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51.
Miho Yamazaki-Nishioka Makiko Shimizu Hiroshi Suemizu Megumi Nishiwaki Marina Mitsui 《Xenobiotica; the fate of foreign compounds in biological systems》2018,48(2):117-123
1.?Benzydamine is used clinically as a nonsteroidal anti-inflammatory drug in oral rinses and is employed in preclinical research as a flavin-containing monooxygenase (FMO) probe substrate. In this study, plasma concentrations of benzydamine and its primary N-oxide and N-demethylated metabolites were investigated in control TK-NOG mice, in humanized-liver mice, and in mice whose liver cells had been ablated with ganciclovir.2.?Following oral administration of benzydamine (10?mg/kg) in humanized-liver TK-NOG mice, plasma concentrations of benzydamine N-oxide were slightly higher than those of demethyl benzydamine. In contrast, in control and ganciclovir-treated TK-NOG mice, concentrations of demethyl benzydamine were slightly higher than those of benzydamine N-oxide.3.?Simulations of human plasma concentrations of benzydamine and its N-oxide were achieved using simplified physiologically based pharmacokinetic models based on data from control TK-NOG mice and from reported benzydamine concentrations after low-dose administration in humans. Estimated clearance rates based on data from humanized-liver and ganciclovir-treated TK-NOG mice were two orders magnitude high.4.?The pharmacokinetic profiles of benzydamine were different for control and humanized-liver TK-NOG mice. Humanized-liver mice are generally accepted human models; however, drug oxidation in mouse kidney might need to be considered when probe substrates undergo FMO-dependent drug oxidation in mouse liver and kidney. 相似文献
52.
Shiori Otsuki Eiko Saito Norie Sawada Sarah K. Abe Akihisa Hidaka Taiki Yamaji Taichi Shimazu Atsushi Goto Motoki Iwasaki Hiroyasu Iso Tetsuya Mizoue Kenji Shibuya Manami Inoue Shoichiro Tsugane 《Annals of epidemiology》2018,28(9):597-604.e6
Purpose
We investigated the association between reproductive history and mortality from all and major causes among Japanese women.Methods
A large-scale population-based cohort study in Japan included 40,149 eligible women aged 40–69 years in 1990–1994. A total of 4788 deaths were reported during follow-up (average 20.9 years). A Cox proportional hazards regression model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CI) for all-cause and major causes of mortality, adjusting for potential confounders.Results
Inverse associations with all-cause mortality were found in parous women (0.74 [0.67–0.82]), women with two or three births compared with a single birth (2 births: 0.88 [0.78–0.99]; 3 births: 0.83 [0.74–0.94]), parous women who breastfed (0.81 [0.75–0.87]), women who were older at menopause (0.88 [0.80–0.97]; p-trend: <0.01), and women who had a longer fertility span (0.85 [0.76–0.95]; p-trend: <0.01). A positive association was seen between all-cause mortality and later age at first birth (≥30 years) than early childbearing (≤22 years).Conclusions
Our study suggests that parous, two or three births, breastfeeding, late age at menopause, and longer reproductive span are associated with lower risk of all-cause of mortality. 相似文献53.
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55.
Tomoyo Hara Ryoko Uemoto Akiko Sekine Yukari Mitsui Shiho Masuda Kiyoe Kurahashi Sumiko Yoshida Toshiki Otoda Tomoyuki Yuasa Akio Kuroda Yasumasa Ikeda Itsuro Endo Soichi Honda Katsuhiko Yoshimoto Akira Kondo Toshiaki Tamaki Toshio Matsumoto Munehide Matsuhisa Masahiro Abe Ken-ichi Aihara 《Journal of diabetes investigation.》2021,12(12):2172-2182
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58.
Hideharu Hagiya Keigo Kimura Hideo Okuno Shigeto Hamaguchi Daiichi Morii Hisao Yoshida Tomomi Mitsui Isao Nishi Kazunori Tomono 《Journal of infection and chemotherapy》2019,25(11):906-908
Corynebacterium striatum, generally considered an opportunistic organism in humans, has recently been known to develop high-level daptomycin resistance (HLDR) shortly after drug exposure. To date, however, only several such clinical isolates have been described in the literature and clinical background of the resistant pathogen remains to be elucidated. Here, we report a case involving a C. striatum strain with HLDR harboring novel nucleotide mutations, together with a review of the relevant literature. To the best of our knowledge, this is the first well-investigated clinical report from Japan including a genetic investigation. Considering the rapid emergence of HLDR C. striatum in vitro experiment, there could be a number of underreporting cases. Scrupulous attention is required when administering daptomycin for the treatment of C. striatum infections, even if the organism has initially exhibited susceptibility. 相似文献
59.
Takehito Ito Daw-An Wu Toshiyuki Marutani Manami Yamamoto Hidenori Suzuki Shinsuke Shimojo Tetsuya Matsuda 《Social cognitive and affective neuroscience》2014,9(10):1546-1551
Changes in preference are inherently subjective and internal psychological events. We have identified brain events that presage ultimate (rather than intervening) choices, and signal the finality of a choice. At the first exposure to a pair of faces, caudate activity reflected the face of final choice, even if an initial choice was different. Furthermore, the orbitofrontal cortex and hippocampus exhibited correlations only when the subject had made a choice that would not change. 相似文献
60.
Yusuke Yamaba Osamu Takakuwa Ziren Wang Manami Saito Daisuke Kawae Misuzu Yoshihara Eiji Kunii Yutaka Ito Kenji Akita 《Internal medicine (Tokyo, Japan)》2020,59(24):3195
A 68-year-old man visited our hospital due to anorexia, weight loss and a fever. We diagnosed the patient with disseminated Mycobacterium avium complex (MAC) and confirmed the presence of interferon (IFN)-γ neutralizing autoantibodies (IFN-γAb). His lesions improved following antibiotic therapy, but chylous ascites (CA) developed seven months after treatment. CA was able to be controlled by subcutaneous octreotide and diet therapy. IFN-γAb is recognized as having a critical role in the pathogenesis of disseminated MAC disease, but its clinical features are not fully understood. CA may be a complication that develops during the treatment of disseminated MAC infection. 相似文献