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111.
Maia Pujara Julian C. Motzkin Joseph P. Newman Kent A. Kiehl Michael Koenigs 《Social cognitive and affective neuroscience》2014,9(6):794-801
Psychopathy is a personality disorder associated with callous and impulsive behavior and criminal recidivism. It has long been theorized that psychopaths have deficits in processing reward and punishment. Here, we use structural and functional magnetic resonance imaging to examine the neural correlates of reward and loss sensitivity in a group of criminal psychopaths. Forty-one adult male prison inmates (n = 18 psychopaths and n = 23 non-psychopaths) completed a functional magnetic resonance imaging task involving the gain or loss of money. Across the entire sample of participants, monetary gains elicited robust activation within the ventral striatum (VS). Although psychopaths and non-psychopaths did not significantly differ with respect to overall levels of VS response to reward vs loss, we observed significantly different correlations between VS responses and psychopathy severity within each group. Volumetric analyses of striatal subregions revealed a similar pattern of correlations, specifically for the right accumbens area within VS. In a separate sample of inmates (n = 93 psychopaths and n = 117 non-psychopaths) who completed a self-report measure of appetitive motivation, we again found that the correlation with psychopathy severity differed between groups. These convergent results offer novel insight into the neural substrates of reward and loss processing in psychopathy. 相似文献
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Ingrid de Siqueira Pereira Marta Marques Maia Allecineia Bispo da Cruz João Paulo Marochi Telles Jose Ernesto Vidal Ricardo Gava Cristina Silva Meira-Strejevitch Vera Lucia Pereira-Chioccola 《Parasite immunology》2020,42(4):e12696
This study investigated the potential of five miRNA candidates for cerebral toxoplasmosis/HIV co-infection (CT/HIV) biomarkers. miR-155-5p, miR-146a-5p, miR-21-5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). From each was collected peripheral blood/EDTA for laboratory diagnosis. Blood cells for DNA extractions (molecular diagnosis), plasma for RNA extractions (gene expression) and ELISA (serological diagnosis). miRNA expression was performed by qPCR, and values were expressed in Relative Quantification (RQ). Among the five miRNAs, miR-21-5p and miR-146a-5p were up-expressed in CT/HIV group when compared with AT and NC groups. RQ means for miR-21-5p and miR-146a-5p in CT/HIV group were 3.829 and 2.500, while in AT group, were 1.815 and 1.661, respectively. Differences between 3 groups were statistically significant (Kruskal-Wallis ANOVA test), as well as CT/HIV and AT groups (Mann-Whitney test). Plasma of CT/HIV and AT groups expressed similar levels of miR-29c-3p, miR-155-5p and miR-125b-5p. As NC group was different of CT/HIV and AT groups, differences between three groups were statistically significant (Kruskal-Wallis ANOVA test). No difference was shown between CT/HIV and AT groups (Mann-Whitney test). These results suggest the host miRNAs modulation by Toxoplasma gondii. 相似文献
113.
Gabriane Nascimento Porcino Luciana Maria Ribeiro Antinarelli Ana Carolina Ribeiro Gomes Maia Priscila Faria‐Pinto Alessandro Taunay‐Rodrigues Paulo Marcos Zech Coelho David Lee Nelson Marcus Luiz Oliveira Penido Elaine Soares Coimbra Eveline Gomes Vasconcelos 《The Journal of pharmacy and pharmacology》2019,71(12):1784-1791
114.
Rafael Centuriao Brinkerhoff Eduarda Santa-Helena Paulo C. do Amaral Diego da C. Cabrera Renata F. Ongaratto Patrick M. de Oliveira Caroline Da Ros Montes D'Oca Carla A. Neves Gonalves Luiz E. Maia Nery Marcelo G. Montes D'Oca 《RSC advances》2019,9(43):24688
Polyhydroquinolines (PHQs) are the unsymmetrical Hantzsch derivatives of 1,4-dihydropyridines with several biological applications. In this work, new fatty 2- and 3-substituted PHQ derivatives from different fatty acids and fatty alcohol feedstocks were synthesized at good yields via a four-component reaction (4CR). The antioxidant activities of fatty PHQs were investigated using three different antioxidant methods. The experiments showed that the compounds derived from 2-nitrobenzaldehyde and fatty palmitic (C16:0) and oleic (C18:1) chains showed better antioxidant activity. This revealed that combining the ortho NO2 group in the aromatic ring with the insertion of fatty chains in the PHQ core contributed to the antioxidant activity. However, among all the fatty PHQs tested, the fatty 2-substituted compound derived from oleyl alcohol and 2-nitrobenzaldehyde showed the highest antioxidant activity (EC50, 2.11–4.69 μM), which was similar to those of the antioxidant standards butylated hydroxytoluene (EC50, 1.98–6.47 μM) and vitamin E (EC50, 1.19–5.88 μM). In addition, this lipophilic compound showed higher antioxidant activity than the antihypertensive drug nifedipine (EC50, 49.25–126.86 μM). These results indicate that the new fatty PHQs may find novel applications as antioxidant additives.The insertion of a fatty long chain into polyhydroquinoline (PHQ) core contributes to antioxidant potential, the new fatty PHQs showed activities similar to commercial antioxidants. 相似文献
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