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71.
Cotesta D Petramala L Zinnamosca L Marinelli C Serafini MC Lefons ML Ciardi A Cavallaro G De Toma G Letizia C 《European review for medical and pharmacological sciences》2011,15(10):1222-1226
A case of adrenal ganglioneuroma incidentally discovered during an abdominal ultrasound examination in a 26 year-old woman patient with recurrent episodes of dysuria. After a diagnostic work-up with laboratory and abdomen CT scan, the patient uderwent a laparotomic removal of the adrenal lesion. Histopathological examination of the adrenal mass confirmed the diagnosis. 相似文献
72.
73.
Daniela Anastasi Gabriella Di Giuseppe Paolo Marinelli Italo F Angelillo 《BMC public health》2009,9(1):463
Background
The purpose of this study was to investigate whether paediatricians have appropriate knowledge, attitudes, and behaviours regarding vaccinations for infants in Italy. 相似文献74.
75.
de Palma L Santucci A Marinelli M Borgogno E Catalani A 《Archives of orthopaedic and trauma surgery》2008,128(6):593-598
Introduction Subtalar dislocation (SD) is an uncommon injury accounting for 1–2% of all dislocations. It involves simultaneous disruption
of the talocalcaneal and talonavicular joints, without involvement of the calcaneocuboid or tibiotalar joints or talar neck
fracture. We present a retrospective study of pure medial and lateral SDs treated conservatively and discuss the pathogenesis,
classification, prognostics and therapeutic aspects of SD.
Materials and methods Thirty patients, 24 men and 6 women (mean age 33 years; range 18–55) with closed isolated SD were treated conservatively and
re-evaluated at 5–12 years. There were 20 medial and 10 lateral dislocations. All patients were managed with immediate closed
reduction under general anaesthesia. Open dislocations and SDs associated with fractures were excluded.
Results The mean AOFAS Ankle–Hindfoot score was 78.8. Seven patients (all with medial SDs) had an AOFAS score of 100; 14 patients
(11 with medial and 3 with lateral SD) had a mean AOFAS score of 85; 6 patients (three with medial and three with lateral
SD) had a mean AOFAS score of 65; and 3 patients (all with lateral SDs) had a mean AOFAS score of 28. The latter patients
subsequently underwent subtalar fusion, with a fair outcome. The mean AOFAS scores of patients with lateral and medial SD
were not significantly different (P = 0.05).
Conclusion Various factors adversely affect outcome, including type of dislocation (lateral/medial, open/closed), severity of the injury,
associated fractures, length of immobilization. Management of closed isolated SD is by immediate conservative treatment in
order to avoid or reduce the incidence of early soft-tissue and vascular complications and poor long-term outcomes due to
post-traumatic arthritis, talus necrosis and subtalar joint stiffness. However, complications may still arise despite correct
treatment. 相似文献
76.
Urso G Palladino E Andriulo N Marinelli T Perrotta N Loffredo D Genova G 《Minerva chirurgica》2007,62(6):497-502
Spontaneous pneumoperitoneum is the radiographic manifestation of free air in the peritoneal cavity without visceral perforations and peritoneal signs, and it occurs in about 10% of the cases of pneumoperitoneum. The etiology can be postoperative, thoracic, abdominal, gynecologic, idiopathic; it generally introduces a benign evolution and does not require surgical treatment but just a conservative approach. The authors describe here a case of spontaneous pneumoperitoneum secondary to thoracic trauma. This case is interesting for the occurrence of pneumoperitoneum without clinical peritoneal signs such as fever and leucocytosis, after closed thoracic trauma in absence of pneumothoracic and pneumomediastinum. Correct clinical approach has allowed a conservative treatment avoiding an useless laparotomy. 相似文献
77.
Cosconati S Marinelli L Lavecchia A Novellino E 《Journal of medicinal chemistry》2007,50(7):1504-1513
L-type Ca2+ channels (LCC) are membrane heteromultimeric proteins that allow the selective entrance of Ca2+ ions into excitable cells upon membrane depolarization. Despite the large amount of compounds (1,4-dihydropyridines, phenylalkylamines, and benzothiazepines) that impede the passage of Ca2+ ions through the channel, it is still not clear how these molecules bind to LCC at an atomic level. In this study, a 3D model of the central pore of LCC was constructed using the X-ray structure of the KcsA K+ channel as template. The resulting LCC model was then used to dock nine different DHPs to shed light on their binding mode. The accordance between the developed model and several experimental data gives us the confidence to propose our model as a valuable platform for future studies aimed at the identification of new potent and LCC-selective ligands. 相似文献
78.
A. Greco A. Gallo M. Fusconi G. Magliulo R. Turchetta C. Marinelli G.F. Macri A. De Virgilio M. de Vincentiis 《Autoimmunity reviews》2013,12(3):396-400
ObjectivesThe objective of our study was to review our current knowledge of the aetiopathogenesis of Cogan's syndrome, including viral infection and autoimmunity, and to discuss disease pathogenesis with relevance to pharmacotherapy.Systematic review methodologyRelevant publications on the aetiopathogenesis and pharmacotherapy of Cogan's syndrome from 1945 to 2012 were analysed.Results and conclusionsCogan's syndrome is a rare autoimmune vasculitis, and its pathogenesis is unknown. Infection, but primarily autoimmunity, may play contributing roles in the pathogenesis of this disease. It is characterised by ocular and audiovestibular symptoms similar to those of Meniere's syndrome. Approximately 70% of patients have systemic disease, of which vasculitis is considered the pathological mechanism. The immunologic theory is based on the release of auto-antibodies against corneal, inner ear and endothelial antigens, and of anti-nuclear cytoplasmic auto-antibodies (ANCA).Corticosteroids are the first line of treatment, and multiple immunosuppressive drugs have been tried with varying degrees of success. Tumour necrosis factor (TNF)-alpha blockers are a category of immunosuppressive agents representing a recent novel therapeutic option in Cogan's syndrome. 相似文献
79.
C Cinque S Pondiki D Oddi M G Di Certo S Marinelli A Troisi A Moles F R D'Amato 《Translational psychiatry》2012,2(8):e155
Social anhedonia, or the diminished capacity to experience pleasure and reward from social affiliation, is a major symptom of different psychiatric disorders, including some forms of infantile autism and schizophrenia spectrum disorders. The brain opioid hypothesis of social attachment is a promising model for achieving insights into how neurobiological and developmental factors contribute to the regulation of social reward. In this study, genetic knocking-out and naltrexone (NTRX) treatment during the first 4 days of life were used to disrupt opioid neurotransmission in mouse pups and their attachment relationships with the mother. Both permanent (genetic) and transient (pharmacological) manipulations of opioid neurotransmission exerted long-term effects on social affiliation. When juveniles, both μ-opioid receptor knockout mice and NTRX-treated pups showed reduced interest in peers and no preference for socially rewarding environment. These results demonstrate that sociability in juvenile mice is highly dependent on the establishment during infancy of a positive affective relationship with their mothers and that opioid neurotransmission has a major role in the regulation of social hedonic capacity. If the validity of this animal model will be confirmed by future research, translational studies focusing on the interaction between early experience and opioid neurotransmission could provide useful insights for identifying endophenotypes of human psychiatric disorders associated with social anhedonia. 相似文献
80.
Infantile congenital agranulocytosis or Kostmann syndrome is a rare hereditary kind of severe neutropenia. The typical symptoms, which appear since the first days of life, are abscesses located on various parts of the body: ear, cutis, lung and oral cavity. These abscesses are due to an almost total disimmunity typical of the neutropenia. The aim of this article is to describe the most typical signs of this pathology in the oral cavity, reporting a case observed in our department in Florence, Italy. On the basis of the personally observed case and of the review of the literature, it is possible to consider, as a characteristic finding in Kostmann syndrome, a typical very serious periodontal pathology, which is similar to the prepubertal periodontitis in deciduous dentition. At the age of 19 years the patient showed a dramatic compromise of the masticatory function. It is obvious that the lack of response of the host can obstruct the interaction between the host and the microbic flora, because the lack of neutrophils increases the susceptibility of the patient to every kind of infection, even to periodontitis. A periodontal prophylaxis, since the very first observations, followed by a rigorous maintenance with frequent and regular professional hygienic treatments could be effective in controlling the effects of periodontal disease and could reduce the tragic evolution. We need to recognise that it could be hard to monitor the oral situation correctly in these patients, as they have a continuously poor systemic condition. Finally in these cases the rehabilitative therapy is very problematical. 相似文献