全文获取类型
收费全文 | 265057篇 |
免费 | 12759篇 |
国内免费 | 984篇 |
专业分类
耳鼻咽喉 | 3160篇 |
儿科学 | 8077篇 |
妇产科学 | 6201篇 |
基础医学 | 38277篇 |
口腔科学 | 8972篇 |
临床医学 | 18675篇 |
内科学 | 58830篇 |
皮肤病学 | 7021篇 |
神经病学 | 23347篇 |
特种医学 | 6444篇 |
外国民族医学 | 3篇 |
外科学 | 28086篇 |
综合类 | 1152篇 |
一般理论 | 71篇 |
预防医学 | 29516篇 |
眼科学 | 5997篇 |
药学 | 19974篇 |
中国医学 | 1067篇 |
肿瘤学 | 13930篇 |
出版年
2023年 | 1725篇 |
2022年 | 2371篇 |
2021年 | 6062篇 |
2020年 | 3634篇 |
2019年 | 5859篇 |
2018年 | 8305篇 |
2017年 | 5609篇 |
2016年 | 6045篇 |
2015年 | 6669篇 |
2014年 | 8112篇 |
2013年 | 11370篇 |
2012年 | 18487篇 |
2011年 | 19435篇 |
2010年 | 10055篇 |
2009年 | 7938篇 |
2008年 | 15663篇 |
2007年 | 16280篇 |
2006年 | 15319篇 |
2005年 | 14580篇 |
2004年 | 13319篇 |
2003年 | 12290篇 |
2002年 | 11423篇 |
2001年 | 5411篇 |
2000年 | 5834篇 |
1999年 | 4719篇 |
1998年 | 1504篇 |
1997年 | 1091篇 |
1996年 | 991篇 |
1992年 | 2516篇 |
1991年 | 2183篇 |
1990年 | 2167篇 |
1989年 | 1859篇 |
1988年 | 1778篇 |
1987年 | 1644篇 |
1986年 | 1702篇 |
1985年 | 1561篇 |
1984年 | 1169篇 |
1983年 | 1018篇 |
1979年 | 1274篇 |
1978年 | 882篇 |
1975年 | 921篇 |
1974年 | 1175篇 |
1973年 | 1199篇 |
1972年 | 1137篇 |
1971年 | 1097篇 |
1970年 | 1027篇 |
1969年 | 1102篇 |
1968年 | 1121篇 |
1967年 | 990篇 |
1966年 | 891篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
101.
Is it possible to make a diagnosis of raw,heated, and baked egg allergy in children using cutoffs? A systematic review
下载免费PDF全文
![点击此处可从《Pediatric allergy and immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
102.
John Lennon Silva Cunha Amanda Almeida Leite Thamiris de Castro Abrantes Lorena Passoni Vervloet Thayn Melo de Lima Morais Gerson de Oliveira Paiva Neto Tatiana Nayara Librio Kimura Snia Maria Soares Ferreira Ricardo Luiz Cavalcanti de Albuquerque‐Júnior Aline Corrêa Abraho Mario Jos Romaach Bruno Augusto Benevenuto de Andrade Oslei Paes de Almeida Ciro Dantas Soares 《Journal of cutaneous pathology》2021,48(1):24-33
103.
104.
105.
Ling Zhang Xue-Jun Shang Hong-Fei Li Yu-Qin Shi Wei Li Maria E Teves Zhi-Qiong Wang Gao-Feng Jiang Shi-Zhen Song Zhi-Bing Zhang 《Asian journal of andrology》2015,17(1):86-93
Mammalian spermatogenesis is a well-organized process of cell development and differentiation. Meiosis expressed gene 1 (MEIG1) plays an essential role in the regulation of spermiogenesis. To explore potential mechanisms of MEIG1''s action, a yeast two-hybrid screen was conducted, and several potential binding partners were identified; one of them was membrane occupation and recognition nexus repeat containing 3 (MORN3). MORN3 mRNA is only abundant in mouse testis. In the testis, Morn3 mRNA is highly expressed in the spermiogenesis stage. Specific anti-MORN3 polyclonal antibody was generated against N-terminus of the full-length MORN3 protein, and MORN3 expression and localization was examined in vitro and in vivo. In transfected Chinese hamster ovary cells, the antibody specifically crossed-reacted the full-length MORN3 protein, and immunofluorescence staining revealed that MORN3 was localized throughout the cytoplasm. Among multiple mouse tissues, about 25 kDa protein, was identified only in the testis. The protein was highly expressed after day 20 of birth. Immunofluorescence staining on mixed testicular cells isolated from adult wild-type mice demonstrated that MORN3 was expressed in the acrosome in germ cells throughout spermiogenesis. The protein was also present in the manchette of elongating spermatids. The total MORN3 expression and acrosome localization were not changed in the Meig 1-deficient mice. However, its expression in manchette was dramatically reduced in the mutant mice. Our studies suggest that MORN3 is another regulator for spermatogenesis, probably together with MEIG1. 相似文献
106.
Tobias Kisch Julia Maria Klemens Katharina Hofmann Eirini Liodaki Matthias Gierloff Dirk Moellmeier Felix Stang Peter Mailaender Jens Habermann Matthias Brandenburger 《Medicine》2015,94(41)
The regrowth of amputated digit tips represents a unique regenerative healing in mammals with subcutaneous volume regrowth, restoration of dactylogram, and suppression of scar formation. Although factor analysis in amphibians and even in mice is easy to obtain, safety of harvesting biomaterial from human digit tip amputations for analysis has not yet been described.The aim of this study was to evaluate if recovering wound exudate does hamper clinical outcome or influence microbiologic or inflammation status.A predefined cohort of 18 patients with fresh digit tip amputations was randomly assigned to receive standard therapy (debridement, occlusive dressing) with (n = 9) or without (n = 9) collection of the whole wound exudate in every dressing change. Primary endpoint (lengthening) and secondary endpoints (regeneration of dactylogram, nail bed and bone healing, time to complete wound closure, scar formation, 2-point discrimination, microbiologic analysis, inflammatory factors interleukin (IL)-1α, tumor necrosis factor-α, IL-4, and IL-6) were determined by an independent, blinded observer.Patients’ characteristics showed no significant differences between the groups. All patients completed the study to the end of 3 months follow-up. Exudate collection did not influence primary and secondary endpoints. Furthermore, positive microbiologic findings as well as pus- and necrosis-like appearance neither impaired tissue restoration nor influenced inflammatory factor release.Here, the authors developed an easy and safe protocol for harvesting wound exudate from human digit tip amputations. For the first time, it was shown that harvesting does not impair regenerative healing. Using this method, further studies can be conducted to analyze regeneration associated factors in the human digit tip.DRKS.de Identifier: DRKS00006882 (UTN: U1111-1166-5723). 相似文献
107.
108.
J. Alarcón-Rodríguez M. Fernández-Velilla A. Ureña-Vacas J.J. Martín-Pinacho J.A. Rigual-Bobillo A. Jaureguízar-Oriol L. Gorospe-Sarasúa 《Radiologia》2021,63(3):258-269
Most of the patients who overcome the SARS-CoV-2 infection do not present complications and do not require a specific follow-up, but a significant proportion (especially those with moderate / severe clinical forms of the disease) require clinicalradiological follow-up. Although there are hardly any references or clinical guidelines regarding the long-term follow-up of post-COVID-19 patients, radiological exams are being performed and monographic surveillance consultations are being set up in most of the hospitals to meet their needs. The purpose of this work is to share our experience in the management of the post-COVID-19 patient in two institutions thathave had a high incidence of COVID-19 and to propose general follow-uprecommendations from a clinical and radiological perspective. 相似文献
109.
Samira Marín-Romero Teresa Elías-Hernández María Isabel Asensio-Cruz Rocío Ortega-Rivera Raquel Morillo-Guerrero Javier Toral Emilio Montero Verónica Sánchez Elena Arellano José María Sánchez-Díaz Macarena Real-Domínguez Remedios Otero-Candelera Luis Jara-Palomares 《Archivos de bronconeumología》2019,55(12):619-626
IntroductionScales for predicting venous thromboembolism (VTE) recurrence are useful for deciding the duration of the anticoagulant treatment. Although there are several scales, the most appropriate for our setting has not been identified. For this reason, we aimed to validate the DASH prediction score and the Vienna nomogram at 12 months.MethodsThis was a retrospective study of unselected consecutive VTE patients seen between 2006 and 2014. We compared the ability of the DASH score and the Vienna nomogram to predict recurrences of VTE. The validation was performed by stratifying patients as low-risk or high-risk, according to each scale (discrimination) and comparing the observed recurrence with the expected rate (calibration).ResultsOf 353 patients evaluated, 195 were analyzed, with an average age of 53.5 ± 19 years. There were 21 recurrences in 1 year (10.8%, 95% CI: 6.8%-16%). According to the DASH score, 42% were classified as low risk, and the rate of VTE recurrence in this group was 4.9% (95% CI: 1.3%-12%) vs. the high-risk group that was 15% (95% CI: 9%-23%) (p <.05). According to the Vienna nomogram, 30% were classified as low risk, and the rate of VTE recurrence in the low risk group vs. the high risk group was 4.2% (95% CI:0.5%-14%) vs. 16.2% (95% CI: 9.9%-24.4%) (p <.05).ConclusionsOur study validates the DASH score and the Vienna nomogram in our population. The DASH prediction score may be the most advisable, both because of its simplicity and its ability to identify more low-risk patients than the Vienna nomogram (42% vs. 30%). 相似文献
110.