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101.
Jelle Koopsen Catharina E. van Ewijk Roisin Bavalia Akke Cornelissen Sylvia M. Bruisten Floor de Gee Alvin X. Han Maarten de Jong Menno D. de Jong Marcel Jonges Norin Khawaja Fleur M.H.P.A. Koene Mariken van der Lubben Iris Mikulic Sjoerd P.H. Rebers Colin A. Russell Janke Schinkel Anja J.M. Schreijer Judith A. den Uil Matthijs R.A. Welkers Tjalling Leenstra 《Emerging infectious diseases》2022,28(5):1012
We report a severe acute respiratory syndrome coronavirus 2 superspreading event in the Netherlands after distancing rules were lifted in nightclubs, despite requiring a negative test or vaccination. This occurrence illustrates the potential for rapid dissemination of variants in largely unvaccinated populations under such conditions. We detected subsequent community transmission of this strain. 相似文献
102.
Dikken JL van de Velde CJ Gönen M Verheij M Brennan MF Coit DG 《Annals of surgical oncology》2012,19(8):2443-2451
Purpose
To evaluate the changes in the 7th edition American Joint Committee on Cancer (AJCC) staging system for stomach cancer compared to the 6th edition; to compare the predictive accuracy of the two staging systems.Methods
In a combined database containing 2,196 patients who underwent an R0 resection for gastric adenocarcinoma, differences between the two staging systems were evaluated and stage-specific survival estimates compared. Concordance probability and Brier scores were estimated for both systems to examine the predictive accuracy.Results
Nodal status cutoff values were changed, leading to a more even distribution for the redefined N1, N2, and N3 group. AJCC 6th edition stage II reflected a highly heterogeneous population, which is now adequately subdivided in the AJCC 7th edition into stages IIA, IIB, and IIIA. The predictive accuracy of N classification improved significantly as measured by concordance. Despite increased complexity, the predictive accuracy of AJCC 7th stage grouping was significantly worse than that of the AJCC 6th edition.Discussion
The increased complexity of the 7th edition staging system is accompanied by improvements in the predictive value of nodal staging as compared to the 6th edition, but it was no better in overall stage-specific predictive accuracy. Future refinements of the tumor, node, metastasis staging system should consider whether increased complexity is balanced by improved prognostic accuracy. 相似文献103.
Donald S. Silverberg Raymond A. Ulan Marcel A. Baltzan Richard B. Baltzan 《Canadian Medical Association journal》1970,103(2):129-133
Six cases of edema, three due to the nephrotic syndrome, one to congestive heart failure and two to chronic renal failure, are reported in which furosemide was administered in oral doses higher than those usually prescribed (up to 720 mg. a day), in order to obtain a satisfactory diuresis. In one case of severe prerenal failure secondary to cardiogenic shock and in one case of acute tubular necrosis secondary to hypotension at the time of operation, intravenous doses up to 990 and 1400 mg. per day respectively were able to reverse the oliguria. In eight additional patients who were on chronic hemodialysis, furosemide was administered to the amount of 1000 mg. per day orally in divided doses for two weeks, and produced a moderate diuretic response.
The use of high doses of furosemide in edema and renal failure resistant to the usual therapeutic measures appears to be safe and effective.
相似文献104.
105.
Validation of a Frailty Index from The Older Persons and Informal Caregivers Survey Minimum Data Set
Jennifer E. Lutomski MS Maria A.E. Baars PhD Janneke A. van Kempen MD Bianca M. Buurman PhD Wendy P.J. den Elzen PhD Aaltje P.D. Jansen PhD Gertrudis I.J.M. Kempen PhD Paul F.M. Krabbe PhD Bas Steunenberg PhD Ewout W. Steyerberg PhD Marcel G.M. Olde‐Rikkert PhD René J.F. Melis PhD 《Journal of the American Geriatrics Society》2013,61(9):1625-1627
106.
107.
Marcel Best Andrew N. Gifford Sung Won Kim Ben Babst Markus Piel Frank Rösch Joanna S. Fowler 《Journal of labelled compounds & radiopharmaceuticals》2012,55(1):39-43
A recent report that the aliphatic dicarboxylic acid, azelaic acid (1,9‐nonanedioic acid) but not related acids, suberic acid (1,8‐octanedioic acid) or sebacic (1,10‐decanedioic acid) acid induces systemic acquired resistance to invading pathogens in plants stimulated the development of a rapid method for labeling these dicarboxylic acids with 11C and 14C for in vivo mechanistic studies in whole plants. 11C‐labeling was performed by reaction of ammonium [11C]cyanide with the corresponding bromonitrile precursor followed by hydrolysis with aqueous sodium hydroxide solution. Total synthesis time was 60 min. Median decay‐corrected radiochemical yield for [11C]azelaic acid was 40% relative to trapped [11C]cyanide, and specific activity was 15 GBq/µmol. Yields for [11C]suberic and sebacic acids were similar. The 14C‐labeled version of azelaic acid was prepared from potassium [14C]cyanide in 45% overall radiochemical yield. Radiolabeling procedures were verified using 13C‐labeling coupled with 13C‐NMR and liquid chromatography–mass spectrometry analysis. The 11C and 14C‐labeled azelaic acid and related dicarboxylic acids are expected to be of value in understanding the mode‐of‐action, transport, and fate of this putative signaling molecule in plants. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
108.
Kimberly A. Babson Matthew Tyler Boden Alex H. Harris Timothy R. Stickle Marcel O. Bonn-Miller 《Journal of substance abuse treatment》2013
Treatments for cannabis dependence are associated with high rates of lapse/relapse, underscoring the importance of identifying malleable risk factors that are associated with quit failure. Whereas research has demonstrated that poor sleep quality following cannabis discontinuation is related to subsequent use, there has yet to be an examination of whether poor sleep quality prior to a quit attempt results in a similar pattern of lapse. The present study addressed this gap by examining the role of pre-quit sleep quality on early lapse to cannabis use following a self-guided quit attempt, among 55 cannabis dependent military veterans. Results indicated that participants who experienced poor pre-quit sleep quality had greater risk for lapse within the first 2 days (out of 7) following their quit attempt. Findings are discussed in terms of improving treatments for individuals who report poor sleep quality prior to a cannabis quit attempt. 相似文献
109.
110.