全文获取类型
收费全文 | 5804篇 |
免费 | 377篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 151篇 |
妇产科学 | 118篇 |
基础医学 | 927篇 |
口腔科学 | 373篇 |
临床医学 | 448篇 |
内科学 | 1250篇 |
皮肤病学 | 147篇 |
神经病学 | 499篇 |
特种医学 | 79篇 |
外科学 | 520篇 |
综合类 | 21篇 |
一般理论 | 2篇 |
预防医学 | 502篇 |
眼科学 | 136篇 |
药学 | 547篇 |
中国医学 | 44篇 |
肿瘤学 | 385篇 |
出版年
2024年 | 7篇 |
2023年 | 86篇 |
2022年 | 196篇 |
2021年 | 349篇 |
2020年 | 209篇 |
2019年 | 270篇 |
2018年 | 260篇 |
2017年 | 194篇 |
2016年 | 214篇 |
2015年 | 238篇 |
2014年 | 339篇 |
2013年 | 373篇 |
2012年 | 517篇 |
2011年 | 500篇 |
2010年 | 253篇 |
2009年 | 189篇 |
2008年 | 314篇 |
2007年 | 308篇 |
2006年 | 302篇 |
2005年 | 217篇 |
2004年 | 209篇 |
2003年 | 153篇 |
2002年 | 137篇 |
2001年 | 58篇 |
2000年 | 39篇 |
1999年 | 25篇 |
1998年 | 26篇 |
1997年 | 27篇 |
1996年 | 16篇 |
1995年 | 14篇 |
1994年 | 14篇 |
1993年 | 12篇 |
1992年 | 18篇 |
1991年 | 16篇 |
1990年 | 19篇 |
1989年 | 22篇 |
1988年 | 14篇 |
1987年 | 9篇 |
1986年 | 12篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1971年 | 1篇 |
1967年 | 5篇 |
1966年 | 1篇 |
1965年 | 3篇 |
1964年 | 1篇 |
排序方式: 共有6218条查询结果,搜索用时 15 毫秒
11.
F. Sasso G. Nucci F. Palmiotto M. Giustacchini E. Alcini 《International urology and nephrology》1990,22(5):475-478
This study reports our experience in 6 cases of acute idiopathic scrotal oedema. Although children were the primary targets, this pathologic condition was also encountered in adults. Specific diagnosis of acute idiopathic scrotal oedema, opposed to other causes of scrotal swelling, is based on history, an objective examination, velocimetric Doppler exam and echography. Correct diagnosis is important in order to avoid unnecessary surgery. We are inclined to consider acute idiopathic scrotal oedema as an allergic disorder and recommend a follow-up within two days. 相似文献
12.
Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mariana D. Dabeva Seong-Gyu Hwang Srinivasa Rao G. Vasa Ethel Hurston Phyllis M. Novikoff Douglas C. Hixson Sanjeev Gupta David A. Shafritz 《Proceedings of the National Academy of Sciences of the United States of America》1997,94(14):7356-7361
The ability to identify, isolate, and transplant progenitor cells from solid tissues would greatly facilitate the treatment of diseases currently requiring whole organ transplantation. In this study, cell fractions enriched in candidate epithelial progenitor cells from the rat pancreas were isolated and transplanted into the liver of an inbred strain of Fischer rats. Using a dipeptidyl dipeptidase IV genetic marker system to follow the fate of transplanted cells in conjunction with albumin gene expression, we provide conclusive evidence that, after transplantation to the liver, epithelial progenitor cells from the pancreas differentiate into hepatocytes, express liver-specific proteins, and become fully integrated into the liver parenchymal structure. These studies demonstrate the presence of multipotent progenitor cells in the adult pancreas and establish a role for the liver microenvironment in the terminal differentiation of epithelial cells of foregut origin. They further suggest that such progenitor cells might be useful in studies of organ repopulation following acute or chronic liver injury. 相似文献
13.
Mariana Diniz Bisi Santos Arthur Braga Pfeifer Marcos Rogério Pupo Silva Claudio Luiz Sendyk WIlson Roberto Sendyk 《Journal of applied oral science : revista FOB》2007,15(2):148-151
One of the causes of implant failures in cemented implant-retained prostheses is the fracture of abutment screw or UCLA abutment. This article reports a case of simultaneous fracture of two UCLA abutments screws occurring in an implant-supported prosthesis placed in the mandibular molar region. The fractured structures were examined under scanning electron microscopy to investigate the probable causes of the failure, which were not related to failures on materials or fabrication of the screws, but rather were due to shear forces. The misfit in cemented prostheses may be the most likely cause of shear force generation. 相似文献
14.
L. Ostrosky-Zeichner C. Sable J. Sobel B. D. Alexander G. Donowitz V. Kan C. A. Kauffman D. Kett R. A. Larsen V. Morrison M. Nucci P. G. Pappas M. E. Bradley S. Major L. Zimmer D. Wallace W. E. Dismukes J. H. Rex 《European journal of clinical microbiology & infectious diseases》2007,26(4):271-276
The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis
in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed
at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3%
(88 cases). The best performing rule was as follows: Any systemic antibiotic (days 1–3) OR presence of a central venous catheter
(days 1–3) AND at least TWO of the following—total parenteral nutrition (days 1–3), any dialysis (days 1–3), any major surgery
(days −7–0), pancreatitis (days −7–0), any use of steroids (days −7–3), or use of other immunosuppressive agents (days −7–0).
The rate of invasive candidiasis among patients meeting the rule was 9.9%, capturing 34% of cases in the units, with the following
performance: relative risk 4.36, sensitivity 0.34, specificity 0.90, positive predictive value 0.01, and negative predictive
value 0.97. The rule may identify patients at high risk of invasive candidiasis.
Results of this project were partially presented at Focus on Fungal Infections 14, New Orleans, LA, USA, 2004. Abstract no.
51. 相似文献
15.
Asma Arabi Mariana Salamoun Hajar Ballout Ghada El-Hajj Fuleihan 《Journal of clinical densitometry》2005,8(3):261-266
Studies have shown a high correlation between measurements of bone mineral density (BMD) obtained on differentdual-energy X-ray absorptiometry machines. Challenger osteodensitometers (Diagnostic Medical System [DMS],Montpellier, France) are becoming widely used but little is known about their clinical performance. The aim of this study was to compare BMD measurements and the resulting patient classification based on T-scores obtained on a DMS Challenger device to those obtained on Hologic 4500A (Bedford, MA) device. Fifty-three volunteers were studied.The BMD of the spine and of the hip were simultaneously measured on both densitometers. BMD values obtained on the Challenger were significantly higher than those obtained with the Hologic QDR4500 (p<0.001). The correlations coefficients between the Hologic QDR4500 and the DMS Challenger measured BMDs were r=0.70 at the femoral neck, r=0.70 at the trochanter, and r=0.83 at the spine (p<0.001). Among the 35 postmenopausal women, there was discordance in the WHO T-score-based classification in 28 subjects (80%) at the spine, 18 subjects (52%) at the femoral neck, and 14 subjects (42%) at the trochanter. The intermachine agreement was low: The kappa score was -0.10 at the spine, 0.2 at the femoral neck, and 0.3 at the trochanter. In conclusion, this study cautions against the use of non established densitometers that leads to underdiagnosis of patients and, subsequently, to inappropriate treatment strategies. 相似文献
16.
Mariana Villarroel Dorrego Paul M. Speight A. William Barrett 《Journal of oral pathology & medicine》2006,35(5):268-273
BACKGROUND: CD40 has a role in the regulation of immune responses, cell proliferation and migration, and apoptosis. Little is known of its distribution in oral mucosal pathology. METHODS: Oral keratinocyte lines were tested for CD40 protein by Western blotting. Immunohistochemistry was used to stain paraffin sections of oral mucosa in health and in inflammatory, reactive, dysplastic and malignant disease. RESULTS: Western blotting confirmed the presence of CD40 in oral keratinocytes. CD40 was generally expressed by keratinocytes in the basal layer, with variable parabasal expression. Langerhans cells also stained positively. Expression was lost in nine of 33 (27%) epithelial dysplasias, seven of which were severe. Eighty-one percent of well, 69% of moderately and 50% of poorly differentiated oral squamous cell carcinomas (OSCC) expressed CD40. Overall, 45 of 65 (69%) OSCC were positive. The pattern of expression was unrelated to tumour differentiation. CONCLUSION: CD40 expression by basal and parabasal oral keratinocytes is physiological. Expression is lost in approximately one-third of oral epithelial dysplasias and OSCC. The significance of such loss remains unknown, but may be related to immunological or other abnormalities of keratinocyte homeostasis. 相似文献
17.
18.
Jonas Bergstrm Mahmood Ahmed Jian Li Tashfeen Ahmad Andris Kreicbergs Mariana Spetea 《Journal of orthopaedic research》2006,24(6):1193-1199
Using immunohistochemical and biochemical techniques, the occurrence of endogenous opioid peptides and their receptors in normal rat bone and joint tissues was investigated. Opioid receptors were detected, quantified, and characterized in homogenates from capsule/synovium and periosteum using radioligand binding assays. Receptor binding of the nonselective opioid [3H]naloxone to tissue homogenates was stereospecific and saturable, showing similar characteristics to that of brain tissue, although with lower binding capacities. By immunohistochemistry, the neuronal occurrence of four different enkephalins was demonstrated in synovium, bone marrow, periosteum, and juxta-articular bone, whereas no neuronal dynorphin immunoreactivity was detected. Double-staining studies disclosed that enkephalins coexisted with substance P in primary afferent fibers. The applied techniques can be used to assess changes in the distribution of endogenous opioids and their receptors in joint tissues in conditions associated with pain and inflammation. The endogenous opioid system now demonstrated might be targeted and exploited therapeutically to obtain peripheral control of symptoms in joint disorders. 相似文献
19.
20.
Rapid production of Candida albicans chlamydospores in liquid media under various incubation conditions. 总被引:1,自引:0,他引:1
Zavalza-Stiker Alicia Ortiz-Saldivar Blanca García-Hernández Mariana Castillo-Casanova Magdalena Bonifaz Alexandro 《Nippon Ishinkin Gakkai Zasshi》2006,47(3):231-234
The production of chlamydospores is a diagnostic tool used to identify Candida albicans; these structures also represent a model for morphogenetic research. The time required to produce them with standard methods is 48-72 hours in rice meal agar and tensoactive agents. This time can be shorted using liquid media such as cornmeal broth (CMB) and dairy supplements. Five media were tested: CMB plus 1% Tween-80, CMB plus 5% milk, CMB plus 5% milk serum, milk serum, and milk serum plus 1% Tween-80, under different incubation conditions: at 28 degrees C and 37 degrees C in a metabolic bath stirring at 150 rpm, and at 28 degrees C in a culture stove. The reading time points were established at 8 and 16 hours. The best results were obtained at 16 hours with CMB plus 5% milk under incubation at 28 degrees C and stirring at 150 rpm. The next most efficient methods were CMB plus 5% milk serum and CMB plus 1% Tween-80, under the same incubation conditions. The other media were ineffective in producing chlamydospores. The absence of stirring at 28 degrees C prevented the formation of chlamydospores within the set time points, and incubation at 37 degrees C decreased their production. This paper reports that the time to form C. albicans chlamydospores can be reduced. 相似文献