全文获取类型
收费全文 | 49016篇 |
免费 | 8184篇 |
国内免费 | 330篇 |
专业分类
耳鼻咽喉 | 759篇 |
儿科学 | 992篇 |
妇产科学 | 898篇 |
基础医学 | 4277篇 |
口腔科学 | 2873篇 |
临床医学 | 8708篇 |
内科学 | 12712篇 |
皮肤病学 | 935篇 |
神经病学 | 5498篇 |
特种医学 | 1806篇 |
外科学 | 7500篇 |
综合类 | 112篇 |
现状与发展 | 2篇 |
一般理论 | 6篇 |
预防医学 | 3840篇 |
眼科学 | 869篇 |
药学 | 1879篇 |
中国医学 | 72篇 |
肿瘤学 | 3792篇 |
出版年
2024年 | 246篇 |
2023年 | 1615篇 |
2022年 | 964篇 |
2021年 | 1877篇 |
2020年 | 1830篇 |
2019年 | 1454篇 |
2018年 | 2626篇 |
2017年 | 2547篇 |
2016年 | 2636篇 |
2015年 | 2728篇 |
2014年 | 3287篇 |
2013年 | 3552篇 |
2012年 | 3360篇 |
2011年 | 3274篇 |
2010年 | 2537篇 |
2009年 | 2768篇 |
2008年 | 2609篇 |
2007年 | 2545篇 |
2006年 | 2433篇 |
2005年 | 2061篇 |
2004年 | 1813篇 |
2003年 | 1653篇 |
2002年 | 1430篇 |
2001年 | 534篇 |
2000年 | 364篇 |
1999年 | 473篇 |
1998年 | 512篇 |
1997年 | 489篇 |
1996年 | 445篇 |
1995年 | 392篇 |
1994年 | 283篇 |
1993年 | 252篇 |
1992年 | 237篇 |
1991年 | 186篇 |
1990年 | 151篇 |
1989年 | 152篇 |
1988年 | 166篇 |
1987年 | 121篇 |
1986年 | 94篇 |
1985年 | 119篇 |
1984年 | 91篇 |
1983年 | 71篇 |
1982年 | 70篇 |
1981年 | 49篇 |
1980年 | 41篇 |
1979年 | 52篇 |
1978年 | 46篇 |
1977年 | 37篇 |
1973年 | 37篇 |
1972年 | 34篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
We conducted a double blind controlled trial in 28 Duchenne muscular dystrophy (DMD) patients with Deflazacort (DF), an oxazoline derivative of prednisolone which reduces its side-effects. Myometric muscle strength measurements, Scott Score and timed tests showed statistically significant improvement for the treated group (P less than 0.05). Side-effects after 9 months of treatment included mild cushingoid appearance in four patients (28%) and moderate in only one (7%), increased appetite in seven (50%), increased body hair in four (28%), irritability and hyperactivity in three (21%). Increased body weight was not prominent and was controlled with dietary measures. No patient had to be withdrawn from medication. More research and long-term follow-up are needed in order to establish the mechanism of improvement and the consequences of long-term steroid administration in DMD. In this regard DF appears as an alternative to prednisone preserving its benefits but with fewer side-effects. 相似文献
53.
54.
55.
Carlos Alberto Herrero de Morais Norberti Bernardineli Roberto B Garcia Marco A H Duarte Danilo M Z Guerisoli 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2006,102(3):417-421
OBJECTIVE: The aim of this study was to evaluate the biocompatibility of Portland cement with the addition of iodoform, compared to MTA (ProRoot). STUDY DESIGN: Eighteen Wistar albino rats were divided into 3 groups of 6 animals each. Polyethylene tubes were filled either with freshly mixed MTA or Portland cement mixed with iodoform (20% wt/wt) and implanted subcutaneously. An empty tube served as control. After 7, 30, or 60 days, the implants together with the surrounding tissues were removed in blocks. Sections were evaluated for the presence and thickness of a fibrous capsule, presence of granulation tissue, and the severity of inflammatory response. Data were submitted to nonparametric statistical analysis with individual comparisons between groups at a significance level of P < 0.05. RESULTS: There were no differences between inflammatory responses at 7 and 30 days. After 60 days from surgical removal, there was significantly more tissue reaction to the MTA and Portland cement compared to the control group. CONCLUSION: There were no significant differences regarding inflammatory responses between MTA and Portland cement with iodoform after 7, 30, or 60 days. After 60 days, the fibrous capsule around the Portland cement appeared more organized than tissue surrounding MTA implants. After 60 days, there was still a significantly increased tissue reaction to the 2 cements compared to the empty polyethylene tubes. 相似文献
56.
A role for decorin in cutaneous wound healing and angiogenesis 总被引:2,自引:0,他引:2
Hannu Järveläinen MD PhD ; Pauli Puolakkainen MD PhD ; Sari Pakkanen MSc ; Eric L. Brown PhD ; Magnus Höök PhD ; Renato V. Iozzo MD ; E.Helene Sage PhD ; Thomas N. Wight PhD 《Wound repair and regeneration》2006,14(4):443-452
Decorin is known to influence tissue tensile strength and cellular phenotype. Therefore, decorin is likely to have an impact on tissue repair, including cutaneous wound healing. In this study, cutaneous healing of both excisional and incisional full‐thickness dermal wounds was studied in decorin‐deficient (Dcn?/?) animals. A statistically significant delay in excisional wound healing in the Dcn?/? mice occurred at 4 and 10 days postwounding and, in incisional wounds at 4, 10, and 18 days when compared with wild‐type (Dcn?/?) controls. Fibrovascular invasion into polyvinylalcohol sponges was significantly increased by day 18 in Dcn?/? mice relative to Dcn+/+ mice. The 18‐day sponge implants in the Dcn?/? mice showed a marked accumulation of biglycan when compared with the corresponding implants in Dcn+/+ mice. Thus, regulated production of decorin may serve as an excellent therapeutic approach for modifying impaired wound healing and harmful foreign body reactions. 相似文献
57.
58.
Streptolysin O enhances keratinocyte migration and proliferation and promotes skin organ culture wound healing in vitro 总被引:1,自引:0,他引:1
Marjana Tomic-Canic PhD ; Stephen W. Mamber PhD ; Olivera Stojadinovic MD ; Brian Lee MSc ; Nadezda Radoja PhD ; John McMichael PhD 《Wound repair and regeneration》2007,15(1):71-79
ML-05, a modified form of the hemolytic and cytotoxic bacterial toxin, streptolysin O, is currently being investigated as a treatment for collagen-related disorders such as scleroderma and fibrosis. Furthermore, ML-05 may be effective in promoting wound healing and alleviating the formation of hypertrophic scars and keloids. To investigate the effects of ML-05 on wound-healing processes, in vitro wound-healing scratch assays (using human primary epidermal keratinocytes and dermal fibroblasts) and a human skin organ culture wound model were utilized. ML-05 markedly enhanced keratinocyte migration and proliferation in wound scratch assays. ML-05 did not affect either proliferation or migration of dermal fibroblasts, indicating that ML-05's effects on cell migration/proliferation may be keratinocyte-specific. ML-05 was tested in a dose-dependent manner in a skin organ culture wound model using two different application methods: Through the culture media (dermal exposure) or direct topical treatment of the wound surface. ML-05 was found to accelerate wound healing as measured by reepithelialization, particularly after topical application. Therefore, ML-05 may have potential as a wound-healing agent that promotes reepithelialization through stimulation of keratinocyte migration and proliferation. 相似文献
59.
Ulrich Weber Christian WA Pfirrmann Rudolf O Kissling Juerg Hodler Marco Zanetti 《BMC musculoskeletal disorders》2007,8(1):20
Background
Ankylosing spondylitis is a chronic inflammatory rheumatic disorder which usually begins in early adulthood. The diagnosis is often delayed by many years. MR imaging has become the preferred imaging method for detection of early inflammation of the axial skeleton in ankylosing spondylitis. 相似文献60.
Max Heiland Philipp Pohlenz Marco Blessmann Christian R Habermann Lars Oesterhelweg Philipp C Begemann Christian Schmidgunst Felix A S Blake Klaus Püschel Rainer Schmelzle Dirk Schulze 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(6):814-820
OBJECTIVE: The aim of this study was to evaluate soft tissue image quality of a mobile cone-beam computed tomography (CBCT) scanner with an integrated flat-panel detector. STUDY DESIGN: Eight fresh human cadavers were used in this study. For evaluation of soft tissue visualization, CBCT data sets and corresponding computed tomography (CT) and magnetic resonance imaging (MRI) data sets were acquired. Evaluation was performed with the help of 10 defined cervical anatomical structures. RESULTS: The statistical analysis of the scoring results of 3 examiners revealed the CBCT images to be of inferior quality regarding the visualization of most of the predefined structures. Visualization without a significant difference was found regarding the demarcation of the vertebral bodies and the pyramidal cartilages, the arteriosclerosis of the carotids (compared with CT), and the laryngeal skeleton (compared with MRI). Regarding arteriosclerosis of the carotids compared with MRI, CBCT proved to be superior. CONCLUSIONS: The integration of a flat-panel detector improves soft tissue visualization using a mobile CBCT scanner. 相似文献