全文获取类型
收费全文 | 2354篇 |
免费 | 124篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 103篇 |
妇产科学 | 83篇 |
基础医学 | 225篇 |
口腔科学 | 66篇 |
临床医学 | 141篇 |
内科学 | 493篇 |
皮肤病学 | 15篇 |
神经病学 | 132篇 |
特种医学 | 92篇 |
外科学 | 366篇 |
综合类 | 29篇 |
预防医学 | 108篇 |
眼科学 | 200篇 |
药学 | 200篇 |
中国医学 | 13篇 |
肿瘤学 | 192篇 |
出版年
2023年 | 31篇 |
2022年 | 58篇 |
2021年 | 82篇 |
2020年 | 53篇 |
2019年 | 62篇 |
2018年 | 67篇 |
2017年 | 57篇 |
2016年 | 65篇 |
2015年 | 97篇 |
2014年 | 137篇 |
2013年 | 140篇 |
2012年 | 230篇 |
2011年 | 202篇 |
2010年 | 111篇 |
2009年 | 103篇 |
2008年 | 125篇 |
2007年 | 135篇 |
2006年 | 101篇 |
2005年 | 105篇 |
2004年 | 111篇 |
2003年 | 90篇 |
2002年 | 76篇 |
2001年 | 15篇 |
2000年 | 15篇 |
1999年 | 20篇 |
1998年 | 9篇 |
1997年 | 11篇 |
1996年 | 11篇 |
1995年 | 7篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 9篇 |
1991年 | 16篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1987年 | 6篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 8篇 |
1975年 | 4篇 |
1974年 | 7篇 |
1971年 | 4篇 |
1970年 | 4篇 |
1969年 | 7篇 |
1968年 | 6篇 |
1967年 | 5篇 |
1966年 | 4篇 |
排序方式: 共有2491条查询结果,搜索用时 15 毫秒
71.
Lucio R. Volino Rolee Pathak Das Rupal Patel Mansukhani Leon E. Cosler 《American journal of pharmaceutical education》2014,78(9)
Objective. To evaluate the impact of counseling in a simulated medication adherence activity.Design. Students were randomized into 2 groups: patient medication monograph only (PMMO) and patient medication monograph with counseling (PMMC). Both groups received a fictitious medication and monograph. Additionally, the PMMC group received brief counseling. A multiple-choice, paper-based survey instrument was used to evaluate simulated food-drug interactions, adherence, and perceptions regarding the activity’s value and impact on understanding adherence challenges.Assessment. Ninety-two students participated (PMMC, n=45; and PMMO, n=47). Overall, a significantly higher incidence of simulated food-drug interactions occurred in the PMMO group (30%) vs the PMMC group (22%) (p=0.02). Doses taken without simulated food-drug interactions were comparable: 46.2% (PMCC) vs 41.9% (PMMO) (p=0.19). The average number of missed doses were 3.2 (PMMC) vs 2.8 (PMMO) (p=0.55). Approximately 70% of the students found the activity to be valuable and 89% believed it helped them better understand adherence challenges.Conclusion. This activity demonstrated the challenges and important role of counseling in medication adherence. 相似文献
72.
Shvetank Bhatt Mahesh Radhakrishnan Ankur Jindal Thangaraj Devadoss Arghya Kusum Dhar 《Indian journal of pharmacology》2014,46(2):191-196
Aim:
The aim of the study was to evaluate a novel 5 HT3 receptor antagonist (6g) on chronic stress induced changes in behavioural and brain oxidative stress parameter in mice. A complicated relationship exists among stressful stimuli, body''s reaction to stress and the onset of clinical depression. Chronic unpredictable stressors can produce a situation similar to human depression, and such animal models can be used for the preclinical evaluation of antidepressants.Materials and Methods:
In the present study, a novel and potential 5-HT3 receptor antagonist (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl) methanone (6g) with good Log P (3.08) value and pA2(7.5) values, synthesized in our laboratory was investigated to study the effects on chronic unpredictable mild stress (CUMS)-induced behavioural and biochemical alterations in mice. Mice were subjected to different stress paradigms daily for a period of 28 days to induce depressive-like behaviour.Results:
The results showed that CUMS caused depression-like behaviour in mice, as indicated by the significant (P < 0.05) decrease in sucrose consumption and locomotor activity and increase in immobility the forced swim test. In addition, it was found that lipid peroxidation and nitrite levels were significantly (P < 0.05) increased, whereas glutathione levels, superoxide dismutase and catalase activities decreased in brain tissue of CUMS-treated mice. ‘6g’ (1 and 2 mg/kg, p.o., 21 days) and fluoxetine treatment (20 mg/kg, p.o., 21 days) significantly (P < 0.05) reversed the CUMS-induced behavioural (increased immobility period, reduced sucrose preference and decreased locomotor activity) and biochemical (increased lipid peroxidation; decreased glutathione levels, superoxide dismutase and catalase activities). However fluoxetine treatment (20 mg/kg, p.o., 21 days) significantly decreased the nitrite level in the brain while ‘6g’ (1 and 2 mg/kg, p.o., 21 days) did not show significant (P < 0.05) effect on the nitrite levels in brain.Conclusion:
Compound ‘6g’ exerted antidepressant-like effects in behavioural despair paradigm in chronically stressed mice by restoring antioxidant mechanisms.KEY WORDS: 5-HT3 receptor antagonist, chronic unpredictable mild stress, depression, oxidative stress 相似文献73.
Fernando Caravaggio Shinichiro Nakajima Carol Borlido Gary Remington Philip Gerretsen Alan Wilson Sylvain Houle Mahesh Menon David Mamo Ariel Graff-Guerrero 《Neuropsychopharmacology》2014,39(12):2769-2776
Using positron emission tomography (PET) and an acute dopamine depletion challenge it is possible to estimate endogenous dopamine levels occupying dopamine D2/3 receptors (D2/3R) in humans in vivo. Our group has developed [11C]-(+)-PHNO, the first agonist radiotracer with preferential in vivo affinity for D3R. Thus, the use of [11C]-(+)-PHNO offers the novel possibility of (i) estimating in vivo endogenous dopamine levels at D2/3R using an agonist radiotracer, and (ii) estimating endogenous dopamine levels at D3R in extrastriatal regions such as the substantia nigra, hypothalamus, and ventral pallidum. Ten healthy participants underwent a [11C]-(+)-PHNO PET scan under baseline conditions and another under acute endogenous dopamine depletion achieved via oral administration of alpha-methyl-para-tyrosine (64 mg/kg). [11C]-(+)-PHNO binding was sensitive to acute dopamine depletion, allowing in vivo estimates of endogenous dopamine in D2R-rich regions (caudate and putamen), mixed D2/3R-rich regions (ventral striatum and globus pallidus), and extrastriatal D3R-rich regions (hypothalamus and ventral pallidum). Dopamine depletion decreased self-reported vigor, which was correlated with the reduction in dopamine levels in the globus pallidus. [11C]-(+)-PHNO is a suitable radiotracer for use in estimating endogenous dopamine levels at D2R and D3R in neuropsychiatric populations. 相似文献
74.
Mahesh R. G. Prasad Anupam Neogi Napat Vajragupta Rebecca Janisch Alexander Hartmaier 《Materials》2021,14(9)
Employing atomistic simulations, we investigated the void collapse mechanisms in single crystal Ni during hydrostatic compression and explored how the atomistic mechanisms of void collapse are influenced by temperature. Our results suggest that the emission and associated mutual interactions of dislocation loops around the void is the primary mechanism of void collapse, irrespective of the temperature. The rate of void collapse is almost insensitive to the temperature, and the process is not thermally activated until a high temperature (∼1200–1500 K) is reached. Our simulations reveal that, at elevated temperatures, dislocation motion is assisted by vacancy diffusion and consequently the void is observed to collapse continuously without showing appreciable strain hardening around it. In contrast, at low and ambient temperatures (1 and 300 K), void collapse is delayed after an initial stage of closure due to significant strain hardening around the void. Furthermore, we observe that the dislocation network produced during void collapse remains the sample even after complete void collapse, as was observed in a recent experiment of nickel-base superalloy after hot isostatic pressing. 相似文献
75.
Phan Derek Q. Goitia Jesse Lee Ming-Sum Gupta Nigel Aharonian Vicken Mansukhani Prakash Moore Naing Brar Somjot S. Zadegan Ray 《Journal of interventional cardiac electrophysiology》2021,61(2):365-374
Journal of Interventional Cardiac Electrophysiology - Conduction disturbances after transcatheter aortic valve replacement (TAVR) requiring pacemaker (PPM) implantation are a known complication and... 相似文献
76.
77.
78.
Mass screening for colorectal cancer 总被引:2,自引:0,他引:2
Dr. Indru T. Khubchandani M.D. Mahesh C. Karamchandani M.D. Francis S. Kleckner M.D. James A. Sheets M.D. John J. Stasik M.D. Lester Rosen M.D. Robert D. Riether M.D. 《Diseases of the colon and rectum》1989,32(9):754-758
A voluntary community colorectal cancer screening project to detect occult blood in the stool of asymptomatic individuals was undertaken; 49,353 Hemoccult® II kits were distributed. A total of 23,674 completed kits were returned to a central repository and processed (compliance rate, 48 percent); 851 participants had positive results (3.6 percent). Of the 640 who underwent further medical evaluation, 299 participants (46.7 percent) who had adequate follow-up had no evidence of disease. Diverse disease entities were detected in 341 participants, which was 1.4 percent of those enrolled. Forty-one patients (0.17 percent) showed significant findings that included 29 cancers (0.12 percent) and 12 (0.05 percent) noninvasive malignant polyps. Of the cancers, there were 27 colorectal, one nonHodgkin's lymphoma, and one carcinoma of the vocal cord. In addition, 107 patients (0.45 percent) had benign polyps and 193 patients (0.82 percent) had various diseases of the gastrointestinal tract and other medical conditions. The cost of the program was modest and the results conformed to those found in previous screening surveys. The heightened public awareness of testing for colorectal disease and the detection of early lesions justifies the guaiac test screening program for mass survey. 相似文献
79.
80.
Mahesh C. Karamchandani M.D. Dr. Robert Riether M.D. James Sheets M.D. John Stasik M.D. Lester Rosen M.D. Indru Khubchandani M.D. 《Diseases of the colon and rectum》1986,29(11):747-749
A patient with nephrocolic fistula secondary to perinephric abscess was treated successfully with nephrectomy, colonic resection,
and colocolostomy.
Supported in part by the Dorothy Rider Pool Health Care Trust Fund. 相似文献