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81.
Giovanni Francesco MARANGI Pierluigi GIGLIOFIORITO Vito TOTO Marika LANGELLA Tiziano PALLARA Paolo PERSICHETTI 《The Journal of dermatology》2010,37(5):488-492
Embolia cutis medicamentosa, also known as Nicolau’s syndrome, is a rare complication due to i.m. injections. Its real incidence is actually underestimated. Many drugs have been associated with it, but at the time only a few studies showed a related pathogenetic mechanism. Symptoms consist of immediate local pain, edema and cutaneous, subcutaneous and even muscular necrosis occurring in the first 48 h. The type of treatment depends mostly on time of diagnosis. A medical resolution can be achieved through heparin and cortisone injections within the first 48 h. Surgical debridement has to be considered as the main treatment in case of late diagnosis. We present three cases of Nicolau’s syndrome presenting to us in a short period of time that we treated with surgical debridement. 相似文献
82.
Charlotte Bergkvist Mattias Öberg Malin Appelgren Wulf Becker Marie Aune Emma Halldin Ankarberg Marika Berglund Helen Håkansson 《Food and chemical toxicology》2008
The dietary intake of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) in terms of toxic equivalents (TEQs) was investigated in Swedish children and young adults. Exposure was estimated from concentration data of six groups of individual food commodities (meat, fish, dairy products, egg, edible fats and other foodstuff) combined with food intake data from a 7-day record book obtained from 670 individuals aged 1–24 years. The results showed that Swedish boys and girls, up to the age of ten, had a median TEQ intake that exceeded the tolerable daily intake (TDI) of 2 pg TEQ/kg body weight. Children exceeding the TDI varied from almost all individuals among the youngest children to about 20% among young men and women. Dairy and fish products were the main sources of exposure for the average child, accounting for 59% of the total TEQ intake. The individuals most highly exposed were, on the other hand, characterized by a high consumption of fish. Since children constitute a vulnerable group, results obtained from the present study show that it is essential to perform age specific dietary intake assessments of pollutants and more carefully consider sensitive and/or highly exposed groups in the population in the risk management processes. 相似文献
83.
Background
There is at present a lack of knowledge of time trends in health related quality of life (HRQL) in common patients with coronary artery disease (CAD) treated in ordinary care. The objective of this study is to assess and compare time trends of health related quality of life (HRQL) and chest pain in patients with coronary artery disease. 相似文献84.
Kiessling K Ellory JC Cossins AR 《Pflügers Archiv : European journal of physiology》2000,440(3):467-475
Hypotonic swelling of teleost erythrocytes activates multiple transport systems leading to the regulatory decrease of cell volume. We have examined using pharmacological manipulation the swelling-induced taurine flux pathway in red blood cells of the rainbow trout and its relationship to swelling-induced K flux pathways. We show that the activation and deactivation of taurine flux is rapid and that the flux is a sigmoidal function of cell volume. N-ethylmaleimide (NEM) and the non-specific protein kinase inhibitor, staurosporine, both inactivated the hypotonically-induced taurine flux with concentrations eliciting half-maximal inhibition (IC50s) of 212 and 17 micromol(-1), respectively. The low taurine fluxes under isotonic conditions were unaffected. By contrast, the tyrosine kinase inhibitor, genistein, partially inhibited taurine flux under both isotonic and hypotonic conditions. The specific phosphatase inhibitor, calyculin A, had no inhibitory or stimulatory effect under either condition whilst the less-specific phosphatase inhibitor, ortho-vanadate, reduced taurine flux only under hypotonic conditions. In these respects the regulatory control of the taurine pathway differs from the Cl-dependent K flux. However, NEM and staurosporine also inhibited the Cl-independent K flux, both with similar IC50s to those observed for taurine fluxes. This supports the idea of the hypotonically-induced taurine flux and the Cl-independent K flux sharing the same transport pathway. 相似文献
85.
J Kiessling T Steffens 《Audiology : official organ of the International Society of Audiology》1991,30(2):70-81
This paper reports on the clinical evaluation of a commercially available head-worn programmable 3-channel automatic gain control (AGC) hearing instrument (Siemens, Triton 3000). A preliminary fitting procedure is developed for the 3-channel AGC amplification system, which is compared by 26 experienced hearing instrument wearers with their own single-channel AGC instruments. The benefits of both amplification systems are assessed by speech audiometry at different signal-to-noise ratios utilizing German rhyme test speech material. In addition, subjective judgements concerning sound quality, speech intelligibility and comparison with the subject's own instrument are evaluated. The results indicate that the multichannel compression instrument is superior to single-channel aids in competitive speech situations. If the 3-channel AGC instrument is used as an automatic noise reduction system in patients requiring a certain amount of low-frequency gain, a markedly better speech recognition can be achieved compared to the subject's personal aids. 相似文献
86.
87.
Prostate stem cell antigen: Identification of immunogenic peptides and assessment of reactive CD8+ T cells in prostate cancer patients 总被引:5,自引:0,他引:5
Kiessling A Schmitz M Stevanovic S Weigle B Hölig K Füssel M Füssel S Meye A Wirth MP Rieber EP 《International journal of cancer. Journal international du cancer》2002,102(4):390-397
Identification of TAAs recognized by CD8(+) CTLs paved the way for new concepts in cancer therapy. In view of the heterogeneity of tumors and their diverse escape mechanisms, CTL-based cancer therapy largely depends on an appropriate number of TAAs. In prostate cancer, the number of antigens defined as suitable targets of CTLs remains rather limited. PSCA is widely distributed in prostate cancer. In this report, we define immunogenic peptides of PSCA which are recognized by circulating CD8(+) T cells from prostate cancer patients and able to activate CTLs in vitro. Screening the amino acid sequence of PSCA for peptides containing a binding motif for HLA-A*0201 resulted in 8 candidate peptides. Specificity and affinity of peptide binding were verified in a competition assay. Frequencies of CD8(+) T lymphocytes reactive against selected epitopes were determined in the blood of prostate cancer patients using the ELISPOT assay. Increased frequencies were revealed for CD8(+) T cells recognizing the peptides ALQPGTALL and AILALLPAL. CTLs from prostate cancer patients were raised against these 2 peptides in vitro when presented by autologous DCs. They specifically recognized peptide-pulsed T2 target cells and prostate cancer cells that were HLA-A*0201- and PSCA-positive, indicating that these peptides were naturally generated by tumor cells. These data suggest that PSCA is a promising target for the immunotherapy of prostate cancer. 相似文献
88.
Purpose: To evaluate
changes in distribution of hepatic arterial blood flow in the liver following
insertion of an uncovered stent and subsequently a stent-graft in the
transjugular intrahepatic portosystemic shunt (TIPS) channel.
Methods: The experiments were performed in eight
healthy pigs under general anesthesia. In a pilot study in one pig,
scintigraphic evaluation of arterial perfusion to the liver was done before and
after inflation of a balloon in the right hepatic vein. In the other pigs,
outflow from the right liver vein was checked repeatedly by contrast injection
through a percutaneously inserted catheter. The arterial perfusion through the
liver was examined by scintigraphy, following selective injection of
macro-aggregate of
99Tc
m-labeled human serum albumin
99Tc
m-HSA) into the hepatic artery. This examination was done
before and after creation of a TIPS with an uncovered stent and subsequently
after insertion of a covered stent-graft into the cranial portion of the shunt
channel. Results: In the pilot study changes in
the arterial perfusion to the liver were easily detectable by scintigraphy. One
pig died during the procedure and another pig was excluded due to dislodgement
of the hepatic artery catheter. The inserted covered stent obstructed venous
outflow from part of the right liver lobe. The
99Tc
m-HSA activity in this part remained unchanged after TIPS
creation with an uncovered stent. A reduction in activity was seen after
insertion of a stent-graft (p= 0.06).
Conclusion: The distribution of the hepatic
arterial blood flow is affected by creation of a TIPS with a stent-graft, in
the experimental pig model. 相似文献
89.
Axel Wilke Marcus J?ger Stefan Endres Maximilian Landgraff Alexander Kiessling Michael Pfeiffer Peter Griss 《European Journal of Trauma》2002,28(5):279-288
Background: Titanium spine implants are well established materials in posterior spondylodesis. The biocompatibility of a semirigid tivanium
cable suitable for pedicle screws in posterior spinal fusion (DDS-Plus?) was tested by a human bone marrow cell culture. In comparison to the tivanium cable implant (Ti6Al4V; DDS-Plus?), hydroxyapatite (HA), commercially pure titanium (cpTi), glass, chromium-cobalt alloy, (CrCoMo), polyaryletherketon (PAEK)
and polyethylene (UHMW-PE) were tested.
Materials and Methods: Scanning electron microscopy (SEM), SEM-energy dispersive X-ray analysis (SEM-EDX), fluorescent activated cell sorter (FACS),
immunohistochemical techniques, light microscopy (LM) and immunochemical extracellular matrix analysis served to judge the
in vitro biocompatibility of the different implants in a human bone marrow cell culture.
Results: The datas of this investigation point out that the tivanium cable is equally biocompatible to commercially pure titanium
and showed less signs of cytotoxicity than the other tested materials in vitro. Beside the titanium alloys, HA showed a high
degree of biocompatibility compated to the polymers and CrCoMo too.
Conclusions: In respect to their in vitro biocompatibility, the semirigid tivanium spine cable could be an alternative for other systems
for posterior spondylodesis. Biomechanical and clinical studies are necessary to improve these datas.
Received: March 29, 2002; revision accepted: September 30, 2002
Correspondence Address Marcus J?ger, MD, Department of Orthopedics, Heinrich Heine University, 40225 Duesseldorf, Moorenstra?e 5, Germany, Phone
(+49/211) 8117960, Fax (+49/202) 9422623, e-mail: drjaegermarcus@yahoo.de 相似文献
90.
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 总被引:6,自引:0,他引:6
Dean F Wong Hiroto Kuwabara David J Schretlen Katherine R Bonson Yun Zhou Ayon Nandi James R Brasi? Alane S Kimes Marika A Maris Anil Kumar Carlo Contoreggi Jonathan Links Monique Ernst Olivier Rousset Stephen Zukin Anthony A Grace Jae Sung Lee Charles Rohde Donald R Jasinski Albert Gjedde Edythe D London 《Neuropsychopharmacology》2006,31(12):2716-2727
In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine. 相似文献