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71.
A long-term follow-up of silicone-rubber interposition arthroplasty for osteoarthritis of the thumb carpometacarpal joint. 总被引:1,自引:0,他引:1
Akio Minami Norimasa Iwasaki Keiji Kutsumi Naoki Suenaga Kazunori Yasuda 《Hand surgery》2005,10(1):77-82
There are several surgical options for osteoarthritis (OA) of the thumb carpometacarpal (CMC) joint. This paper presents our long-term clinical and radiographic review of 12 thumbs in ten patients treated by partial trapezial excision and silicone-rubber interposition arthroplasty. The follow-up period averaged 15; three years with a ten-year minimum. Although the procedure provided early pain relief in most thumbs, all but two had mild to severe pain at follow-up. The average range of post-operative palmar abduction was 23 degrees. The average post-operative grip strength was 9.5 kg. Both tip and key pinch between thumb and index finger averaged about 50% that of normal subjects. Dislocation of the implant occurred in two joints and breakages in five. Bony erosions around the implant, which we attributed silicone synovitis, were found in four thumbs. The indications for silicone-rubber interposition arthroplasty for OA of the thumb CMC joint should be severely restricted as these produced unsatisfactory long-term results. 相似文献
72.
Hepatitis B virus (HBV) is usually transmitted from mother to infant, and genotype C is prevalent in Japan. Because of these features, guidelines for HBV treatment from other countries are not directly adaptable to Japanese patients. Age is an important factor in deciding the treatment strategy, because many vertically transmitted HBV carriers naturally show spontaneous remission by the age of 25–30 years. In addition, genotype C is considered more refractory to antiviral therapies than genotypes A and B. Considering these differences, we propose a treatment for HBV in Japanese patients. Although the guidelines indicate who to treat and when therapy should be started, it is unclear for how long patientsshould be treated. This situation arises because current lamivudine and interferon monotherapies are not potent at curing HBV infection. To develop a more efficient treatment, we performed a pilot study of lamivudine/interferon sequential therapy in Japan. The biochemical and virological responses were comparable or superior to lamivudine or interferon monotherapies, and this protocol can be a potent alternative because we can take advantage of both the mild side-effects of lamivudine and finite duration of interferon. 相似文献
73.
T Osanai H Matsumura T Kikuchi O Minami Y Yokono R Akiba H Eidou A Konta T Kanazawa K Onodera 《Japanese circulation journal》1990,54(5):507-514
The purpose of this study was to clarify how the metabolism of vascular prostacyclin (PGI2) and thromboxane (TX) A2 in spontaneously hypertensive rats (SHR) is involved in aging and development of hypertension. We removed the aortic walls from 5-week-old and 20 to 25-week-old SHR and age-matched Wistar Kyoto rats (WKY). At 5 weeks of age, there was no significant difference in basal and maximal (arachidonic acid 0.1 mM) 6-keto-PGF1 alpha production between SHR and WKY, but the TXB2 generation in the SHR aortic wall was markedly enhanced as compared with that in WKY. At 20 to 25 weeks of age, the SHR aortic wall synthesized about 1.5 times more 6-keto-PGF1 alpha in the basal condition and twice as much as in the maximal condition as did the WKY wall. However there was no significant difference in TXB2 production between SHR and WKY. Age-dependent increase of vascular 6-keto-PGF1 alpha was greater in SHR than in WKY. Moreover, the maximal/basal 6-keto-PGF1 alpha production ratio increased with age in SHR, but not in WKY. The synthesis of vascular TXB2 was enhanced with age in WKY, but did not change with age in SHR. These data suggest that not only the enhanced basal generation of vascular 6-keto PGF1 alpha but also a much greater reservoir of 6-keto-PGF 1 alpha synthesis in SHR was induced by both hypertension and maturity. The increased production of vascular TXB2 in young SHR may affect the development of hypertension. 相似文献
74.
75.
76.
Dai?Okayama Tsuyoshi?Suzuki Tsuyoshi?ShigaEmail author Yuichiro?Minami Shuichi?Tsuruoka Nobuhisa?Hagiwara 《Am J Cardiovasc Drugs》2015,15(4):289-293
Introduction
Arginine vasopressin-stimulated reabsorption of urea occurs in the collecting duct via increased expression of the urea transporter.Objective
The aim of this study was to evaluate whether the blood urea nitrogen/creatinine (BUN/Cr) ratio is useful for predicting tolvaptan response in patients with decompensated heart failure (HF).Methods
Among 71 consecutive patients with HF who received oral tolvaptan between 2010 and 2014, we retrospectively studied 33 patients with decompensated HF without any mechanical circulatory assistance or inotropic support who had already been treated with loop diuretics. A responder to tolvaptan was defined as an individual who experienced a ≥30 % increase in their respective 24-h urine volume.Results
Among the 33 patients, 21 met the criteria of a responder. The area under the receiver operating characteristic curves of BUN/Cr and BUN were 0.790 and 0.714, respectively, and the respective cut-off values for responders to tolvaptan were 23.8 and 49.0. BUN/Cr and BUN retained their significant relationships with the responder status (odds ratio for BUN/Cr >23.8: 20.9; 95 % confidence interval [CI] 2.7–531.1; p = 0.002; odds ratio for BUN ≥49: 7.7; 95 % CI 1.4–65.8; p = 0.02).Conclusion
Our results suggest that high BUN/Cr may be a predictor of response to tolvaptan in decompensated HF patients. A prospective study with a large sample size is required to confirm this preliminary finding.77.
78.
Kohki Nakamura MD PhD Takehito Sasaki MD Yutaka Take MD PhD Kentaro Minami MD Mitsuho Inoue MD Chisa Asahina MD Wataru Sasaki MD Shohei Kishi MD Shingo Yoshimura MD Yoshinori Okazaki MD Hiroyuki Motoda MD PhD Katsura Niijima MD PhD Yuko Miki MD PhD Koji Goto MD PhD Kenichi Kaseno MD PhD Eiji Yamashita MD PhD Keiko Koyama MD PhD Nobusada Funabashi MD PhD Shigeto Naito MD PhD 《Journal of cardiovascular electrophysiology》2021,32(1):16-26
79.
S Katagiri T Tsubakio G Minami Y Higashimoto T Yonezawa S Tarui S Hori N Suehara N Taniguchi T Kitani 《Acta haematologica》1983,70(2):119-121
A successful embolization for life-threatening uterine hemorrhage is described in a patient with acute promyelocytic leukemia and disseminated intravascular coagulation. On admission the patient was in the 6th week of gestation with incomplete abortion and uterine hemorrhage. In addition to combination chemotherapy and anticoagulant therapy, dilatation and curettage were also performed. After the operation the uterine hemorrhage was progressively increased in amount and was not responsive to usual measures. Embolization of bilateral uterine arteries using Gelfoam was performed with a dramatic improvement of the hemorrhage. 相似文献
80.
On the diagnosis of backache, at first ask patients detailed questions about medical history of backache, the situation at the time of onset and process of the pain, intensity and location on the body of the pain, which movement to strengthen them or which posture to moderate them. Following them, check the abnormality of how to walk and the normal curvature of the spine at standing from behind and the side. Examine the movement and flexibility of the lumbar spine in bending forward, backward and twisting. After them, examine the neurological functions on their legs to search paralysis, muscle weakness, reflex changes and sensory changes. Observe lumbar part and check the presence of redness, swelling and hyperthermia, and examine a location of tenderness. X-rays, CT or MRI examination can be performed if necessary, but should not be fascinated by only image findings, and it is necessary to evaluate in total them with the results of physical examinations. 相似文献