全文获取类型
收费全文 | 35508篇 |
免费 | 2121篇 |
国内免费 | 160篇 |
专业分类
耳鼻咽喉 | 508篇 |
儿科学 | 827篇 |
妇产科学 | 634篇 |
基础医学 | 4210篇 |
口腔科学 | 657篇 |
临床医学 | 3439篇 |
内科学 | 8436篇 |
皮肤病学 | 412篇 |
神经病学 | 3346篇 |
特种医学 | 1430篇 |
外国民族医学 | 1篇 |
外科学 | 6210篇 |
综合类 | 221篇 |
一般理论 | 18篇 |
预防医学 | 2088篇 |
眼科学 | 472篇 |
药学 | 2022篇 |
中国医学 | 45篇 |
肿瘤学 | 2813篇 |
出版年
2024年 | 25篇 |
2023年 | 205篇 |
2022年 | 394篇 |
2021年 | 890篇 |
2020年 | 542篇 |
2019年 | 883篇 |
2018年 | 1089篇 |
2017年 | 749篇 |
2016年 | 765篇 |
2015年 | 921篇 |
2014年 | 1357篇 |
2013年 | 1829篇 |
2012年 | 2687篇 |
2011年 | 2887篇 |
2010年 | 1643篇 |
2009年 | 1577篇 |
2008年 | 2483篇 |
2007年 | 2623篇 |
2006年 | 2445篇 |
2005年 | 2360篇 |
2004年 | 2133篇 |
2003年 | 1997篇 |
2002年 | 1798篇 |
2001年 | 274篇 |
2000年 | 172篇 |
1999年 | 240篇 |
1998年 | 393篇 |
1997年 | 310篇 |
1996年 | 223篇 |
1995年 | 224篇 |
1994年 | 183篇 |
1993年 | 176篇 |
1992年 | 98篇 |
1991年 | 112篇 |
1990年 | 88篇 |
1989年 | 78篇 |
1988年 | 60篇 |
1987年 | 58篇 |
1986年 | 59篇 |
1985年 | 69篇 |
1984年 | 87篇 |
1983年 | 88篇 |
1982年 | 84篇 |
1981年 | 80篇 |
1980年 | 66篇 |
1979年 | 37篇 |
1978年 | 37篇 |
1977年 | 26篇 |
1975年 | 24篇 |
1974年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
101.
Cranial sutures and craniometric points detected on MRI 总被引:2,自引:0,他引:2
Cotton F Rozzi FR Vallee B Pachai C Hermier M Guihard-Costa AM Froment JC 《Surgical and radiologic anatomy : SRA》2005,27(1):64-70
The main goal of the study was to determine on MRI the cranial sutures, the craniometric points and craniometric measurements, and to correlate these results with classical anthropometric measurements. For this purpose, we reviewed 150 cerebral MRI examinations considered as normal (Caucasian population aged 2049 years). For each examination we individualized 11 craniometric landmarks (Glabella, Bregma, Lambda, Opisthocranion, Opisthion, Basion, Inion, Porion, Infra-orbital, Eurion) and three measurements. Measurements were also calculated independently on 498 dry crania (Microscribe 3-DX digitizer). To validate the MRI procedure, we measured four dry crania by MRI and with compass or digital caliper gauges. Cranial sutures always appeared without signal (black), whatever the MRI sequence used, and they are better visualized with a 5 mm slice thickness (compact bone overlapping). Slice dynamic analysis and multiplanar reformatting allowed the detection of all craniometric points, some of these being more difficult to detect than others (Porion, Infra-orbital). The measurements determined by these points were as follows: VertexBasion height=135.66±6.56 mm; EurionEurion width=141.17±5.19 mm; GlabellaOpisthocranion length=181.94±6.40 mm. On the midline T1-weighted sagittal image, all median craniometric landmarks can be individualized and the GlabellaOpisthocranion length, VertexBasion height and parenchyma indices can be calculated. Craniometric points and measurements between these points can be estimated with a standard cerebral MRI examination, with results that are similar to anthropometric data. 相似文献
102.
Michael Bilous Mitch Dowsett Wedad Hanna Jorma Isola Annette Lebeau Aberlardo Moreno Frédérique Penault-Llorca Josef Rüschoff Gorana Tomasic Marc van de Vijver 《Modern pathology》2003,16(2):173-182
Knowledge of HER2 status is a prerequisite when considering a patient's eligibility for Herceptin (trastuzumab) therapy. Accurate assessment of HER2 status is essential to ensure that all patients who may benefit from Herceptin are correctly identified. There are several assays available to determine HER2 status: the most common in routine clinical practice are immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Various factors can affect the results achieved with these assays, including the assay antibody/probe, the methodology and the experience of personnel. Many countries have implemented national testing guidelines in an attempt to standardize testing procedures and make results more accurate. These guidelines vary in the level of detail and the number of recommendations. This review looks at areas of consensus between the different national testing guidelines and highlights where errors may arise during the testing procedure. The key point underlined by this review is that whatever method is used to test for HER2 status, the technology must be validated first, and there must be regular internal and external quality control and quality assurance procedures. 相似文献
103.
104.
Ruth Tachezy Eva Hamsikova Jaroslav Valvoda Marc Van Ranst Jan Betka Robert D. Burk Vladimir Vonka 《Journal of medical virology》1994,42(1):52-59
Recurrent respiratory papillomatosis (RRP) is the most common benign tumour of the larynx, affecting both children and adults. We present a series of 25 patients, including 10 cases of juvenile multiple, 8 cases of adult solitary, and 7 cases of adult multiple RRP. Biopsy tissue from each patient was screened by Southern blot hybridization and polymerase chain reaction for the presence of human papillomavirus (HPV) DNA. Sera from patients and age- and sex-matched controls were tested for the presence of HPV-specific antibodies using a synthetic pep-tide derived from the minor capsid protein (L2) of HPV 6/11. By Southern blot hybridization and/or polymerase chain reaction, biopsies from all patients were positive for HPV 6/11 DNA. There was no difference in antibody response between cases and controls. Female cases and controls had significantly higher antibody titers than male subjects. A correlation was observed between the HPV-specific antibody level and the number of surgery-necessitating recurrences. © 1994 Wiiey-Liss, Inc. 相似文献
105.
Isabelle Knott Marc Dieu Maggi Burton Véronique Lecomte José Remacle Martine Raes 《Inflammation research》1993,39(3-4):126-131
The effects of interleukin-1 and were tested on the [3H]-arachidonic acid release and the prostaglandin synthesis by human cultured synovial cells and chondrocytes. Both forms of interleukin-1 stimulated the arachidonic acid release but interleukin-1 was more potent than IL-1. Human synovial cells and chondrocytes synthesized three types of prostaglandins upon stimulation with interleukin-1 or : prostaglandin E2, F2 and 6-keto-prostaglandin F1. Regarding the synthesis of these prostaglandins, IL-1 was again more potent than IL-1. A comparison between interleukin-1-stimulated synovial cells and chondrocytes revealed neither significant quantitative nor qualitative differences in both the arachidonic acid release and the prostaglandin synthesis. 相似文献
106.
107.
Although thin fibre muscle afferents possess acid sensing ion channels (ASICs), their contribution to the exercise pressor reflex is not known. This lack of information is partly attributable to the fact that there is no known selective in vivo antagonist for ASICs. Although amiloride has been shown to antagonize ASICs, it also has been shown to antagonize voltage-gated sodium channels, thereby impairing impulse conduction in sensory nerves. Our aim was to test the hypothesis that lactic acid accumulation in exercising muscle acted on ASICs located on thin fibre muscle afferents to evoke the metabolic component of the exercise pressor reflex. To test this hypothesis, we determined in decerebrate cats if amiloride attenuated the pressor and cardioaccelerator responses to static contraction, to tendon stretch and to arterial injections of lactic acid and capsaicin. We found a dose of amiloride (0.5 μg kg−1 ; i.a .) that attenuated the pressor and cardioaccelerator responses to both contraction and lactic acid injection, but had no effect on the responses to stretch and capsaicin. A higher dose of amiloride (5 μg kg−1 , i.a. ) not only blocked the pressor and cardioaccelerator responses to lactic acid and contraction, but also attenuated the responses to stretch and to capsaicin, manoeuvers in which ASICs probably play no significant role. In addition, we found that the low dose of amiloride (0.5 μg kg−1 ) had no effect on the responses of muscle spindles to tendon stretch and to succinylcholine, whereas the high dose (5 μg kg−1 ) attenuated the responses to both. Our data suggest the low dose of amiloride used in our experiments selectively blocked ASICs, whereas the high dose blocked ASICs and impulse conduction in muscle afferents. We conclude that ASICs play a role in the metabolic component of the exercise pressor reflex. 相似文献
108.
Constance Schrander-Stumpel Christine de Die-Smulders Marc de Krom Suzanne Schyns-Fleuren Ben Hamel Deni Jaeken Jean-Pierre Fryns 《Clinical genetics》1993,43(6):303-308
Schrander-Stumpel C, de Die-Smulders C, de Krom M, Schyns-Fleuren S, Hamel B, Jaeken D, Fryns J-P. Marden-Walker syndrome: case report, literature review and nosologic discussion.
Clin Genet 1993: 43: 303–308. © Munksgaard, 1993
The Marden-Walker syndrome is characterized by psychomotor retardation, a mask-like face with blepharophimosis, micrognathia and a high-arched or cleft palate, low-set ears, kyphoscoliosis and joint contractures. We report on a male patient with the clinical features of the syndrome. In addition, he had a Dandy-Walker malformation with hydrocephalus and vertebral abnormalities. During pregnancy, there were feeble fetal movements and polyhydramnios. We propose that Marden-Walker syndrome is one of the etiologic possibilities in children with the heterogeneous fetal a(hypo)kinesia deformation sequence (FADS). Differential diagnosis is discussed. The etiology is probably heterogeneous. 相似文献
Clin Genet 1993: 43: 303–308. © Munksgaard, 1993
The Marden-Walker syndrome is characterized by psychomotor retardation, a mask-like face with blepharophimosis, micrognathia and a high-arched or cleft palate, low-set ears, kyphoscoliosis and joint contractures. We report on a male patient with the clinical features of the syndrome. In addition, he had a Dandy-Walker malformation with hydrocephalus and vertebral abnormalities. During pregnancy, there were feeble fetal movements and polyhydramnios. We propose that Marden-Walker syndrome is one of the etiologic possibilities in children with the heterogeneous fetal a(hypo)kinesia deformation sequence (FADS). Differential diagnosis is discussed. The etiology is probably heterogeneous. 相似文献
109.
Jean Bergeron Thierry Normand Adl Bharucha M. R. van Murtby Pierre Julien Claude Gagné Carole Dionne Marc de Braekeleer Daniel Brun Michael R. Hayden Paul J. Luplen 《Clinical genetics》1992,41(4):206-210
Familial lipoprotein lipase deficiency (FLD) is of particular interest to the French Canadian population of Québec since the largest concentration of homozygotes and carriers of this genetic disease in the world resides in this area. We have previously described a missense mutation (M-188) in the lipoprotein lipase (LPL) gene which was present in FLD patients belonging to different ancestries, including a number of French Canadians (Monsalve MV et al. J Clin Invest 1990: 86: 728-734). In the present report, we show that this mutation, although found in largest absolute numbers among French Canadians as compared to other groups in the world, accounts for only a small proportion (24%) of all the LPL mutant alleles in this population. The M-188 occurs either in the homozygote state or as a compound heterozygote with another LPL mutation. Analysis of geographic distribution indicates that the M-188 is more prevalent in western Québec, with the highest carrier rate in the Mauricie region. Genealogical reconstruction leads to the recognition of four founders for M-188, all emigrants from France to Québec in the 17th century. 相似文献
110.
Bresciani JP Ernst MO Drewing K Bouyer G Maury V Kheddar A 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2005,162(2):172-180
We tested whether auditory sequences of beeps can modulate the tactile perception of sequences of taps (two to four taps per sequence) delivered to the index fingertip. In the first experiment, the auditory and tactile sequences were presented simultaneously. The number of beeps delivered in the auditory sequence were either the same as, less than, or more than the number of taps of the simultaneously presented tactile sequence. Though task-irrelevant (subjects were instructed to focus on the tactile stimuli), the auditory stimuli systematically modulated subjects tactile perception; in other words subjects responses depended significantly on the number of delivered beeps. Such modulation only occurred when the auditory and tactile stimuli were similar enough. In the second experiment, we tested whether the automatic auditory-tactile integration depends on simultaneity or whether a bias can be evoked when the auditory and tactile sequence are presented in temporal asynchrony. Audition significantly modulated tactile perception when the stimuli were presented simultaneously but this effect gradually disappeared when a temporal asynchrony was introduced between auditory and tactile stimuli. These results show that when provided with auditory and tactile sensory signals that are likely to be generated by the same stimulus, the central nervous system (CNS) tends to automatically integrate these signals. 相似文献