 2篇 |
妇产科学 | 11篇 |
基础医学 | 35篇 |
口腔科学 | 1篇 |
临床医学 | 15篇 |
内科学 | 91篇 |
皮肤病学 | 14篇 |
神经病学 | 47篇 |
特种医学 | 57篇 |
外科学 | 35篇 |
综合类 | 1篇 |
预防医学 | 46篇 |
眼科学 | 1篇 |
药学 | 18篇 |
肿瘤学 | 86篇 |
出版年
2024年 | 2篇 |
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 12篇 |
2019年 | 8篇 |
2018年 | 13篇 |
2017年 | 7篇 |
2016年 | 12篇 |
2015年 | 7篇 |
2014年 | 15篇 |
2013年 | 14篇 |
2012年 | 43篇 |
2011年 | 24篇 |
2010年 | 12篇 |
2009年 | 14篇 |
2008年 | 21篇 |
2007年 | 23篇 |
2006年 | 20篇 |
2005年 | 13篇 |
2004年 | 23篇 |
2003年 | 32篇 |
2002年 | 9篇 |
2001年 | 18篇 |
2000年 | 13篇 |
1999年 | 10篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 8篇 |
1990年 | 6篇 |
1989年 | 8篇 |
1988年 | 7篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 8篇 |
1978年 | 10篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1973年 | 1篇 |
排序方式: 共有463条查询结果,搜索用时 0 毫秒
81.
82.
Margheri M Pacini N Tani A Nosi D Squecco R Dama A Masala E Francini F Zecchi-Orlandini S Formigli L 《European journal of pharmacology》2012,681(1-3):34-43
Melatonin has been shown to inhibit breast cancer cell growth in numerous studies. However, our understanding of the therapeutic effects of this hormone is still marginal and there is little information concerning its combination with other antitumor agents to achieve additional potential benefits. All-trans retinoic acids or somatostatin have been used in combination with melatonin in several pre-clinical and clinical trials, but they have never been combined altogether as an anti-breast cancer treatment. In the present study, we investigated whether the association of melatonin, all-trans retinoic acid and somatostatin leads to an enhanced anticancer activity in MCF-7 breast cancer cells. In such conditions, MCF-7 cells were investigated for cell growth/viability and proliferation, as well as for the expression of cyclin A, and components of the Notch and EGFR pathways, by Western blotting and confocal immunofluorescence. Electrophysiological, morphological, and biochemical analysis were also performed to reveal signs of cell damage and death. We found that melatonin in combination with all-trans retinoic acid and somatostatin potentiated the effects of melatonin alone on MCF-7 cell viability and growth inhibition; this phenomenon was associated with altered conductance through Ca2? and voltage-activated K? (BK) channels, and with substantial impairments of Notch-1 and epidermal growth factor (EGF)-mediated signaling. The combined treatment also caused a marked reduction in mitochondrial membrane potential and intracellular ATP production as well as induction of necrotic cell death. Taken together our results indicate that co-administration of melatonin with all-trans retinoic acid and somatostatin may be of significant therapeutic benefit in breast cancer. 相似文献
83.
Donatella Marazziti Mario Catena Dell'Osso Stefano Baroni Irene Masala Bernardo Dell'Osso Giorgio Consoli Gino Giannaccini Laura Betti Antonio Lucacchini 《Psychiatry research》2010,175(1-2):54-57
The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures. 相似文献
84.
L. Ottini V. Silvestri C. Saieva P. Rizzolo I. Zanna M. Falchetti G. Masala A. S. Navazio V. Graziano S. Bianchi S. Manoukian M. Barile P. Peterlongo C. D’Amico L. Varesco S. Tommasi A. Russo G. Giannini L. Cortesi A. Viel M. Montagna P. Radice D. Palli 《Breast cancer research and treatment》2013,138(3):861-868
It is well-known that male breast cancer (MBC) susceptibility is mainly due to high-penetrance BRCA1/2 mutations. Here, we investigated whether common low-penetrance breast cancer (BC) susceptibility alleles may influence MBC risk in Italian population and whether variant alleles may be associated with specific clinicopathological features of MBCs. In the frame of the Italian Multicenter Study on MBC, we genotyped 413 MBCs and 745 age-matched male controls at 9 SNPs annotating known BC susceptibility loci. By multivariate logistic regression models, we found a significant increased MBC risk for 3 SNPs, in particular, with codominant models, for rs2046210/ESR1 (OR = 1.71; 95 % CI: 1.43–2.05; p = 0.0001), rs3803662/TOX3 (OR = 1.59; 95 % CI: 1.32–1.92; p = 0.0001), and rs2981582/FGFR2 (OR = 1.26; 95 % CI: 1.05–1.50; p = 0.013). Furthermore, we showed that the prevalence of the risk genotypes of ESR1 tended to be higher in ER? tumors (p = 0.062). In a case–case multivariate analysis, a statistically significant association between ESR1 and ER? tumors was found (OR = 1.88; 95 % CI: 1.03–3.49; p = 0.039). Overall, our data, based on a large and well-characterized MBC series, support the hypothesis that common low-penetrance BC susceptibility alleles play a role in MBC susceptibility and, interestingly, indicate that ESR1 is associated with a distinct tumor subtype defined by ER-negative status. 相似文献
85.
Heinz Freisling Pedro T. Pisa Pietro Ferrari Graham Byrnes Aurelie Moskal Christina C. Dahm Anne-Claire Vergnaud Marie-Christine Boutron-Ruault Guy Fagherazzi Claire Cadeau Tilman Kühn Jasmine Neamat-Allah Brian Buijsse Heiner Boeing Jytte Halkjær Anne Tjonneland Camilla P. Hansen J. Ramón Quirós Noémie Travier Esther Molina-Montes Pilar Amiano José M. Huerta Aurelio Barricarte Kay-Tee Khaw Nicholas Wareham Tim J. Key Dora Romaguera Yunxia Lu Camille M. Lassale Androniki Naska Philippos Orfanos Antonia Trichopoulou Giovanna Masala Valeria Pala Franco Berrino Rosario Tumino Fulvio Ricceri Maria Santucci de Magistris H. Bas Bueno-de-Mesquita Marga C. Ocké Emily Sonestedt Ulrika Ericson Mattias Johansson Guri Skeie Elisabete Weiderpass Tonje Braaten Petra H. M. Peeters Nadia Slimani 《European journal of nutrition》2016,55(6):2093-2104
86.
Fabiola Atzeni Maurizio Benucci Rossella Talotta Ignazio Francesco Masala Piercarlo Sarzi-Puttini Marcello Govoni 《Expert review of clinical pharmacology》2016,9(11):1403-1411
Introduction: Treatment with biological DMARDs (bDMARDs) has meant that remission or low disease activity (LDA) is now a realistic goal for patients with rheumatoid arthritis (RA). However, as in the case of all long-term therapies, potential side-effects give rise to concern. The main reasons for withdrawing or tapering bDMARDs are safety and the sustainability of national healthcare systems. Given these data our review has been focused on important question: whether conventional, including steroids, or bDMARDs can be reduced or even stopped in patients with stable established RA or early RA.Areas covered: The studies included in the evaluation had to be RCTs, observational studies, systematic reviews evaluating the withdrawing or tapering bDMARDs in RA patients who have been on long-term treatment and have achieved remission or LDA. A search was made in the MEDLINE and EMBASE databases from 1980 to May 2016.Expert commentary: There is curently no standardised way of identifying the patients for whom reducing bDMARD therapy is appropriate. Clinical experience and data from de-escalation studies suggest that patients with RA in sustained remission are the best target population for studying drug-tapering regimens, and that LDA should not be considered an adequate indication for bDMARD de-escalation because it could hide a persistent amount of inflammation. 相似文献
87.
Yujia Zhao MSc Anushree Ray MSc Karin Broberg PhD Maria Kippler PhD Christina M. Lill MD MSc Paolo Vineis PhD Verena A. Katzke PhD Miguel Rodriguez-Barranco PhD María-Dolores Chirlaque MD MHSc PhD Marcela Guevara MD PhD Jesús-Humberto Gómez MD Johnni Hansen PhD Salvatore Panico MD Lefkos T. Middleton MD FRCP Giovanna Masala MD Valeria Pala ScD Ana Vinagre-Aragon MD Maurizio Zibetti MD PhD Roel Vermeulen PhD Susan Peters PhD 《Movement disorders》2023,38(12):2302-2307
88.
Uccini S Scarpino S Ballarini F Soriani A Chilosi M Montesu MA Masala MV Cottoni F Ruco L 《The American Journal of dermatopathology》2003,25(5):377-383
Tissue expression of CC and CXC chemokines and chemokine receptors was investigated in 6 cases of classic non-AIDS Kaposi sarcoma (KS) using immunohistochemistry and RNase protection assay (RPA). Immunostaining of frozen sections of KS skin biopsies revealed that KS spindle cells express several chemokine receptors. In KS nodules, almost all KS spindle cells were intensely stained for CXCR4 and CCR5. Other chemokine receptors as CCR1, CXCR3, and CCR2 were also detected in the large majority of KS spindle cells. A minority of KS spindle cells also expressed the fractalkine receptor (FK-R) CX3CR1.The immunohistochemical findings were confirmed at RNA level. In fact, the RNase protection assay (RPA) revealed in 6 of 6 cases the presence of consistent amounts of mRNAs for CXCR4 and CCR1 and in 5 of 6 cases also for CCR5 and CXCR3.Expression of chemokine receptors by KS cells was associated with chemokine production within the lesions. In the same cases, RPA demonstrated the presence of mRNAs for MCP-1, RANTES, IP-10, MIP-1alpha, and MIP-1beta. Chemokine-producing cells, as detected by immunohistochemistry, were mainly spindle-shaped cells resembling tissue macrophages outside KS lesions and some scattered cells (<5%) present within KS nodules.The demonstration of chemokine receptors in KS cells raises the possibility that recruitment of KS cells in response to locally produced chemotactic stimuli may be one of the events involved in the pathogenesis of Kaposi sarcoma. 相似文献
89.
Stefano Marcia Luca Saba Giovanni Carlo Anselmetti Stefano Marini Emanuele Piras Mariangela Marras Salvatore Masala Bassem Georgy 《Cardiovascular and interventional radiology》2014,37(5):1329-1335
Background
The purpose of this retrospective observational study was to demonstrate the efficacy of a percutaneous screws system in the treatment of lumbar pain caused by high-level disc degeneration combined with facet joint hypertrophy and canal stenosis especially in the L5–S1 levels.Methods
Thirty-eight patients (25 males, 13 females, mean age 63 years) with lumbar pain and/or neuralgia-claudication were treated with interpeduncular dynamic screws. Diagnosis was based on clinical\medical history evaluation and X-ray, CT, and MR examinations. All patients completed the visual analogic scale (VAS) for evaluation of clinical efficacy and pain measurement both before and after (1 month and after 2 years) the procedure. Patients also were given the Oswestry disability index (ODI) before and after treatment. The area of the neuroforamina also was measured.Results
Thirty-eight intervertebral spaces were treated. The VAS pain scale showed a reduction of pain symptoms at 1 month and after 2 years (VAS pre 8.7 ± 1.1; after 1 month 5.1 ± 2.2; after 2 years 6.5 ± 2.1; p = 0.001). ODI also showed improvement (pre 56.7 ± 18.6 %; after 1 month: 31.9 ± 26.3%; after 2 years: 42 ± 24.2 %, p = 0.001). The study showed a widening of the neuroforaminal area of 15.5 % in the right neuroforamen and 17 % in the left ones (right foraminal area pre 0.94 mm2, post 1.08 mm2; left foramina area pre 0.95 mm2, post 1.11 mm2). In addition, the spinal canal area displayed a statistically significant reduction (pre = 1.97 and post = 2.23; p < 0.0001).Conclusions
Our study indicates that patients treated with dynamic screws have VAS pain reduction as well as ODI improvement. Moreover, we found a statistically significant widening of the neuroforaminal area. 相似文献90.
Masala S Roselli M Manenti G Mammucari M Bartolucci DA Simonetti G 《Cardiovascular and interventional radiology》2008,31(3):669-672
A 70-year-old man with a painful vertebral metastasis was treated with combined percutaneous cryoablation and vertebroplasty
therapy (CVT) in one session. The patient was suffering from diffuse visceral metastasized cholangiocarcinoma. After several
weeks of back pain, magnetic resonance imaging documented a single L2 bone metastasis. In consultation with the oncologists,
palliative combined CVT was administered with the aim of obtaining pain relief and bone stabilization. In our experience this
combined treatment is safe and effective for immediate pain relief in painful bone metastases when other standard palliative
treatments have failed. 相似文献