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排序方式: 共有978条查询结果,搜索用时 15 毫秒
111.
112.
Edward Harrison was a distinguished and innovative physician, an educationalist who had a profound influence on the treatment of spinal deformities. He founded the first infirmary for the treatment of spinal diseases in London in 1837. Little is known of this institution but much of Harrison's legacy rests with his disciples who followed Harrison's principles of treatment to treat spinal deformity. Like Harrison they were unconventional individuals, influenced by religious beliefs and liberal political and social ideologies. After his death, initially they followed his methods of treatment but subsequently they were not afraid to pursue new forms of treatment including homeopathy at a time when traditional medicine had little to offer. 相似文献
113.
114.
Côrtes C Palin MF Gagnon N Benchaar C Lacasse P Petit HV 《The British journal of nutrition》2012,108(8):1390-1398
The objectives of the study were to investigate the effects of dietary supplementation of flax hulls and/or flax oil on the activity of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)) in plasma and the mammary gland and the relative mRNA abundance of antioxidant genes in the mammary gland of dairy cows. A total of eight dairy cows were used in a replicated 4?×?4 Latin square design. There were four treatments: control with no flax hulls (CONT), 9·88?% flax hulls in the DM (HULL), control with 500?g flax oil/d infused in the abomasum (COFO), 9·88?% flax hulls in the DM and 500?g flax oil/d infused in the abomasum (HUFO). Plasma GPX activity tended to decrease with flax oil supplementation. Cows fed HULL had higher levels of CAT, GPX1 and SOD1 mRNA in the mammary gland and lower mRNA abundance of GPX3, SOD2 and SOD3 compared with those fed CONT. Abundance of CAT, GPX1, GPX3, SOD2 and SOD3 mRNA was down-regulated in the mammary gland of cows fed HUFO compared to those fed CONT. The mRNA abundance of CAT, GPX1, GPX3 and SOD3 was lower in the mammary gland of cows fed COFO than in the mammary gland of cows fed CONT. The present study demonstrates that flax hulls contribute to increasing the abundance of some antioxidant genes, which can contribute to protecting against oxidative stress damage occurring in the mammary gland and other tissues of dairy cows. 相似文献
115.
116.
Marie-France Mamzer-Bruneel Emmanuelle Grand Laforêt Henri Kreis Éric Thervet Frank Martinez Renaud Snanoudj Christian Hervé Christophe Legendre 《Néphrologie & thérapeutique》2012,8(7):547-556
One of the most significant advances in medicine during the last 50 years is the development of organ transplantation. In the context of chronic kidney diseases, renal transplantation offers patients a better clinical outcome than other treatment options. However, the benefits of organ transplantation have not been maximized due to an inadequate supply of organs for transplantation. Despite the establishment of elaborate legal rules for organs procurement, both on deceased and living donors in numerous countries, ethical concerns remain. Most of them are consequences of the strategies implemented or proposed to address the so-called organ shortage. The involvement of society in these complex problems is crucial as numerous questions emerge: could actual state of organ procurement change? Is it possible and/or realistic to increase the number of organs, with respects to living donors or deceased persons? Is the shortage an indicator to limit the use of kidney transplantation? How do we maintain efficiency and justice, in this context. 相似文献
117.
Danielle R. Bouchard Bianca Porneala Ian Janssen Marie-France Langlois Jean-Patrice Baillargeon Caroline S. Fox James B. Meigs Ralph B. D'Agostino Michael Pencina Marie-France Hivert 《Journal of diabetes and its complications》2013,27(3):214-218
AimMid-life obesity is associated with T2D risk. However, less is known about the cumulative effect of obesity during adulthood.MethodsFramingham Offspring Study participants who had an examination at 35 ± 2 years and were initially free of T2D were included in this study (N = 1026). A cumulative excess weight (CEW) score (year*kg/m2) was calculated until T2D diagnostic or the end of follow-up.ResultsEighty-four individuals (8.2%) developed T2D over 20 ± 6 years. Mean CEW scores were 118.0 ± 114.6 year*kg/m2 in individuals who developed T2D and 30.2 ± 91.4 year*kg/m2 in those who did not develop T2D (P < 0.01). T2D risk was doubled for each standard deviation increase in the CEW score (OR = 1.99 [1.64-2.40]; P < 0.001). However, CEW score was only significantly associated with T2D incidence for participants with a baseline BMI < 25 kg/m2 (OR = 2.13 [1.36–3.36]; P < 0.001).ConclusionsAccumulating weight between the mid-thirties to the mid-fifties increases the risk of developing T2D. However, BMI in mid-thirties remains a stronger predictor of T2D risk. 相似文献
118.
Nathalie Auger Mark Daniel Bärbel Knäuper Marie-France Raynault Barry Pless 《BMC pediatrics》2011,11(1):26
Background
How youth perceive marketing messages in sports is poorly understood. We evaluated whether youth perceive that the imagery of a specific sports marketing advertisement contained smoking-related messages. 相似文献119.
Marie-France Vaillant Maud Alligier Nadine Baclet Julie Capelle Marie-Paule Dousseaux Evelyne Eyraud Philippe Fayemendy Nicolas Flori Esther Guex Véronique Hennequin Florence Lavandier Caroline Martineau Marie-Christine Morin Fady Mokaddem Isabelle Parmentier Florence Rossi-Pacini Gaëlle Soriano Elisabeth Verdier Didier Quilliot 《Nutrition Clinique et Métabolisme》2019,33(4):235-253
120.
Bani D Flagiello D Poupon MF Nistri S Poirson-Bichat F Bigazzi M Bani Sacchi T 《Virchows Archiv : an international journal of pathology》1999,435(5):509-519
Previous studies showed that the hormone relaxin acts on human breast cancer MCF-7 cells in vitro by modulating cell proliferation
and promoting cell differentiation toward a duct epithelial phenotype. The present study was designed to investigate whether
relaxin retains these properties when acting in vivo on MCF-7 cell tumors developed in athymic nude mice. Mice bearing MCF-7
cell tumors transplanted under the mammary fat pad and estrogenized to sustain tumor growth were treated systemically with
relaxin (10 μg/day) for 19 days. Vehicle-treated mice were used as controls. Thirty days later, the mice were sacrificed and
tumor fragments were analyzed by light and electron microscopy and immunocytochemistry. Measurements of tumor volume were
recorded weekly for the overall experimental period. The results obtained indicate that relaxin treatment promotes differentiation
of tumor cells towards both myoepithelial-like and epithelial-like cells, as judged by the ultrastructural features of the
cells and by the increased expression of smooth muscle actin and cadherins. Measurements of tumor size and of the number of
cycling cells show that relaxin, at the doses and times of exposure used in this study, does not significantly influence tumor
growth and cell proliferation.
Received: 3 March 1999 / Accepted: 28 May 1999 相似文献