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排序方式: 共有1879条查询结果,搜索用时 15 毫秒
991.
992.
Pomara C Neri M Riezzo I Turillazzi E Fineschi V 《International journal of cardiology》2009,136(3):e54-e57
The cardiovascular manifestations of tetanus consist of disturbances of heart rate and rhythm, blood pressure instability, arrhythmias, myocardial dysfunction and sympathetic overactivity. It was suggested that either a sudden loss of catecholamine stimulation or myocardial damage caused by the direct action of the tetanus toxin, could be involved in cardiac dysfunction described in tetanus. However, histologic evidence of myocardial necrosis in tetanus was demonstrated in few cases. We report a fatal case of tetanus in which we investigated the cardiac morphology and the expression of TNFalpha to elucidate the heart involvement in this case. Since it is well known that myocardial damage caused by catecholamines can induce synthesis of cytokines by myocytes, cytokines, specifically those with known cardiodepressant properties such as TNF-alpha, could be an alternative mechanism involved in cardiac dysfunction in the setting of tetanus. 相似文献
993.
Sperti C Beltrame V Milanetto AC Moro M Pedrazzoli S 《World journal of gastrointestinal oncology》2010,2(6):272-281
Standard pancreatic resections, such as pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy, result in an important loss of normal pancreatic parenchyma and may cause impairment of exocrine and endocrine function. Whilst these procedures are mandatory for malignant tumors, they seem to be too extensive for benign or border-line tumors, especially in patients with a long life expectancy. In recent years, there has been a growing interest in parenchyma-sparing pancreatic surgery with the aim of achieving better functional results without compromising oncological radicality in patients with benign, border-line or low-grade malignant tumors. Several limited resections have been introduced for isolated or multiple pancreatic lesions, depending on the location of the tumor: central pancreatectomy, duodenum-preserving pancreatic head resection with or without segmental duodenectomy, inferior head resection, dorsal pancreatectomy, excavation of the pancreatic head, middle-preserving pancreatectomy, and other multiple segmental resections. All these procedures are technically feasible in experienced hands, with very low mortality, although with high morbidity rate when compared to standard procedures. Pancreatic endocrine and exocrine function is better preserved with good quality of life in most of the patients, and tumor recurrence is uncommon. Careful patient selection and expertise in pancreatic surgery are crucial to achieve the best results. 相似文献
994.
Effects of Belimumab on Flare Rate and Expected Damage Progression in Patients With Active Systemic Lupus Erythematosus
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995.
Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2‐related Parkinson's disease
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![点击此处可从《Movement disorders》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Rita G. Nunes PhD Raquel Bouça‐Machado MSc Daisy Abreu MSc Nilza Gonçalves MSc Tiago Soares MSc Margherita Fabbri MD Catarina Godinho PhD Patrícia Pita Lobo MD Dulce Neutel MD Marialuisa Quadri PhD Miguel Coelho MD PhD Mario M. Rosa MD PhD Jorge Campos MD PhD Tiago F. Outeiro PhD Cristina Sampaio MD PhD Vincenzo Bonifati MD PhD Joaquim J. Ferreira MD PhD 《Movement disorders》2017,32(9):1331-1333
996.
Pain perception in patients with chronic disorders of consciousness: What can limbic system tell us?
Rocco Salvatore Calabrò Antonino Naro Alfredo Manuli Antonino Leo Rosaria De Luca Viviana Lo Buono Margherita Russo Alessia Bramanti Placido Bramanti 《Clinical neurophysiology》2017,128(3):454-462
Objective
Although it is believed that patients with Unresponsive Wakefulness Syndrome (UWS) do not feel pain, recent neuroimaging and neurophysiologic studies have demonstrated some residual traces of nociceptive processing.Methods
To confirm this growing evidence, we evaluated 21 patients suffering from chronic disorders of consciousness (DOC) (both UWS, n = 11, and Minimally Conscious State – MCS –, n = 10), using an Event-Related Potential (ERP) Low-Resolution Brain Electromagnetic Tomography (LORETA) approach, based on nociceptive repeated laser stimulation (RLS). We delivered laser stimuli to the dorsum of both hands and analysed the γ-band LORETA activations and the ERP γ-power magnitude induced by laser stimulation, as well as the heart rate variability (HRV).Results
We found partially preserved cortical activations and ERP γ-power magnitude in all MCS and two UWS individuals. These effects were paralleled by a purposeful behaviour, and a reduced HRV concerning nociceptive stimulation, whereas the two UWS individuals showed no more than reflex behaviours, besides a strong limbic activation.Conclusions
Some UWS patients may somehow perceive the affective components of nociceptive stimulation.Significance
The diagnosis of functional locked-in syndrome should be taken into account when dealing with DOC differential diagnosis. 相似文献997.
998.
Barbara Begni Lucio Tremolizzo Simona Andreoni Margherita Contri Orlando Uccellini Francesca Neri Carlo Ferrarese 《Neuroscience letters》2009
Neurotransmitter ligand binding in blood cells was assessed in borderline personality disorder (BDP) patients, testing the possibility that different biochemical endophenotypes might lie beneath a specific clinical presentation. The density of peripheral benzodiazepine receptors (PBR) and serotonin transporters were assessed in peripheral blood mononuclear cells (PBMC) and platelets, respectively, showing a decrease of both parameters. Moreover, a further significant decrease of PBR in PBMC was shown for those patients with a depressive trait. Further confirmation of the presence of different molecular endophenotypes underlying the dissimilar clinical presentations in BPD may advance our possibility of successfully treating these patients. 相似文献
999.
Panaro MA Cianciulli A Calvello R Saccia M Sisto M Acquafredda A Mitolo V 《Immunopharmacology and immunotoxicology》2009,31(1):88-93
In this article we analyze some of the structural characteristics of the coding section and the intron of the human chemokine CXC receptor 4 (a 7-transmembrane receptor) pre-mRNA. In the coding sequence the frequencies of the individual nucleotides do not depart significantly from 0.25, while in the intron the frequencies of the As and Gs are significantly lower and higher, respectively, than expected from a random distribution. Analysis of the pattern of association of nucleotides into triplets or couples shows that some triplets or couples occur with frequencies significantly higher or lower than expected when assuming a random association of nucleotides. In particular, in the intron combinations of the same nucleotide are over-represented. 7-or-more nucleotide repeats occur in both the coding section and the intron with frequencies which exceed the confidence limits for a random distribution. For the coding sequence this is possibly explained by the alternans of relatively similar hydrophobic-coding sections and relatively similar intervening intracellular and extracellular hydrophilic-coding sections. 7-or-more nucleotide repeats in reverse order and in reverse/complemented order occur in the intron, but not in the coding section, with frequencies which significantly exceed a random distribution. The numerous intronic repeats in reverse/complemented order may be of relevance for the secondary structure of the intron and might be one important element of the integrated splicing code. 相似文献
1000.
Emanuela Turillazzi Margherita Neri Cristoforo Pomara Irene Riezzo Vittorio Fineschi 《Neuropathology》2009,29(1):68-71
A 65‐year‐old man fell in his garden and sustained a right pre‐radial cutaneous laceration associated with a Colles' fracture. His status for tetanus immunization was uncertain; so a course of antitetanus treatment was immediately started. Two days after admission the man suddenly developed severe nucal pain, rigidity and dysphagia. A brain CT scan was negative. His condition progressively worsened and then he developed trismus. Cultures from the wound were negative for Clostridium tetani; the CSF analysis was negative. On the 9th day after admission, the man died. A presumptive clinical diagnosis of tetanus was made. Autopsy was performed 24 h after death. An immunohistochemical study was conducted with an antibody directed against tetanus toxin fragment C (TTC). By immunohistochemical evaluation, large motor neurons in the ventral horn were immunopositive for TTC. High power magnification of the ventral horn of spinal cord gray matter samples showed TTC immunoreactivity in motor neuron axons and cell bodies, using a confocal laser scanning microscope. The correct diagnosis could be established on the basis of pathological examination with TTC immunostaining. 相似文献