收费全文 | 258604篇 |
免费 | 16849篇 |
国内免费 | 1639篇 |
耳鼻咽喉 | 3332篇 |
儿科学 | 5482篇 |
妇产科学 | 5494篇 |
基础医学 | 36200篇 |
口腔科学 | 5066篇 |
临床医学 | 25595篇 |
内科学 | 50376篇 |
皮肤病学 | 5640篇 |
神经病学 | 21879篇 |
特种医学 | 11873篇 |
外国民族医学 | 3篇 |
外科学 | 37756篇 |
综合类 | 3215篇 |
现状与发展 | 5篇 |
一般理论 | 207篇 |
预防医学 | 17763篇 |
眼科学 | 6344篇 |
药学 | 19959篇 |
中国医学 | 1699篇 |
肿瘤学 | 19204篇 |
2023年 | 1527篇 |
2022年 | 3639篇 |
2021年 | 6832篇 |
2020年 | 3743篇 |
2019年 | 5612篇 |
2018年 | 6881篇 |
2017年 | 4999篇 |
2016年 | 6104篇 |
2015年 | 7834篇 |
2014年 | 10227篇 |
2013年 | 12955篇 |
2012年 | 19952篇 |
2011年 | 19981篇 |
2010年 | 11691篇 |
2009年 | 10091篇 |
2008年 | 16176篇 |
2007年 | 16358篇 |
2006年 | 15380篇 |
2005年 | 14687篇 |
2004年 | 13673篇 |
2003年 | 12073篇 |
2002年 | 10945篇 |
2001年 | 5194篇 |
2000年 | 4567篇 |
1999年 | 4132篇 |
1998年 | 2502篇 |
1997年 | 1898篇 |
1996年 | 1682篇 |
1995年 | 1535篇 |
1994年 | 1333篇 |
1993年 | 1216篇 |
1992年 | 2005篇 |
1991年 | 1962篇 |
1990年 | 1669篇 |
1989年 | 1518篇 |
1988年 | 1428篇 |
1987年 | 1302篇 |
1986年 | 1248篇 |
1985年 | 1153篇 |
1984年 | 947篇 |
1983年 | 812篇 |
1982年 | 727篇 |
1981年 | 652篇 |
1980年 | 556篇 |
1979年 | 612篇 |
1978年 | 531篇 |
1977年 | 492篇 |
1976年 | 419篇 |
1974年 | 416篇 |
1973年 | 396篇 |
Methods: A retrospective cohort design and data from two US healthcare claims repositories were employed. The study population included patients who had non-metastatic cancer of the breast, colon/rectum, lung or ovaries, or non-Hodgkin’s lymphoma (NHL), and who received myelosuppressive chemotherapy regimens with an intermediate/high risk for FN. For each patient, the first cycle of the first course was characterized in terms of PP-CSF use and FN episodes. Crude incidence proportions for PP-CSF and FN during the first cycle were estimated by calendar quarter (2010–2016); multivariable logistic regression models were used to estimate quarter-specific adjusted mean probabilities of FN by PP-CSF use.
Results: The study population totaled 142,730 patients with breast cancer (61%), colorectal cancer (14%), NHL (11%), ovarian cancer (10%) or lung cancer (5%). PP-CSF use increased from 52% in 1Q2010 to 58% in 4Q2016; pegfilgrastim was the most commonly used agent (>96% across quarters). PP-CSF administration on the same day as chemotherapy ranged from 8 to 11% until 1Q2015, and increased to 64% by 4Q2016. Adjusted incidence proportions for FN in the first chemotherapy cycle ranged from 2.7% (95% CI: 2.3–3.0) to 3.7% (95% CI: 3.1–4.3) among those who did not receive PP-CSF, and was 2.6% (95% CI: 2.5–2.7) across quarters among those who received PP-CSF.
Conclusions: Although the use of PP-CSF is commonplace in current US clinical practice, underutilization in cancer patients receiving chemotherapy regimens with an intermediate/high risk for FN may still be an issue. Use of same-day PP-CSF increased markedly from the end of 2015, although this finding reflects (at least in part) increased uptake of pegfilgrastim delivered via an on-body injector as well as the recent change in clinical practice guidelines. Overall, patients receiving PP-CSF appear to have a lower risk of FN during the first cycle of chemotherapy. 相似文献
Background
In Leriche syndrome, postoperative graft thrombosis remains one of the most significant clinical challenges.Methods
We reviewed 51 patients who underwent surgery for aortoiliac occlusive disease at our hospital from January 2007 to December 2014. The factors associated with graft patency were determined using the Cox proportional hazard model.Results
The 2-year prosthetic graft patency rate was 72.5%. Younger age (p = 0.017, Odd ratio (OR) = 1.112), postoperative uncontrolled hypertension (p = 0.044, OR = 3.797), and associated Trans Atlantic Inter-Society Consensus for the Management of Peripheral Arterial Disease II (TASC II) D femoropopliteal lesion (p = 0.008, OR = 11.139) were significantly related factors for prosthetic graft patency after surgical repair. The existing comorbidities of the patients that indicated the need for axillo-bifemoral bypass seemed to be related to lower graft patency or other complications.Conclusions
For better graft patency after an open surgical repair of Leriche syndrome, strict postoperative hypertension control and distal run-off resolution are necessary. 相似文献![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)