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71.
Mamoru Doi Hidetoshi Kasuya Mikio Watanabe Akira Ogawa David A. Cook 《Neurological research》2013,35(6):553-558
AbstractWe have investigated the relationship between angiographic vasospasm and the ability of spastic vessels to relax in response to agents which promote release of endothelium derived relaxing factor. Vasospasm was induced in dogs by the 'single hemorrhage' technique. Animals received a single intracisternal injection of blood, blood activated with thromboplastin or collagen, or inert material, and angiograms were obtained day 0 and day 7. Vasospasm was estimated by measuring the ratio of the diameter of the vessel before and after treatment. Rings of cerebral artery obtained from these animals were suspended in a standard organ- bath arrangement, contracted with prostaglandin F2(X and then treated with increasing doses of adenosine triphosphate or bradykinin, both of which cause relaxation by an endothelium-dependent process. The arteries from animals with moderate to severe vasospasm showed a response to bradykinin and adenosine- triphosphate which was reduced, absent or converted to a contraction, when compared with normal vessels. Vessels in which vasospasm was mild or absent relaxed as expected to these agents. The reduction in vessel diameter showed a highly significant correlation with the reduction in relaxation to bradykinin or adenosine-triphosphate. These results have demonstrated that impairment of endothelium-dependent vasorelaxation correlates with the existence of vasospasm. [Neurol Res 1996; 18: 553-558] 相似文献
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Asuka?Yasueda Tsunekazu?Mizushima Riichiro?Nezu Ryoko?Sumi Mamoru?Tanaka Junichi?Nishimura Yasuyuki?Kai Masaki?Hirota Hideki?Osawa Kiyokazu?Nakajima Masaki?Mori Toshinori?ItoEmail author 《Surgery today》2016,46(8):939-949
Purpose
Ulcerative colitis (UC) is a chronic, relapsing, and refractory disorder of the intestine. Total proctocolectomy with ileal pouch anal anastomosis (IPAA) is the preferred and standard surgical procedure for patients’ refractory to medical therapy. Pouchitis is one of the most common long-term complications after IPAA. In the present study, the safety and efficacy of Clostridium butyricum MIYAIRI (CBM) as a probiotic were examined.Methods
A randomized and placebo-controlled study was performed. Seventeen patients were recruited from 2007 to 2013. Nine tablets of MIYA-BM® or placebo were orally administered once daily. The cumulative pouchitis-free survival, pouch condition (using the modified pouch disease activity index), and blood parameters were evaluated. A fecal sample analysis was also performed.Results
Subjects were randomly allocated to receive MIYA-BM or placebo (9 and 8 subjects, respectively). One subject in the MIYA-BM group and four subjects in the placebo group developed pouchitis. No side effects occurred in either group. Characteristic intestinal flora was observed in each group.Conclusions
Our results suggest that probiotic therapy with CBM achieved favorable results with minimal side effects and might be a useful complementary therapy for the prevention of pouchitis in patients with UC who have undergone IPAA.74.
Factors affecting N‐terminal pro‐brain natriuretic peptide elevation in the acute phase of Kawasaki disease 下载免费PDF全文
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Hagihara Kiyotaka Haraguchi Naotsugu Nishimura Junichi Yasueda Asuka Fujino Shiki Ogino Takayuki Takahashi Hidekazu Miyoshi Norikatsu Uemura Mamoru Matsuda Chu Mizushima Tsunekazu Yamamoto Hirofumi Mori Masaki Doki Yuichiro Eguchi Hidetoshi 《Annals of surgical oncology》2022,29(12):7435-7445
Annals of Surgical Oncology - Colorectal cancer (CRC) is a major cause of cancer-related deaths. Metastasis is enhanced through epithelial-mesenchymal transition (EMT), a process primarily induced... 相似文献
77.
Daigo Nagahara Tomoaki Nakata Akiyoshi Hashimoto Toru Takahashi Michifumi Kyuma Mamoru Hase Kazufumi Tsuchihashi Kazuaki Shimamoto 《Circulation journal》2006,70(4):419-425
BACKGROUND: Measurement of circulating biomarkers has enabled early diagnosis and risk assessment of acute coronary syndrome. This study sought diagnostic values of the first single-point data of biomarkers obtained soon after patient arrival by comparing with scintigraphically quantified myocardial injury in patients presenting with acute chest pain at an emergency room. METHODS AND RESULTS: Serial blood samples were taken soon after arrival in an emergency department in 74 patients with suspected acute coronary syndrome to quantify blood levels of troponin-T (TnT), heart-type fatty acid-binding protein (H-FABP), myocardial-bound creatine kinase (CK-MB), and myoglobin. Myocardial perfusion and metabolic defects were scintigraphically quantified. The first single-point data had high positive predictive values for detecting the defects (80-100%) but low negative predictive values (15-41%). CK-MB and TnT had higher specificities (73-100%) but significantly lower positive rates (22-27%) than the others (61-68%), resulting in greater sensitivities of H-FABP and myoglobin (75-80%) than those of CK-MB and TnT (29-35%). Among biomarkers, TnT peak concentrations most closely correlated with scintigraphic abnormalities. CONCLUSION: H-FABP can contribute to early detection of myocardial injury and TnT is most likely to correlate with injured myocardial mass. The differential features of biomarkers are complementary in patients with acute chest pain presenting at an emergency room. 相似文献
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Masao Yoshida Shinichiro Take Mamoru Ishikawa Akatsuki Kokaze Kanae Karita Matsuko Harada Hideki Ohno 《Environmental health and preventive medicine》2014,19(2):100-107