夏季修剪和冬季修剪对金银花产量和生长的影响研究

通过安排田间小区试验,研究了金银花生长前3年,夏季修剪和冬季修剪对金银花早期产量和生长的影响。通过分析,夏季修剪对地径增粗的影响较小;在金银花定植的第1年,进行过重的夏季修剪不仅不能增加地径粗度,反而有相反作用,冬季修剪对地径增粗影响显著,即冬季修剪可使金银花主干增粗。相对于不修剪,较轻的夏季修剪和冬季修剪均可显著提高"九丰1号"金银花植株高度,减少发枝数并缩减冠幅;相对于轻剪,较重的修剪使树体被过度削弱,使株高降低、发枝数减少。夏季修剪和冬季修剪均对产量有影响,但冬季修剪对产量的影响更显著,在金银花定植早期(第2年)修剪会使金银花产量降低,且重剪降低程度甚于轻剪,但是当植株生长到第3年,合理的修剪可有效增加金银花产量,且三年产量总和最高。研究表明,金银花早期最为合理的增产修剪方案为冬季轻剪和夏季轻剪处理。     

皮肤外洗1号方离子喷雾治疗女性外阴皮炎湿疹50例

目地:观察皮肤外洗1号方离子喷雾治疗女性外阴皮炎湿疹的疗效.方法:治疗组50例在口服盐酸西替利嗪片10mg,每天1次的基础上,给予皮肤外洗1号方,对照组给予盐酸西替利嗪片10mg,每天1次.同时给予丁酸氢化可的松软膏外擦患处,一天2次.结果:治疗组总有效率为96％,而对照组为74％.两组比较有显著性差异(P＜0.05).结论:皮肤外洗1号方离子喷雾治疗女性外阴皮炎湿疹效果满意.     

信息时代教学方式革命的思考

现代信息技术正在成为知识的一种崭新和高效的积累与传播方式。国外知名高等院校的网站已演变为教学资源的重要载体和知识交换的手段。我国已初步形成了国家、省、校三级精品课程资源体系，然而网站资源“闲置”的情况却相当严重。文章试图从国际经验中分析信息技术在现代高等教育改革中的意义，以期为中国医学教学方式变革提供有益启示。     

小儿Amyand's疝的临床特点分析

目的 探讨小儿Amyand's疝的临床特点及治疗经验.方法 回顾性分析2002年1月至2009年12月17例Ⅱ、Ⅲ型Amyand's疝的临床资料.结果 17例患儿中男孩15例,女孩2例;中位年龄1.1岁(25 d至6岁5个月).临床共同的特征是:腹股沟区疼痛性肿块17例,呕吐9例,发热(≥38.5°)9例;X线平片显示肠梗阻5例;B超表现为腹股沟区混合性包块17例;实验室检查17例患儿白细胞均升高(＞10 000).17例Ⅱ、Ⅲ型Amyand's疝患儿顺利完成了疝环松解+阑尾切除+疝内容物还纳+疝囊高位结扎术,术后恢复较快,均痊愈出院.术后病理诊断为单纯性阑尾炎7例,化脓性阑尾炎8例,坏疽性阑尾炎2例.随访10个月至8年,无一例复发.结论 Amyand's疝临床较少见,Ⅰ型AH在处理上与一般的嵌顿疝相似,阑尾直接还纳入腹腔;Ⅱ、Ⅲ型AH行疝环松解+阑尾切除+疝内容物还纳+疝囊高位结扎术.提高对本病的认识,正确处理不同类型的AH,是提高治愈率的关键.

Abstract：

Objective To study clinical features and treatment experience of Amyand's hernia in children. Methods Clinical information of 17 cases of types Ⅱ and Ⅲ hernia was studied retrospectively from January 2002 to December 2009. Results There were 15 boys(88. 24%) and 2 girls (11.76%)in the study, the median age was 1.1 years (25 days to 6 years and 5 months). The common presenting symptom was painful inguinal or inguinoscrotal swelling (100%), vomiting (52. 94%), fever (≥ 38. 5 °) (52. 94%). X-ray showed intestinal obstruction (29. 41 %). Ultrasound found mixed mass in the groin area (100%). All of 17 cases presented with elevated WBC (＞10,000). 17 cases of types Ⅱ and Ⅲ Amyanc's hernia were completed successfully by the cut-down herniorrhaphy + appendectomy. The specimens were proved appendicitis in 7 cases, suppurative appendicitis in 8 cases, and gangrenous appendicitis in 2 cases by pathological diagnoses. No recurrence was found within the follow-up time (10m ～ 8y). Conclusions Amyand's hernia is rare, the treatment of type Ⅰ Amyanc's hernia is similar to generally incarcerated hernia, putting the appendix into the abdominal cavity, directly; type Ⅱ and Ⅲ Amyand's hernia were treated by the cut-down herniorrhaphy and appendectomy.     

盐酸氨溴索治疗新生儿感染性肺炎的临床疗效研究

目的研究盐酸氨溴索用于治疗感染性肺炎新生儿的临床效果。方法选取2018年9月至2019年9月本院收治的86例感染性肺炎新生儿作为研究对象,按照随机数字表法分为对照组和观察组,各43例。对照组接受基础治疗,观察组在对照组基础上应用盐酸氨溴索治疗,比较两组疗效、炎症因子水平、不良反应发生率。结果治疗后,观察组肺部湿啰音消失时间、呼吸恢复平稳时间、体温恢复正常时间、住院时间均短于对照组(P<0.05);治疗后,两组WBC、CRP水平均低于治疗前,且观察组低于对照组(P<0.05);观察组不良反应发生率为11.63%,对照组不良反应发生率为9.30%,两组比较差异无统计学意义。结论新生儿感染性肺炎应用盐酸氨溴索治疗可有效改善症状,缓解实验室指标水平,且不增加不良反应发生率。     

血小板富集血浆治疗肌腱病的研究进展

血小板富集血浆(PRP)是血小板浓度高于体内正常浓度且富含各种生长因子的血浆制品,通过全血离心去除红细胞后获得。PRP通过释放丰富的细胞因子,促进肌腱细胞及肌腱干细胞增殖、分化及基质的合成分泌,从而促进组织修复和再生。同时,通过抑制疼痛相关因子的表达,缓解患者的疼痛症状。目前大量临床研究表明,PRP对于髌腱病、肱骨外上髁炎、足底筋膜炎等肌腱疾病有着较好的修复作用,但也有一些研究显示其效果不确切,主要是由于PRP提取流程不一致、患者病程不同以及注射方案不同等所导致。因其安全,可作为肌腱病保守治疗的选择,尤其是在其他保守治疗无效的情况。相信通过更多严谨的基础研究及临床试验,规范其使用过程,PRP将在肌腱病的治疗上发挥更重要的作用。     

The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models

The Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity against human and rat plasma kallikrein (K_iapp 2.4 nmol/L and 5.2 nmol/L, respectively). This inhibitory activity is possibly responsible for an effect on hemostasis by prolonging activated partial thromboplastin time (aPTT). Because the association between cancer and thrombosis is well established, we evaluated the possible antithrombotic activity of this protein in venous and arterial thrombosis models. Vein thrombosis was studied in the vena cava ligature model in Wistar rats, and arterial thrombosis in the photochemical induced endothelium lesion model in the carotid artery of C57 black 6 mice. BbKI at a concentration of 2.0 mg/kg reduced the venous thrombus weight by 65% in treated rats in comparison to rats in the control group. The inhibitor prolonged the time for total artery occlusion in the carotid artery model mice indicating that this potent plasma kallikrein inhibitor prevented thrombosis.     

Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery

Interest in the antithrombotic potential of diets enriched with fish oil-derived polyunsaturated fatty acids (omega-3 PUFAs) prompted us to examine how these fatty acids, when taken preoperatively, affect hemostasis, plasma lipid levels, and production of prostacyclin (PGI2) by vascular tissues in atherosclerotic patients undergoing coronary artery bypass graft surgery. Fifteen patients with angiographically proven coronary artery disease received 3 g/day eicosapentaenoic acid and 1.3 g/day docosahexaenoic acid as capsules of purified fish oil for 28 days before surgery. Platelet aggregation induced by low concentrations of ADP, collagen, and epinephrine decreased (p less than 0.05) and serum thromboxane B2 decreased 36% (p less than 0.01) from baseline values. Bleeding times increased 40% (p less than 0.01) from baseline. Serum triglycerides decreased 50% (p less than 0.05) without a change in total serum cholesterol. Spontaneous production of PGI2 measured as 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha), its stable hydrolytic product, by saphenous vein and aortic and atrial tissues obtained at surgery was greater in tissues from patients receiving omega-3 PUFA supplements than in tissues from matched controls (13.8 +/- 2.2 versus 8.6, 21.0 +/- 3.1 versus 11.5 +/- 2.1, and 166 +/- 13 versus 102 +/- 15 ng/g, respectively, all p less than 0.05). Arachidonate-stimulated production of PGI2, as indicated by increased levels of 6-keto-PGF1 alpha, was increased. Despite changes in platelet function, bleeding time, and vascular PGI2, the perioperative blood loss was not increased in subjects receiving fish oil supplements. Thus, omega-3 PUFAs at moderate dosages may exert antithrombotic effects by increasing prostacyclin production by vessel walls as well as by direct inhibition of platelet activity.