全文获取类型
收费全文 | 8769篇 |
免费 | 605篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 67篇 |
儿科学 | 354篇 |
妇产科学 | 237篇 |
基础医学 | 1384篇 |
口腔科学 | 126篇 |
临床医学 | 1258篇 |
内科学 | 1594篇 |
皮肤病学 | 158篇 |
神经病学 | 953篇 |
特种医学 | 202篇 |
外科学 | 718篇 |
综合类 | 45篇 |
一般理论 | 8篇 |
预防医学 | 836篇 |
眼科学 | 152篇 |
药学 | 525篇 |
中国医学 | 9篇 |
肿瘤学 | 776篇 |
出版年
2023年 | 78篇 |
2022年 | 81篇 |
2021年 | 201篇 |
2020年 | 150篇 |
2019年 | 219篇 |
2018年 | 264篇 |
2017年 | 182篇 |
2016年 | 232篇 |
2015年 | 233篇 |
2014年 | 315篇 |
2013年 | 465篇 |
2012年 | 663篇 |
2011年 | 654篇 |
2010年 | 360篇 |
2009年 | 316篇 |
2008年 | 640篇 |
2007年 | 608篇 |
2006年 | 566篇 |
2005年 | 593篇 |
2004年 | 513篇 |
2003年 | 456篇 |
2002年 | 436篇 |
2001年 | 75篇 |
2000年 | 41篇 |
1999年 | 63篇 |
1998年 | 98篇 |
1997年 | 81篇 |
1996年 | 67篇 |
1995年 | 69篇 |
1994年 | 51篇 |
1993年 | 50篇 |
1992年 | 23篇 |
1991年 | 32篇 |
1990年 | 28篇 |
1989年 | 27篇 |
1988年 | 23篇 |
1987年 | 16篇 |
1986年 | 30篇 |
1985年 | 29篇 |
1984年 | 30篇 |
1983年 | 26篇 |
1982年 | 21篇 |
1981年 | 37篇 |
1980年 | 25篇 |
1979年 | 15篇 |
1978年 | 19篇 |
1977年 | 12篇 |
1976年 | 17篇 |
1972年 | 10篇 |
1971年 | 11篇 |
排序方式: 共有9402条查询结果,搜索用时 15 毫秒
201.
Marianne Hoogeveen‐Westerveld Rosemary Ekong Sue Povey Karin Mayer Nathalie Lannoy Frances Elmslie Martina Bebin Kira Dies Catherine Thompson Steven P. Sparagana Peter Davies Ans van den Ouweland Dicky Halley Mark Nellist 《Human mutation》2013,34(1):167-175
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 or TSC2 genes. The TSC1 and TSC2 gene products, TSC1 and TSC2, form a complex that inhibits the mammalian target of rapamycin (mTOR) complex 1 (TORC1). Here, we investigate the effects of 78 TSC2 variants identified in individuals suspected of TSC, on the function of the TSC1–TSC2 complex. According to our functional assessment, 40 variants disrupted the TSC1–TSC2‐dependent inhibition of TORC1. We classified 34 of these as pathogenic, three as probably pathogenic and three as possibly pathogenic. In one case, a likely effect on splicing as well as an effect on function was noted. In 15 cases, our functional assessment did not agree with the predictions of the SIFT amino acid substitution analysis software. Our data support the notion that different, nonterminating TSC2 mutations can have distinct effects on TSC1–TSC2 function, and therefore, on TSC pathology. 相似文献
202.
203.
Marianne B. Havnes Marius Widerøe Marte Thuen Sverre H. Torp Alf O. Brubakk Andreas Møllerløkken 《European journal of applied physiology》2013,113(6):1405-1414
In this study, the effect of a simulated dive on rat brain was investigated using several magnetic resonance imaging (MRI)-methods and immunohistochemistry. Rats were randomly assigned to a dive- or a control group. The dive group was exposed to a simulated air dive to 600 kPa for 45 min. Pulmonary artery was monitored for vascular gas bubbles by ultrasound. MRI was performed 1 h after decompression and at one and 2 weeks after the dive with a different combination of MRI sequences at each time point. Two weeks after decompression, rats were sacrificed and brains were prepared for histology. Dived rats had a different time-curve for the dynamic contrast-enhanced MRI signal than controls with higher relative signal intensity, a tendency towards longer time to peak and a larger area under the curve for the whole brain on the acute MRI scan. On MRI, 1 and 2 weeks after dive, T2-maps showed no signal abnormalities or morphological changes. However, region of interest based measurements of T2 showed higher T2 in the brain stem among decompressed animals than controls after one and 2 weeks. Microscopical examination including immunohistochemistry did not reveal apparent structural or cellular injuries in any part of the rat brains. These observations indicate that severe decompression does not seem to cause any structural or cellular injury to the brain tissue of the rat, but may cause circulatory changes in the brain perfusion in the acute phase. 相似文献
204.
205.
206.
207.
208.
Dendritic cells fused with core binding factor-beta positive acute myeloid leukaemia blast cells induce activation of cytotoxic lymphocytes 总被引:1,自引:0,他引:1
Banat GA Usluoglu N Hoeck M Ihlow K Hoppmann S Pralle H 《British journal of haematology》2004,126(4):593-601
Several reports have described various strategies of dendritic cell (DC) vaccination to induce specific T-cell responses in patients with acute myeloid leukaemia (AML). About 50-60% of AML cases blasts have chromosomal abnormalities, such as inv(16) or t(8,21), which could encode for leukaemia-specific antigenic peptide sequences, possibly presented in the context of self-major histocompatibility complex (MHC) molecules. As the co-culture of AML blasts with T lymphocytes seldom resulted in T-cell stimulation, we fused AML blasts with autologous DC to enhance this effect. The fusion cells expressed MHC class I and II, CD40, B7-1, B7-2, CD209 and several adhesion molecules. In a mixed lymphocyte hybrid reaction, the fusion cells induced the proliferation of autologous T cells. Moreover, in the special case of fusion cells established from AML blasts with the chromosomal abnormality inv(16), the autologous T lymphocytes could be primed to induce cytotoxicity against up to 70% autologous AML blasts in a effector:target ratio of 20:1. Blocking assays demonstrated that the lysis was chiefly mediated by CD8(+), CCR7(-) T lymphocytes, which could be further expanded in the form of effector memory CD8(+) T cells by repeated co-cultures with the autologous fusion cells. 相似文献
209.
210.
Severely elevated C‐reactive protein accompanied by prolonged high fever and leukocytosis in a healthy peripheral blood stem cell donor: an atypical granulocyte–colony‐stimulating factor reaction?
下载免费PDF全文
![点击此处可从《Transfusion》网站下载免费的PDF全文](/ch/ext_images/free.gif)