全文获取类型
收费全文 | 938篇 |
免费 | 36篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 23篇 |
妇产科学 | 24篇 |
基础医学 | 140篇 |
口腔科学 | 4篇 |
临床医学 | 92篇 |
内科学 | 168篇 |
皮肤病学 | 32篇 |
神经病学 | 59篇 |
特种医学 | 71篇 |
外科学 | 91篇 |
综合类 | 5篇 |
预防医学 | 101篇 |
眼科学 | 2篇 |
药学 | 74篇 |
中国医学 | 3篇 |
肿瘤学 | 84篇 |
出版年
2023年 | 2篇 |
2022年 | 12篇 |
2021年 | 23篇 |
2020年 | 6篇 |
2019年 | 12篇 |
2018年 | 22篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 7篇 |
2014年 | 15篇 |
2013年 | 35篇 |
2012年 | 57篇 |
2011年 | 66篇 |
2010年 | 34篇 |
2009年 | 31篇 |
2008年 | 73篇 |
2007年 | 86篇 |
2006年 | 90篇 |
2005年 | 69篇 |
2004年 | 72篇 |
2003年 | 69篇 |
2002年 | 50篇 |
2001年 | 11篇 |
2000年 | 5篇 |
1999年 | 17篇 |
1998年 | 10篇 |
1997年 | 9篇 |
1996年 | 12篇 |
1995年 | 4篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有977条查询结果,搜索用时 234 毫秒
121.
PROMOTIONOFINVITROGROWTHOFHUMANMEDULLOBLASTOMACELLSBYEXOGENEOUSIL-6LiuJiai刘佳;LiHong李宏;HamouMarie-France;NicolasdeTribolet(1Di... 相似文献
122.
Marie-France Cesbron-Delauw 《Parasitology research》1995,81(5):444-445
In the search for similar cysteine distribution patterns among surface antigens of members of the phylum of Apicomplexa, we found a resemblance between TgSAG2, a 22-kDa surface antigen ofToxoplasma gondii, and the C-terminal half of a 31-kDa surface antigen ofSarcocystis muris, SmSAG1. The overall degree of similarity is low, corresponding to 28% of identity in the 146 amino acids aligned. However, the conservative spacing between the cysteine residues suggest that this similarity might have functional implications. The described amino acid similarity provides a new clue to the molecular relationship between two closely related coccidian parasites. 相似文献
123.
Marie-France Lecompte Marcel Jozefowicz 《Macromolecular chemistry and physics.》1977,178(6):1761-1771
D. c. electrical solid state conductivity of either native or heat-denatured calf thymus DNA sodium it has been studied as a function of the acidic state of the samples. Conductivity implies major ionic carriers and depends on the secondary structure of the DNA sample. Its variation is correlated to the ion exchange properties of DNA solid phase suspension in a solvent. Partial renaturation of heat denatured DNA samples, induced by salt addition, increases the DNA solid state d.c. conductivity. 相似文献
124.
Batrice Payelle Marie-France Poupon Genevi Lespinats 《International journal of cancer. Journal international du cancer》1981,27(6):783-788
Semi-allogeneic somatic hybrid cells derived from the fusion of a C57BL/6 fibrosarcoma (MCB6–1) and A9 cells (C3H origin) were used to immunize C57BL/6 mice against the parental tumor cells. These hybrid cells expressed H-2 histocompatibility antigens of both parental cells (H-2b and H-2k), and failed to produce tumors in normal C57BL/6 mice. A single i.p. injection of hybrid cells induced anti-tumor immunity which could be transferred to normal C57BL/6 recipient mice by immune spleen or peritoneal cells; the efficient cells were T cells, as this activity was completely abrogated by treatment with anti-Thy-1–2 antiserum and complement. Among immune splenic T cells, only the light-density T cells, obtained after fractionation on Percoll gradient, were effective in the transfer of immunity. Immunity induced by the hybrid cells was specific for MCB6-1 parental tumor cells. This immunity could be transferred during two brief periods, 7 to 12 days, and 40 to 50 days, after hybrid cell injection; there appeared to be an intermediate period, 12 to 40 days after immunization, during which no immunity could be transferred. These results suggest a suppressive mechanism implicated during hybrid cell immunization and interacting with the anti-tumor immune response. 相似文献
125.
126.
Demierre MF 《Current treatment options in oncology》2006,7(3):181-186
Opinion statement Melanoma incidence has continued to increase in all white populations, and mortality from melanoma remains high in older men
worldwide. In Australia, Europe, and the United States, a substantial number of thick melanomas in older men are of the nodular
subtype, a subtype lacking asymmetry or color change. Educating the public and pro-fessionals about the significance of evolving
pigmented lesions as emphasized in the revised ABCDE of pigmented lesions is relevant. Targeting screening efforts toward
older men will be necessary to decrease worldwide melanoma mortality. Among preven-tion strategies, emphasizing multiple methods
of sun protection in early childhood, adolescence, and adulthood is needed to decrease sunburn rates. Chemoprevention research
in melanoma should become a research priority to complement ongoing prevention strategies. 相似文献
127.
The composition of the essential oil obtained by hydrodistillation of the leaves of Strychnos spinosa (Loganiaceae) was analysed by GC-FID and GC-MS. Out of twenty-two compounds identified in the oil, the main constituents were palmitic acid (34.3%), linalool (16.0%), and (E)-phytol (6.7%). Since the leaves of this plant are used in African traditional medicine to treat African trypanosomiasis, we evaluated the in vitro activity of the essential oil as well as of 15 of its components on Trypanosoma brucei brucei bloodstream forms and on mammalian cells (J774 murine macrophages) to evaluate the selectivity of the antitrypanosomal effect. The essential oil was active on the parasites without a great selectivity [IC50 on T. b. brucei = 13.5 microg/mL with a selectivity index (SI) of 4.4]. (E)-Nerolidol, a minor component of the hydrodistillate, as well as linalool, were shown to have a more potent and selective effect on the trypanosomes [IC50 = 1.7 and 2.5 microg/mL (7.6 and 16.3 microM) with SI = 35.7 and > 40, respectively]. These two oxygenated terpenes have promising activity and it would be of interest to study their mechanism of action as well as their in vivo activity. 相似文献
128.
Martin-Eauclaire MF Alami M Giamarchi A Missimilli V Rosso JP Bougis PE 《Vaccine》2006,24(12):1990-1996
In this study, we have used Amm VIII, a natural anatoxin from the scorpion Androctonus mauretanicus mauretanicus, to elicit specific polyclonal antibodies in rabbit. Using liquid-phase radioimmunoassay, we have studied its selectivity and its neutralizing activity both in vitro and in vivo for the most lethal scorpion alpha-toxins described, in particular the alpha-toxin of reference AaH II. We have shown that the anti-Amm VIII serum prevents the association of 125I-AaH II with its receptor and is able to remove 125I-AaH II already bound to its site (the half-life of the complex 125I-AaH II-receptor site was 12 min in the absence of anti-Amm VIII serum but decreased to only 2 min in the presence of anti-Amm VIII serum). In vivo, the serum also has a protective effect in mice: 42 LD50 of AaH II by millilitre are neutralized, measured by subcutaneous injection. 相似文献
129.
Caroline Binsinger Patrick Laure Marie-France Ambard 《Journal of Sports Science and Medicine》2006,5(1):123-129
Physical activity is often presented as an effective tool to improve self-esteem and/or to reduce anxiety. The aim of this study was to measure the influence of a regular extra curricular sports practice on self-esteem and anxiety. We conducted a prospective cohort study, which has included all of the pupils entering the first year of secondary school (sixth grade) in the Vosges Department (east France) during the school year 2001-2002 and followed during three years. Data were collected every six months by self-reported questionnaires. 1791 pupils were present at each of the six data collection sessions and completed all the questionnaires, representing 10,746 documents: 835 boys (46.6 %) and 956 girls (53.4 %), in November 2001, the average age was 11.1 ± 0.5 years (mean ± standard deviation). 722 pupils (40.3 %) reported that they had practiced an extra-school physical activity in a sporting association from November 2001 to May 2004 (ECS group), whereas, 195 (10.9 %) pupils had not practiced any extra-school physical activity at all (NECS group). The average global scores of self-esteem (Rosenberg’s Scale) and trait anxiety (Spielberger’s Scale) of the ECS pupils were, respectively, higher and lower than those of the NECS group. However, the incidence density (number of new cases during a given period / total person-time of observation) of moderate or severe decrease of self-esteem (less than “mean - one standard deviation ”or less than “mean - two standard deviations”) was not significantly different between the two groups, a finding that was also evident also in the case of trait anxiety. Finally, among ECS pupils, the incidence density of severe decrease of self-esteem was lower at the girls’. Practitioners and physical education teachers, as well as parents, should be encouraged to seek out ways to involve pupils in extra-school physical activities.
Key Points
- A regular extra-curricular sports practice is associated to better levels of self-esteem and trait anxiety among young adolescent.
- This activity seems to protect girls from severe variations of self-esteem.
- Boys do not seem to be protected from moderate or severe variations, neither of self-esteem, nor of trait anxiety, by a regular extracurricular sport practice.
130.
Bertrand MF Semez G Leforestier E Muller-Bolla M Nammour S Rocca JP 《Lasers in surgery and medicine》2006,38(6):615-623
BACKGROUND AND OBJECTIVES: The purpose of this study was to assess the performances of a single-component adhesive system when an Er:YAG laser was used to prepare cavities. STUDY DESIGN/MATERIALS AND METHODS: Shear bond strength tests were performed on composite rods bonded with a single-component adhesive system to dentin surfaces prepared using either bur+acid, Er:YAG laser (fluence = 44 J/cm2), or Er:YAG laser+acid. Class V cavities were prepared differently according to the molar surface: buccal surfaces were prepared using a diamond bur, and lingual surfaces using the Er:YAG laser. In group 1, cavity walls were not acid treated after Er:YAG laser preparation. In group 2, only the enamel walls were acid treated. In group 3, all the enamel and dentin walls were acid treated. Microleakage was assessed using a methylene blue dye penetration method. RESULTS: Bond strength values did not differ significantly between the three groups (P = 0.162). Better marginal adaptation was obtained between the composite resin and cavity walls when Er:YAG laser preparation was followed by a total acid etching (P = 0.008). CONCLUSIONS: Our results supported the use of single-component adhesive systems in cavities prepared using Er:YAG laser. The step of acid etching must be maintained for the whole cavity walls in regard of the microleakage values. 相似文献